on the evolution of the integrative activity of the central nervous system in the phylogeny of vertebrates
Báo cáo sinh học: "The long term effects of chemotherapy on the central nervous system" docx
... certain brain tumors, especially for the very young Because of the rapid myelinization that occurs in infants, the finding by Noble and colleagues [1] of the adverse effects of chemotherapy on ... vulnerable, population of patients Chemotherapy-induced cognitive decline in the absence of radiation The best data on the cognitive effects of chemotherapy alone have come from studies of children with ... were the leukemia and lymphoma cell lines In addition, sublethal concentrations of the drug were associated with suppression of cell division in clonal assays Systemic treatment with AraC in vivo...
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Báo cáo y học: "The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI" ppsx
... randomised arms in the proportions tested Further information on the tests employed, standardisation of tests, statistical power calculations and choice of controls is detailed at the end of the paper ... higher in the case of the latter Analysis of the IQ scores in our control group suggests the presence of a practice effect Out of 132 controls tested at the year time point, 37 were taking their ... and in fact in other areas of acute brain injury, such as head injury, girls usually have better outcomes than boys Again, changes in therapy protocols such as lack of co-administration of high-dose...
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Cancer of the Brain and Other Central Nervous System doc
... Malignant brain tumors in the temporal, frontal, parietal lobes and overlapping lesions of the brain were the most common locations in the brain Malignant tumors in cerebrum and tumors in the occipital ... other CNS cancer, the spine was the most common primary site (53.9% of total), followed by the brain (41.3% of total) and other (4.8% of total) Other CNS cancers in the brain (malignant meningiomas) ... 80 Brain cancer occurring in the frontal lobes (25.8% of total), temporal lobe (20.1% of total), parietal lobe (14.6% of total) and overlapping lesions of the brain (19.8% of total) were the most...
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báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... areas of the spinal cord displaying focal inflammation and demyelination (Fig 2E) Quantification of CCR1, CCR2 and CCR5 mRNAexpressing cells in relation to the stage of demyelinating activity The ... basis of MS [31] A key issue in understanding the pathogenesis of MS is the reliable identification of phagocytes capable of degrading myelin Since infiltration of leukocytes including monocyte-derived ... have demonstrated apoptosis of infiltrating cells in the CNS of animals with EAE [80] The limitation of inflammation seen in the CNS could also be the result of a diminished antigen-presenting capability...
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Báo cáo sinh học: "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system" doc
... disruption of myelination We examined the DPOAE as an indicator of cochlear function and ABRs to provide information on changes in conduction velocity from the ear to the brain, an indicator of myelination ... reduction in the dividing DCX+ population at both day and day 56 In addition, the proportion of GFAP+ cells in the CC was increased among the BrdU+ population at both time points examined Data ... clinically relevant concentrations, we used the following information: routinely used continuous intravenous infusions of 5-FU can result in steady-state plasma and cerebrospinal fluid (CSF) concentrations...
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Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
... immunoreactivity were found in a proportion of the neurons in the brainstem and the staining pattern was similar to those of control brains with nonneurological diseases In the microabscesses, iNOS ... (Zymed) Results Constitutive expression of nNOS and iNOS in the nonneurological control brain Both nNOS and iNOS immunoreactivity was recognized in the brain of control goats No inflammatory cells ... suppurative meningoencephalitis in the midbrain (Fig 2, A), and occasionally in the cerebellum The lesions consisted of microabscesses containing neutrophils, and perivascular cuffing of lymphocytes...
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báo cáo khoa học: "Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature" pdf
... responding to steroids alone [9] But Barron et al [24] indicated that steroid therapy alone failed to improve the condition This finding is consistent with ours Others recommended combination therapy ... viral infections initiate the inflammatory process that somehow becomes self-sustaining [5] It is also speculated that there may be a genetic predisposition in certain individuals leading to ... pathological diagnosis TJ was the surgeon and gave the final approval of the version to be published Competing interests The authors declare that they have no competing interests Received: 18 May...
