isolated thoracic perfusion with chemofiltration itp f for advanced and pre treated non small cell lung cancer
Báo cáo y học: "Clinical significance in the number of involved lymph nodes in patients that underwent surgery for pathological stage III-N2 non-small cell lung cancer" pot
... Committee of Lung Cancer Registry Prognosis of 6644 resected non- small cell lung cancers in Japan: a Japanese lung cancer registry study Lung Cancer 2005, 50:227-34 11 Andre F, Grunenwald D, Pignon ... patients with non- small cell lung cancer J Thorac Oncol 2010, 5:825-9 Ou SH, Zell JA: Validation study of the proposed IASLC staging revisions of the T4 and M non- small cell lung cancer descriptors ... first line treatment for individuals with stage I-II NSCLC However, more than half of the patients with NSCLC are diagnosed with N2-3 or M1 disease [14] While chemotherapy for patients with advanced...
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báo cáo hóa học:" Randomized phase II study with two gemcitabine- and docetaxel-based combinations as first-line chemotherapy for metastatic non-small cell lung cancer" docx
... Kim K, Fairclough D, Cella D, Cella D, Kugler J, Rowinsky E, Jiroutek M, Johnson D: Comparison of survival and quality of life in advanced non- small- cell lung cancer patients treated with two ... Tonato M: Gemcitabine and cisplatin versus mitomycin, ifosfamide, and cisplatin in advanced non- small- cell lung cancer: a randomized phase III study of the Italian Lung Cancer Project J Clin ... Int J Cancer 2001, 94:153-156 Non- small Cell Lung Cancer Collaborative Group: Chemotherapy in non small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomized...
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Báo cáo khoa học: " Absence of toxicity with hypofractionated 3-dimensional radiation therapy for inoperable, early stage non-small cell lung cancer" pot
... escalation in non- small- cell lung cancer Int J Radiat Oncol Biol Phys 2001, 49:23-33 Abratt RP, Bogart JA, Hunter A: Hypofractionated radiation for non- small cell lung cancer Lung Cancer 2002, ... hypofractionated radiation therapy (3DHRT) for this group of patients is yet to be defined Hypofractionation may result in an increase of normal tissue effects and a careful evaluation of acute and ... treatment of stage I non- small cell lung cancer Lung Cancer 2003, 41:1-11 Zimmermann FB, Bamberg M, Molls M, Jeremic B: Radiation therapy alone in early stage non- small cell lung cancer Semin Surg...
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báo cáo khoa học: "Radical cyberknife radiosurgery with tumor tracking: an effective treatment for inoperable small peripheral stage I non-small cell lung cancer ppsx
... patients undergoing lung cancer surgery? Outcomes and quality of life before and after surgery Chest 2002, 122:21-30 El-Sherif A, Gooding WE, Santos R, Pettiford B, Ferson PF, Fernando HC, Urda SJ, ... appearance of radiation injury of the lung and clinical symptoms after stereotactic body radiation therapy (SBRT) for lung cancers: are patients with pulmonary emphysema also candidates for SBRT for lung ... Hoopes DJ, Tann M, Fletcher JW, Forquer JA, Lin PF, Lo SS, Timmerman RD, McGarry RC: FDG-PET and stereotactic body radiotherapy (SBRT) for stage I non- small- cell lung cancer Lung Cancer 2007, 56:229-234...
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Báo cáo sinh học: "Silencing the epidermal growth factor receptor gene with RNAi may be developed as a potential therapy for non small cell lung cancer" pot
... c d Figure The effects of dsRNA-EGFR on A549 (A) and SPC-A1 (B) cell count and colony formation (C) The effects of dsRNA-EGFR on A549 (A) and SPC-A1 (B) cell count and colony formation (C) Cells ... specific for EGFR also inhibited tumor cell growth To investigate the functional effect of the down regulation of the EGFR expression, we performed two experiments; one was a cell count assay and ... (d) FITC staining of cells transfected with dsRNA-EGFR (B) EGFR gene expression was quantified in both control and transfected cells by a flow cytometry with excitation and emission settings of...
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Báo cáo hóa học: " Detection of EGFR mutations with mutation-specific antibodies in stage IV non-small-cell lung cancer" pdf
... sensitivity of 36% and a specificity of 97% for L858R and a sensitivity of 40% and a specificity of 99% for E746-A750 In the present study, we found a sensitivity of 100% and a specificity of 100% for ... antibody and 79% for the exon 19 deletion antibody Brevet et al [14] reported a sensitivity of 84.6% and a specificity of 98.9% for E746-A750 and a sensitivity of 95.2% and a specificity of 98.8% for ... of specific antibodies against EGFR mutation proteins might be useful for the diagnosis and treatment of lung cancer Figure IHC analysis of EGFR mutations in five human NSCLC cell lines A549 and...
