management basic principles of drug therapy
Báo cáo khoa học: The in vitro effects of CRE-decoy oligonucleotides in combination with conventional chemotherapy in colorectal cancer cell lines potx
... irrespective of the chemotherapy used Consequently, the effects of 5-FU on the cell lines are presented, which were most representative of the effects seen with any of the three drugs studied ... may have been a result of an inhibition of cellular proliferation Therefore, at the end of each of the culture schedules, cells were pulsed with BrdU for 30 mins The extent of BrdU incorporation ... the G1, S or G2 phases of the cell cycle, suggesting that the reduction in cell number may have been the result of a general and simultaneous blockade of all three phases of the cell cycle Cell...
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RESPIRATORY HEALTH EFFECTS OF PASSIVE SMOKING: LUNG CANCER AND OTHER DISORDERS ppt
... Lebowitz, Professor of Internal Medicine, University of Arizona College of Medicine, Division of Respiratory Sciences, Tucson, AZ 85724 Dr Howard Rockette, Professor of Biostatistics, School of Public ... Associate Professor of Medicine, Department of Medicine, University of California, San Diego Medical Center, 225 Dickenson Street, San Diego, CA 92103-1990 Dr Delbert Eatough, Professor of Chemistry, ... the Office of Health and Environmental Assessment (OHEA) within the Office of Research and Development, with major contract funding provided by the Indoor Air Division within the Office of Air...
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báo cáo hóa học:" Pain in cancer. An outcome research project to evaluate the epidemiology, the quality and the effects of pain treatment in cancer patients" pptx
... epidemiology of cancer pain and of its treatments, the quality of analgesic -drug therapy and the effect of alternative analgesic strategies in a large, prospective, unselected cohort of cancer patients ... in issues related to cancer pain [13]; b) drug utilization and appropriateness: an evaluation of the volume and quality of prescriptions of analgesic drugs in a large administrative data base ... available in the list of reimbursable drugs in most of Italian regions, as well as some "strong" WHO-step III opioids, making it difficult for physicians the appropriate prescription of drugs and creating...
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Báo cáo y học: "Anti-tumorigenic and Pro-apoptotic effects of CKBM on gastric cancer growth in n" potx
... Adjunct Professor of University of Toronto and is Honorary or Visiting Professor of over ten universities Int J Med Sci 2004 1(3): 137-145 142 Chi-Hin Cho, PhD, is Chair Professor of Pharmacology ... Officer of CK Life Sciences Limited Dr Pang was the Head of Department of Physiology at University of Hong Kong prior joining the company He had been the founding Editor and Editor-in-Chief of ... Section of International Union of Pharmacology He serves on the editorial board of several journals such as European Journal of Pharmacology, Journal of Gastroenterology & Hepatology, and Journal of...
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Báo cáo khoa học: "A paraneoplastic manifestation of metastatic breast cancer responding to endocrine therapy: a case report" ppsx
... review of 31 reported cases of paraneoplastic neurological syndromes due to breast cancer reported only 29% of patients responded to chemotherapy with an improvement in neurological deficits [3] Often ... Pattern of serum IgG and CK levels with time from treatment Pattern of serum IgG and CK levels with time from treatment Page of (page number not for citation purposes) World Journal of Surgical ... visceral disease Biopsy of the axillary lymph node confirmed the diagnosis of an oestrogen receptor (ER) positive invasive carcinoma of mammary type Mammography and ultrasound of the breasts were...
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Báo cáo khoa học: " Effects of osteopontin inhibition on radiosensitivityof MDA-MB-231 breast cancer cells" doc
... OPN and its role in cancer progression to improve the opportunities of cancer therapy, especially the effectiveness of radiotherapy It is well known that OPN plays an important role in breast ... accelerator at a dose rate of Gy/min Referring to the fractionated daily dose in therapy treatment and DMF 10 -value of the MDA-MB-231 cell line, we have chosen a radiation dose of Gy and Gy, respectively ... (Sigma) The number of colonies was counted to determine the survival fraction (SF), determined as the ratio of number of colonies formed by irradiated cells to the number of colonies formed by...
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Báo cáo khoa học: "Effects of propranolol in combination with radiation on apoptosis and survival of gastric cancer cells in vitro" ppsx
... sensitizer in gastric cancer therapy Guidelines of the NCCN on gastric cancer Figure Quantification of mRNA expression of different genes Analysis of mRNA expression of COX-2, VEGF and EGFR was ... due to the decrease in expression of NF-B via inhibited b-ARs Discussion Gastric cancer is one of the major causes of cancer mortalities in the world, and radiotherapy is an important treatment ... concentrations of drugs were chosen from our previous research The b-AR antagonist propranolol and the b-AR stimulator isoproterenol were purchased from Sigma Chemical After 24 h of drug exposure,...
