nad biosynthetic genes and telomere capping
Báo cáo y học: "Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas" ppsx
... genes in relation to MYCN and c-MYC levels has not yet been defined in neuroblastoma subtypes Here, we defined a core set of MYCN and c-MYC target genes by using oligonucleotide microarrays and ... these genes Similar profiles were observed with direct MYCN target genes, such as MDM2 and MCM7 (Additional data file 1) We used SH-EPMYCN cells for a global search of MYCN and cMYC target genes ... I and II Subgroup I genes (clusters 140, 168, and 195) were expressed at equal levels in SH-EPMYCN cells expressing endogenous c-MYC (2 hours) and in those fully expressing ectopic MYCN (24 and...
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báo cáo khoa học: "Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties" pot
... hemi-methylated strands, UHRF1 is recruited with DNMT1 and/ or likely DNMT3a and DNMT3b, in order to perpetuate gene repression, and particularly that of TSGs in cancer cells Recently, two novel and interesting ... other tumour suppressor genes such as p53 and p73 products [46,67] This suggests that the appearance of genetic and/ or epigenetic abnormalities of TSGs including p53 and p73 genes, in various human ... activates growth-promoting genes (proto-oncogenes), promoters of tumour suppressor genes are frequently hypermethylated and this contributes to carcinogenesis [16] Various TSGs are silenced in...
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Báo cáo y học: "Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units"
... count and respiratory rate (r = 0.195, P = 0.011), between the eosinophil cell count and heart rate (r = -0.335, P < 0.001), and between the eosinophil cell count and Acute Physiology and Chronic ... between eosinophils and CRP groups Authors' contributions KA and IK contributed equally to the work KA and IK drafted the manuscript and participated in the acquisition of data and the study design ... count between noninfected patients (negative, SIRS) and infected patients (sepsis, severe sepsis, and septic shock), and between SIRS patients and infected patients on the day of admission to the...
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Báo cáo sinh học: " High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916" potx
... cycle and response studies CM participated in the design of the study and performed the statistical analysis YD, MAH, CM conceived of the study, and participated in its design and coordination and ... sensitive and diploid T-ALL cell line MOLT16, and a polyploid and resistant T-ALL cell line CTV-1 were treated with increasing concentrations of GSK1070916 for different time periods, and a flow ... Karyotype and Mutation Data Karyotype data included both G-banding and Spectral Karytoyping (SKY) was collected from a variety of public sources including the DSMZ [16], ATCC [17], and the NCBI...
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o cáo hóa học:" High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916" ppt
... cycle and response studies CM participated in the design of the study and performed the statistical analysis YD, MAH, CM conceived of the study, and participated in its design and coordination and ... sensitive and diploid T-ALL cell line MOLT16, and a polyploid and resistant T-ALL cell line CTV-1 were treated with increasing concentrations of GSK1070916 for different time periods, and a flow ... Karyotype and Mutation Data Karyotype data included both G-banding and Spectral Karytoyping (SKY) was collected from a variety of public sources including the DSMZ [16], ATCC [17], and the NCBI...
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C elegans PRDM1 blimp1 homolog BLMP 1 is a positive regulator of bed 3 transcription
... Wnt8 and Otx genes in a Cisregulatory module and induces the transcription of eve and hox11/13b (Davidson et al., 2002b; Yuh et al., 2004; Minokawa et al., 2005; Livi and Davidson, 2006; Smith and ... Location and enhancer activity analysis of NspI and its sub-fragments…………….32 A: Location and enhancer activity analysis of NspI, F1, F2, F3 and sub-fragments of F2 (including SF1, SF2 and SF3) ... Materials and methods C elegans strains, alleles and transgenic lines Worms were maintained as described (Brenner, 1974) The strains and alleles used in this study are shown in Table and Table N2 (standard...
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C elegans PRDM1 blimp1 homolog BLMP 1 is a positive regulator of bed 3 transcription
... Wnt8 and Otx genes in a Cisregulatory module and induces the transcription of eve and hox11/13b (Davidson et al., 2002b; Yuh et al., 2004; Minokawa et al., 2005; Livi and Davidson, 2006; Smith and ... Location and enhancer activity analysis of NspI and its sub-fragments…………….32 A: Location and enhancer activity analysis of NspI, F1, F2, F3 and sub-fragments of F2 (including SF1, SF2 and SF3) ... Materials and methods C elegans strains, alleles and transgenic lines Worms were maintained as described (Brenner, 1974) The strains and alleles used in this study are shown in Table and Table N2 (standard...