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báo cáo khoa học: "In vivo observation of gold nanoparticles in the central nervous system of Blaberus discoidalis" potx
... [32] This correlation of activity and the effect of the nAuNPs on the CNS of the insect are due to how the brain of the cockroach controls its muscle response and locomotion [6] There is a significant ... eliminated by using only young males in this study The effects of temperature, humidity, and wind were diminished by maintaining them in a controlled environment However, the fluctuations in Rocha ... by the nAuNPs The XPS was used to verify the presence of nAuNPs embedded in the brain tissue The confocal microscope and TEM were used to gain insights into the interaction of nAuNPs and the insect’s...
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báo cáo khoa học: "Extensive central nervous system involvement in Merkel cell carcinoma: a case report and review of the literature" docx
... but not in the surrounding edema Although the morphologic findings of the supratentorial mass on conventional MRI were consistent with meningioma, the occurrence of the extensive edema and the MR ... Because the patient’s general condition deteriorated rapidly, further radiation therapy against the intraspinal tumors was not possible The patient died two weeks after the detection of the intraspinal ... only Chemotherapy only leptomeningeal metastases of MCC In addition, inguinal and retroperitoneal metastases were found, but the site of the patient’s primary MCC remained unknown Hitherto, only...
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Báo cáo y học: "MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system" docx
... miR-181b nervous thezebrafish brain miR-181a providingthe the zebrafishbrain miR-153a usedfiguresinthe zebrafishnucleic miR-138 testother inthedpf information acid miR-137 expressionininthezebrafish ... situations, the cell would contemporaneously require both the function of the miRNA and its targets We find one class of miRNA expression profile highly suggestive of functioning in this way A few of the ... amacrine cells of the inner nuclear layer (INL in Figure 2d) These patterns indicate expression of some miRNAs is not associated with a transition in the maturation state of the expressing cells...
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Báo cáo y học: "Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender" pdf
... during aging in brain regions were upregulated in the spinal cord, including genes of the UPS, for example (Table S3 in Additional data file 1) In contrast to the spinal cord, very few genes in ... cohort may confound findings concerning the numbers of genes identified as changed in the old group compared to the younger group A change in the expression of a gene during aging might contribute ... of white matter (olidodendrocytes) in the spinal cord may also contribute to the greater effect of aging on the spinal cord transcriptome compared to the four brain regions examined Interestingly,...
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The role of hydrogen sulfide in the central nervous system implications in the treatment of alzheimers disease
... inhibit the production of Aβ or escalate its clearance in the brain The most common mechanisms of action of these drugs are the inhibition of the rate limiting steps of Aβ generation i.e β- and/or ... 6OHDA-induced cell injury (Tiong et al., 2010) These findings in vitro studies were supported by the observations done in animal models of PD Hu et al found out that the systemic administration of ... assembly It serves as a binding for the tubulin Mutations in α-synuclein lead to loss of this binding ability, resulting in tubulin and α-synuclein aggregation Properly functioning microtubules are...
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Genetic engineering and surface modification of baculovirus derived vectors for improved gene delivery to the central nervous system
... functions of the therapeutic genes 1.1.2 Non-viral and Viral Gene Delivery Systems Depending on the usage of vectors, there are two main types of gene delivery systems: non-viral and viral systems ... 1998) Even in the presence of peripheral infection with adenovirus, there is virtually no immune response in the brain following direct injection of “gutless” vectors in rats However, the high ... human body, in which case they are more controllable and have reduced risk in the gene therapy applications In the following section, one type of viral vectors derived from the insect origin, namely...
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Development of hybrid promoters and viral vectors for improved gene delivery to the central nervous system
... functional cells in the nervous system, carrying out the fundamental tasks of receiving, conducting and transmitting signals Therapeutic protection of these cells is one of the main goals of gene therapy ... (Mountain, 2000) The promoter is one of the key issues of gene therapy The expression level and specificity of the therapeutic gene is primarily determined by the activity of the promoter at the ... expression in the rat brain after single injection of recombinant baculoviruses Fig 2.12 Activity of CMV E/PDGF promoter in cortical neurons after injection of baculovirus vectors into the striatum...
