molecular mechanisms of salmonella virulence and host resistance
Báo cáo y học: "Advances in Molecular Diagnosis of HBV Infection and Drug Resistance"
... necessary should the rate of emergence of resistance and the impact of such mutations turn out to be clinically relevant for therapy management Molecular Mechanisms of Drug Resistance HBV is a small ... resistance in vitro and molecular mechanisms of nucleoside resistance Semin Liver Dis 2002;22:23-31 21 Doo E, Liang TJ Molecular anatomy and pathophysiologic implications of drug resistance in hepatitis ... technology, molecular beacons) that decrease the number of handling steps, reduce contamination, and increase throughput and the accuracy of quantification will further enhance the utility of these...
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Báo cáo khoa học: Molecular basis for substrate recognition and drug ˚ resistance from 1.1 to 1.6 A resolution crystal structures of HIV-1 protease mutants with substrate analogs pptx
... a standard Nle and a hydroxyl-Nle with relative occupancies of 0.7 and 0.3 Mass spectroscopic studies of crystals and separated peptide analog showed no significant change in molecular mass of ... interactions at P1¢ and P3¢ were enhanced (Fig 6A) mainly by movements of the side chains of P1 Nle and P3¢ Arg ˚ and partially by the small (0.3 A) shift of the CA atom of Ala82 ⁄ 82¢ P1¢-Nle ... such as V82A and I84V Structural comparison of the complexes with the p6pol-PR analog The structures had two conformations of p6pol-PR with relative occupancies of 0.6 and 0.4 and 0.8 and 0.2 for...
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Báo cáo y học: " Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin c" ppsx
... known whether p-BSQ of CS causes apoptosis and emphysematous lung damage We have addressed this question for better understanding of the cellular and molecular mechanisms of emphysema, so that ... and Bcl-2 of the lung extracts of guinea pigs exposed to air or CS supplemented with A, Immunoblots of caspase 3, PARP, A, Immunoblots of caspase 3, PARP, Bax and Bcl-2 of the lung extracts of ... mean perimeter (contour length) of air space and A is the area of air space [6] The number of air spaces and the S/V values calculated after 7, 14 and 21 days of smoke exposure are significantly...
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Báo cáo y học: "Lung epithelium as a sentinel and effector system in pneumonia – molecular mechanisms of pathogen " pdf
... burden of pneumonia, the increasing number of antibiotic- resistant bacteria, and the emergence of new pulmonary pathogens into account, an exact analysis of molecular mechanisms of disease is mandatory ... peptidoglycans of basically all bacteria [117,118] However, as for many of the TLRs and their agonists, there is no formal proof for the binding of the peptidoglycan motifs to the LRR domains of NOD1 and ... liberation of immunodulatory cyto- and chemokines and up-regulation of adhesion molecules mediates the acute immune response by e.g recruitment of leucocytes to the site of infection and modulates...
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Molecular mechanisms of mechanosensing at cell cell and cell matrix adhesion 2
... molecular mechanisms, often referred to as functional modules, work together to govern these complex and robust processes [2, 17] This thesis work devotes to understand the molecular mechanisms of a ... question: Mechanosensing mechanisms of talin and αcatenin 16 Strategies and Methods 2.1 19 Theory of force induced structural transitions of protein 20 2.1.1 2.1.2 ... study the mechanical stability of the rod domains of talin and central domain of α-catenin using both wild type and mutant constructs Both talin vii rod domain and α-catenin central domain undergo...
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Molecular biology and pathogenesis of coronavirus virus and host factors involved in viral RNA transcription
... that modulate the host environment to the advantage of the virus while inhibiting host activities One of the most important interactions between virus and host is the modulation of host cell environment, ... Virus -host interactions In a coronavirus infection, the virus replicates in the host cytosol, amid a myriad of host signaling pathways and systems, interaction between the virus and the host systems ... 3.2: Band densities of MADP1 (normalized with band densities of actin for each cell line) in 16 cell lines classified by tissue of origin 163 ix List of Figures Figure 1.1: Schematic diagram of...
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Dendritic cells respond differently to live and killed bacteria molecular mechanisms of pathogen recognition by dendritic cells and implications for vaccine development
... the mechanisms of initiation of the immune response to E coli and on aspects of invasiveness, pathogenicity and the persistence of E coli This may provide a strategy for improving the efficacy of ... proliferation and the generation of antibodies (for B cells) and the generation of armed effector T cells such as cytotoxic T cells and helper T cells (Th) (for T cells) Some of these B and T cells ... fixation and heating (82-85), and molecular markers were used to assess DC 16 activation Therefore, further understanding on how bacteria interacts with DCs in terms of induction of DC maturation and...