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Báo cáo khoa học: "The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation" pot
... ability to increase cytotoxic efficacy of chemotherapy and radiotherapy in preclinical investigations [10-12] Induction of apoptosis by ErPC3 and related drugs occurs mainly via the mitochondrial ... levels of anti-apoptotic Mcl-1 The rather low levels of Bcl-2 in the PC3 cells may explain why the radiation-induced down-modulation of Bcl-2 was of minor importance for the response of PC3-cells ... mechanism of action will have differential effects in prostate tumors with a distinct genetic background A detailed molecular profiling of the tumor cells of each patient as well as the definition of...
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Báo cáo khoa học: "Effects of radiation therapy on tissue and serum concentrations of tumour associated trypsin inhibitor and their prognostic significance in rectal cancer patients" doc
... further supports the potential utility of TATI as a prognostic biomarker in patients with cancer of the colon and rectum, irrespective of neoadjuvant RT Page of 10 Additional material Additional ... Research Funds of Skåne University Hospital Author details Department of Clinical Sciences, Division of Pathology, Lund University, Skåne University Hospital, Lund, Sweden 2Department of Clinical ... collection of tissue samples and data AB participated in the conception of the study, BN assisted with the TMA construction and revision of the manuscript, UHS participated in revision of the manuscript,...
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Báo cáo khoa học: " Distinct effects of rectum delineation methods in 3D-confromal vs. IMRT treatment planning of prostate cancer" pdf
... wall due to gravity With CT density values of the rectal wall often very similar to the density of the filling a precise delineation of the inner contour of the rectal wall was difficult for some ... rectal wall based on manual delineation of the inner and outer contour of the rectal wall 2) rectal wall based on manual delineation of the outer contour of the rectal wall and automatic calculation ... dimensional conformal radiotherapy (3D-CRT) in comparison to conventional radiotherapy resulted in lower rates of late rectal toxicity [4] and allowed the safe administration of doses up to 80Gy Intensity-modulated...
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Báo cáo y học: " mRNA expression profiles show differential regulatory effects of microRNAs between estrogen receptor-positive and estrogen receptor-negative breast cancer" pdf
... hsa-miR-517a hsa-miR-769-5p RE-score profiles of microRNAs for the classification of ER+ and ER- breast tumors Figure RE-score profiles of microRNAs for the classification of ER+ and ER- breast tumors ... animals [17-23] Overexpression of miRNA in cell lines cause moderate down-regulation of a large number of transcripts, many of which contain the complementary sequences of the over-expressed miRNA ... suggest that expression profiles of miRNAs are informative for the classification of human cancers Based on miRNA-expression profiles, Lu et al [13] reported the classification of 334 leukemia and...
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báo cáo khoa học: " XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate cancer cells" docx
... periods of time We found a time-dependent manner of up-regulation of XAF1 mRNA and protein in the cells treated with somatostatin and Octreotide (Figure 2, and 4) Xing et al Journal of Experimental ... Page of Figure Expression of XAF1 mRNA and protein in human prostate cell lines a RT-PCR analysis of XAF1 mRNA; the b-actin transcript was analyzed as a control b Western blot analysis of XAF1 ... of LNCaP, medium invasive ability for DU145 and a higher ability for PC3 The varying expression of XAF1 suggests a causal changing of androgen dependency and invasiveness in the development of...
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báo cáo khoa học: "Enhancive effects of Lewis y antigen on CD44-mediated adhesion and spreading of human ovarian cancer cell line RMG-I" pps
... contained µL of 5× PrimeScript™Buffer, µL of PrimeScript™RT Enzyme Mix I, µL of 50 µmol/L Oligo dT Primer, µL of 100 µmol/L Random mers, µL of total RNA, and 11 µL of RNase-free dH2O The reaction conditions ... SYBR® Premix Ex Taq™, 0.5 μL of μmol/L PCR forward primer, 0.5 μL of μmol/L PCR reverse primer, µL of cDNA, and µL of dH2O The reaction conditions were 45 cycles of denaturation at 95°C for 20 ... Foundation of China (No 30170980, 30571958, 30872757, 81072118); Natural Science Foundation of Liaoning Province, China (No 20052107); Ph D Programs Foundation of Ministry of Education of China...
