jak stat pathway is also used by il 6
Báo cáo khoa học: "Impaired antiviral activity of interferon alpha against hepatitis C virus 2a in Huh-7 cells with a defective Jak-Stat pathway" pdf
... with defective Jak- Stat pathway Antiviral activity of IFN-a is impaired against HCV 2a subgenomic clone in Huh-7 cell clone with a defective JakStat pathway The role of the Jak- Stat pathway in the ... phosphorylated Stat1 and Stat2 All the resistant cell lines have defects in the phosphorylation of Stat1 and Stat2 protein, whereas the S-Huh-7 clone showed a high level of phosphorylation of Stat1 and Stat2 ... with a functional Jak- Stat pathway Replication of the full-length and sub-genomic clone of a HCV 2a strain was not inhibited by IFN-a in Huh-7 cell clones with a defective Jak- Stat pathway Infection...
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Báo cáo y học: " Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells" potx
... acute lymphoblastic leukaemia by a Jak- 2 inhibitor Nature 19 96, 379 (65 66) :64 5 -64 8 Wang LH, Kirken RA, Erwin RA, Yu CR, Farrar WL: JAK3 , STAT, and MAPK signaling pathways as novel molecular targets ... phosphorylation status of glycogen synthase kinase-3β (GSK-3β) that is not regulated by Jak- Stat pathway (Figure 3E), suggesting that effect of AG490 is specific for Jak- Stat pathway To determine ... 5'-gatcAGATTTAGTTTAATTCAAATC-3' To identify Stat proteins in the DNA-protein complex revealed by EMSA, we used specific antibodies for various Stat family proteins including Stat1 , Stat2 , Stat3 , Stat4 and Stat5 (Santa Cruz...
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Báo cáo khoa học: Long-term extracellular signal-related kinase activation following cadmium intoxication is negatively regulated by a protein kinase C-dependent pathway affecting cadmium transport ppt
... is the most activated PKC isotype following cadmium exposure FEBS Journal 2 76 (2009) 166 7– 167 9 ª 2009 The Authors Journal compilation ª 2009 FEBS 166 9 Cd-induced ERK activation is inhibited by ... were used at : 4000 final dilution Signals were revealed by chemiluminescence FEBS Journal 2 76 (2009) 166 7– 167 9 ª 2009 The Authors Journal compilation ª 2009 FEBS 167 7 Cd-induced ERK activation is ... (Fig 6B, insert) Total ERK was unchanged (data not shown) This indicates that modulation of cadmium FEBS Journal 2 76 (2009) 166 7– 167 9 ª 2009 The Authors Journal compilation ª 2009 FEBS 167 3 Cd-induced...
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Báo cáo y học: "Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor" docx
... 4.4 2.5 4.83 0 0.1 0.1 0 4.23 0 2.1 0.5 9.5 16. 7 5 .64 0 3.3 1.1 6. 6 15.1 4.73 0 4.9 4.3 4 .6 11 5 .62 DAS28 IL- 15 non-neutr.b IL- 15 neutr.b IL- 1ßb IL- 1αb IFN-γa TNFa Week Patient 3.7 4.4 2.8 3.91 ... Immunohistochemistry with the saponin method is a well established Available online http://arthritis-research.com/content/8/1/R18 Figure IL- 15 is present in synovial tissue in rheumatoid arthritis ... markers CD3, CD19/20, CD68 and CD 163 Statistical analysis A Mann-Whitney U test was used for the analysis of differences between groups Wilcoxon's signed-rank test was used Table Individual quantification...
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Báo cáo y học: "JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin" ppsx
... mediated IL- 6 production by renal epithelial cells in the tubulointerstitial inflammation, a hallmark of most renal diseases is regulated by JNK [41] JNK pathway is also involved in IL- 6 gene expression ... Microsystems AG, Wetzlar, Germany) equipped with a 63 0×oil immersion objective Statistical analysis Data were analyzed using one-way analysis of variance followed by Tukey's test as a post hoc test Differences ... examined because this antibody is not commercially available The suppressive effect of SP600125 on the reduced nuclear translocation of the p50 subunits was also confirmed by examination with...
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CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes ppt
... result is shown STAT3 activation induced by IL- 6 plus sIL-6R in RAFLS (Figure 8) Discussion In this study, we demonstrated that OSM activates the JAK/ STAT and MAPK pathways in FLS Furthermore, CP690,550 ... result is shown of IL- 6 Therefore, the JAK/ STAT pathways are essential in the transduction of OSM signaling and regulation of IL- 6 genes inRA-FLS Modulation of the JAK/ STAT pathways by CP690,550 ... determined, it is possible that CP690,550 inhibits IL- 6 induction as well as IL- 6mediated signaling by affecting the JAK/ STAT pathway Page of 10 We have provided evidence that CP690,550 is a potent...
