mouse models of the fragile x premutation and the fragile x associated tremor ataxia syndrome
Mouse models of breast cancer metastasis: Anna Fantozzi and Gerhard Christofori pdf
... expand, proliferate, and invade neighboring tissue The cross-talk and interactions between tumor cells and the surrounding stroma, the extracellular matrix (ECM), and infiltrating cells of the ... research and in the testing of experimental therapies, the use of mouse models carries several limitations There are obvious differences between human and mouse tumorigenesis, among which are the ... for example in the wellcharacterized MMTV-Neu and MMTV-PyMT mouse models of breast carcinogenesis or in improved versions of these MMTV-PyMT Mammary gland-specific expression of PyMT under the...
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báo cáo hóa học: " Gait dynamics in mouse models of Parkinson''''s disease and Huntington''''s disease" doc
... ameliorate gait abnormalities [12,13] Mouse models of PD and HD are used to understand the pathologies of the diseases and to accelerate the testing of new therapies to correct motor defects Although ... placement of the paw relative to the treadmill belt The color images were converted to their binary matrix equivalents, and the areas (in pixels) of the approaching or retreating paws relative to the ... MPTP-treated mouse Gait signals in a MPTP-treated mouse Gait signal of the right hind limb of a MPTP-treated mouse superimposed over the gait signal of the right hind limb of a saline-treated mouse...
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báo cáo hóa học: " Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD" pptx
... untreated alone and the Tg-SwDI mouse model of cerebral amyloid angiopathy (CAA) [28,33] Differences in the gene expression profiles between the mouse models were observed In the Tg-2576 mouse (Fig ... profile Alternative activation gene profiles in mouse models of AD Since alternative activation could be demonstrated in vitro using the expression of specific genes, we determined if mouse models ... induction was observed with IFNγ treatment and, with the exception of AG1 (A), treatment of BV2 cells with the combination of IFNγ and IL-4 reduced mRNA expression of each gene studied; Panel F- Primary...
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Báo cáo y học: "Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination" pot
... to further characterise the evolution of ACPA responses in human RA, and to determine if the evolution and/ or expansion of ACPA responses is associated with the persistence and severity of RA ... chronic CIA and EAE The native counterparts of the targeted citrullinated proteins were not targeted by the autoantibody responses in these models Figure Our findings extend the results of others who ... files and 2) The synovial and myelin microarrays contained mouse and/ or human versions of the proteins and peptides, depending on their availability from the collaborators that provided these...
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báo cáo khoa học: " Models of the human metabolic network: aiming to reconcile metabolomics and genomics" pps
... list of reaction names (enzyme s names) in the metabolic system across the top of the columns of the matrix The matrix is often gigantic, having as many columns as there are enzymes, and the metabolite ... E101 E100+K … X (d) (c) H α β γ E5000 E5001 (a) δ E5000+k … ζ (b) Figure Reminder of the complexity of the control of the activity of an enzyme In the bottom metabolic pathway, the generic metabolite ... with the metabolites entering and leaving above the arrows The tools of genomics include the polymerase chain reaction (PCR) for gene amplification and thence sequencing, and identification of the...
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Báo cáo y học: " Pharmacological characterisation of antiinflammatory compounds in acute and chronic mouse models of cigarette smoke-induced inflammation" ppt
... DW, and CSS contributed to the acquisition and analysis of the data, have contributed to the drafting of the manuscript, read and approve of the final version of this manuscript CSS designed the ... with their ability to block cell infiltrates Finally, investigating the molecular mechanisms responsible for the effects of these compounds in the models was beyond the scope of these studies and ... 12 weeks of exposure days exposure BAL Macrophages M days exposure 12 weeks of exposure B BAL Lymphocytes Fold-change (versus shamcontrol) Page of 10 16 C 12 days exposure 12 weeks of exposure...