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báo cáo khoa học: " Potent cytotoxic effects of Calomeria amaranthoides on ovarian cancers" pps
... Figure Changes in abdomen size for control and treated mice In spite of the introduction of new drugs into the management of ovarian cancer there is still need for more novel treatments Conclusion ... required to verify the mechanisms and mode of action of EPD, and to further validate the potential of EPD as an anti-cancer drug in ovarian cancer and other types of cancer Acknowledgements We thank ... ovarian cancer cells indicated fraction (309 mg, 0.09% of the dried plant; out of the twelve Page of fractions, see above) as the fraction with most of the cytotoxicity and its main chemical constituent...
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báo cáo khoa học: "Effects of ulinastatin and docetaxel on breast cancer invasion and expression of uPA, uPAR and ERK" docx
... http://www.jeccr.com/content/30/1/71 Page of Figure Effects of ulinastatin and docetaxe on mRNA level of uPA, uPAR and ERK in MDA-MB-231 cells and MCF-7 cells （1）Shown are the RT-PCR results of relative mRNA levels of uPA (a) ... of Figure Effects of docetaxe and ulinastatin on expression of uPA, uPAR and p-ERK1/2 in mouse exografts Shown are the quantitative results of uPA, uPAR and p-ERK1/2 expression in exografts of ... promoter of uPA gene has NF-B binding sites, therefore, p-ERK can increases expression of uPA through activation of NFB[10] In addition, a large number of studies in recent Luo et al Journal of Experimental...
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báo cáo khoa học: " Effects of metastasis-associated in colon cancer 1 inhibition by small hairpin RNA on ovarian carcinoma OVCAR-3 cells" pot
... of Organization and Embryology of Basic Medical College of Zhengzhou University for providing us plasmid psuper-EGFP as a kind gift for free Authors’ contributions ZR participated in design of ... rates of apoptosis.*P < 0.05 versus control groups Zhang et al Journal of Experimental & Clinical Cancer Research 2011, 30:83 http://www.jeccr.com/content/30/1/83 Page of 12 Figure Knockdown of ... level of Met protein was down-regulated significantly, as well as expressions of p-MEK1/2 and p-ERK1/2 protein, but expression of p-Akt was uninfluenced Therefore, we presumed that inhibition of...
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báo cáo khoa học: " Effects of RNA interference-mediated gene silencing of JMJD2A on human breast cancer cell line MDA-MB-231 in vitro" pptx
... of histones like methylation is now generally recognized as an important factor in the regulation of gene expression [19,20] The combination of different modifications and the incorporation of ... generated by reverse transcription of μg of total RNA using random primers and PrimeScript RT Master Mix Perfect Real Time (TaKaRa, Dalian, China) in a total reaction volume of 40 μl according to the ... levels of JMJD2A protein expression in the siRNA group (0.093 ± 0.051) Li et al Journal of Experimental & Clinical Cancer Research 2011, 30:90 http://www.jeccr.com/content/30/1/90 Page of were...
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báo cáo khoa học: " Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells" pdf
... methylation of these genes’ promoter as well as the malignant phenotype of tumor cells, which might contribute to the investigations of functions and regulation roles of DNMT1 in cervical cancer Page of ... containing μl of DNA template, μl of × Master Mix, μl ddH2O and μl of each primer The relative changes in the extent of promoter methylation were determined by measuring the amount of promoter ... Journal of Experimental & Clinical Cancer Research 2011, 30:98 http://www.jeccr.com/content/30/1/98 Page of Figure Effects of DNMT1 silencing on cell cycle and apoptosis (A): Phases of cell cycle of...
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báo cáo khoa học: "The effects of β-glucan on human immune and cancer cells" pptx
... actual usefulness of this group of herbs as well as their active ingredients are lacking In recent years, one of the active ingredients responsible for the immunomodulation of many of these herbs ... survival of the 3F8 plus β-glucan group was 5.5-fold higher than that of the control groups, and up to 47% of the mice remained progression free in contrast to
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báo cáo khoa học: " A case of limbic encephalitis presenting as a paraneoplastic manifestation of limited stage small cell lung cancer: a case report" ppsx
... only 32% of patients had isolated limbic encephalitis The neurological symptoms often precede identification of the tumor by weeks or months and the non-specific nature and diversity of symptoms ... (Figure 1) was abnormal with left hilar shadowing A biochemical profile showed hyponatremia with a serum sodium level of 128mmol/L In view of her significant smoking history the most likely diagnosis ... cells We therefore performed a CT-guided biopsy (Figure 4) of the left lower lobe lesion It was suggestive of neoplastic infiltration of lung parenchyma by small cell carcinoma Furthermore, immunohistochemistry...
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