molecular and cellular mechanisms
MOLECULAR AND CELLULAR MECHANISMS LEADING TO SIMILAR PHENOTYPES IN DOWN AND FETAL ALCOHOL SYNDROMES
... University, August 2012 Molecular and Cellular Mechanisms Leading to Similar Phenotypes in Down and Fetal Alcohol Syndromes Major Professor: Randall J Roper Down syndrome (DS) and Fetal Alcohol Syndrome ... GRADUATE SCHOOL Research Integrity and Copyright Disclaimer Title of Thesis/Dissertation: Molecular and Cellular Mechanisms Leading to Similar Phenotypes in Down and Fetal Alcohol Syndromes For ... Signature of Candidate 05/22/2012 Date (month/day/year) *Located at http://www.purdue.edu/policies/pages/teach_res_outreach/c_22.html MOLECULAR AND CELLULAR MECHANISMS LEADING...
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Studies on the molecular and cellular mechanisms underlying the process of learning and memory formation body
... pyramidal cells (Blackstad and Kjaerheim, 1961; Andersen et al., 1966; Andersen et al., 1971) The MFs form distinct synapses with excitatory and inhibitory cells of the hilus and area CA3 It has been ... synaptic protein rabphilin and Rab3A are required for the MFs LTP expression (Lonart et al., 1998a and 1998b) In summary, the biochemical mechanisms responsible for induction and expression of presynaptic ... circuitry in relation to learning and memory formation requirements Furthermore, the molecular mechanisms underlying the MFs redistribution during learning and memory formation are still under...
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Studies on the molecular and cellular mechanisms underlying the process of learning and memory formation
... different molecular mechanisms involved in amygdala-related cuedor tone-dependent fear conditioning xi List of Tables Table 4.1 Average concentrations and standard errors of Fe Cu and Zn in different ... 110 5.1.3 Pharmacological studies on Cdk5 in learning and memory 112 5.1.4 Rational and objective .113 5.2 Materials and methods .113 5.2.1 Animals .114 ... training 115 5.2.3.2 Short-term contextual memory and cued memory test 115 5.2.3.3 Retention and extinction of long-term contextual memory and cued memory 116 5.2.4 Genotyping analysis...
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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface pdf
... pericytes and severe defects in the brain and heart, leading to vascular leakage and edema [55–57] Ligand–receptor signaling between two types of cells may mediate cellular communication and, in ... insulin, transferrin and leptin, to cross the BBB [13] Molecular basis of brain angiogenesis and barriergenesis Hypoxia and the hypoxia-inducible factor system As an embryo develops and its structure ... from tight, adherens and gap junctions enhances transcellular, rather than paracellular, transport when the brain parenchyma Regulation of angiogenesis and barriergenesis and blood exchange factors...
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Tài liệu Báo cáo khoa học: Molecular and cellular specificity of post-translational aminoacyl isomerization in the crustacean hyperglycaemic hormone family docx
... [52] [53] [11] [50] [21] Present Study Dermal gland – Venom gland – Ganglia ⁄ heart Muscle Heart Venom duct Venom gland Sinus gland – spider [6] and cone snails [7] l- to d-aminoacyl isomerization, ... situation in the lobster, VIH and CHH are synthesized and released by different cellular types in woodlouse [46] and in Norway lobster [47] Similarly, moultinhibiting hormone and CHH are localized in ... involved in androgenic gland growth [29] In the present study, we describe an experimental strategy that was applied to determine the difference between VIH I and II from the X organ–sinus gland system...
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molecular and cellular biology of neuroprotection in the cns - christian alzheimer
... Molecular and Cellular Biology of Neuroprotection in the CNS Molecular and Cellular Biology of Neuroprotection in the CNS Edited by Christian ... publication Molecular and Cellular Biology of Neuroprotection in the CNS Edited by Christian Alzheimer ISBN 0-306-47414-X AEMB volume number: 513 ©2002 Kluwer Academic / Plenum Publishers and Landes ... progress has been made in unravelling many of the cellular and molecular players in neuronal death and survival However, as the field develops into more and more specialized branches, the notion of...
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Báo cáo sinh học: "Molecular and cellular correlates of the CIITA-mediated inhibition of HTLV-2 Tax-2 transactivator function resulting in loss of viral replication" pot
... interaction is regulated by a series of cellular and molecular mechanisms whose outcome dictates in many instances the subtle equilibrium between control of infection and pathological consequences for ... results and drafted the manuscript GT participated in the design and coordination of the study and in the discussion of the results RSA conceived the study, and participated in its design and coordination ... pathways involving importin beta and importin 13 Mol Cell Biol 2005, , 25: 5339-5354 doi:10.1186/1479-5876-9-106 Cite this article as: Orlandi et al.: Molecular and cellular correlates of the CIITA-mediated...
