new and emerging therapeutic modalities for treatment of aml in the elderly
Báo cáo khoa học: A new and efficient method for inhibition of RNA viruses by DNA interference pptx
... of different tags on either the 5¢-end or the 3¢-end [5] Despite common features of RNA silencing, there are differences between the animal and plant kingdoms The mechanism of RNA silencing in ... TAR-RNA-binding protein [10] and Argonaute (Ago) proteins [11] It is thought that Dicer–Ago protein complex formation is crucial for siRNA channelling into RISC and mediating the transition between the ... the initiation and execution phases of RNAi Ago proteins are key components of RISC responsible for the cleavage of the target RNA The cleavage is catalysed by a Piwi domain of Ago proteins, the...
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Báo cáo y học: "Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection" potx
... levels of these cytokines in control serum and the injected ACS TGF-β1 levels in SF were lower than in the injected ACS, and OPG levels in SF were higher than in ACS (P < 0.01) During the course of ... and interpreted the data and drafted the manuscript DS participated in design and coordination of the study and revised the manuscript WD was involved in design of the study and revised the manuscript ... of Il-1 signalling in OA, in the one human clinical study using recombinant IL-1ra as a treatment for OA, a single injection into the knee joint did not result in an improvement of OA symptoms...
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Báo cáo y học: "Response to: Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection – authors’ reply" ppt
... De Uithof, 3584 CL Utrecht, The Netherlands Published: 17 December 2010 References Moser C: Response to: Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro ... metabolism and intra-articular levels after injection Arthritis Research Ther 2010, 12:410 Rutgers M, Saris DBF, Dhert WJA, Creemers LB: Cytokine profile of autologous conditioned serum for treatment of ... to whether this treatment merits registration Page of Abbreviations ACS, autologous conditioned serum; IL-1, interleukin-1; OA, osteoarthritis Competing interests The authors declare that they...
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Update on the management of constipation in the elderly: new treatment options doc
... assess the amount of fiber and water intake, and the number of meals and when they are consumed The history should also include the number, type and frequency of laxatives used In the elderly, ... straightening the anorectal angle Simultaneously, the voluntary efforts of bearing down increases the intra-abdominal pressure, facilitating the development of a stripping wave, resulting in stool ... reported that colchicine increases prostaglandin synthesis, intestinal secretion and gastrointestrial motility.45 It also reduces water and electrolyte absorption in the intestine and increases secretion...
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Báo cáo y học: "Cost-effectiveness model comparing olanzapine and other oral atypical antipsychotics in the treatment of schizophrenia in the United States" ppt
... to examine the uncertainty in the model and the stability of the results The first PSA allowed the input values for adherence rates, relapse rates, treatment discontinuation rates, and the generic ... $38 [71] These results remain robust despite the fact that they are assumed to occur in the first quarter of treatment initiation, rather than weighing the increase in the rates over the quarterly ... quarter based on the findings of Leslie and Rosenheck [84] The baseline assumption for the quarterly costs of statins for hyperlipidemia therapy is $225 and is based on a 50% market share of 40 mg generic...
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Tài liệu Gulf War and Health: Volume 4. Health Effects of Serving in the Gulf War docx
... agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities The Council ... achievements of engineers Dr Wm A Wulf is president of the National Academy of Engineering The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of ... services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public The Institute acts under the responsibility given to the National...
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báo cáo hóa học:" Medication quality and quality of life in the elderly, a cohort study" doc
... participated in the statistical analysis and the drafting of the manuscript PE participated in the design of the study and the drafting of the manuscript All authors read and approved the final manuscript ... Today there are guidelines for treatment of individual diseases, but there is a lack of guidelines and goals for treatment of the elderly with many diseases [38] In the healthcare system there ... satisfaction and capability of managing the medication and the dosage regimen/dispensing and screening for cognitive impairment since this is often omitted and is a main issue for the patients’...
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Báo cáo y học: "Usefulness of procalcitonin for diagnosis of sepsis in the intensive care unit" doc
... assays were blinded to the clinical status of the patient The PCT results were not available during the study period Routine cultures of blood and urine, and of samples from trachea and suspected ... conditions for statistical analysis of diagnostic reliability of serum PCT and cytokines Using Youden’s Index, the best cutoff value for PCT was 2.415 ng/ml The best cutoff value and AUC for all ... resistance strains Further studies of the early phases of sepsis are necessary to define the role of PCT in possible therapeutic strategies, such as antimicrobial and immunological therapies, and cost...
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Báo cáo khoa học: "The key advance in the treatment of sepsis in the last 10 years … doing less" pot
... R: Intensive insulin therapy in the medical ICU N Engl J Med 2006, 354:449-461 Singer M, Glynne P: Treating critical illness: the importance of first doing no harm PLoS Med 2005, 2:e167 Page of ... AR, Young D, Black N, Rowan K: Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland Crit Care Med 2003, 31:2332-2338 Annane ... gains but at the expense of longer-term detriment [13] A greater understanding of both disease pathophysiology and iatrogenic harm will, I believe, lead to even better management, and thus further...
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Báo cáo y học: " Therapeutic targets for HIV-1 infection in the host proteome" pot
... SDF-1 is the ligand for the CXCR4 co-receptor and can block HIV-1 infection via co-receptor binding Therefore, the expression of the SDF receptor could serve as an alternate binding site for SDF-1, ... HIV-1 and thus necessitate further study, seem to be the CAP-binding protein complex interacting protein, tropomyosin beta, BTG3, the IL-10R, PPGB, and cathepsins Z and L2 [see Additional File and ... contribution of PPGB in HIV1 infection, a number of reports have illustrated the importance of NA in increasing the efficiency of viral binding and entry [35,36] NA is a sialidase that exposes sites on the...
