medical management of peyronie s disease
Medical Management of Diabetes and Heart Disease - part 1 pps
... reduction of insulin resistance with the use of thiazolidinediones diminishes the rate of progression of atherosclerotic disease as judged from ultrasonic interrogation of carotid arteries and assessment ... artery disease is strongly associ- Sobel and Schneider ated with insulin resistance in patients with type diabetes has led to a reformulation of its presumed pathogenesis Insulin resistance and its ... and diagnosis Because the polycystic ovarian syndrome is a syndrome of insulin resistance, its nature and predisposition to coronary disease are considered in Chapter Heart disease associated...
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Medical Management of Diabetes and Heart Disease - part 2 pps
... measurement of insulin resistance is small, but many studies have shown a relationship between insulin resistance and specific measures of atherosclerosis such as arterial lesion size In particular, ... (insulin-sensitive variant) (6) Their insulinsensitive patients had none of the components of the insulin resistance syndrome, while the insulin-resistant patients had the classic insulin resistance ... Laurence-Moon-Biedl syndrome Pseudo-Refsum s syndrome Other rare hereditary neuromuscular disorders Insulin resistance associated with genetic syndromes 44 Cefalu Recognition and Assessment of Insulin Resistance...
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Medical Management of Diabetes and Heart Disease - part 3 ppt
... thiazolidinediones, represented by agents such as troglitazone, rosiglitazone, and pioglitazone, represent a class of drugs considered true insulin sensitizers, as insulin-stimulated glucose disposal is enhanced ... in the assessment of insulin sensitivity Diabetes Care 2000; 23: 57–63 Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC Homeostasis model assessment: insulin resistance and ... health and disease: new insights into the genesis of cardiovascular disease Am J Med 1998; 105(1A):3 2S 3 9S Recognition and Assessment of Insulin Resistance 63 97 Avena R, Mitchell ME, Nylen ES, Curry...
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Medical Management of Diabetes and Heart Disease - part 4 docx
... O, Olsson AG, Thorgeirsson G Cholesterol lowering with simvastatin improves prognosis of diabetic patients with coronary artery disease A subgroup analysis of the Scandanavian Simvastatin Survival ... atherosclerosis, microthrombi present on the luminal surface of vessels can potentiate progression of atherosclerosis by exposing the vessel wall to clotassociated mitogens In later stages, mural ... insulin-resistant states such as obesity, hypertension, and the polycystic ovarian syndrome Coagulation and Fibrinolytic Systems 111 Increased expression of PAI-1 is a marker of increased risk...
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Medical Management of Diabetes and Heart Disease - part 5 pot
... tissue insulin resistance is easily understood if both the techniques usually used to assess resistance to insulinmediated glucose disposal and the differences in the dose-response characteristics ... half-maximally suppress adipose tissue lipolysis As a result, plasma FFA levels are maximally suppressed in all subjects, and differences in adipose tissue resistance to insulin cannot be discerned It is ... glucose disposal by muscle is the conventional way of assessing insulin resistance, adipose tissue appears to be as resistant to regulation by insulin as muscle The belated recognition of adipose...
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Medical Management of Diabetes and Heart Disease - part 6 pdf
... ratio less than indicates an abnormal response Blood Pressure Response to Standing: A decrease in the systolic blood pressure of more than 30 mmHg after of standing is considered to be consistent ... glucose tolerance test in women with PCOS that are obese, display signs of insulin resistance (acanthosis nigricans), or have a significant family history of type diabetes mellitus Fasting plasma ... echocardiographic stress test should be based on the available resources and local expertise Among diabetics with significant peripheral vascular disease, a pharmacological stress test may lend higher sensitivity...
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Medical Management of Diabetes and Heart Disease - part 7 pps
... Further, DM is an important predictor of subsequent saphenous vein graft occlusion as well as progression of atherosclerosis in both bypassed and nonbypassed vessels As described previously, the ... the results of insulin- or sulfonylurea-first treatments, since randomizations for those two parts of the UKPDS were performed several years apart Nonetheless, the results of the UKPDS suggest very ... on the vasculature and accelerate the development of atherosclerosis Recent results suggest that the deleterious effects of insulin or proinsulin on native vessel walls and on vessels subjected...
