mechanism and causes of protein destabilization
Báo cáo khoa học: Phosphorylation mechanism and structure of serine-arginine protein kinases pot
... SRPK1 and SRSF1, together with crystal structures of SRPK1 bound to peptide and protein substrates and the recent structures of CLK1 and CLK3, suggest an elegant mechanism of recognition and phosphorylation ... structure and mechanism G Ghosh and J A Adams spliceosome, a macromolecular complex composed of five small nuclear ribonucleoproteins (U1, U2, U4, U5, and U6) and over 100 auxiliary proteins [4] ... sequential and processive phosphorylation of an SR protein by SRPK1 Mol Cell 29, 563–576 29 Ma CT, Ghosh G, Fu XD & Adams JA (2010) Mechanism of dephosphorylation of the SR protein ASF ⁄ SF2 by protein...
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Báo cáo y học: "Creation and disruption of protein features by alternative splicing a novel mechanism to modulate function" docx
... skipping of exon leads to a protein with this feature We provide evidence for this mechanism by considering four protein features: TM helices, phosphorylation and glycosylation sites, and Pfam ... the inclusion of two exons resulted in a loss of one TM domain as well as the gain of three others (Figure 1b) The massive reconstruction of TM domains in the respective protein isoforms can have ... between exon and Disruption of the single TM domain, soluble protein DPP8 Dipeptidylpeptidase NM_017743 NM_197961 Exon between exon 15 and 16 Disruption of the single TM domain, soluble protein COX7A2...
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Tài liệu Báo cáo khoa học: Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates pdf
... key features of PDH specificity and mode of inhibition of the enzyme Results and Discussion Structural analysis and model quality Crystal structures of three different complexes of LlPDH have ... parameters (B-factors) and, where appropriate, the ligand occupancies Superposition of subunit A on B and C (468 Ca atoms) in complex II and III of LlPDH gives an rmsd of ˚ 1.6 A in each case, ... of B on C ˚ gives an rmsd of only 0.3 A We analysed this difference using the program dyndom [20] and identified a movement of the cofactor-binding domain of subunit A relative to subunits B and...
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Báo cáo khoa học: Molecular cloning, expression and characterization of protein disulfide isomerase from Conus marmoreus pdf
... integrated elution peak areas, and the PDI’s oxidase and isomerase activities were expressed as the initial rate of decrease of linear tx3a and the initial rate of increase of nTx3.1, respectively To ... prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites Protein Eng 10, 1–6 13 Song J, Quan H & Wang C (1997) Dependence of the anti-chaperone activity of protein disulphide ... of disulfide oxidase and isomerase based on the model of hirudin folding Anal Biochem 339, 94–103 Walker KW, Lyles MM & Gilbert HF (1996) Catalysis of oxidative protein folding by mutants of protein...
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Báo cáo Y học: Structure, mechanism and function of prenyltransferases docx
... condensation kinetics and mechanism of trans-IPPS and cis-IPPS for the production of linear polyprenyl pyrophosphates, and the reaction mechanism and structures of protein prenyltransferases and isoprenyl ... diagram of Ras FTase and (B) the molecular ruler mechanism for substrate specificity of FTase and GGTase (A) The heterodimeric enzyme consists of two subunits, a and b, colored in cyan–blue and yellow–green, ... distribution of the UPPS and OPPS reactions is that, when the Ó FEBS 2002 Structure, mechanism and function of prenyltransferases (Eur J Biochem 269) 3347 concentration of the UPPS and FPP complex...
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Báo cáo khoa học: The Yin and Yang of protein folding doc
... properties of different ensembles on the folding energy landscape [19,20] Mechanisms of protein misfolding and aggregation A large number of protein- misfolding diseases belong to a class of grave ... The Yin and Yang of protein folding T R Jahn and S E Radford subglobal unfolding events For most proteins, however, the cooperativity of the protein folding process, and the assistance of the ... offering another route for therapeutic intervention [48,49] A clear understanding of the mechanism of the association of these cofactors with amyloid fibrils may expose further possibilities of...
