iκbα nf κb pathway in the synergistic effect of muscarinic receptor stimulation with cse
Báo cáo y học: " Expression and function of human hemokinin-1 in human and guinea pig airways" pdf
... expression of hHK-1 and the contractile and inflammatory effects of this peptide in human airways Thus, the aims of the present study were to determine the presence of tachykinins, tachykinin receptors ... antagonists and the role of hemokinin in T lymphopoiesis Blood 2003, 102(6):2165-2172 16 Weinstock JV: The role of substance P, hemokinin and their receptor in governing mucosal inflammation and ... patterns of tachykinin genes along the respiratory tract since we used smaller bronchi than in the work of Pinto et al and since differences in the response to tachykinins have been reported according...
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Báo cáo Y học: Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells potx
... stimuli to the caspase One of the most relevant aspects in the regulation of apoptosis is the involvement of mitogen-activated protein kinases (MAPKs), a family of serine/threonine kinases that ... family of cysteine proteases, play a pivotal role in the execution of apoptosis [26] We therefore examined the involvement of caspases in the apoptosis induced by Py/Zn PARP is a substrate of caspases, ... unclear In this study, we investigated the molecular mechanism underlying the mode of action of the induction of apoptosis by elevation of intracellular Zn levels Table Changes in levels of trace...
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Báo cáo y học: "Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-α and matrix metalloproteinase-13 in human chondrocyte" ppsx
... To further strengthen the relation of inhibition of the NF- κB pathway and the expression of TNFα in our studies, we next investigated the effect of a pharmacological agent (MG-132, a known inhibitor ... modulation of the activation and DNA binding activity of NF- κB Inhibition of IKKβ kinase activity by EGCG The effect of EGCG on the phosphorylating activity of IKKβ kinase was determined using an ... deviation and NF- κB activation in human chondrocytes Our results also point out that inhibition of NF- κB was achieved by inhibiting the degradation of the inhibitor IκBα in the cytoplasm of human...
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Báo cáo y học: " Profiles of cytokine and chemokine gene expression in human pulmonary epithelial cells induced by human and avian influenza viruses" doc
... findings that the cytokine/ chemokine response profile varied with the time-course of infection Our results showed that at the early phase of avian influenza virus infection, the transcription of ... CCL-5/RANTES The induction of these cytokines/chemokines might be initially achieved by a trace amount of TNF-a secretion as detected during the initial phase of infection Therefore, initial TNF-a secretion ... phase of viral infection The quantitative real-time RT-PCR results showed that during the early phase of infection (i.e and hours post-infection), there was an induction of pro-inflammatory cytokines/chemokines...
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Aerodynamics and aerosol transportation in human airways
... profiles were defined in FLUENT 6.1 at the beginning of the transition from G3 to G4, at the beginning and end of each branch of G4, and at the beginning of the branches in G5 The labeling of the ... defined as the ratio of the lowest velocity in the neighbourhood of the centerline to the highest velocity in the vicinity of the wall at a particular section in the daughter branches The minimum ... planes and profiles was in accordance to the generation in which the plane or profile was in first, then the branch in which the plane or profile was located and finally the order in which the plane...
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3D Videocommunication Algorithms concepts and real time systems in human centred communication
... OF TELEPRESENCE The sense of being together and interacting with others within a real physical space can be traced back to the work of Goffman (1963), who used the concept of co-presence to indicate ... sense that they are close enough to be perceived in whatever they are doing, including their experiencing of others, and close enough to be perceived in this sensing of being perceived Goffman (1963), ... paintings had been a well-known phenomenon since Roman times, and such paintings would create the illusion of, for instance, walls containing a window to the outside world or a ceiling containing...
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Báo cáo khoa học: Transport of L-arginine and nitric oxide formation in human platelets pdf
... present on the trans-side of the membrane Moreover system y+L is inhibited by L-leucine in the presence, but not in the absence of Na+ The small inhibition of L-arginine in ux by L-leucine in the absence ... neutral amino acid transport [16], several experiments in the absence of Na+ were performed L-Leucine was ineffective on + L-arginine in ux in the absence of Na , confirming the presence of the system ... greatly exceed the Km of endothelial NOS [37] The compartmentalization of L-arginine within cells may explain the dependence of NO synthesis on extracellular L-arginine despite saturating intracellular...
