mice are susceptible to increased lung inflammatory cell influx in response to cs
Báo cáo y học: "Suppression of LPS-induced matrixmetalloproteinase responses in macrophages exposed to phenytoin and its metabolite, 5-(p-hydroxyphenyl-), 5-phenylhydantoin" pptx
... macrophage-derived cytokines, MMPs and TIMP levels are altered in response to PHT and HPPH Here we investigated the effects of these agents on production of MMPs, TIMPs, and pro -inflammatory cytokines in human ... required for inhibition of TNF-a In macrophages, increased TNF-a production in response to LPS challenge is associated with a transient increase in intracellular calcium [72,73] so that intracellular ... messenger in TLR4-dependent signaling [72,74] Insight into a possible mechanism linking intracellular calcium and cytokine levels was recently demonstrated using RAW macrophages [75] Using a pharmacological...
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Báo cáo y học: " High sensitivity C-reactive protein is associated with lower tibial cartilage volume but not lower patella cartilage volume in healthy women at mid-life" pdf
... protein levels are associated with local inflammatory findings in patients with osteoarthritis Osteoarthritis Cartilage 2007, 15:516-523 Matsumoto T, Tsurumoto T, Shindo H: Interleukin-6 levels in ... synovial inflammatory infiltration in OA [23] and RA [24] CRP is an acute-phase protein that is produced in large amounts by hepatocytes, upon stimulation by the cytokines interleukin (IL)6, ... Although OA disease activity appears to be limited to involved joints, release of cytokines into the systemic circulation during the subclinical phase of OA may explain the association we have seen...
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Báo cáo khoa học: H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae An experimental and theoretical approach pot
... (a) the main if not unique source of inosine is the intracellular pool of adenine nucleotides, (b) the decrease in ATP and the increase in inosine, promoted by H2O2, cannot be explained solely ... correspond to a derivative of adenosine Effect of H2O2 on yeast cells growing in the presence of glycerol or ethanol To obtain further insight into the oxidative effect of H2O2 (see below), yeast cells ... accompanied by an increase in the rate of synthesis of Ino, without any need to modify the kinetic parameters or activities of the enzymes involved in the pathway from ATP to Ino Being aware of the...
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Báo cáo y học: "Aspergillus fumigatus allergen expression is coordinately regulated in response to hydrogen peroxide and cyclic AMp" doc
... choline) are expected to be encountered by fungi during entry into or colonization of the lung Here we tested allergen expression levels in Page of 11 response to transfer to media containing ... expression was used in subsequent experiments to determine whether certain stimuli induced or repressed expression relative to this defined condition Allergen gene expression in response to oxidative ... temperature The cells were resuspended in ml of RPMI 1640-L-glutamine containing 10% Foetal Bovine Serum, 100 U/ml penicillin and 0.1 mg/ml streptomycin, and counted under a haemocytometer (diluted...
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Báo cáo khoa học: Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids docx
... I, 10 nM insulin, E, lM epinephrine; P, 0.5 mM palmitate; P + I, palmitate + insulin; P + E, palmitate + epinephrine The bars indicate ± S.E.M Values are means of between five and nine independent ... phosphatidylinositol 3-kinase inhibitor wortmannin, no other details of this insulin process are known A novel and physiologically interesting observation of the present study was that palmitate totally ... lipase, creatine kinase, glycogen synthase, phosphofructokinase 2, ceramide synthesis, glucose uptake, apoptosis, insulin receptor substrate 1, mammalian target of rapamycin kinase (mTOR), mitogen-activated...
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Báo cáo khoa học: Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation pot
... treated cells with different MAPK pathway inhibitors to block hDlg phosphorylation [17] We then examined hDlg loss in cells treated with inhibitors and exposed to sorbitol Both p38MAPK inhibitors, ... the concentrations indicated Cells were exposed to 0.5 M sorbitol for 60 min, and then incubated for h in sorbitol-free medium (in the continued absence or presence of inhibitor) Endogenous levels ... dissociation from the cytoskeletal protein GKAP, therefore releasing it from the cytoskeleton into the cytoplasm [3] Our aim in this study was to gain a better understanding of the role of hDlg...
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Báo cáo khoa học: The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury pdf
... transfection, cells were split and plated in media containing Geneticin to select for cell containing vector DNA After three weeks, the number of cells was determined by fixing cells and staining with ... key role in minimizing cell injury and maintaining tissue integrity in response to damaging levels of an environmental agent As such, the integrity of this system plays a role in modifying progression ... p53– cell lines [27], in order to determine whether we needed to consider the p53 status in dissecting DCAmediated signalling The HCT116 (p53+) isogenic cell line was incubated with increasing...