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o cáo hóa học:" Molecular and cellular correlates of the CIITA-mediated inhibition of HTLV-2 Tax-2 transactivator function resulting in loss of viral replication" potx
... interaction is regulated by a series of cellular and molecular mechanisms whose outcome dictates in many instances the subtle equilibrium between control of infection and pathological consequences for ... results and drafted the manuscript GT participated in the design and coordination of the study and in the discussion of the results RSA conceived the study, and participated in its design and coordination ... pathways involving importin beta and importin 13 Mol Cell Biol 2005, , 25: 5339-5354 doi:10.1186/1479-5876-9-106 Cite this article as: Orlandi et al.: Molecular and cellular correlates of the CIITA-mediated...
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Molecular and Cellular Signaling docx
... networks, and cellular automata Equally important will be coverage of applied aspects of biological and medical physics and biomedical engineering, such as molecular electronic components and devices, ... the molecular and cellular signaling processing comprising the control layer The topic is a vast one, and it is not possible to cover every possible aspect and still keep the text concise and ... signals that promote mating and colonial behavior in unicellular organisms, and it includes the signals in multicellular plants and animals that allow cells in tissues and organs to work together...
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Molecular and cellular functions of the alternatively spliced isoforms of GDNF receptor complex in neuronal differentiation
... 159 9.2.4 Functions of miRNA in GFL signaling and neurogenesis 159 CHAPTER 10 MATERIALS AND METHODS 161 10.1 Ligands and Chemicals 161 10.2 Cloning and Vector Construction 161 10.3 Cell Culture ... jointly organized by International Union of Biochemistry and Molecular Biology (IUBMB) & Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB), Melbourne, Australia Best ... activities upon ligand stimulations (6) and suggested that ligand activation of GFRα2a and GFRα2c may regulate distinct signaling pathways as compared to GFRα2b Figure 3.1 GDNF and NTN induced neurite...
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Proteolytic and cellular mechanisms in prohormone and proprotein processing 1570595534
... California, U.S.A R.G LANDES COMPANY AUSTIN, TEXAS U.S.A MOLECULAR BIOLOGY INTELLIGENCE UNIT Proteolytic and Cellular Mechanisms in Prohormone and Proprotein Processing R.G LANDES COMPANY Austin, ... sorting and activation of Proteolytic and Cellular Mechanisms in Prohormone and Proprotein Processing, edited by Vivian Y.H Hook ©1998 R.G Landes Company stimulated release of lysosomal enzymes and ... modifications and efficiency of prosegment cleavage of the prohormone convertases 24 Proteolytic and Cellular Mechanisms in Prohormone and Proprotein Processing PC1 and PC2: Glycosylation, sulphation and...
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báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... study and from previous ones on the role of CCR1 and its ligand CCL3 in the pathogenesis of MS [39,40,42] and EAE [22,44,46], have provided evidence for an important role of CCR1 in MS and EAE ... pathogenetic mechanisms leading to demyelination and tissue injury are not fully understood, activated macrophages and microglia seem to play a central role in the destructive process both in MS and in ... demyelination [31] and axonal injury and loss [32] Our results demonstrate a prominent accumulation of monocytes and macrophages expressing CCR1, CCR2 or CCR5 mRNA within and around inflammatory...
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Báo cáo y học: "Cellular mechanisms underlying the effects of an early experience on cognitive abilities and affective states." ppt
... http://www.annals-general-psychiatry.com/content/4/1/8 MR GR NON-HANDLED NON-HANDLED HANDLED HANDLED 45 NO N HANDLED HANDLED 40 35 30 25 20 15 10 NUM R OF POSIT VE IVE CE L L S NUM R OF POSIT VE IVE CE L L S 45 NO N HANDLED HANDLED 40 35 30 ... http://www.annals-general-psychiatry.com/content/4/1/8 A 120 NO N HANDLED HANDLED 100 SECONDS 80 60 40 20 B NO N HANDLED HANDLED 25 SE CONDS 20 15 10 TARGET O PPO S ING Effects of handling on spatial learning and memory in the Morris ... NON HANDLED NON HANDLED HANDLED B HANDLED NUMBER OF POSITIVE CELLS 35 30 25 20 15 10 CA4 Figure handling on BDNF immunoreactivity in the CA4 region of the hippocampus Effect of3 Effect of handling...
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Báo cáo sinh học: " DNA-vaccination via tattooing induces stronger humoral and cellular immune responses than intramuscular delivery supported by molecular adjuvants" ppt
... using a tattoo device elicited much stronger and more rapid humoral and cellular immune responses than intramuscular needle delivery together with molecular adjuvants Tattooing is an invasive ... Genetic Vaccines and Therapy 2008, 6:4 http://www.gvt-journal.com/content/6/1/4 is a rather inefficient process and various improvements using different physical, biochemical and biological methods ... higher than that after intradermal injection [7,8] and gene gun delivery [8] DNA vaccines delivered by tattoo were able to induce both cellular [6,7] and humoral antigen-specific responses [6,8] Compared...