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Báo cáo y học: " The utilization of humanized mouse models for the study of human retroviral infections" docx
... development over the past 30 years The bottom half of the timeline denotes the emergence of key humanized mouse models The top half of the timeline denotes the application of the models to HIV-1 and HTLV1 ... we focus on the development of each of these models for the study of human retroviral infection, i.e., with HIV-1 and HTLV-1 The comparison of all of these models in historical context, as illustrated ... infection in these mouse models; however, they are not the natural routes of HIV-1 exposure in humans Therefore, some recent studies have investigated the proficiency of these humanized mouse models...
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Báo cáo khoa học: cGMP and glutathione-conjugate transport in human erythrocytes The roles of the multidrug resistance-associated proteins, MRP1, MRP4 and MRP5 pot
... Uptake of [3H]cGMP in the absence of ATP but in the presence of the nonhydrolysable ATP analogue, ATP-c-S, was less than 5% of the uptake in the presence of ATP The amount of [3H]cGMP taken up by these ... concentration, Umax the maximum uptake, Kd the apparent dissociation constant and n is the Hill coefficient, here expected to lie between and The data were fitted to minimize the sum of squared proportional ... uptake of [3H]DNP-SG into one-step, inside out erythrocyte membrane vesicles The maximum uptake rates, Umax1 and Umax2, the dissociation constants, Kd1 and Kd2, and the Hill coefficients, n1 and n2...
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báo cáo hóa học: " Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer''''s disease" potx
... characteristic of these transgenic models [8,21] The transgenic mouse models used to study AD exhibit some of the pathological features seen in the AD patient brain and show an increased production of inflammatory ... the same node The farther one needs to travel across the tree to reach another member, the greater the dissimilarity suggests that the presence of these inflammatory molecules is related to the ... administration of fibrillar Aβ into rat brain [30] In order to further understand the correlation between the amount of Aβ and cytokine levels in the brains of transgenic mice, levels of both soluble and...
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Báo cáo toán học: "How to include organ interactions in models of the root system architecture? The concept of endogenous environment " potx
... Therefore, these three examples show the existence and various aspects of an “endogenous environment” of the organs, which may vary in space and time according to the structure and function of ... carbohydrate demand, taking into account both the amount of structural carbohydrate and the energy cost The global demand of the root system, calculated as the sum of all root individual demands, can ... describing the interactions between the roots and their exogenous environment, the soil However, the organs of the plant, especially the roots, not interact only with their exogenous environment, but also...
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Báo cáo y học: " Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation" pps
... smoke exposure, thus distinguishing the chitinase expression profile elicited by cigarette smoke from the one elicited by allergens The induction of BRP-39 and the infiltration of cells into the ... further validation of this model, we previously reported levels of carboxyhemoglobin (a measurement of the saturation of hemoglobin with carbon monoxide) and cotinine (a metabolic product of ... vivo models (reviewed in [33]) Thus, the objective of this study was to determine the expression and relevance of the chitinases BRP-39 and AMCase in cigarette smoke-induced airway inflammation and...
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Báo cáo y học: " Models of epidemics: when contact repetition and clustering should be included" pps
... " && " Figure Mixed models Mixed models Subfigures a-p show the decrease of the total outbreak size relative to the size of the total population when the fraction of repetitive and clustered contacts ... order of magnitude of the population size in either the fixed or the exponential case Implications for some exemplar diseases Information on the per-contact transmission rate β and the number of ... for the difference between random mixing models and models accounting for contact repetition and clustering are the correlations between the number of contacts per day and contact repetition and...
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Báo cáo sinh học: " Cloning and expression profiling of the VLDLR gene associated with egg performance in duck (Anas platyrhynchos)" docx
... out the study and drafted the manuscript YZG contributed to the study design and helped in revising the manuscript SJL and WHY participated in the collection of duck blood and the measurement of ... its expression in ovary, and the development of the growing oocytes and yolk lipoprotein deposition The association analysis also confirmed the crucial role of VLDLR on the development of yolk ... egg traits QWX and CL collected data of recorded traits YPF and XLP participated in the design of the study All authors read and approved the final manuscript Competing interests The authors declare...
