mechanisms and clinical significance in cancer hdac inhibitor induced apoptosis pdf
Báo cáo y học: "Differential cytopathogenesis of respiratory syncytial virus prototypic and clinical isolates in primary pediatric bronchial epithelial cells" pdf
... findings indicate that the use of RSV A2 in host-pathogen interaction studies might not be representative of recent RSV clinical isolates in terms of virus growth kinetics, CPE and chemokine induction ... syncytium formation in these cells Interestingly, RSV BT4a-infected PBECs and mock-infected controls were indistinguishable in terms of CPE Similar data were obtained following infection at MOI ... not affect growth kinetics Differential chemokine/cytokine secretion following RSV A2 and clinical isolate infection Chemokines/cytokines are important mediators of innate and adaptive immune...
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Clinical significance of cancer stem cell markers and other related proteins in colorectal carcinomas biological and methodological considerations
... capacity to self-renew and differentiate In this thesis, the molecular and clinical significance of cancer stemcell markers and its related proteins in colorectal cancers were investigated Tissue ... The MLH1 and MSH2 protein are essential in the mismatch repair machinery and mutations in MLH1 and MSH2 have been implicated in HNPCC (Boland et al., 1998) Many colorectal cancers with an intact ... inhibiting TYMS that causes depletion of thymidines and disruption DNA and RNA synthesis As a result, the cell undergoes apoptosis by “thymineless” death Interestingly, part of the interest in...
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Báo cáo y học: "yrosine kinase – Role and significance in Cancer"
... ATP binding site serves as a docking site for specific binding of cytoplasmic signaling proteins containing Src homology-2 (SH2) and protein tyrosine binding (PTB) domains These proteins in turn ... carcinoma Bladder cancer Glioblastoma multiforme Autocrine-paracrine loop Glioma Autocrine-paracrine loop PDGFR and PDGF IGFR and IGF I and II Breast cancer Table Protein kinase inhibitors in clinical ... tyrosine kinase inhibitors Inhibiting the activity of tyrosine kinases by low molecular weight compounds capable of interfering with either ligand binding (in the case of receptor tyrosine kinases)...
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Coexisting Bronchogenic Carcinoma and Pulmonary Tuberculosis in the Same Lobe: Radiologic Findings and Clinical Significance doc
... within the tumor was seen in 20 patients (39.2%), and was located eccentrically in 15 cases and centrally in five Cavitation within the tumor was observed in five patients (9.8%), and mediastinal ... curative surgery, the pathologic findings were reviewed to determine whether scar cancer was present This was defined as a tumor which according to the histologic and clinical evidence arose from a ... lymphadenopathy in 42 (82.4%) The stage of non-small-cell lung cancer was I in ten patients, II in two, IIIA in four, IIIB in 11, and IV in 20 At the time of diagnosis, all small-cell lung cancers (n=4)...
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Báo cáo hóa học: " Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer" potx
... SQ participated in acquiring clinical samples and follow-up clinical information MSC participated in study design and coordination, data analysis and interpretation and final writing of the manuscript ... analysis and interpretation, and drafted the manuscript PP and LG participated in acquiring clinical and laboratory data, data analysis and data interpretation and drafted the manuscript LG, JV, and ... Methods Lung cancer cell lines Six NSCLC cell lines consisting of three adenocarcinoma cell lines (A549, H522 and H358), two large carcinoma cell lines (H460, H661), and one squamous cell carcinoma...
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Báo cáo hóa học: " Co-evolution of cancer microenvironment reveals distinctive patterns of gastric cancer invasion: laboratory evidence and clinical significance" pptx
... components included in this study were MMPs and type IV collagen, two major factors for and against cancer invasion, and TAMs which are double-edge swords facilitating or deterring cancer invasion ... macrophages infiltration in developing neoplasms is now well recognized, and infiltrating macrophages play an important role in tumor cell invasion into surrounding normal tissues [24,25], including ... the interface of tumor nest and stroma is the main location of infiltrating macrophages in gastric cancer, and phagocytosis of cancer cells by macrophage, indicating the coexistence of M1 and...