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Báo cáo y học: "Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients"
... complement, cytokines, fibrin, activated platelets and leucocytes, and changes in oxygenation or blood flow [8,15] Orfanos and colleagues [25] and Ganter and colleagues [22] reported that in septic ... supervised the project and reviewed the manuscript JTK designed and supervised the research, enrolled patients and reviewed the manuscript PK and AL contributed equally to the work and are both considered ... low Ang-1 and VEGF; Ang-2 correlates with severity of illness (APACHE II and SOFA scores), pulmonary dysfunc- Page of (page number not for citation purposes) tion (PaO2/FiO2 and PaO2) and tissue...
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Tài liệu .An ARCO Book ARCO is a registered trademark of Thomson Learning, Inc., and is used herein under pptx
... GMAT stand for Graduate Management Admission Test, which is a standardized exam given at various locations in the United States and Canada and around the world Throughout North America and in ... 376 Answer Key and Explanations 378 Roots and Radicals 379 Exercise 381 Answer Key and Explanations 382 Factoring and Algebraic Fractions ... test preparation, and financial aid Its Web site offers searchable databases and interactive tools for contacting educational institutions, online practice tests and instruction, and planning tools...
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Tài liệu Báo cáo khoa học: Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase d and S6K1 and regulating cell growth docx
... the ER and POLDIP3 genes Array of 76 polyA+ RNA samples isolated from various human adult and fetal tissues and cancer cell lines was hybridized with the radiolabeled ER cDNA probe (A) and after ... gel and stained with silver [40] Mass spectrometry A protein band was excised from a gel and analyzed by tandem mass spectrometry at Laboratory of Mass Spectrometry, Institute of Biochemistry and ... SKAR(A-K)] and the b-galactosidase X-gal colony-lift filter and histidine prototrophy assays were performed Results are shown as ‘+’ and ‘–’ in the presence (both tests were positive) and absence...
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Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx
... concentrations of LPS and IFN NO production is reported to be stimulated by LPS and IFN through independent signal pathways; LPS and IFN stimulate cells by activating NF-jB and the interferon regulatory ... the effects of inhibitors of PKA and PKC on TS-enhanced NO production As shown in Fig 5A, the PKA inhibitors KT-5720 and H8 and the PKC inhibitors Ro31-2880 and GF109203X did not affect apparently ... Effects of PKA inhibitors (KT-5720 and H8) and PKC inhibitors (Ro31-8220 and GF109203X) on the enhancement by TS of LPS/IFNinduced NO production in VSMC (A), and Western blot analysis of PKCa...
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Báo cáo khoa học: Xenopus Rbm9 is a novel interactor of XGld2 in the cytoplasmic polyadenylation complex pptx
... MS2-U1A and MS2-PABP) and the Luc-MS2 reporter were supplied by N Minshall and N Standart (University of Cambridge, UK) [29] The plasmid encoding HA-MS2-XGld2 was supplied by L Rouhana and M Wickens ... reagents, advice and assistance during the two-hybrid screen We are grateful to Nicola Minshall and Nancy Standart for the tethering assay constructs, and to Marvin Wickens and Labib Rouhana ... co-precipitate endogenous XRbm9 with XGld2 and CPEB Reciprocally, overexpressed XGld2 and endogenous CPSF100 and CPEB were co-precipitated with the XRbm9, CPEB and XGld2 antibodies Finally, in oocytes...
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Báo cáo khoa học: "Creative Language Retrieval: A Robust Hybrid of Information Retrieval and Linguistic Creativity" pot
... level, as in “priests and imams” or “mosques and synagogues” More generally, consider the pattern “X and Y”, where X and Y are proper-names (e.g., “Zeus and Hera”), or X and Y are inflected nouns ... We can evaluate the effectiveness of ? and @, and indirectly that of ^ too, by comparing the use of ? and @ as category builders to a hand-crafted gold standard like WordNet Other researchers ... and ? are derived automatically, via pattern-matching and corpus analysis Nonetheless, ad-hoc categories in creative IR are often populated with the bindings produced by uses of @ and 284 ? and...
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Báo cáo khoa học: Insect cytokine, growth-blocking peptide, is a primary regulator of melanin-synthesis enzymes in armyworm larval cuticle pptx
... enzyme genes in the dorsal integument requires cytoplasmic Ca2+ Specific expression of TH and DDC genes in the integument To produce black stripes, GBP has to activate expression of TH and DDC genes ... enzyme genes is regulated by Ca2+ concentration To test this possibility, isolated integuments were incubated with the calcium ionophore A23187, and the 1770 L6D1 expression levels of TH and DDC genes ... Ninomiya and Y Hayakawa Stop 1884 531 3’UTR 5’UTR Fig Gene structures of P separata TH expressed in integuments and brains Epidermis (AB274834) and brain (AB274835) forms of P separata TH genes...
