... time-point concentration at post-dose The trend of drug concentration profile in brain tissue simulated in the absence of P-gp activity but in the presence of additional efflux transporter is now in accordance ... distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A J Clin Invest 199 5, 96 :1 698 –705 Greenblatt DJ and von Moltke LL: Interaction of warfarin with drugs, natural substances, and ... quality and robustness of this analysis can be improved, reducing thus the uncertainty pertaining to the extrapolation This study focused on the mechanisms of drug distribution in non-eliminating tissues...
... Assessment of contribution of each amino acid residue of E51 sequence to substrate recognition Alanine substitution mutants in the E51 sequence were produced as GST(QN) fusion proteins, and then incubated ... glygol)–NaCl and then used for subsequent rounds After panning five times in all, DNA sequences ofthe displayed peptides ofthe selected phage clones were determined Construction ofthe expression ... manufacture’s instructions (BD Bioscience, San Jose, CA, USA) The concentration ofthe purified protein was determined by quantification ofthe intensity for the separated bands in SDS ⁄ PAGE analysis using...
... combining 4.43 and 4. 49 Acknowledgment This work was supported by the National Natural Science Foundation of China Grant no 1 090 10 89 References M G Krein, “On certain problems on the maximum and ... eigenvalues of one-dimensional p-Laplacian,” Northeastern Mathematical Journal, vol 19, no 1, pp 39 50, 2003 Y Lou and E Yanagida, “Minimization ofthe principal eigenvalue for an elliptic boundary ... 13 P A Binding and B P Rynne, “Variational and non-variational eigenvalues ofthe p-Laplacian,” Journal of Differential Equations, vol 244, no 1, pp 24– 39, 2008 14 M Zhang, The rotation number...
... proteins, whereas the other is independent ofthe processing capacity ofthe proteinase and involves the HPX domain A DNA-binding domain was found in the HPX domain, as an antiMMP-3 HPX antibody ... form of hemozoin The HPX domain of proMMP -9 can bind to both hemin and b-hematin, which results in an autocatalytic truncation of parts ofthe enzyme’s prodomain [68] The truncation in the presence ... ratio and binding constants in the nanomolar range [26] These SIBLINGs and MMPs are also co-expressed and colocalized in salivary glands of humans and mice [27] The interaction between the SIBLING...
... BSA concentrations could prevent the enzyme to act on the substrate and an inhibitory action is observed Addition of divalent cations in the incubation mixture resulted in a dose-dependent inhibition ... buffer) The final concentration ofthe tissue in the homogenization buffer was 10% w/v Further homogenization ofthe tissue by sonication (4 · 20 s with intervals of min) was followed The homogenates ... important to determine the concentration of Tris solution in order to achieve the best experimental conditions for the determination of acetyltransferase BSA concentrations up to 0.5 mgÆmL)1 had no...
... Increased No Change Increased Increased No Change Increased Increased No Change No Change No Change No Change No Change Increased No Change Increased Increased Increased No Change * Rodent only- ... significantly increased in AD Discussion The regulation of gene transcription in macrophages during immune activation is dependent on multiple factors including the type of phagocytic ligands, the ... [8-11] The induction ofthe genes characteristic of alternative activation during an immune response provides an antiinflammatory balance to an acute, pro-inflammatory response Consequently, alternatively...
... maximizing the instantaneous SNR at the destination The conditional variance ofthe equivalent received noise is obtained in (6) Thus, using (1), (2), and (4), the instantaneous received SNR at the ... command “fmincon” designed to find the minimum ofthe given constrained nonlinear multivariable function Figure demonstrates that using the power control schemes of Section 5, about and dB gain will ... performance analysis,” IEEE Transactions on Communications, vol 51, no 11, pp 193 9– 194 8, 2003 [3] J N Laneman and G W Wornell, “Energy-efficient antenna sharing and relaying for wireless networks,” in Proceedings...
... given and the procedure is repeated - When the work has finished, the students open them and, in writing, join the fragments of information together to make it more interesting and logical - The ... as long as their purpose in the writing lesson is clear and they not overshadow what the 90 students feel objectives to be their main III SOME WRITING GAMES EMPLOYED IN THE WRITING LESSON In this ... target of teaching writing to the first year students with an intermediate knowledge of English who study in Vinh university The writing games can be classified into group according to the teaching...
... representation of GLn , the number of up-down tableaux of shape µ of size k on at most n rows is the multiplicity ofthe representation with highest weight µ in the kth tensor power ofthe defining ... /(2 N) ), corresponding to standard ndimensional Brownian motion at time N In order to get the random walk and Brownian motion to have the same variance, we let the time t for standard Brownian ... n/ 2 NN det L|S| (51) Combining the Riemann sum from (50) with the approximation to the Riemann sum (51), and then undoing the change of variables, we have lim N →∞ chamber |λ|
... which included only the characters considered independent from the size ofthe leaf, and in which the individuals ofthe mixed zones were not considered in the construction ofthe canonical axes, ... present significant differences and ofthe genotype P : + /n Knowing the frequency PA+ ofthe phenotype A+ and f, the frequency ofthe allele p could be + found solving the equation: This equation ... (Rushton, 197 7; Aas, 199 1; Steinhoff, 199 3) However, the morphology of crosses Natural interspecific hybridization has long been recognized as a common phenomenon in many plant groups (Stebbins, 195 0;...