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Báo cáo khoa học: Characterization of rat cathepsin E and mutants with changed active-site residues and lacking propeptides and N-glycosylation, expressed in human embryonic kidney 293T cells ppt
... H+-ATPase, the processing and maturation of pro-cathepsin E was completely inhibited, with a concomitant increase in a secreted form of pro-cathepsin E in the culture Recombinant cathepsin E and its mutants ... sort cathepsin E from lysosomal enzymes Role of the N-glycosylation of cathepsin E in processing and maturation To determine the role of N-glycosylation in the correct folding, processing, maturation, ... necessary for the processing and maturation of procathepsin E To determine the intracellular localization of wildtype cathepsin E expressed in HEK-293T cells, indirect immunofluorescence staining was...
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Báo cáo khoa học: "Characterizing and Recognizing Spoken Corrections in Human-Computer Dialogue" pot
... some preliminary efforts subjects Four of the participants were members in the study of corrections in speech input of the system development staff, fourteen were In analyzing and identifying self-repairs, ... 737 ening played a role However, in only one of these studies was input "conversational", the other was a form-filling application, and neither involved spoken system responses, relying instead ... Although changes in pitch maxima and minima were not significant in themselves, the increases in rise slopes for CME's in contrast to flattening of rise slopes in CRE's combined to form a highly...
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Báo cáo Y học: Monitoring the structural consequences of Phe12 fi D-Phe and Leu15 fi Aib substitution in human/rat corticotropin releasing hormone Implications for design of CRH antagonists pdf
... [38,40] The changes engineered in the sequence of the peptide, either through the nature of the side chain of the new amino acids or through their non-native conformational features, increase the ... 12–20 Indeed, helix bending diminishes the exposure of the hydrophobic core of Phe12, Aib15 and Val18 to the solvent, while establishing the structural basis for the side-chain interaction of the ... which is considered the ÔinterfaceÕ between the 6–19 region, where the side-chains of the hydrophobic part of the helix play a key role in receptor binding and activation [54], and the 20–41 region,...
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Báo cáo khoa học: Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons ppt
... event in the QUIN-induced excitotoxic cascade mediated by Ca2+ in ux Effect of EPCG, catechin hydrate, curcumin, apigenin, naringenin and gallotannin on QUIN-induced intracellular Ca2+ in cultured ... Attenuation of increased Ca2+ in ux was greatest with EPCG and curcumin 372 compared with apigenin and naringenin (Fig 5) Interestingly, catechin hydrate did not ameliorate a QUIN-induced increase in intracellular ... QUIN stimulation induced a significant increase in intracellular Ca2+ Each of the polyphenols, EPCG, curcumin, apigenin, naringenin and gallotannin, significantly reduced intracellular Ca2+ in ux...
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Báo cáo khoa học: cGMP and glutathione-conjugate transport in human erythrocytes The roles of the multidrug resistance-associated proteins, MRP1, MRP4 and MRP5 pot
... producing 50% inhibition of the inhibitable component, U0 is the uptake in the absence of the inhibitor, Unoninh is the uptake which cannot be inhibited and ni is the Hill coefficient for the inhibitor ... numbers of fitting parameters were compared using an F-test on the ratio of the variance associated with the reduction in degrees of freedom to the variance of the fit with the smaller number of degrees ... [3H]cGMP in the absence of ATP but in the presence of the nonhydrolysable ATP analogue, ATP-c-S, was less than 5% of the uptake in the presence of ATP The amount of [3H]cGMP taken up by these vesicles...
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Báo cáo khoa học: DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine pptx
... DYRK1A ⁄ minibrain kinase in determining the number of neurons during post-embryonic neurogenesis: mutation of minibrain causes reduction of the size of the optic lobes and central brain hemispheres ... concentrations in cells strongly suggests that inhibition of this kinase is involved in the biological activity of harmine in vivo Interestingly, our results show that harmine not only inhibits the protein–serine ... concentrations of the inhibitor were required, presumably because of the elevated levels of DYRK1A in the cells (Fig 4D) We also analysed the effect of lm harmine on the phosphorylation of Thr125...
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Báo cáo khoa học: "INTEGRATING MULTIPLE KNOWLEDGE SOURCES FOR DETECTION AND CORRECTION OF REPAIRS IN HUMAN-COMPUTER DIALOG*" potx
... shows the distributions of these repairs with respect to two parameters: the length in words of the matched string, and the number of words between the two matched strings Numbers in parentheses indicate ... found in repairs are likely to be found in fluent speech, acoustic information can be quite effective when combined with other sources of information, in particular with pattern matching In studying ... Positives In examining the MI[M1 repair pattern, we found that the strongest distinguishing cue between the repairs (N = 20) and the false positives (N = 20) was the interval between the offset of the...