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Báo cáo y học: ":The expression of the receptor for advanced glycation end-products (RAGE) in RA-FLS is induced by IL-17 via Act-1" ppsx
... effect of IL- 17 on IL- 1-induced IL- 6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines J Immunol 1998, 161 :409-414 16 Li X, Commane ... RA-FLS also increased with IL- 17, IL- 1b, and the combined stimuli of IL- 17 and IL- 1b (Figure 3b) We also measured RA-FLS RAGE protein production by Western blot IL- 17 and IL- 1b each enhanced RAGE ... Andersson U, Harris HE: High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis Arthritis Rheum 2002, 46: 2598- 260 3 Andersson U, Erlandsson-Harris H: HMGB1 is a potent...
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Besides increasing the number of universities,rasing the education quality is also urgent problem
... in this field – with a bachelor’s degree Quality the big problem 13 According to MOET, Vietnam will need 3 86 universities and junior colleges by 2010 and 410 by 2015 The figure will be 60 0 by 2020: ... campaign will be carried out from the beginning of this new school year till Octorber , 2008 2- BID TO BOOST ETHNIC PUPILS ‘ LITERACY The move is expected to facilitate ethnic minority children’s ... money is not enough for him to pay his tuition , which has increased by VND 1mil per semester 10- HIGH HOPES FOR NEW SCHOOL YEAR Four new projects will be implemented this school year The first will...
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AN INVESTIGATION INTO LINGUISTIC FEATURES OF MODALITY MARKERS USED BY TEACHERS IN LECTURES IN ENGLISH
... descriptive method is used in order to give a detailed description of some typical linguistics features of AWAI and VWAI Secondly, the analytic method is also indispensable By using this method the ... his M.A thesis “A Study on the Language in English Blogs Written by American People” investigates the language in English blogs writtten by American people to find out its distinctive linguistics ... thesis, we choose to research into the written form which authors show his/her viewpoint on a current event Visitors may express their agreement or disagreement about an issue by “like” or “dislike”...
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A STUDY ON LANGUAGE USED BY FLIGHT ATTENDANTS
... disability, military and veteran status, sexual orientation, marital status, or any other characteristic protected by state or federal law Most aviation companies are strongly committed to this ... English for Aviation is used which is actually a bit more specific It implies that the English taught is specific technical language that would be used in the context of aviation Such language is ... administered without regard to race, creed, color, sex, age, national origin, disability, military and veteran status, sexual orientation, marital status or any other characteristic protected by...
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Tài liệu Excerpts From Your Word is Your Wand By Florence Scovel Shinn ppt
... All bonding is an illusion of the race consciousness There is always a way out of every situation, under grace Every man is free to the will of God Sure-ism is stronger than Optimism Divine ideas ... waves," to control conditions His word is his wand and he transmutes apparent failure into success He knows his universal supply is endless and immediate and all his needs manifest instantly on ... Man's will is powerless to interfere with God's will God's will is now done in my mind, body and affairs God's plan for me is permanent and cannot be budged I am true to my heavenly vision The...
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A STUDY ON ENGLISH READING STRATEGIES USED BY THIRD YEAR ENGLISH MAJORS OF THAI AND MUONG ETHNIC MINORITIES AT TAY BAC UNIVERSITY
... comprehension Table 6: Factor affecting reading comprehension Answer Group N Mean S.D t-value A Muong 2 .66 6 8 16 -1.103 Thai 3. 166 752 Muong 1. 166 408 Thai 1. 166 408 Muong 2 .66 6 1.211 Thai 3.333 8 16 Muong ... but also uses this information to extend the general knowledge in his mind This opinion is quite similar to Aldersons’ definition of interactive model He states that interactive approach is a ... strategies, (3) no special instruction in LLS for listening, speaking, and vocabulary acquisition skill by O’Malley (1987) and acquisition skill, they discovered that the controlled group for vocabulary...
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Tài liệu Báo cáo khoa học: The thioredoxin-independent isoform of chloroplastic glyceraldehyde-3-phosphate dehydrogenase is selectively regulated by glutathionylation docx
... 212–2 26 ª 20 06 The Authors Journal compilation ª 20 06 FEBS 215 Glutathionylation of chloroplastic GAPDH 100 % Intensity A M Zaffagnini et al 363 53 80 60 40 20 360 00 368 00 364 00 37200 3 760 0 38000 ... % Intensity 80 60 40 20 35000 3 560 0 362 00 368 00 37400 38000 Mass (m/z) +dithiothreitol H2O2 + GSH 366 44.0 100 363 41.2 % Intensity 80 60 40 20 35000 3 560 0 362 00 368 00 37400 Mass (m/z) a partial ... (2007) 212–2 26 ª 20 06 The Authors Journal compilation ª 20 06 FEBS 219 Glutathionylation of chloroplastic GAPDH M Zaffagnini et al 363 26. 0 100 % Intensity 80 60 40 20 35000 3 560 0 362 00 368 00 37400...