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Báo cáo khoa học: Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase pptx
... The actual and detailed mechanism of GC activation by ANP, namely the signal transduction mechanism, must await determination of NPRA’s GCD structure and ultimately the structure of full-length ... structure and signaling A Fig (A, B) Crystal structures of the apoECD dimer (Protein Data Bank: 1DP4) and the ANP–ECD complex (Protein Data Bank: 1T34) [17,34] ANP is shown in green Protein- bound ... cGMP-sensitive and amiloride-sensitive cation channels on the luminal membrane of collecting duct cells (by direct inhibition of the channels by cGMP and by suppression via cGMP-dependent protein kinase and...
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báo cáo hóa học:" Psychometric properties and the prevalence, intensity and causes of oral impacts on daily performance (OIDP) in a population of older Tanzanians" potx
... a Cronbach's alpha of 0.90 (Table 6) Prevalence, extent, intensity and causes of OIDP A total of 43.2% and 44.5% had impact scores of zero (floor effect) using the OIDP ADD and the OIDP-total ... different settings, and distinction between disability and handicap A critique of papers on the application of the International Classification of Impairments, Disabilities, and Handicaps Int Disabil ... measurement of "ultimate" oral impacts, thus covering the fields of disability and handicap [4,5] It consists of items that assess the impact of oral conditions on basic activities and behaviours...
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báo cáo khoa học: "The expression and role of protein kinase C (PKC) epsilon in clear cell renal cell carcinoma" ppt
... values of P < 0.05 considered statistically significant Results PKCε expression in renal tissues The expression of PKCε protein in 15 specimens of normal renal tissues and 128 specimens of RCC ... both cytoplasm and nuclei, sometimes on the membrane, of 769P cells (Figure 2B) Effects of PKCε on proliferation, migration, and invasion of 769P cells To examine the functions of PKCε, we knocked ... contributions to acquisition of data XBL, SJG and ZW performed the statistical analysis BH, JXC and SPQ participated in the design of the study BH and KYC drafted the manuscript XPM and SPQ revised the...
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báo cáo khoa học: "Design and characterization of protein-quercetin bioactive nanoparticles" doc
... loss of the a-helix during aggregation Meanwhile, the broadening of this band and the increase of the band intensity at 1665 cm-1 implies the increase of the random-coil content in the protein ... and Q (Figures 10 and 11, Tables and 5) The bands near 1339 [31,32] and 758 [33] cm-1 have been found to be indicators of the hydrophobicity of the Trp environment, and a decrease in these band ... variation of the zeta potential of the BSA, Lys, and Mb systems versus the concentration of DMSO (A, A’, and A’’) and Q (B, B’, and B’’) With increasing DMSO concentration, the zeta potential values of...
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Báo cáo y học: "Refinement and prediction of protein prenylation motifs" ppt
... Figure GGT1 substrates Sequence logos [74] and physicochemical property profiles of FT and Sequence logos [74] and physicochemical property profiles of FT and GGT1 substrates Selected physical properties ... folds back to protein core and reduces flexibility and accessibility of C-terminus Corr, correlation; LS, learning set; nrLS, nonredundant; prof, profile (and listed in Tables and together with ... or selections of the single predictors Details of the profile and physical property terms of the scoring function are provided and can also be used to check and rationalize whether and why certain...
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an inquiry into the nature and causes of the wealth of nations phần 1 doc
... Parts of the Price of Commodities 41 CHAPTER VII Of the Natural and Market Price of Commodities 47 CHAPTER VIII Of the Wages of Labour 55 CHAPTER IX Of the Profits of Stock 73 CHAPTER X Of Wages and ... corn of England, though, in opulence and improvement, France is perhaps inferior to England The corn-lands of England, however, are better cultivated than those of France, and the corn-lands of ... that of a nailer in the remote and inland parts of the Highlands of Scotland Such a workman at the rate of a thousand nails a day, and three hundred working days in the G.ed p32 The Wealth of Nations...