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Molecular interactions of tectonin proteins in host and pathogen recognition
... TABLE OF CONTENTS Acknowledgements Table of Contents Summary List of Tables List of Figures List of Abbreviations List of Primers i iii vi viii viiii xiii xv General introduction and overview ... Construction of bacterial and saccharide structures ……………… 2.1.4 Protein-protein and protein-ligand docking ……………………… 2.1.5 Identification of LPS-binding motifs ……………………………… 2.1.6 Design and synthesis of ... the assembly of PRRs to prompt the innate immune response 1.7 Structures of hCRP, TtCRP and LpCRP 10 1.8 The structure of TL-1 11 1.9 Oligomers of TPL-1 and GBP 11 1.10 An example of a beta-propeller...
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Tài liệu Molecular Neurobiology of Alzheimer Disease and Related Disorders doc
... topics of neurobiological study of Alzheimer’s disease include the unraveling of the molecular mechanisms of neurofibrillary tangle formation in neuronal and glial cells; the molecular processing of ... of the Department of Psychiatry and Behavioral Proteomics, Preface XI Osaka University Graduate School of Medicine, since the time of Professor Jiro Kaneko and Professor Tsuyoshi Nishimura, and ... Institute of Science and Technology (NAIST), Takayama, Department of Clinical Neuroscience, Psychiatry, Graduate School of Medicine, Osaka University, Suita, Japan and Department of Biochemistry and Molecular...
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Tài liệu Báo cáo khoa học: Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites pdf
... Antiviral Program of the Office of the Director of NIH and by AIDS FIRCA Grant TW01001 The contents of this publication not necessarily reflect the views or policies of the Department of Health and Human ... models of the P1¢ residue of peptides 7, 10, 11 and 14 (Table 4) are shown occupying the S1¢ binding site of wild-type HIV-1 PR suggest that the maximization of the van der Waals interactions of ... Construction and purification of HIV-1 PR mutants Fig Sequence around the NC/p1 and p1/p6 cleavage sites in HIV-1 The sequence of HIV-1IIIB, a member of the B subtype, is shown The P4-P3¢ region of the...
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Xpert MTB/RIF test for detection of pulmonary tuberculosis and rifampicin resistance (Protocol) pptx
... percentage of contaminated cultures; review question B: the name and manufacturer of the reference standard • Details of index test: software version of test • Details of comparator: type of microscopy: ... 2010a) Early and accurate diagnosis and effective treatment is the cornerstone of TB care and control (Dye 2010) A basic tenet of early and accurate diagnosis is the identification of smear-negative ... et al.Rapid molecular detection of tuberculosis and rifampin resistance New England Journal of Medicine 2010; 363:1005–15 Foundation Foundation for Innovative Diagnostics Automated molecular detection...
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Báo cáo khoa học: Molecular mechanisms of the phospho-dependent prolyl cis ⁄ trans isomerase Pin1 docx
... FEBS 5213 Molecular mechanisms of Pin1 G Lippens et al Fig Schematic view of the parallel between Pin1 and CKS in protein degradation Top: Model of the SCFCDC4 E3 ligase and the role of Pin1 Pin1 ... monomer and swapped dimer are mainly limited to the conformation of the Glu-Pro dipeptide in the hinge region between the last b-strand and the core of CKS The crystal structure of the complex of ... exact role of Pin1 in human disease, and Molecular mechanisms of Pin1 thereby its potential as a molecular target for novel drugs Acknowledgements We thank two anonymous reviewers and Dr E Appella...
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Báo cáo khoa học: Sequences, geographic variations and molecular phylogeny of venom phospholipases and threefinger toxins of eastern India Bungarus fasciatus and kinetic analyses of its Pro31 phospholipases A2 docx
... mutational rates of the exon of the 3FTx genes are much faster than those of the PLA genes, leading to high variation of KBf-3FTx Cloning and cDNA sequencing Venom glands of only one of the KBf specimens ... present in B candidus venom, while 3FTx-RK is 84% identical to bucain [25] of B candidus Calcium binding and kinetic parameter of the P31-PLAs Four PLAs (Va, Vb-2, VI and II) of KBf and Bf contain ... the prey of Bf and king cobra consists mainly of snakes and reptiles, which are distinct from those of other kraits (e.g B candidus and B multicinctus, which prey on small catfishes, eels and rodents...
