... and Malignant Diseases oftheProstate Benign and Malignant Diseases ofthe Prostate: Introduction Benign and malignant changes in theprostate increase with age. Autopsies of men in the ... converted by the enzyme 5α-reductase to dihydrotestosterone in the gland. The periurethral portion ofthegland increases in size during puberty and after the age of 55 due to the growth of nonmalignant ... decade of life show hyperplastic changes in >90% and malignant changes in >70% of individuals. The high prevalence of these diseases among the elderly, who often have competing causes of...
... proviso that the risks and benefits ofthe performance of these Chapter 091. Benign and Malignant Diseases oftheProstate (Part 2) Diagnosis and Treatment by Clinical State The disease ... were high-grade [37% (280 of 757 cancers) vs. 22% (237 of 1068 cancers) for the placebo group] have been shown to be an artifact ofthe reduced volume ofthe malignant epithelial cells in finasteride-treated ... trial. Theprostate cancer detection rate was 18.4% (803 of 4364) in the finasteride group and 24.4% (1147 of 4692) in the placebo group. Early concerns that the cancers detected in the finasteride...
... amount of cancer is quantified based on the length ofthetumor within the core and the percentage ofthe core involved. accuracy for men with a PSA between 4 and 10, the risk of cancer ... Benign and Malignant Diseases oftheProstate (Part 3) The PSA criteria used to recommend a diagnostic prostate biopsy have evolved over time. The goal is to increase the sensitivity ofthe test ... to die ofthe disease and to reduce the frequency of detecting cancers of low malignant potential in elderly men more likely to die of other causes. Age-specific reference ranges reduce the upper...
... Malignant Diseases oftheProstate (Part 4) Pathology The noninvasive proliferation of epithelial cells within ducts is termed prostatic intraepithelial neoplasia. PIN is a precursor of ... confined to thegland (T2), and those that have extended outside thegland (T3 and T4) (Table 91-1). DRE alone is inaccurate with respect to the extent ofthe disease within the gland, the presence ... The most poorly differentiated area oftumor (i.e., the area with the highest histologic grade) often determines biologic behavior. The presence or absence of perineural invasion and extracapsular...
... radiation therapy, or active surveillance. Choice of therapy requires the consideration of several factors: the presence of symptoms, the probability that the untreated tumor will adversely affect the ... treatment, and the probability that thetumor can be cured by single-modality therapy directed at theprostate or requires both local and systemic therapy to achieve cure. As most ofthe tumors detected ... treatment. Data from the literature do not provide clear evidence for the superiority of any one treatment. Comparison of outcomes of various forms of therapy is limited by the lack of prospective...
... intensity-modulated radiation therapy Chapter 091. Benign and Malignant Diseases oftheProstate (Part 6) Radical Prostatectomy The goal of radical prostatectomy is to excise the cancer completely ... disruption ofthe vascular supply and not the nerve fibers. Neoadjuvant hormone therapy has also been studied in combination with radiation therapy. The aim is to decrease the size oftheprostate ... younger patient with a low probability of cure. Prostatectomy techniques continue to improve as the ability to determine whether thetumor is localized to thegland improves based on different biopsy...
... undergone surgery, prostatectomy for patients who had undergone radiation therapy. The decision to recommend radiation therapy after prostatectomy is often made on the basis ofthe pathologic findings ... disease had spread outside ofthe area oftheprostate bed and is unlikely to be controlled with radiation therapy. disease. The practice evolved from studies of predominantly elderly men ... waiting, or deferred therapy, is a policy of monitoring the illness at fixed intervals with DREs, PSA measurements, and repeat biopsies oftheprostate as indicated, but with no therapeutic intervention(s)...
... shown in Table 3.TheMYMOP2scalesofSymptom1andProfileshowed a moderate negative correlation with the General Wellbeing (GWB) and Energy scales of the W-BQ12. The Wellbeing scale ofthe MYMOP2 had ... latter setting, the W-BQ12 was notfound to be responsive. The authors of this latter studyattributed the lack of responsiveness ofthe W-QB12 totwo possible causes: either the socioeconomically ... assess chiropractic care in terms of health statusand general well-being. The official MYMOP website[16] lists the strengths and weaknesses ofthe MYMOP2questionnaire. The major strengths are...
... (SPN), the experience with the management of disseminated disease is very limited in the literature6, therefore, attention to the therapy strategy of this neoplasm in the future may allow a ... (SPT) ofthe pan-creas is a very rare entity with a reported incidence of 0.13% to 2.7% of all pancreatic tumors,1 whi ch w as once described in many other terms, such as Frantz’s tumor, ... Despite the increases in recognition of characteristics of this tumor, which include a distinct female pre-ponderance and low malignant potential, there is a n increasing incidence ofthe disease...
... translation of the reporter gene. Alternatively the cells were left in the presence of the antibody for t he complete length of this period.In both cases the result was the same. As shown in Fig. 7, the ... obtained with the highdose of M EM53 mAb. The activity was determined as the incorporation of 32P in the GST–ATF2 fusion proteinsubstrate, and was normalized with respect to the amount of the HA ... and at the bottom is the quantification of the increase in incorporation of radioactivity detected in the GST–ATF2fusion protein with respect to the HA epitope. The results are the mean of four...
... in ways that construct the meaning of gender for both men and women.Given the history of Title VII and the PDA, the story behind the evolution of interpretations of these statutes raises interesting ... disabilities in their roles as workers, including Title VII ofthe Civil Rights Act of 1964, Title I ofthe ADA, and most recently the FMLA.Although these statutes explicitly recognize the status of women ... two ofthe primary legal theories for proving discrimination under Title VII and the PDA: dispa-rate treatment theory and disparate impact theory.14 Disparate treatment theory requires proof...