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Báo cáo y học: "Treatment of hypophosphatemia in the intensive care unit: a review" doc
... PES, and MJS participated in drafting and reviewing the manuscript All authors approved the final version of the manuscript Competing interests The authors declare that they have no competing interests ... AZ, The Netherlands Department of Intensive Care Medicine, Gelre Hospitals, location Lukas, PO Box 9014, Apeldoorn, 7300 DS, The Netherlands 6Laboratory of Experimental Intensive Care and Anesthesiology ... Taking this into account, the indication for – and recommended frequency of – laboratory monitoring and treatment remains debatable Correction of hypophosphatemia is possible via oral or intravenous...
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Prevention of falls in the elderly living at home pdf
... the prevention of falls It is intended for all those who are involved in the care of the elderly and is an invitation to all health and sociomedical actors to join forces for the well-being of ... evidence for the relation between a given risk factor and falling [table I] Assessment of the level of risk for the elderly person Screening tools and means of assessment for the risk of falls in the ... and socioeconomic advances have led to considerable improvement in the health of the elderly, thus extending the period of physical autonomy, and retarding the onset of the effects of aging The...
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Compression of morbidity in the elderly pot
... Similar declines occur in other organ systems What would be the full range of eects if declines in the immune and in ammatory systems were prevented or reversed in the setting of declines in other ... one-half the amount of disability in 1587 the last one or two years of life The same results obtained in males and in females, and in those without disability in 1962 and 1986 This 100% decrease in ... of death shifts from external towards intrinsic factors The formally assigned ``cause of death'' becomes increasingly irrelevant compared with the underlying frailty, the inability of the aging...
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Epidemiology of hypertension in the elderly pptx
... Based on the Hellenic Society for the Study of Hypertension guidelines (2008) the aim of the screening of blood pressure in the hypertensive subjects under 65 years old is to maintain the blood ... increase is being associated with increased salt intake, with the elderly and the obese being the more sensitive On the other hand, an inverse relationship between potassium dietary intake and blood ... conducted in the special infrastructures for the protection of the elderly in Greece, it has been reported that 72.9% of the males and 77.1% of females had high blood pressure 15, nevertheless,...
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Tài liệu Báo cáo khoa học: Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases pptx
... in ammation induces a state of ‘leptin resistance’ in obese animals and humans resulting in development of hyperleptinemia Similarly, hyperleptinemia is a consequence of the development of insulin resistance ... overexpression of ANGPTL6 ⁄ AGF in the liver of diet-induced obese mice results in elevated ANGPTL6 ⁄ AGF serum levels and amelioration of diet-induced obesity and insulin resistance [14] Taken together, these ... The expression of in ammatory cytokines (tumor necrosis factor-a, interleukin-6 and interleukin-1b) was increased in the adipose tissue of ANGPTL2 transgenic mice compared with that of wild-type...
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Báo cáo y học: "Inhalation with Fucose and Galactose for Treatment of Pseudomonas Aeruginosa in Cystic Fibrosis Patients"
... factor-α, interleukin-10) were performed before and after treatment The study protocol was approved by the local Ethics Committee of the City of Hamburg, Germany Sputum sampling After rinsing their ... vilrulence of this bacterium (10) Therefore blocking of these lectins may prevent ongoing colonization and inflammation Although fucose/galactose has been demonstrated to be effective in vitro and in ... present there is no information available on the clinical effect of fucose/galacatose when given to CF patients In the present study both inhalation of fucose/galactose solution alone and combined therapy...
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Daptomycin for Treatment of Complicated Skin and Skin Structure Infections pot
... complicated skin and skin structure infections—developing antimicrobial drugs for treatment 1998 Arbeit RD, et al The safety and efficacy of daptomycin for the treatment of complicated skin and skin-structure ... prolonging the dosing interval, increasing the dose of daptomycin may place patients at high risk for CPK elevation In a phase III clinical trial evaluating daptomycin 6 mg/kg/day for treatment of ... within 30–60 minutes after the end of a 30-minute IV i nfusion Within the typical therapeutic dosing ranges and interval, the steady-state Cmax and AUC of daptomycin rises proportionally to increasing...
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Compendium of new and emerging health technologies ppt
... directing white light into the skin of the newborn and measuring the intensity of the specific wavelengths that are returned By knowing the spectral properties of the components within the skin, ... xylocaine) may be injected in the area just before inserting the device to make it pain free For the insertion of the device, the local health worker/nurse previously involved in delivering the ... restraint is placed in a rear seat of the vehicle and is put in the rear or forward facing configuration based on the size and weight of the child Then, it is secured to the seat of the car using the...
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Báo cáo khoa học: "Electro-acupuncture and Chinese herbs for treatment of cervical intervertebral disk disease in a dog" potx
... dniw lepxe ot nesohc saw alumrof tsrif ehT ]51,31[ ,alumrof cinot a yb dewollof , dna :tnemtaert rof nesohc erew )1 elbaT( salumrof labreh esenihC lanoitidart gniwollof ehT seigrene yendiK dna neelpS ... laitini sa hcus sgnidnif no desab dna yrotsih lacinilc fo noitaulave yb demrofrep saw sisongaid MCT skeew 21 gnirud demrofrep saw tnemtaert erutcnupucaortcele elohw ehT snoitacilppa tsal eht rof ... stes hthgie dna htneves eht pu edam stniop lacol lacivrec ruof eht dna stes htxis dna htfif eht 6PS/93BG dna 06LB/3IK ,tes htrof eht demrof 32LB ,tes driht eht pu edam ,edis thgir eht no detacol...
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