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Medical Management of Diabetes and Heart Disease - part 9 docx
... Special Therapeutic Considerations 239 by postangioplasty restenosis and is best explained by more aggressive disease progression in the diabetic patients, disease progression that ... myocardial perfusion studies has led to the use of this method in many centers (13,14) Further studies of these issues to include an analysis of cost effectiveness of routine follow-up testing in diabetic ... relation of risk factors to the development of atherosclerosis in saphenous vein bypass grafts and the progression of disease in the native circulation: a study 10 years after aortocoronary bypass surgery...
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Medical Management of Diabetes and Heart Disease - part 10 potx
... (SSPI), 118 Stent or Surgery (SOS), 244 Stents, 242–245 vs CABG, 244–246 CAD, 197–198 restenosis, 198–199 STOP-2, 74 Stress imaging test, coronary atherosclerosis, 164 Stress testing, asymptomatic ... Index SSPG, 118–119 SSPI, 118 Stable angina, chronic, myocardial revascularization, 236 Statins, 98–99 side effects, 99 Steady-state plasma glucose (SSPG), 118–119 Steady-state plasma insulin (SSPI), ... myocardial insults VI SUMMARY A worldwide epidemic of diabetes is in progress In the United States alone, over 16 million subjects have the disease Many more are insulin-resistant The progression of cardiovascular...
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FAILURES IN LOGISTICS MANAGEMENT OF VINALINK’S LOGISTICS DEPARTMENT AND RECOMMENDATIONS
... reserve stock As a result, it is more necessary for Vinalink s warehouses to make good use of space to stock as much goods as possible Having many wide aisles becomes a disadvantage in this case because ... access to stock at the same time, one suggestion for warehouse management is to design suitable systems of aisles for each section in the warehouse For reserve stock, the number and width of aisles ... organizations regarding particular situation of each one Experiences from predecessors will save successors time and money to find the optimal solutions for their businesses Moreover, these lessons will...
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Tài liệu Guidelines for the Management of Inflammatory Bowel Disease (IBD) in Children in the United Kingdom pdf
... risk of immuno-suppression, bone marrow suppression and malignancy must be discussed and the discussion recorded in the notes Disease activity can be expressed using a disease activity index such ... treatments such as corticosteroids or immunosuppressive drugs can cause secondary health problems ≥ Side effects such as weight gain and acne can be significant issues with adolescents ≥ Procedures such ... Induction of Remission ASA/Sulphasalazine (mild disease) Corticosteroids (moderate to severe disease) Maintenance Aminosalicylates Recurrent relapse or treatment resistance Second line treatment Specific...
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Tài liệu THERAPEUTICS of PARKINSON’S DISEASE and OTHER MOVEMENT DISORDERS docx
... robust model of parkinsonism Proceedings of the National Academy of Sciences, of the United States of America, 102, 2174 2179 1: THE ETIOPATHOGENESIS OF PARKINSON S DISEASE: BASIC MECHANISMS OF ... which slows or stops disease progression ACKNOWLEDGEMENT This study was supported by grants from the NIH/NINDS (1 RO1 NS045999-01), the Bendheim Parkinson s Disease Center, and the Morris and ... these positive symptoms of PD ANIMAL MODELS OF PARKINSON S DISEASE AND PARKINSONISM Early animal models of PD were based on lesions of midbrain areas in monkeys (Poirier et al., 1975) These anatomical...
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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx
... a-syn, proteins that displayed increased (›) or decreased (fl) expression as a consequence of a-synuclein overexpression; complex, proteins that displayed altered levels as a result of the association ... silver-stained gel images revealed 28 spots whose intensity was significantly different in at least one of the four groups considered (Fig 2) Two groups of spots showing remarkable changes in the isoform ... present study could represent a valuable starting-point for focused investigations aiming to better understand the key issues of PD pathogenesis Materials and methods Cells Human neuroblastoma SH-SY5Y...