... measured on 383 young bulls (generation G1 ) born between 198 8 and 199 4 from 210 G0 dams and the 60 G0 sires After weaning at 32 weeks of age, the bull calves entered the fattening station and were ... where N is the number of animals (sires, females or males) n= 1 with measured traits, tn the number of traits measured on the animal n (with tn 6) and rnt the number of repeated measures ofthe ... mean age of 514 days and a mean weight of 650 kg The carcass fat content was 13.7% on average (Tab I) The slaughter age logically influenced beef traits of growing animals The lengthening of the...
... conditions were used: denaturation at 94 °C for minutes, annealing at 72°C for 30 seconds then denaturation at 94 °C for 30 seconds The coding sequences for human VEGF (accession no NM_000 493 , NM_001844, ... drafting of part ofthe manuscript TDT contributed to the ATII cell culture and drafting of part ofthe manuscript NBN contributed to the immunohistochemistry and drafting of part ofthe manuscript ... recovery following injury[ 19, 29, 35,36] In one LPSinduced murine model of lung injury, intrapulmonary levels of VEGF increased following injury for 96 hours, mirroring the increase in bronchoalveolar...
... Because the unit of randomization is days and not individuals, an unknown intracluster (intraday) correlation coefficient must be considered The standard χ2 statistic, which assumes independence of ... beds The two units admit between 90 0 and 1000 patients annually, with the number of hospitalization days amounting to 5500 each year The patient population in unit A includes infants of extremely ... alterations to treatment decisions but they not dictate treatment Randomization The units of randomization are calendar days Randomization is generated through pre-specified assignment of 15 working...
... Jatropha planting in Ba Vi district (belong to Northern region of Vietnam) and Huong Hoa district (belong to the Central region of Vietnam) s Pointing to climatic, soil and land use conditions • ' ... BIOPHYSICAL AND SOCIO-ECONOMIC CONDITIONS FOR JATROPHA PLANTATION IN BA VI AND QUANG TRI, VIETNAM PROGRESS REPORT 2012 NGUYEN Cao Huan, NGUYEN An Thinh, NGUYEN Thi Hoang Ha, DU Vu Viet Quan (HUS, VNUH) ... Selection and Cultivation of oil plants in Japan - P rof Yoshiaki Kitaya (OPU) 10:20-10:40 Group Selection and Cultivation of oil plants in Vietnam - Prof Nguyen Thi Quynh (VNUHCM), P rof Le Dinh...
... in an Arp2/3 independent manner The actin nucleating activity of formins and profilin are of paramount importance in the formation of actin cables in yeast Formins, Bni1p and Bnr1p, are potent ... significance, as the protein is not commonly seen in the nucleus Both in vitro and in the cell, Prk1p behaves as a threonine kinase (Zeng and Cai, 199 9, Huang et al, 2003) The recognition motif of ... closer look at the putative interactions between the consensus motif (in black) and the various points of contact between the recognition sequence and the amino acids in the kinase (in red) (Reproduced...
... any annotated gene, implying independent transcription with their own promoters However, some miRNAs lie within predicted introns of genes encoding proteins In 80% of these cases, the introns ... effect on gene expression by annealing to the 3¢-UTR of target genes Functional miRNA-binding sites in the coding region or 5¢-UTR of endogenous mRNAs have not been clearly identified, because they ... compilation ª 20 09 FEBS No claim to original French government works 6511 Function of miR-375 and 124a in pancreas and brain NN Baroukh and E Van Obberghen abundant in the upstream sequences of two...
... it In the course ofthe re-annotation ofthe M pneumoniae genome sequence the two genes MPN032 and MPN 294 were proposed as possible candidates enco2 897 Signal peptidase I activity in M pneumoniae ... pneumoniae Microbiology 146, 741–747 Layh Schmitt G & Herrmann R ( 199 4) Spatial arrangement of gene products ofthe P1 operon in the membrane of Mycoplasma pneumoniae Infect Immun 62, 97 4 97 9 ... & Herrmann R ( 199 2) Localization and biochemical characterization ofthe ORF6 gene product ofthe Mycoplasma pneumoniae P1 operon Infect Immun 60, 290 6– 291 3 Saleh MT, Fillon M, Brennan PJ & Belisle...
... cathepsin E and cathepsin D in tetanus toxin: implications for T cell epitope generation J Immunol 1 59, 4 693 –4 699 26 Rhodes JM & Andersen AB ( 199 3) Role of cathepsin D in the degradation of human serum ... SRFQPSQSSTYSQPG Preincubation of CatE with the antibody showed a dose-dependent inhibition of antibody binding (IC50 ¼ 48.6 ng; Fig 2C) Increasing concentrations of CatD did not affect antibody binding This ... E, O’Higgins N, Fennelly JJ, Maudelonde T & Rochefort H ( 199 1) Cathepsin D concentration in breast cancer cytosols: correlation with biochemical, histological, and clinical findings Clin Chem 37,...