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an inquiry into the nature and causes of the wealth of nations phần 2 doc
... and people of good credit in the capital, and in many other parts of the kingdom, at three and a half, four, and four and a half per cent Since the time of Henry VIII the wealth and revenue of ... of their own gains They complain only of those of other people 81 CHAPTER X G.ed p116 OF WAGES AND PROFIT IN THE DIFFERENT EMPLOYMENTS OF LABOUR AND STOCK 238 [1] 239 [2] 240 [3] T HE whole of ... demand for labour increases in years of sudden and extraordinary plenty, and diminishes in those of sudden and extraordinary scarcity, that the money price of labour sometimes rises in the one and...
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an inquiry into the nature and causes of the wealth of nations phần 3 pdf
... whole price of cattle would fall, and along with it both the rent and the profit of all those lands of which cattle was the principal produce, that is, of the greater part of the lands of the country ... industry and skill of their artificers and manufacturers; in every sort of machinery which can facilitate and abridge labour; in shipping, and in all the other instruments and means of carriage and ... purchase, and of the low price of that food But in countries of equal art and industry, the money price of the greater part of manufactures will be in proportion to the money price of labour; and in...
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an inquiry into the nature and causes of the wealth of nations phần 4 pot
... inhabitants of the country, either as the wages of their labour, the profits of their stock, or the rent of their land But though the whole value of the annual produce of the land and labour of every ... other person, as the rent of his land Thus, of the produce of land, one part replaces the capital of the farmer; the other pays his profit and the rent of the landlord; and thus constitutes a revenue ... of keeping at all times in its coffers, for answering the occasional demands of the holders of its notes, a large sum of money, of which it loses the interest; and, secondly, in the expense of...
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an inquiry into the nature and causes of the wealth of nations phần 5 ppsx
... prohibition of exporting gold and silver was in France and England confined to the coin of those respective countries The exportation of foreign coin and of bullion was made free In Holland, and in ... same manner as the corn in Poland is at this day exchanged for the wines and brandies of France and for the silks and velvets of France and Italy A taste for the finer and more improved manufactures ... flourished in Flanders, and which were introduced into England in the beginning of the reign of Elizabeth; and such are the present silk manufactures of Lyons and Spit6 [Smith] See Sandi Istoria...
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an inquiry into the nature and causes of the wealth of nations phần 6 ppt
... rich and industrious nations; and the merchants and manufacturers of each dread the competition of the skill and activity of those of the other Mercantile jealousy is excited, and both inflames, and ... land carriage consequently, or of the greater part of the inland commerce of the country By regulating the money price of all the other parts of the rude produce of land, it regulates that of ... the proportion of gold and silver to the annual produce of the land and labour of Spain and Portugal, and to that of other countries It is said accordingly to be very considerable, and that you...
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an inquiry into the nature and causes of the wealth of nations phần 7 pps
... a year That of New Hampshire and Rhode Island, 3,500l each That of Connecticut, 4,000l That of New York and Pennsylvania, 4,500l each That of New Jersey, 1,200l That of Virginia and South Carolina, ... has improved and cultivated the sugar colonies of England has, a great part of it, been sent out from England, and has by no means been altogether the produce of the soil and industry of the colonists ... be doubted Some part of the produce of America is consumed in Hungary and Poland, and there is some demand there for the sugar, chocolate, and tobacco of that new quarter of the world But those...
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an inquiry into the nature and causes of the wealth of nations phần 8 pps
... only of what is properly called Political Œconomy, or of the nature and causes of the wealth of nations, but of every other branch of the system of civil government, all follow implicitly and ... cowardice of its last king The militias of all the civilised nations of the ancient world, of Greece, of Syria, and of Egypt, made but a feeble resistance to the standing armies of Rome The militias of ... The first of those causes or circumstances is the superiority of personal qualifications, of strength, beauty, and agility of body; of wisdom and virtue, of prudence, justice, fortitude, and moderation...
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an inquiry into the nature and causes of the wealth of nations phần 9 pptx
... they are commonly called, of hunters, of shepherds, and even of husbandmen in that rude state of husbandry which precedes the improvement of manufactures and the extension of foreign commerce In ... supposed to be one-fifth, not only of the rent of all the land, but of that of all the houses, and of the interest of all the capital stock of Great Britain, that part of it only excepted which is ... stock in the cultivation of land A very considerable part of the produce of this tax arises from the rent of houses, and the interest of capital stock The land-tax of the city of London, for example,...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25