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Báo cáo y học: "Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy (ART) in sub-Saharan Africa: Frequency and clinical significance" ppt
... a center of excellence in HIV care, training, and research at Makerere University Medical School and Mulago Teaching Hospital in Kampala, Uganda Since 2004, the IDI clinic (IDC) has provided ... positive patients, and by December, 2007, IDC had enrolled 20,000 patients into HIV care, of whom 13,000 are in active follow-up and 4700 have initiated ART according to WHO and Uganda Ministry of Health ... Patients were included in the analysis if they had attained and sustained HIV-RNA viral load ≤ 400 copies per ml at 6, 12 and 24 months The chi square test was used to compare the baseline clinical...
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Báo cáo y học: "Clinical significance in the number of involved lymph nodes in patients that underwent surgery for pathological stage III-N2 non-small cell lung cancer" pot
... adenocarcinomas (53.7%), 39 squamous cell carcinomas (32.2%) and 13 large cell carcinoma (10.7%) and adenosquamous carcinomas (3.3%) There were 27 patients in T1, 53 in T2, 32 in T3, and in T4 (stage ... M: Randomized phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small-cell lung cancer: ... IIIB) Clinical stages were diagnosed as stage I in 46 patients, stage II in 6, and stage III in 69 A pneumonectomy was performed in 25 (20.7%), a bilobectomy in (7.4%), and a lobectomy in 87...
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báo cáo khoa học: "Expression and prognostic significance of cancer-testis antigens (CTA) in intrahepatic cholagiocarcinoma" ppt
... according to the following inclusion criteria: having archived formalin-fixed, paraffin-embedded specimens available; having complete clinicopathological and followed-up data; receiving no anticancer ... evaluated and scored by two and independent observers according to the previous criteria [14] Positive CTA expression was assigned to any extent of immunostaining in sections and further graded into ... Gallstones and the risk of biliary tract cancer: a population-based study in China Br J Cancer 2007, 97:1577-1582 Suri A: Cancer testis antigens–their importance in immunotherapy and in the early...
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Báo cáo y học: " Expression, regulation and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseases" pptx
... component in pulmonary inflammation/infection and may represent a promising marker and therapeutic target in respiratory diseases The expression, regulation and clinical significance of sCD14 and mCD14 ... treatment resulted in increased mCD14 expression on monocytes [21] and alveolar macrophages [34] Our findings indicate that 40 h incubation with LPS and CpG induced sCD14 secretion and increased mCD14 ... of incubation was protease-independent since PMSF did not inhibit CpG -induced sCD14 release by PBMCs After 40 hours of incubation, LPS and CpGs cooperated in the induction of sCD14 levels and...
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Báo cáo y học: "Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults" pot
... the correlated readings within an individual and examine the association between changes in WOMAC scores (pain, function, and stiffness) and continuous changes in BML size Standard diagnostic ... based sample using a quantitative measure; and 2) examine the clinical correlates of BMLs, including pain, function, and stiffness scores and total knee replacement surgery Materials and methods ... changes in the five WOMAC pain sub-scales and changes in BML size, stratified by ROA Changes in knee pain when walking on a flat surface, going up and down stairs, and at night while in bed was...
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Báo cáo khoa học: A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer pot
... RNA-binding-domain protein that is a homologue of the HIV transactivating response RNA-binding protein (TRBP) The functional strand of the miRNA duplex guides the RNA -induced silencing complex (RISC) ... lymphomagenesis in mice [44] The miRNA miR-21 is overexpressed in many solid tumors, including breast, colon, lung, prostate and stomach, and in endocrine pancreas tumors, glioblastomas and uterine leiomyomas ... examined to date [8,52], a feature that could be particularly useful in diagnosing incident cancers in otherwise normal tissues Indeed, this approach discriminates normal and neoplastic tissues in...
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NUTRITION AND METABOLISM Underlying Mechanisms and Clinical Consequences pdf
... coordinated so that the resulting volume imparts greater knowledge than the sum of the information contained in the individual chapters Nutrition and Metabolism: Underlying Mechanisms and Clinical ... shifting in such a way that the continued increase in body fatness is increasingly being recognized as underlying several chronic disease states This phenomenon is slowing or even reversing gains ... constellation of clinical findings including obesity, hypertension, hyperlipidemia, and insulin resistance, with increased risk for type diabetes and cardiovascular disease It has also been linked with...