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báo cáo hóa học: " Health state utilities for non small cell lung cancer" pot
... Treatment of Cancer Quality-of-Life Questionnaire -Lung Cancer- 17 items; EQ-5D: EuroQoL-5 Dimensions; HRQL: Healthrelated Quality of Life; NSCLC: Non- Small Cell Lung Cancer; SF-36: Short-Form 36 ... MW: Staging of small cell and non- small cell lung cancer University of Iowa Virtual Hospital; 1999 Hopwood P, Stephens RJ: Symptoms at presentation for treatment in patients with lung cancer: Implications ... of Quality of Life in the Supportive Care setting of the Big Lung Trial in Non- Small- Cell Lung cancer Journal of Clinical Oncology 2005, 30:7417-7427 Silvestri G, Pritchard R, Welch HG: Preferences...
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Báo cáo khoa học: "Pathological complete response induced by first-line chemotherapy with single agent docetaxel in a patient with advanced non small cell lung cancer" pptx
... Editor-in-Chief of this journal Page of Tzelepatiotis E, Samaras N: Docetaxel versus docetaxel/cisplatin in patients with advanced non- small- cell lung cancer: preliminary analysis of a multicenter, randomized ... chemotherapy for non- operable patients with NSCLC The search for either molecular or genetic markers predictive for docetaxel sensitivity might constitute future targets of investigation Finally, ... response induced by first-line chemotherapy with single agent docetaxel in a patient with advanced non small cell lung cancer World Journal of Surgical Oncology 2010 8:8 Conflict of interests The...
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Báo cáo khoa học: "Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with concurrent chemotherapy and intensity-modulated radiotherapy" pot
... Joyce P, Fisher P: Fatal pulmonary fibrosis associated with induction chemotherapy with carboplatin and vinorelbine followed by CHART radiotherapy for locally advanced nonsmall cell lung cancer ... Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non- small cell lung cancer treated with concurrent chemotherapy and ... of pneumonitis risk from dose-volume histogram parameters of the lung in patients with lung cancer treated with 3-D conformal radiotherapy Strahlenther Onkol 2003, 179:548-556 Fay M, Tan A, Fisher...
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Báo cáo khoa học: "Clinical outcomes of stereotactic body radiotherapy for stage I non-small cell lung cancer using different doses depending on tumor size" ppsx
... years (Figure 1) The 3-year OAS was 79% for the 85 stage IA patients treated with 48 Gy in fractions and 56% for the 37 stage IB patients (p = 0.05) The 3-year CSS was 91% for the former group and ... Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results Radiat ... tumors with a maximum diameter of 1.5-3 cm, and 52 Gy in fractions for those with a maximum diameter larger than cm Assuming an a/b ratio of 10 Gy, the biological effective dose (BED) was 92 Gy for...
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Báo cáo khoa học: " Comparison of outcomes in patients with stage III versus limited stage IV non-small cell lung cancer" docx
... records of patients with NSCLC who were treated at the University of Rochester from 2000-2008 with curative-intent radiotherapy (with or without chemotherapy) for stage III NSCLC or SBRT for limited ... Additional file and Figure The 2year and 5-year OS for all patients with stage III NSCLC was 43% and 7% respectively versus 43% and 14% for initial limited stage IV (p = 0.30) The OS calculated from ... stage and net GTV were assessed for affect on OS from date of initial NSCLC diagnosis as shown in Additional file On univariate analysis of OS from date of initial NSCLC diagnosis, GTV at time of...
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Báo cáo khoa học: "Recommendations for implementing stereotactic radiotherapy in peripheral stage IA non-small cell lung cancer: report from the Quality Assurance Working Party of the randomised phase III ROSEL study" pps
... schedule of fractions of 20 Gy or fractions of 18 Gy and a conservative fractionation schedule of fractions of 12 Gy or fractions of 11 Gy could be allowed For type B models, the standard fractionation ... influence of different planning algorithms on the planning of stereotactic radiotherapy Therefore, an additional planning study was performed in 22 stage IA and stage 1B non- small cell lung cancer ... Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma Cancer 2004, 101:1623-1631 El-Sherif A, Gooding WE, Santos R, Pettiford B, Ferson PF, Fernando HC, Urda...
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Báo cáo khoa học: " Exclusion of elective nodal irradiation is associated with minimal elective nodal failure in non-small cell lung cancer" potx
... site of disease failure, followed by IFF and any ENF (p < 0.0001, log-rank test) Five of 115 patients developed ENF and only of ENFs were isolated ENFs Page of (page number not for citation purposes) ... Scientific Publication Office for their help with preparing this manuscript A preliminary analysis of this data was presented in abstract form at the 47th Annual Meeting of the American Society of ... rate for patients receiving definitive radiotherapy, with isolated ENF rates of 0% to 8% [5] Rosenzweig and colleagues recently published results for a series of 524 patients treated definitively...
