new concepts on the critical functions of cancer and metastasis initiating cells in treatment resistance and disease relapse molecular mechanisms signaling transduction elements and novel targeting therapies
... cases: the lower the ratio ofthe top to middle income quintiles (the closer is the middle class to the rich), the higher is the sharegain ofthe top quintile andthe lower is the sharegain ofthe ... leftwing and whether this effect is conditional onthe age ofthe left-wing party The specifications and estimation methodology are the same as in columns three and four in Table 1, adding the ... left-wing party, the smaller is the sharegain ofthe poor andthe larger (although still negative) is the sharegain ofthe rich The effects are large: a one standard deviation increase inthe age of...
... all chemotherapy sensitivity in physical, cognitive and role functioning and not inthe scales being strongly correlated with the ICS, as emotional functioning and only at one point inthe global ... specific individual skills of adaptation detecting tool There are significant limitations in our study inthe lack of parallel recording ofthe SOC scale inthe first and second part ofthe study In ... between cancer patients and healthy control and confirmed a good responsiveness ofthe ICS during cancertreatment Therefore, ICS could be an interesting instrument to capture the feeling of inner...
... from the Orthopaedic Research & Education Foundation andthe Royal College of Surgeons in Ireland Neither of these organizations participated in study design; inthe collection, analysis, and interpretation ... contributions HG, BB, KJS and KJM all made substantial contributions to conception and design, acquisition of data, analysis and interpretation of data; KJM, KJS and HG were involved in drafting the ... changes in all components ofthe WOMAC, a disease specific measure The second factor is based on changes inthe KSS functional component, physician based VAS of patient severity andon changes in the...
... efficacy of analog drawing The first day and a half of drawing exercises includes the lessons in this book through the drawing ofthe hand The twofold objective ofthe drawing lessons is to present the ... responding to? You were seeing and responding to the felt, individual qualities of each “drawn” line or set of lines You responded to the felt speed ofthe line, the size and spacing ofthe marks, ... understanding at this time Drawing onthe Right Side ofthe Brain, I believe, was one ofthe first practical educational applications of Roger Sperry’s pioneering insight into the dual nature of human...
... classification: 05C69 Introduction In this paper, we continue the study of domination in graphs Domination in graphs is now well studied in graph theory The literature on this subject has been surveyed and ... detailed proof of Theorem is very technical, we provide here only a summary ofthe main ideas ofthe proof A detailed proof of Theorem is provided inthe appendix the electronic journal of combinatorics ... least one component of G∗ must therefore belong to the family F and this component of G∗ in F contains no vertex from X The graph G∗ has at most two components, namely a component Gb containing the...
... Impact ofthe density of inoculations with Ophiostoma brunneo-ciliatum into bark of young Scots pine trees on: (a) the length ofthe induced reaction zones inthe bark tissues; (b) the fraction of ... pine The different markers of susceptibility ofthe trees to the fungus behaved very dissimilarly in response to increasing inoculation densities The length ofthe induced reaction zone inthe ... points andofthe width of inoculation belts on different parameters describing the responses ofthe trees P (at 5%) Hydraulic conductivity of inoculated stem segments (Ks) Reaction length in the...
... well-known consequence ofthe matrix-tree theorem that the number ofelementsofthe sandpile group with sink w∗ is equal to κ(G, w∗ ) For a basic exposition ofthe properties ofthe sandpile group, the ... the kernel of τ is contained inthe k-torsion of K(LG, e∗ ), and to show equality it suffices to show that σ is injective The case where k = is trivial since there are no G satisfying the hypotheses: ... a and David B Wilson Chip-firing and rotor-routing on directed graphs InInand out of equilibrium 2, volume 60 of Progr Probab., pages 331–364 Birkh¨user, Basel, a 2008 [3] Lionel Levine Sandpile...
... conditions and at developing kinetic models for the pyrolysis and combustion of these fuels, for which there is lack of information inthe literature The obtained data should be useful for the ... corrosion, slagging and fouling of boilers and agglomeration when used in fluidized beds [12] Onthe other hand, RDF ash is richer in calcium and silicon, while poorer in phosphorus and alkali, indicating ... Part ofthe decomposition above 700°C (not shown onthe graph) was attributed to the calcium carbonate ofthe sample, the content of which was about 45% in ash Therefore, the DTG peaks of the...
... domain of b1 or b3 [68] contribute to the regulation of integrin function Therefore, we speculate that modification of particular sites, which are involved in regulation ofthe conformation of integrin, ... regulates integrin and E-cadherin function Integrin sugar chains play important roles inthe biological functionsof integrins A growing body of evidence indicates that the presence ofthe appropriate ... binding site The C-terminal segments traverse the plasma membrane and mediate interactions with the cytoskeleton and with signaling molecules Onthe basis of extensive searches ofthe human and...