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Tài liệu The Mother''''s Manual of Children''''s Diseases ppt
... of their parents.[1] Scrofula, which is another disease closely allied to consumption, is hereditary also; and hip disease, disease of the spine, abscesses, and enlarged glands in any members ... great causes of mortality in infancy, and of sickliness in later life The statistics of Foundling Hospitals bear sad testimony to the fact of its dangers, and the researches of physicians show that ... with a blush of redness Thrush in the child is of far less serious import than in the grown person In the latter it indicates the existence of some very serious, almost hopeless disease, and hence...
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Tài liệu THE MANAGEMENT OF SICKLE CELL DISEASE ppt
... 2000;(4 Suppl) :S1 -46], is used throughout this book: Genotype Full Name Abbreviation s s Sickle cell disease- SS SCD-SS s / βc Sickle cell disease- SC SCD-SC s / / βo thalassemia s / β+ thalassemia ... thalassemia SCD -S βo thal Sickle cell disease -S β+ thalassemia SCD -S β+ thal Sickle cell disease -S βo DIAGNOSIS AND COUNSELING W ORLD W IDE W EB R ESOURCES SICKLE CELL AND GENETIC WEB SITES Sickle ... result of a formalized consensus process but rather represents the efforts of those who have dedicated their professional careers to the care of individuals with sickle cell disease The names of...
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Tài liệu The Diagnosis, Evaluation, and Management of von Willebrand Disease ppt
... 7.8 4.3 Case series Case series Case series Case series Case series Retrospective review 26 3.1 N/A 3.3 Case series 9.1 N/A 8.3 N/A 10.2 10 Case series Case series 14 N/A N/A N/A Retrospective ... FVIII Because of the specific characteristics of von Willebrand Disease hemostasis and fibrinolysis on mucosal surfaces, symptoms in VWD are often greater in these tissues Plasma VWF is primarily ... genetic diseases and includes large deletions, frameshifts from small insertions or deletions, splice-site mutations, nonsense mutations causing premature termination of translation, and missense...
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Management of Sickle Cell Disease in Children doc
... pneumonia (acute chest crisis) Possible Concurrent Conditions • CNS event (stroke) • priaprism • aplastic crisis • fever/sepsis • acute chest syndrome • acute sequestration crisis Assessment and Treatment: ... initiation assessment Baseline Assessment: HR, BP, RR, O2 Sat, sedation score and pain score Administration Assessment: (usual infusion rate per dose, 15-20 minutes) HR, BP, RR O2 Sat and sedation score ... Previous episodes of severe sepsis or meningitis CPG 21-1 Management of Sickle Cell Disease in Children Page of 15 Table I: Antimicrobial Therapy Guidelines STAT dose within 30 minutes of presentation...
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PET in the Evaluation of Alzheimer’s Disease and Related Disorders docx
... as AD progresses Behavioral and personality changes, including agitation, aggression, and psychosis, often emerge as the disease progresses Depressed mood often occurs with AD Brain autopsies ... Parkinson s disease than in DLB The diagnosis is supported by a history of syncope, falls, confusion, extreme sensitivity to the movement side effects of neuroleptics, delusions, and other types of ... 18 DeKosky S Early intervention is key to successful management of Alzheimer disease Alzheimer Dis Assoc Disord 2003;17(Suppl 4) :S9 9–104 19 Leifer BP Early diagnosis of Alzheimer s disease: clinical...
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Surgical Treatment of Parkinson’s Disease and Other Movement Disorders pot
... development of a variety of movement disorders These diseases are conventionally categorized into either hypokinetic disorders, such as Parkinson s disease, or hyperkinetic disorders such as hemiballism ... existence of movement disorders such as Huntington s disease (HD) or dystonia, which seem to cross the boundary between these diseases Another common misconception is that movement disorders are ... this time 3.2 Dyskinetic Disorders In disorders associated with dyskinesias, basal ganglia output is thought to be reduced, resulting in disinhibition of thalamocortical systems and dyskinesias...
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