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Báo cáo khoa học: " Evalution of surface-based deformable image registration for adaptive radiotherapy of non-small cell lung cancer (NSCLC)" pptx
... distortion of the vertebral body and the aorta without using meshes of these organs for deformable registration in e) a b c d e f Figuredeformed follow-up CTfollow-uptarget CT and deformed follow-up ... e f Figuredeformed follow-up CT using all targetat the end of treatment; c) difference image betweenorgans-at CT and follow-up nal cord; f) difference image between planning CT and deformed follow-up ... mm ± 1.2 mm for CTplan versus CTFU after DR was performed However, in two patients the performance of the DR was not sufficient for reliable analysis of the GTV shape in CTdeform and these two...
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Báo cáo khoa học: " Accelerated high-dose radiotherapy alone or combined with either concomitant or sequential chemotherapy; treatments of choice in patients with Non-Small Cell Lung Cancer" pps
... in fractions of Gy for compensation of a split period For patients a dose of 55 Gy in daily fractions of 2.75 Gy was administered For one patient the mean lung dose was considered too high for ... and in Europe lung cancer is the most common cause of cancer related-death with an increasing incidence each year The majority of patients has Non- Small Cell Lung Cancer (NSCLC) and 75% has advanced ... radiotherapy with or without chemotherapy for the group treated with radiotherapy alone (18%), but the differences were not statistically significant Age and stage had no influence on DFS For local...
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Báo cáo y học: "proteomic characterization of non-small cell lung cancer in a comprehensive translational thoracic oncology database" docx
... 157,300 deaths from lung cancer [4] Lung cancer has traditionally been dichotomized into two groups based on the histological features of the tumor: small cell and non- small cell lung cancer NSCLC is ... patient’s name, and date of birth Statistics We have used the database to correlate proteomic information with clinical parameters for patients with nonsmall cell lung cancer Within this database, ... with non- small cell lung cancer comprise the majority of cases annotated within the database Other cancers contained in the database include small cell lung cancer, mesothelioma, esophageal cancer, ...
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báo cáo khoa học: "EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features" pptx
... immunohistochemically for EGFR and COX-2 expression and their prognostic values were explored after deparaffinization and rehydration, the samples were treated with sodium citrate buffer and microwave for epitope ... detection of Figure Survival curves with different level of EGFR protein expression The solid blue line indicates the survival for EGFR negative and the green line represents survival for EGFR positive ... potential predictive value of cyclooxygenase-2 expression and increased risk of gastrointestinal hemorrhage in advanced nonsmall cell lung cancer patients treated with erlotinib and celecoxib Clin Cancer...
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báo cáo khoa học: " Comparison of KRAS and EGFR gene status between primary non-small cell lung cancer and local lymph node metastases: implications for clinical practice" pdf
... Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non- small- cell lung cancer (The IDEAL Trial) [corrected] J Clin Oncol 2003, 21:2237-2246 Page of 11 Kris ... MR: Paclitaxel/ifosfamide or navelbine/ifosfamide chemotherapy for advanced non- small cell lung cancer: CALGB 9532 Lung cancer 2000, 28(1):63-68 17 Yang P, Allen MS, Aubry MC, Wampfler JA, Marks ... epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non- small- cell lung cancer treated with chemotherapy alone and in combination with erlotinib...
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báo cáo khoa học: " Correction: EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features" pps
... Level of Differentiation 0.474 0.518 Level of Differentiation 0.258 Poor Differentiated 40% Poor Differentiated 80% Moderate and Well Differentiated 21 19 47.50% Moderate and Well Differentiated ... Dianying, Shen Yali, Xu Feng, Wang Jin: EGFR and COX-2 protein expression in non- small cell lung cancer and the correlation with clinical features Journal of Experimental & Clinical Cancer Research 2011, ... Li et al.: Correction: EGFR and COX-2 protein expression in non- small cell lung cancer and the correlation with clinical features Journal of Experimental & Clinical Cancer Research 2011 30:32...
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báo cáo khoa học: "CyberKnife radiosurgery for inoperable stage IA non-small cell lung cancer: 18F-fluorodeoxyglucose positron emission tomography/computed tomography serial tumor response assessment" docx
... failure The value of 1 8F- FDG PET/CT imaging for surveillance following lung SBRT deserves further study Abbreviations BED Gy3: biologic effective lung dose; BED Gy10: biologic effective tumor dose; ... radiotherapy for stage I non- small cell lung cancer mature results for medically inoperable patients Lung Cancer 2006, 51:97-103 Lax I, Panettieri V, Wennberg B, et al: Dose distributions in SBRT of lung ... body radiotherapy (SBRT) for stage I non- small- cell lung cancer Lung Cancer 2007, 56:229-234 17 Henderson MA, Hoopes DJ, Fletcher JW, et al: A pilot study of serial 18ffluorodeoxyglucose positron...
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