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INVESTIGATION OF MEMBRANE PROPERTIES IN THE CENTRAL NERVOUS SYSTEM OF DROSOPHILA MELANOGASTER STUDIED BY FLUORESCENCE CORRELATION SPECTROSCOPY
... fluctuations could be studied using FCS These intensity fluctuations contain information which can be extracted by analysing the rates and the amplitudes of the intensity fluctuations and subjecting them ... self-similarity of a signal in time The derivation on the right is based on the assumption that the statistical properties of the process are independent of time The ACF can also be written in terms of intensity ... limitations The breakthrough in FCS only came in 1993 when Rigler et al introduced a small pinhole in the image plane of their confocal microscope illumination configuration and used a strongly...
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The study of the mediation of ohanin, a king cobra (ophiophagus hannah) toxin through the central nervous system
... to study in detail the regions of interaction of the protein with components in the brain, as this might be useful to the understanding of the control of locomotion and pain responses The identification ... protein wаѕ further confirmed uѕing N-terminаl ѕequencing by Edmаn degrаdаtion The N-terminаl ѕequence of the recombinаnt ohаnin wаѕ АЅPPG, which correѕpondѕ to the N-terminаl of the nаtive protein ... for cloning into the expression vector, VectorM, to express pro-ohanin in E coli BL21/DE3 strain The sub-cloning 21 resulted in expression of fusion protein with hexahistidine tag and thrombin cleavage...
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Section III - Drugs Acting on the Central Nervous System docx
... Here, the axon of an interneuron ends on the terminal of a long-distance neuron as that terminal contacts a dendrite in the dorsal horn Many presynaptic axons contain local collections of typical ... blockade of the synthesis of 5-HT by p-chlorophenylalanine Other evidence against this explanation of LSD-induced hallucinations is potentiation of the effects of LSD by administration of the precursor ... the lungs to blood and then to the brain, including (1) concentration of the anesthetic agent in inspired gas, (2) pulmonary ventilation delivering the anesthetic to the lungs, (3) transfer of...
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Báo cáo y học: "Ischemia as a possible effect of increased intraabdominal pressure on central nervous system cytokines, lactate and perfusion pressures" ppsx
... further impeding CSF absorption from the arachnoid villi Taking into consideration the current knowledge concerning the impact of IAH on the CNS we conducted an experimental study in animals in ... mmHg, in order to augment the impact of IAH on CNS and draw safer conclusions for this relationship Finally, the increase of IAP in phase T3 is considered as ACS, according to definitions of the ... Citerio G, Malbrain M: The influence of intra-abdominal hypertension on the central nervous system: current insights and clinical recommendations, is it all in the head? Acta Clinica Belgica 2007,...
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Characterization of MP2 cell division and pins function on spindle asymmetry of drosophila central nervous system
... CHARACTERIZATION OF MP2 CELL DIVISION AND PINS FUNCTION ON SPINDLE ASYMMETRY OF DROSOPHILA CENTRAL NERVOUS SYSTEM LIN SHUPING (M.Sc.) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ... identity defined by the position of formation within a segment, its time of formation, the combination of specific genes that it expresses and the largely invariant clone of neurons 17 Chapter Introduction ... region of the insc locus and inscP49 which removes part of its genomic region (Kraut and Campos-Ortega, 1996) The expression of Insc is first observed in the cells of mitotic domain (in the procephalic...
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Effects of central nervous system free fatty acids, prostaglandins and lysophospholipids on allodynia in a mouse model of orofacial pain
... control theory of pain (Melzack and Wall, 1965), concentrated on the measurement of the pain intensity However the gate control theory of pain led to the recognition that pain rarely has a one-to-one ... amount of solution is estimated to result in final extracellular concentration of µM of compounds, assuming diffusion in the cerebrospinal fluid and distribution in 1.5 ml of central nervous ... Verification of injection site: These coordinates had earlier been verified by injection of Indian ink into the ventricles 37 (b) Facial carrageenan injection All mice received a facial injection of...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25