monty python and the holy grail knights of the round table song lyrics
Báo cáo khoa học: Revisiting the 13C-label distribution of the non-oxidative branch of the pentose phosphate pathway based upon kinetic and genetic evidence doc
... increase in the number of distinct C2 and C3fragment pools. As a result of these segregated pools, the 13C labeling of the C2 and C3fragments (and, consequently, the labeling of the metabolites ... formedbetween the carbonyl group of the ketose substrate(f6p, s7p) and the e-amino group of a lysine residue of the active site of the enzyme, leading to the formation of either g3p or e4p ... expected, the largest differences are found for the PPP split-ratio and the fluxes of the nonoxidative branch of the PPP. The minimized covariance-weighted sum of squared residuals (SSres) in these...
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Báo cáo khoa học: Structural characterization of the large soluble oligomers of the GTPase effector domain of dynamin potx
... for formation of short helices, transiently, and the chain as such is highly dynamic.Structure of the core of the oligomersBecause of the large size of the core of the oligomer, the NMR spectra ... assembles in the form of ringsaround the necks of budding vesicles, and then a con-formational change in the dynamin collar aids the scis-sion of the vesicle from the parent membrane. The coiled-coil ... characteristics of the individual domains has the potential to throw valuable light on the interac-tions of the individual domains, and the mechanism and variety of the overall functions of the full lengthprotein....
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Tài liệu Integrative Medicine and the Health of the Public: A Summary of the February 2009 Summit docx
... publication, Integrative Medicine and the Health of the Public: A Summary of the 2009 Summit, provides an account of the discussion and presentations of the two -and- a-half day summit in Washington, ... address the behavioral and social ele-ments of health care; they focused on the sickest patients in the practice and went to extraordinary effort to keep these patients out of the hospital; and they ... Snyderman, chair of the summit plan-ning committee, and Fineberg, president of the IOM, both thanked all of the participants for their time, their active engagement, and their energy and enthusiasm...
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Tài liệu Báo cáo khoa học: Long-distance interactions between enhancers and promoters The case of the Abd-B domain of the Drosophila bithorax complex pdf
... However, when the combination of the PTS and the bound-ary is placed 3Â to one of the reporter genes, the enhancer istargeted to one or the other promoter over the boundary (lowerpanel). E1 and E2: ... later than in the case of the histone gene cluster [10]. This difference in the tim-ing of somatic pairing perhaps reflects the differencebetween the complexities of the regulation of the twosystems: ... locate and physically approach theirproper target promoter in the viscous environment of the nucleus.Somatic pairing of chromosomes and the regulation of Abd-BA peculiarity of Drosophila is the...
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Tài liệu Báo cáo Y học: Importance of the amino-acid composition of the shutter region of plasminogen activator inhibitor-1 for its transitions to latent and substrate forms pdf
... affecting the rate of passage of the RCL through the gate region. Based on the amino-acid sequence of the RCL and b strand 5A being directlycontinuous, it may be proposed that movements of the RCLduring ... an effect on the conformation of b strand 5A and of the buried cluster in positions 53, 56, and 334.In contrast, in the presence of vitronectin, the K335Asubstitution caused a twofold to fivefold ... effects of the K335A substitution in the absence and presence of vitronectin, we propose that the conformational change of PAI-1 following the binding of vitronectin implicates a reorientation of the...
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Báo cáo khoa họcRe-engineering the discrimination between the oxidized coenzymes NAD+ and NADP+ in clostridial glutamate dehydrogenase and a thorough reappraisal of the coenzyme specificity of the wild-type enzyme docx
... than the true value, underlining the impact of quite asmall level of contamination on these results.Reassessment of the effects of the mutations oncoenzyme specificityIn view of the dramatically ... moiety of the coenzyme resultingfrom splitting off the nicotinamide ring, suggestingthat the covalent bond between the nicotinamide and the ribose of the coenzyme is particularly labile. The signal ... identification of NAD+peakIsolation and mass spectroscopic analysis confirmed the identity of the contaminant. Comparison with the spectrum of an authentic NAD+sample revealedtotal similarity of the...
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Báo cáo khoa học: Solution structure and backbone dynamics of the XPC-binding domain of the human DNA repair protein hHR23B docx
... further our knowledge withrespect to the mechanisms of action of these proteins,it is crucial that we define the precise boundaries of the STI1-homologous domain and compare the struc-tures of ... structure. The quality of the struc-tures was assessed using the refined energy terms and the procheck program [37]. The surface electrostatic potentialdistribution of the best overall model of XPCB–hHR23Bwas ... fitting, and those of the 15N-1H NOEs were obtainedfrom the difference of two independent experiments. The values of error were adjusted for the proper tensor2 analy-sis, by increasing of the...
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Báo cáo khoa học: The oxidative effect of bacterial lipopolysaccharide on native and cross-linked human hemoglobin as a function of the structure of the lipopolysaccharide A comparison of the effects of smooth and rough lipopolysaccharide ppt
... comparison of the effects of roughandsmoothLPSsofE. coli, both in the presence and absence of EDTA (Fig. 1). The rate of oxidation wasincreased in the presence of the LPSs of both the smooth and rough ... measure of the rate of oxidation of oxyHb.RESULTS The effect of pH on the auto-oxidation of cross-linked Hbwas studied. The rate of decrease of the concentration of oxyHb increased as the pH ... of oxidation in the presence of EDTA.A comparison of rough and smooth LPSs of E. coli and S. minnesota in the presence of EDTA revealed that both in the presence and absence of EDTA, the oxidation of cross-linked...
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Báo cáo khoa học: Structure and topology of the transmembrane domain 4 of the divalent metal transporter in membrane-mimetic environments docx
... in the presence and absence of the paramagnetic metal ions. The amplitudes of the spectra in the presence of the paramagnetic metal ionswere normalized to the least affected cross-peaks. The paramagnetic ... biology aspects of DMT1 since the discovery of this gene, there has so far been no structuralcharacterization of either this integral protein or a segment of it. Analysis of the structure of membrane ... structures of the 16 conformers at pH 7.5 in the segment of Leu9–Val17, except Ile12 and Phe16 in some of the conformers. Table 1. Structural statistics for DMT1-TM4 in the presence of SDS atpH 6.0 and...
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Tài liệu Report of the Independent Monitoring Board of the Global Polio Eradication Initiative pptx
... approach and accountability over the last year, led from the most senior levels of the spearheading partners and of the governments of the countries affected by polio. The World Health Assembly has ... gone. Their skills and experience will be of great value to other health services. If no-one communicates this, then their concern for themselves and their families is a distraction from the ... example, the delivery of vaccination campaigns is reliant on NGOs contracted by the Ministry of Public Health to implement the Basic Package of Health Services. The accountability of these NGOs...
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