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EVOLUTION OF THE MOLECULAR BIOLOGY OF BRAIN TUMORS AND THE THERAPEUTIC IMPLICATIONS pdf
... infiltration of the surrounding tissue The presence and functions of hyaluronic acid (hyaluronan, HA), PGs and various types of GAGs have already been intensively investigated to clarify the molecular mechanisms ... composed of iduronacid and N-acethylgalactosa‐ mine polymer and protein core), heparansulphate (glycuronacid and N-sulphoglucosa‐ mine polymer and protein core) and keratansulphate (galactose and ... mortality of the patient Moreover, the presence of the blood-brain barrier (BBB) limits the passage of a wide variety of anticancer agents The high incidence of recur‐ rence and poor prognosis of malignant...
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Báo cáo khoa học: Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and tyrosine hydroxylase pptx
... alignment and knowledge of the crystal coordinates of PAH and TH has been used to model the full length structure of TPH [24] We have modeled the catalytic sites of PAH and TH and introduced BH4 and ... 2003 Fig Placement of BH4 in the catalytic site of PAH and TH Distance-energy diagrams obtained after docking BH4 into the active sites of PAH (A) and TH (B) Total energies of candidate positions ... oxidation of the catalytic iron provoked by the Ó FEBS 2003 Modeled ligand–protein complexes of PAH and TH (Eur J Biochem 270) 1073 Fig Hydroxylation of tyrosine and a possible sequence of events...
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Báo cáo sinh học: " Application of FTA technology for sampling, recovery and molecular characterization of viral pathogens and virus-derived transgenes from plant tissues" doc
... bring to sampling and molecular study of viral crop diseases, we tested the efficacy of FTA for retrieval of viral pathogens from infected leaf tissues and for the detection of viralderived transgene ... consisted of 30 cycles of 94°C for min., 58°C for and 72°C for MSV F &MSVR : PCR conditions consisted of 30 cycles of 94°C for min, 59°C for and 72°C for mins C1F &C2R: PCR conditions consisted of 94°C ... &EAB555/R: PCR conditions consisted of 30 cycles of 94°C for min, 58°C for and 72°C for mins JSP001 &JSP002: PCR conditions consisted of 30 cycles of 94°C for min, 45°C for and 72°C for mins Uni F &Uni...
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báo cáo hóa học:" Application of FTA technology for sampling, recovery and molecular characterization of viral pathogens and virus-derived transgenes from plant tissues" doc
... bring to sampling and molecular study of viral crop diseases, we tested the efficacy of FTA for retrieval of viral pathogens from infected leaf tissues and for the detection of viralderived transgene ... consisted of 30 cycles of 94°C for min., 58°C for and 72°C for MSV F &MSVR : PCR conditions consisted of 30 cycles of 94°C for min, 59°C for and 72°C for mins C1F &C2R: PCR conditions consisted of 94°C ... &EAB555/R: PCR conditions consisted of 30 cycles of 94°C for min, 58°C for and 72°C for mins JSP001 &JSP002: PCR conditions consisted of 30 cycles of 94°C for min, 45°C for and 72°C for mins Uni F &Uni...
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Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 1) potx
... presence of potentially pathogenic microbes in or on a host) , infection (attachment and growth of pathogens and avoidance of host defenses), and disease (often, but not always, the result of activities ... consequence of its route of entry into the body The most common sites of entry are mucosal surfaces (the respiratory, alimentary, and urogenital tracts) and the skin Ingestion, inhalation, and sexual ... alimentary tract of sandflies and are injected by bite into a susceptible host Trypanosomes are ingested from infected hosts by reduviid bugs, multiply in the insects' gastrointestinal tract, and are...
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Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 2) potx
... Coxsackievirus Viral coat proteins CAR and histocompatibility major class I antigens Bacterial Pathogens Neisseria spp Pili Membrane cofactor protein (CD46) Pseudomonas Pili and flagella Asialo-GM1 Lipopolysaccharide ... Herpes simplex Glycoprotein C Heparan sulfate HIV Surface glycoprotein CD4 and chemokine herpesvirus type virus receptors (CCR5 and CXCR4) Epstein-Barr Envelope protein CD21 (=CR2) Adenovirus Fiber ... pneumophila Mycobacterium tuberculosis Fungal Pathogens Blastomyces dermatitidis Candida albicans matrix proteins and integrins Int1p Extracellular proteins matrix Protozoal Pathogens Plasmodium...
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Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 3) doc
... residues on globosides of the human P blood groups Both of these types of pili have proteins located at the tips of the main pilus unit that are critical to the binding specificity of the whole pilus ... structures A and B Traditional electron micrographic images of fixed cells of Pseudomonas aeruginosa Flagella (A) and pili (B) projecting out from the bacterial poles can be seen C and D Atomic ... greatest detail are bacterial pili and flagella (Fig 114-1) Pili or fimbriae are commonly used by gram-negative and gram-positive bacteria for attachment to host cells and tissues In electron micrographs,...
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