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Tài liệu Báo cáo khoa học: Altered inactivation pathway of factor Va by activated protein C in the presence of heparin doc
... k¢3 06 Wild-type 37-loop 60 -loop 37 +60 loop 6. 83 4.09 2 .60 7.72 a In the presence of UFH k5 06 · · · · 105 105 1 06 1 06 1.17 3.24 1 .65 2.13 k3 06 · · · · 108 1 06 108 1 06 1.55 5.93 3. 86 9 .64 k¢3 06 · ... Cys6 56, which is the last residue in the homology model based on ceruloplasmin, formed by Asp659-Asp 660 Asp 661 -Glu 662 -Asp 663 may also play a role during the docking of APC on to the FVa Arg5 06 ... 1.55 5.93 3. 86 9 .64 k¢3 06 · · · · 1 06 105 1 06 105 k5 06 2.17 · 1 06 NDa 3.38 · 1 06 3.13 · 1 06 9. 96 1.29 1.97 2.21 k3 06 · · · · 1 06 1 06 107 1 06 The value for k¢3 06 in the presence of heparin in FVaLeiden,...
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Common sentences used by native speakers
... could fill in a few blanks for me What I really want is a breakdown ( sport [countable] a written statement explaining the details of something such as a bill or the cost of a plan ) by Julie ... be rained off British English be rained out American English if an event or activity is rained off or rained out, it has to stop because there is too much rain ) anyway this game's a really ... with you without having his head bitten off ? ( to answer someone or speak to them very angrily, when there is no good reason for doing this ) Like I said before, this isn't really my scene I...
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Báo cáo khoa học: Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines docx
... +1) is critical for binding of STAT5 but not of STAT1 or STAT3 , whereas the glutamine in position P +3 is required for binding of STAT1 and STAT3 , but is not relevant for STAT5 This result is ... leptin and IL- 6 stimulated tyrosine phosphorylation of STAT3 to a similar degree, but leptin again induced activation of a broader spectrum of STAT factors (STAT1 , STAT3 , STAT5 , STAT6 ) Leptin ... (Lep, leptin; sIL-6R, soluble IL- 6 receptor; GH, growth hormone) for 15 Total cellular lysates were used for Western blot analysis with phospho-specific antibodies against STAT1 , STAT3 , STAT5 A ⁄ B,...
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Báo cáo khoa học: The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors pdf
... the lung, but also the digestive tract, as already shown for Muc2 expression by GATA-4 [15], MUC4 by GATA-4 ⁄ GATA-5 ⁄ GATA -6 [ 16] and MUC6 by GATA-5 ⁄ GATA -6 (I Van Seuningen, unpublished observations) ... comparison P < 0.05 was considered to be significant and is indicated by an asterisk Three asterisks indicate P < 0.001 Acknowledgements We thank Dr M.-P Buisine (Inserm U837, Team #5, Lille, ... therapy, in inflammatory diseases and cancer? Front Biosci 6, D12 16 D1234 Mesquita P, Jonckheere N, Almeida R, Ducourouble MP, Serpa J, Silva E, Pigny P, Silva FS, Reis C, Silberg D et al (2003)...
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Báo cáo khoa học: Thyroid Ca2+/NADPH-dependent H2O2 generation is partially inhibited by propylthiouracil and methimazole ppt
... enzymatic system in vitro is similar to that produced by the glucose– glucose oxidase system used here, so it is possible that MMI also decreases the availability of H2O2 produced by NADPH oxidase in ... Cohen, G., Heikkila, R.E., Allis, B., Cabbat, F., Dembiec, D., MacNamee, D., Mytilineou, C & Winston, B (19 76) Destruction of sympathetic nerve terminals by 6- hydroxydopamine: protection by 1-phenyl-3-(2-thiazolyl) ... at 360 nm, emission at 460 nm) Results are expressed as mean ± SEM obtained in at least three different experiments Data were analyzed by parametric one-way analysis of variance followed by Newman-Keuls...
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Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf
... (4 .6 ± 0.2) [0.9] (6. 3 ± 0.2) [1.2] (6. 3 ± 0.2) [1.2] 3.9 · 104 a [1] (8.5 ± 0.3) [2.2] · 1 06 (9) · 1 06 (9) · 1 06 (8) · 1 06 (9) · 1 06 (10) · 1 06 (10) · 1 06 (9) £ 6. 9 · 10)5 c · 1 06 (14) £ 6. 9 ... member of family 1, is appreciably different from that in cystatin B; in particular, His75 of cystatin B is substituted by Gly in cystatin A [1] Moreover, the NMR structure of cystatin A shows ... contrast with cystatin B, this role is exerted predominantly by only one residue, Leu73, which is highly conserved in family I cystatins The major role of Leu73 in the interactions is in stabilizing...
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