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Báo cáo hóa học: " Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects" potx
... with a peak increase of approximately 53% in the number of CD34 expressing cells and and a 90% increase in CD133 cells in circulation Furthermore, a significant augmentation of cells possessing ... markers of EPC [25], we sought to examine whether Stem-Kine affected EPC levels in the periphery EPC phenotypically have been characterized by co-expression of CD34 and the kinase insert domain receptor ... two capsules of Stem-Kine in the morning and two in the evening for 14 days Phenotypic assessment of circulating stem cells Peripheral blood mononuclear cells (PBMC) were isolated by the Ficoll-Hypaque...
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Báo cáo hóa học: " Fowlpox virus recombinants expressing HPV-16 E6 and E7 oncogenes for the therapy of cervical carcinoma elicit humoral and cell-mediated responses in rabbits" pot
... humans Further improvements of the recombinants, using the E6 and E7 transgenes deleted of the p53 and p105Rb cellular binding domain, might further increase the safety of the vaccine Recently, ... hypothesise a non-specific immune stimulation by the doubling of the amount of the FP vector used in Protocol However, when plates were coated with CaSki lysates instead of the E6 or E7 proteins ... difficulty of growing the virus in tissue cultures VLP-based vaccines targeting the major L1 viral capsid protein of high- and low-risk HPVtypes [44] proved effective in preventing persistent infection...
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báo cáo hóa học:" Effect of borax on immune cell proliferation and sister chromatid exchange in human chromosomes Malinee Pongsavee" docx
... variety of chemical and physical agents exhibiting diverse modes of interaction with DNA These agents are capable of inducing SCE The SCE technique is a sensitive means of monitoring DNA damage The ... decreased [18], minor skeleton variation with the exception of short rib XIII in rats [19] Figure SCE in the control group The black arrow indicated SCE in human chromosome In this study, the results ... increased in the borax concentrations of 0.15, 0.2, 0.3 and 0.6 mg/ml experimental subgroups comparing with the control group Competing interests The author declares that they have no competing...
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Báo cáo hóa học: " Subcellular forms and biochemical events triggered in human cells by HCV polyprotein expression from a viral vector" doc
... polyprotein expressing cells and in staurosporine treated cells, in contrast with cells infected with the VT7-HCV7.9 in the absence of IPTG or in uninfected cells These results indicate the ability of ... following infection of HepG2 with VT7-HCV7.9 Hepatocyte cell alterations following infection of HepG2 with VT7-HCV7.9 HepG2 cells uninfected or infected with the recombinant VT7-HCV7.9 in the presence ... cells infected with VT7-HCV7.9 in the presence of IPTG were apoptotic in contrast with the 26% determined when cells were infected with VT7-HCV7.9 in the absence of the inducer (Fig 6A) Since...
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Báo cáo y học: "α Does protein kinase R mediate TNF-α- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism" pps
... 2-aminopurine; PKR, protein kinase R; TNF, tumour necrosis factor inhibitor of PKR to investigate the role of PKR in the TNF-α- and ceramide-signalling pathways in cartilage degradation The use of ... dependent The amount of sGAG remaining within the cartilage explant after 24 hours of treatment with TNF-α and C2-ceramide in the presence and absence of 2-AP was determined by papain digestion ... content of the cartilage explants Treatment with 2-AP alone (1 mM) had no effect on the amount of sGAG left within the explant and so this concentration was used to determine whether inhibition of...
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Báo cáo y học: "Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes" ppt
... effective, the amount of IGF-1 delivered within the joint in this way should exceed the binding capacity of local IGFBPs In addition to noninvasive intervention, one of the main advantages of our ... IGF-binding proteins (IGFBPs), in insulin-like of NBI-31772, a small-molecule inhibitor of the binding of priActivitygrowth rabbit chondrocytes lin-like growth factor (IGF)-1 to IGF-binding proteins ... a small-molecule inhibitor of the binding of insulin-like growth factor (IGF)-1 to IGF-binding proteins (IGFBPs), with 125Ilabeled IGF-1 binding to cartilage labeled IGF-1 binding to cartilage...
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