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Wireless and cellular telecommunications
... Chapter 11 Handoffs and Dropped Calls 11.1 Value of Implementing Handoffs / 485 11.1.1 Why Handoffs / 485 11.1.2 Types of Handoff / 485 11.1.3 Two Decision-Making Parameters of Handoff / 486 ... Hard Handoffs / 487 11.1.5 Number of Hard Handoffs Per Call / 487 11.1.6 Area of Soft Handoffs in a Cell / 488 11.2 Initiation of a Hard Handoff / 489 11.3 Delaying a Handoff / 490 11.3.1 Two-Handoff-Level ... Advantage of Delayed Handoffs / 491 11.4 Forced Handoffs / 491 11.4.1 Controlling a Handoff / 491 11.4.2 Creating a Handoff / 491 11.5 Queuing of Handoffs / 492 11.6 Power-Difference Handoffs / 493 11.7...
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Tài liệu Báo cáo khoa học: Molecular and biochemical characterization ofD-phosphoglycerate dehydrogenase fromEntamoeba histolytica A unique enteric protozoan parasite that possesses both phosphorylated and nonphosphorylated serine metabolic pathways docx
... set of enzymes involved in amino acid synthesis of Ser from Gly and Ala from Cys and conversions between Asp and Asn and between Glu and Gln [49] Serine metabolic pathways are often absent in parasitic ... residue between 58 and 59 of EhPGDH (also missing in other Type III organisms and Type IIB B anthracis) in the substrate binding domain and five–ten residues between amino acid 172 and 173 (Fig 2) ... cyanobacteria, Clostridiales, Actinomycetales and archaebacteria belong to Type I, while b- and c-proteobacteria and Bacteroidales belong to Type IIA and Type III, respectively It is worth noting...
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Tài liệu Báo cáo khoa học: Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms ppt
... VEGF-induced MAP kinase activation and cell proliferation [29] To distinguish between the extracellular effects of PF-4 acting on ligand/receptor activation and intracellular effects on signalling ... obtained ` through local maternity units (Lariboisiere Hospital and Saint Isabelle Clinic) under approval, and with appropriate understanding and consent of the subjects DNA synthesis HUVEC were seeded ... induced by VEGF165 and VEGF121 was maximal between 10 and 15 of stimulation and decreased thereafter (Fig 4C,E) PF-4 strongly decreased ERK phosphorylation, to only 34% (VEGF165) and 22% (VEGF121)...
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Tài liệu Báo cáo khoa học: Molecular and functional characterization of adenylate kinase 2 gene from Leishmania donovani pdf
... Asian and Mediterranean countries [15] This paper describes the cloning and functional characterization of an AK gene from a genomic library of L donovani as well as its expression and molecular ... characterization Materials and methods Materials Plasmids pGEM-3Zf(+) and pQE30 were from Promega and QIAGEN, respectively [32P]dCTP[aP] (3000 CiÆ mmol)1) was from DuPont-NEN Restriction enzymes and Taq DNA ... as all enzymes showed only one band, except those which cut once into the gene sequence (BamHI, KpnI and SalI), which exhibited two hybridizing bands Chromosomal bands from L donovani 1S2D strain...
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Báo cáo khoa học: Molecular and functional characterization of novel CRFR1 isoforms from the skin pptx
... CRFR1e1 protein (band 10) with molecular mass of 20 kDa (Fig 2) Proteins with lower molecular mass than expected included band (39 kDa) for CRFR1f, band (34 kDa) for CRFR1g; and band (30 kDa) for ... controls and ligand-stimulated cells are denoted as follows *P < 0.05 and **P < 0.01 smear ranging from 50 to 60 kDa was noted (bands 3, Fig 2) Proteins with different than expected molecular ... expected molecular mass included bands 1, 2, 6–8 and 10 Protein with molecular mass 85–90 kDa (band 1) was seen in all isoforms containing transmembrane domains (Fig 2) and therefore it may represent...
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Báo cáo khoa học: The stop transfer sequence of the human UDPglucuronosyltransferase 1A determines localization to the endoplasmic reticulum by both static retention and retrieval mechanisms docx
... in a band with a molecular mass similar to that of the nontreated polypeptide as well as a band of kDa smaller corresponding to the nonglycosylated form (Fig 3A) The high molecular mass band was ... residues of human UGT1A6 (1593–1576) followed by a stop codon and XhoI site The PCR product was cut with BamHI and XhoI and cloned into BamHI and XhoI sites of pTM1 expression vector in frame with CD4 ... from the properties of the TMD and its interaction with the membranes It has been demonstrated that TMD of the yeast Sec12p and UBC6 (ubiquitin-conjugating enzyme 6) and of the rabbit cytochrome...
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