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Báo cáo sinh học: "Metabolic reconfiguration is a regulated response to oxidative stress" pdf
... study are likely to provide new insights into how cells coordinate their metabolic pathways to meet their differing needs during the varied growth and stress conditions to which all cells can be ... and is known to have a role in protection against oxidative stress [11,12] Confirming this role, G6PDH and 6PGDH enzyme activities have been shown to be maintained in yeast cells during oxidant ... lifespan in diverse cell types Studies in yeast cells have shown that altered carbohydrate metabolism fluxes are important in extending lifespan during calorie restriction [15] Whether regulating...
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báo cáo khoa học: " The Arabidopsis translocator protein (AtTSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism" potx
... localization in plant cells is complex, involving a relocation of the protein from ER and vesicles to chloroplasts during salt-stress In recent years, several new mechanisms for import of proteins into ... remains to be established There are, however, many reports suggesting that alterations in tetrapyrrole flow can be involved in salt tolerance Exogenous 5-Aminolevulinate (ALA) can improve salt tolerance ... containing the coding region of AtTSPO as well as fusions starting at methionine 21 and 42 were generated and cloned into pK7FWG2 [62] (Table 3) according to the manufacturer’s instructions (Invitrogen,...
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báo cáo khoa học: "The grapevine guard cell-related VvMYB60 transcription factor is involved in the regulation of stomatal activity and is differentially expressed in response to ABA and osmotic stress" ppt
... factors belonging to the R2R3 MYB subfamily as key modulators of physiological responses in stomata [8,9] In particular, AtMYB60 has been shown to be differentially expressed in guard cells in response ... analysis of GUS expression in pVvMYB60:GUS leaves in response to ABA (H) GUS staining of stomata in a control leaf (I), GUS staining of stomata following hours of exposure to 100 μM ABA Galbiati ... leading to the possibility of engineering stomatal conductance in grapevine, reducing water loss and helping this species to tolerate drought under extreme climatic conditions Background Grapevine...
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Báo cáo y học: " The mode of lymphoblastoid cell death in response to gas phase cigarette smoke is dose-dependent" potx
... saline buffer or growth medium The practice of CSC or CSE results in an overwhelming toxic shock to a small number of cultured cells The lung epithelium cells are interconnected in a vast area ... grown in suspension, prior to staining, cells were attached onto microscope slides using Shandon Cytospin Cytocentrifuge (Thermo Scientific, MA, USA) Active caspase-3 staining was performed using ... death and a decline in immune cell function Exposure of cells to CS by means of CSC or CSE does not provide a reliable simulation system of normal smoking In human lungs, the inhaled tobacco smoke...
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Báo cáo y học: " Research Upregulation of CD23 (FcεRII) Expression in Human Airway Smooth Muscle Cells (huASMC) in Response to IL-4, GM-CSF, and IL-4/GM-CSF" pot
... supporting the role of γc chain in CD23 expression by IL-4 The signs of signal transduction in response to IL-4, and the increase in protein content of the cell in response to IL-4 and GM-CSF combination ... low affinity IgE receptor [17] Hakonarson, et al have also demonstrated that ASMC in vitro exposed to human atopic sera results in an initial increase in TH2 cytokines including IL-5 and GM-CSF ... exists in the phenotypic expression of the ASMC in culture [25] In addition to the combination of IL-4/GM-CSF inducing increased expression of CD23, both IL-4 and GM-CSF alone independently increased...
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Báo cáo y học: " The histone deacetylase Rpd3p is required for transient changes in genomic expression in response to stress" ppt
... rpd3Δ strain (Figure S3 in Additional data file 1) A similar defect was observed in cells harboring a mutant histone H4 (H4KQ), in which amino-terminal lysines were changed to glutamine to mimic ... are highly expressed in actively growing cells but sharply repressed, with slightly different expression profiles, in response to stress Genes induced in the ESR ('iESR genes') are involved in ... to that we have previously shown in cells lacking Msn2p and/or Msn4p [3] Thus, Rpd3p is an important cofactor in initiating the ESR Models for how Rpd3p fits into the ESR regulatory network are...