... reflect the mechanism of Ca2+ switching involving the alternative binding ofthe C-terminal region of TnI to actin or TnC in a Ca2+dependent manner [17,19] Onthe other hand, the inhibitory effect of ... vertebrates and mollusks In molluskan troponin, the activation is probably induced by strengthening ofthe interaction between the structural TnCbinding site andthe C-domain of TnC accompanying Ca2+ binding ... TnC-binding site [16] This interaction induces the dissociation ofthe inhibitory region, which is adjacent to the regulatory TnC-binding site, from actin, resulting inthe release ofthe inhibition...
... short-sale constraint on asset The net result of imposing a short-sale constraint onthe IPO stock is to increase the IPO price whenever the constraint is binding This 28 result hence con…rms the intuition ... domination of Microsoft inthe software market for personal computers and network computers Amazon.com, the pioneer of online retailing, imposed intense competitive pressure on traditional “bricks -and- mortar” ... From the point of view that innovation is the source of sustained economic growth and economic development (Schumpeter 1934, 1942), new enterprises represent the future ofthe economic system Therefore,...
... Limestone Limestone Limestone Limestone Limestone Limestone Limestone Limestone Limestone Limestone Limestone Limestone Claystone Claystone Claystone Claystone Claystone Claystone Claystone Claystone ... Claystone Claystone Claystone Claystone Claystone Sandstone Sandstone Sandstone Sandstone Sandstone Sandstone Sandstone Sandstone Sand Sand Sand Sand Loess Loess Loess Loess Loess Loess Loess Loess ... closely related to the carbonate buffering system inthe soil Onthe other hand, Fe, S and all trace elements were not considered Inthe absence of a comprehensive set of N mineralization data, we used...
... terms of physiological and morphological changes that allow the plant acclimatization to thenew conditions [5] Inthe case of increase in irradiance as a result of opening the stand, seedlings ... forest, one ofthe southernmost ofthe species, was nearby At the beginning of 1998, a felling was carried out in a strip ofthe pinewood Trees in alternate rows following level lines were cut ... DISCUSSION Irradiance level, estimated from light index increased inthe understory inthe two years after the thinning of pine trees The increase in stomatal density, blade Inthe present study the...
... retention of less than 200 ml and a length of stay above the median was related to improved success of feeding Ofthe remaining interventions, the administration of contrast via the tube, the need ... aimed at obtaining a continuous and long-term overall insight into the volume, energy content and amount of proteins administered to and actually received by the patient The objective of this study ... routine for optimal continuation ofthe feeding process in comparison with the efforts taken to support patients in need of ventilation and assisted circulation Improvement of nutritional intake...
... estimated 13.0% inthe 1820’s to only 0.5% ofthe total land area and it is now found only in small patches inthe northern part ofthe Singapore main island andon Pulau Tekong and Pulau Ubin (Hsiang, ... stated inthe previous section These questions form the basis for the structure of this thesis Each research question is elaborated herein andthe corresponding chapters discussing the question are ... corresponding influence to current flow Inthe main body of this thesis, each chapter has chapter conclusion that make clear what is the main findings about the results and how the findings advance...
... falcipains has not been convincing 74 In this section, the likelihood of chalcones acting on targets inthe digestive vacuole of Plasmodium is investigated The decision to focus on events involving ... chalcones, in particular, the 2’hydroxychalcones There is also a strong preference for naphthalene and pyridine rings among the hematin-binding chalcones In contrast, quinoline andthe usual benzenoid ... determined with a scintillation counter Controls consisted of samples processed without test compound ([14C] methemoglobin and lysate) and samples containing only [14C] methemoglobin inthe incubation...
... dual-acting drug Onthe other hand, there might be reasons to focus on only one activity to the exclusion ofthe other Regardless ofthe objective, defining structure-activity relationships for ... measures ofthe ease of electron loss and electron gain ofthe compound 61 respectively When the HOMO of a compound has a low energy value, the tendency for electron donation is poor Onthe other hand ... moment The energies of HOMO and LUMO serve as indicators ofthe electron donating and electron acceptor abilities ofthe molecule respectively The higher the energy of HOMO, the better its electron...
... DESIGN AND SYNTHESIS OF TARGET COMPOUNDS 3.1 Introduction In this section, the rationale behind the design ofthe chalcones is presented The synthetic methods employed inthe preparation ofthe ... electronic factors 3.3.2 Characterization of chalcones The successful synthesis ofthe targeted chalcones was confirmed by monitoring the position ofthe α,β-unsaturated carbonyl linkage inthe infrared ... properties of flavonoids have been ascribed to the participation ofthe dihydroxy groups in ring A andthe 2,3-double bond in conjugation with the 4oxo function inthe C ring (Scheme 1.5) 134 Flavonoids...
... domain G ⊂ Cn and w0 ∈ bG This finishes the proof By the definition of strong u-property, lemmas and 4, we obtain the following corollary Corollary Suppose that D and G are C ∞ -smooth domains in ... we use ≈ for the combination ofand Definition (see [27]) We say that a domain D has the strong u-property at the boundary z0 if it has the u-property with u satisfying the following: +∞ (i) ... (see the detailed proof in Section 4) This finishes our proof This paper is organized as follows In Section 2, we prove Theorem In Section 3, we prove several lemmas to be used mainly inthe proof...