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Comparison of accounting-based bankruptcy prediction models of Altman (1968), Ohlson (1980), and Zmijewski (1984) to German and Belgian listed companies during 2008 - 2013
... 1980) The model of Ohlson (1980) is as follows: Ohlson = - 1.3 - 0. 4X1 + 6. 0X2 - 1. 4X + 0. 8X4 - 2. 4X5 - 1. 8X6 + 0. 3X7 - 1. 7X8 - 0. 5X9 (eq.2) Where X1 = log (Total assets / GNP price-level index) X2 = ... the prediction of company failure are primarily selected on their basis of their ex- hypothetical capability to indicate the financial soundness or sickness of a company and on the basis of their ... results on the three different accounting-based bankruptcy prediction model were evaluated to answer the two hypotheses of the Master Thesis Therefore, the accuracy rate of the models of Altman...
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Models of Economic Geography Dynamics, Estimation and Policy Evaluation
... reports the results of a policy evaluation exercise carried out in the summer of 2000, wherein the construction of a high-speed rail connection between the West and the North of the Netherlands ... ways and at uncertain times Thus the new theories of economic geography and economic growth gave to economists an understanding of the dynamics of regions, gave them insight in the stability of the ... specify a host of parameters to even start working: the conditions of firm entry, the heterogeneity of the good, and the type of market are just a few among them The outcome of the model is highly...
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báo cáo hóa học:" Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival" doc
... 51-75%, >75%).Examples of tumors with low AR expression are visualized in the left panels and tumors with high expression in the right panels Bars in the middle represent the distribution of positive ... reduced AR expression was an independent predictor of decreased OCSS in serous tumors The main limitation of this study is the absence of data on residual disease and future studies of AR expression ... DB performed the statistical analysis and drafted the manuscript KJ participated in the conception and design of the study, performed the histopathological re- Nodin et al Journal of Ovarian Research...
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Báo cáo khoa học: "Serous adenocarcinoma of the fallopian tube, associated with verrocous carcinoma of the uterine cervix: a case report of synchronic rare gynecological tumors" pps
... Discussion Figure vix, the exophitic pattern is apparent carcinoma Microscopic picture of the verrucous (HE 4×) of the cerMicroscopic picture of the verrucous carcinoma of the cervix, the exophitic pattern ... the relationship of verrucous carcinoma with HPV is suspected because the main site of the lesion is the outer labium of the cervix, which presupposes a sexual transmission pathway Notwithstanding ... picture of salpinx tumor Microscopic picture of salpinx tumor The neoplasm shows a papillary pattern with atypia in the cells (HE 10×) Verrucous carcinoma of the cervix represents less than 1% of...
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báo cáo khoa học:" Osteoid osteoma of the ethmoid bone associated with dacryocystitis" pps
... shaft of long bones [2] Most commonly occurs in the femur, tibia and spine, while the ribs, the mandible and the calvarium are the rarest sites of involvement [1,2] Grayeli et al reported a case of ... Resonance Imaging appearance depends on the amount of calcification within the nidus, the size of the fibrovascular zone, reactive sclerosis and the amount of edema in the bone; so it may not be diagnostic ... osteoma from osteoblastoma, because of the similarity of histopathological features In these cases, diagnosis is based on the size of the nidus, and the presence of reactive bone formation, while...
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Tài liệu Characterization of the Polymorphic Behavior of an Organic Compound Using a Dynamic Thermal and X-ray Powder Diffraction Technique pptx
... of Mixtures of Polymorphs and Potential New Solids Forms By using the combined and dynamic DSC/ XRPD, several mixtures of disodium salt samples were identified, and the components of these mixtures ... however, the assignment of component polymorphs to sample mixtures depended on the XRPD results Conclusions Interconversions of the Polymorphs of Disodium Salt The interconversions of polymorphs of the ... on the thermal and XRPD characterization of each form The ability to simultaneously observe dynamic thermal events (via DSC) and the corresponding structural events (via XRPD) through use of the...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng 9 tr 25