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Báo cáo khoa học: A designed curved DNA segment that is a remarkable activator of eukaryotic transcription potx
... TLN and pST0 ⁄ TLN-7 ⁄ EBVori have been reported previously [12,14] In the construct names, ‘ST’, ‘LHC’ and ‘RHC’ indicate straight, left-handed curved and right-handed curved, respectively, and ... periodicities smaller than 10.5 bp give left-handed curves, and those larger than 10.5 bp give right-handed curves [12,13] Based on this knowledge, left-handed or righthanded curved DNA segments were prepared ... with EcoRI and BamHI The fragment was then blunted and ligated to phosphorylated PstI linkers (5¢-GCTGCAGC-3¢) Subsequently, the resulting fragment was digested with SacII, and blunted and digested...
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Báo cáo khoa học: Ets-1/ Elk-1 is a critical mediator of dipeptidyl-peptidase III transcription in human glioblastoma cells pdf
... 7B; lanes and 7), Upregulation of DPP-III expression and promoter activity by v-Ha-ras Promoter deletion analysis, site-directed mutagenesis, EMSA and ChIP assays demonstrated that Ets-1 and Elk-1 ... CLR and CLDR cells before and after treating cells with either U0126 (10 lgÆmL)1) or dimethylsulfoxide was reverse transcribed and subjected to real time PCR using DPP-III (DPP F20 and AAS1) and ... using DPP-III F-124 and DPP-III R-21 as the sense and antisense primers pAAS-1 was used as a template for the PCR The 99 bp amplified fragment was digested with XhoI and HindIII and cloned into the...
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Báo cáo khoa học: Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein potx
... inflammation, wound healing and cancer progression Further experiments of tissue injury and inflammation using genetically engineered mouse models of the HGFA and MSP genes are needed to explore ... Japan) and random primers (6-mer) (Takara Bio) using 200 units of ReverTraAceÔ (TOYOBO, Osaka, Japan), and 1/30 of the resultant cDNA was processed for each PCR with 0.1 lm of both forward and reverse ... roles in survival, repair and regeneration of the injured tissue [12,19] The activity of HGFA is tightly regulated by PCI in human serum and also by HGFA inhibitor type and type on the epithelial...
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Báo cáo khoa học: Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours pot
... tumour development In this kind of tumour, AP-1 and c-fos were shown to be able to downregulate tumour suppressor genes and favour angiogenesis and tumour invasiveness [68] Therefore, AP-1 activation ... cancer cells the oxygen and nutrients essential for their survival and proliferation In the absence of angiogenesis and new blood vessel formation, tumour growth is restricted, and the tumour size ... [18,22,23,35] The use of these techniques and their combination allow a better understanding of spatial and temporal changes in hypoxia in solid tumours, and also allow the linkage of these changes...
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Báo cáo khoa học: The leech product saratin is a potent inhibitor of platelet integrin a2b1 and von Willebrand factor binding to collagen pdf
... thank Steve P Watson and Andras Gruber for stimulating discussions, and Dr Barry Coller for the generous gifts of 6F1 and 6D1 Tara C White and Michelle A Berny are ARCS scholars, and David K Robinson ... adhesion and activation Three such molecules, LAPP (an approximately 13 kDa leech antiplatelet protein isolated from Haementeria officinalis) and calin and saratin (approximately 65 kDa and 12 kDa ... stenosis in carotid endarterectomized rats [19] and to reduce platelet adhesion and intimal hyperplasia in both a nondiseased environment [20] and in the state of hyperhomocystinemia [21] Moreover,...
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Báo cáo khoa học: Myocyte enhancer factor 2 (MEF2) is a key modulator of the expression of the prothoracicotropic hormone gene in the silkworm, Bombyx mori ppt
... expression of BmMEF2 and PTTH genes RT-PCR and Southern blot analysis (A, B) were performed during embryogenesis h (2 h) and (3d), (5d), and (9d) days after oviposition (Em) and on day in fifth ... homo- and heterodimers through the consensus MEF2 binding sequence, C ⁄ TTA(A ⁄ T)4TAG ⁄ A [12] This sequence is found in the upstream regions of numerous genes including muscle-specific genes, and ... cells These cells coexpress PERIOD and various peptides, such as FMRFamide, and leu-enkephalin [20,21] Furthermore, the genes of Antheraea pernyi, timeless, and period are also expressed exclusively...
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