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ONCOGENOMICS AND CANCER PROTEOMICS – NOVEL APPROACHES IN BIOMARKERS DISCOVERY AND THERAPEUTIC TARGETS IN CANCER pot
... Wnt/βcatenin and cadherin pathway genes including N-cadherin and P-cadherin but low E-cadherin protein expression This finding demonstrated the highgrade serous ovarian cancer contained messenchymal ... targets in cancer are also included Chapters in “Oncogenomics and Cancer Proteomics - Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer present comprehensive and expert ... associated with increased breast cancer risk in all Chinese in Tianjin, Nanjing, Taiwan and Hong Kong This was also in agreement with three studies conducted in Japanese women (Nagoya, MEC and Nagano)...
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cell cycle control mechanisms and protocols methods in molecular biology - tim humphrey, gavin brooks
... posttranslational mechanisms including phosphorylation, inhibition by cyclin-kinase inhibitors, destruction of cyclins, and destruction of the inhibitors at the appropriate time in the cell cycle These mechanisms ... cell cycle proteins including G1 cyclins (Cln1 and Cln2), Cdk inhibitors The Budding and Fission Yeasts 11 (Sic1, Far1, and Rum1), and replication proteins (Cdc6 and Cdc18; reviewed in ref 55) SCF ... Kinase Inhibitors CDK-cyclin activity can also be inhibited through binding of CDK inhibitor proteins In budding yeast there are potentially three CKIs, Far1p (32), Sic1p (33), and Cdc6 (34) In fission...
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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
... propagates inflammatory responses and is a significant RAGE ligand in the setting of sepsis and acute inflammation HMGB1 is an apparent autocrine/paracrine regulator of monocyte invasion, involving ... reductase inhibitors (ARI's) derived from quinazoline They, in addition to vitamin C and E, have ameliorative benefits in decreasing intracellular oxidative stress [174] Vitamin E is effective in part ... upregulation of inflammation in this setting [181] Another RAGE ligand, AGE-CML, is present in endoneurial and epineurial mononuclear cells in chronic inflammatory demyelinating polyneuropathy and vasculitic...
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báo cáo hóa học: "Estimation of minimally important differences in EQ-5D utility and VAS scores in cancer" pot
... European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology J Natl Cancer Inst 1993, 85(5):365-376 de Haes ... Health and Quality of Life Outcomes 2007, 5:70 clinical trials in oncology are increasingly incorporating generic preference-based measures such as EQ-5D EQ-5D is an indirect measure ... DE: Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy (FACT) anemia and fatigue scales J Pain Symptom...
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Báo cáo hóa học: " Colistin: recent data on pharmacodynamics properties and clinical efficacy in critically ill patients" pot
... colistin -induced nephrotoxicity in approximately 30% of patients [27,28] Apart from adults, intravenous colistin also has been administered with safety and efficacy in children and neonates, including ... aeruginosa and Acinetobacter baumannii in Siriraj Hospital, Bangkok, Thailand Int J Infect Dis 2007, 11:402-406 28 Kim J, Lee KH, Yoo S, Pai H: Clinical characteristics and risk factors of colistin -induced ... Optimizing colistin dose based on PK/PD properties The optimal dose of colistin has not been determined in the ICU setting, because since there is a lack of relative clinical studies In addition,...
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Báo cáo y học: "The Inventory of Personality Organisation: its psychometric properties among student and clinical populations in Japan" pptx
... others (having warm, satisfying, trusting relationships with others), (3) autonomy (self-determination and independence), (4) environmental mastery (a sense of mastery and competence in handling one's ... scores decreased with increasing participant age The above findings were virtually the same even after controlling for age and gender (one and two cases were missing for age and gender, respectively) ... the IPO in clinical and non -clinical populations If future studies agree with our findings, the Japanese version of the IPO will prove an excellent tool to screen for personality pathology in busy...
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