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PURIFICATION OF SIMPL ANTIBODY AND IMMUNOFLUORESCENCE OF SIMPL SUB-CELLULAR LOCALIZATION IN RESPONSE TO TNFα- AND IL-1
... the inflammatory response The cells were grown to 40% confluency on coverslips To ensure that the cytokine conditions were 20 capable of inducing an inflammatory response in the endothelial cells, ... which contain the targeted receptor These cells in turn differentiate into cytotoxic T cells as well as memory T cells The helper T cells remain in the lymph tissue where they secrete cytokines and ... of inflammatory response dysregulation are diverse and far reaching An overly robust inflammation response could result in extensive cellular damage Elevated levels of pro -inflammatory cytokines...
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Báo cáo y học: "TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders"
... concentrations in all MPD patients (All), in those achieving complete response (CR) and those attaining partial response or failure of response (PR+F), in relation to values prior to start of anagrelide ... relates to the model of action of TPO with its receptor on target cells It is well established that serum levels of TPO are regulated by the binding of the ligand to the receptor and the endocytosis ... Warshamana-Greene S A preliminary investigation into the action of anagrelide: Thrombopoietin-c-Mpl receptor interactions Exp Haematology 2006;34:87-96 Hou M, Carneskog J, Mellqvist UH, Stockelberg D, Hedberg...
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Báo cáo khoa học: "Kerbs von Lungren 6 antigen is a marker of alveolar inflammation but not of infection in patients with acute respiratory distress syndrome" docx
... mode of lung injury Previous studies have indicated that the mode of lung injury can influence the inflammatory milieu and pulmonary mechanics of the lung in ARDS [14] To address this indication ... glycoprotein is predominantly expressed on alveolar type II cells in the lung, with expression increasing in proliferating, regenerating or injured type II cells more than normal type II cells [7-9] Thirty ... in epithelial lining fluid [8,9] It has been suggested that an increase in circulating KL-6 levels in interstitial pneumonitis is therefore due to an increase in KL-6 production by regenerating...
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Báo cáo y học: "Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk – A Meta-Analysis"
... factor, which leads to cell cycle arrest for DNA repair or apoptotic cell death [41] Both mice and humans harboring germ line inactivating mutations in one p53 allele are highly susceptible to ... with increased esophageal SCC risk [40], it is worth mentioning that there are main forms of esophageal cancer histologically, squamous cell carcinoma (SCC) and adenocarcinoma, and each has distinct ... ability to induce apoptosis in vitro than p53Arg/Arg.[15] In a pilot study, Zhang et al.[44] showed that subjects carrying the p53 72Pro/Pro genotype had a >2-fold increased risk for developing esophageal...
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In order to become competent in a foreign language, it is important for language learners not only to acquire new vocabularies and a new set of phonological and syntactic rules but also to learn what Wilson (1986)
... môi trường hoàn to n Sinh hoạt sản xuất Nam Bộ gắn bó với đổi thay, biến động nước, dòng sông thủy triều Những biểu văn minh sông nước thể rõ phương thức lao động, nhòp sống sinh hoạt, tín ngưỡng, ... ngữ to n dân đòa phương cụ thể với nét khác biệt so với ngôn ngữ to n dân hay với phương ngữ khác “[8; 24] Ở đây, thấy cần phân biệt ngôn ngữ to n dân phương ngữ Phương ngữ biến thể ngôn ngữ to n ... lớn nước Ven biển có rừng ngập mặn rộng lớn Từ Cà Mau đến Kiên Giang có rừng nguyên sinh U Minh Thượng, U Minh Hạ Rừng có nhiều loài động thực vật quý Hình ảnh quen thuộc sân chim, kèo ong, sếu...
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Tài liệu Báo cáo khoa học: Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process docx
... endogenous proteins was monitored in total protein extracts by immunoblotting using the indicated antibodies (B) In ubiquitinated Rac1L61, ubiquitin moieties are linked through Lys48 HEK293 cells were ... ubiquitin in Rac1L61 polyubiquitin chain extension Also in agreement with this view, the monoubiquitinated form of Rac1 was found to be clearly accumulated in cells expressing UbR48 (Fig 1B), indicating ... activated Rac1 was shown to be essential during the early stages of hepatocyte growth factor-induced epithelial cell scattering [24] To gain insight into the mechanism and biological significance...
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Cytoskeleton reorganization mediates alpha beta integrin-associated actions of laminin on proliferation and survival, but not on steroidogenesis of ovine granulosa cells pdf
... mitogen-activated protein kinase in insulin and insulin-like growth factor I (IGF-I) signaling cascades for progesterone and IGF-binding protein-1 production in human granulosa cells J Clin Endocrinol Metab ... gene by insulin and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase a, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase ... cell death In various cell models, such as kidney epithelial cells [49], hepatocytes [50] or carcinoma cells [51], cytochalasin has been shown to induce cell detachment from the substratum, to...
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