... She was lying in her bed when the phone rang (ring) During the war they shot many people (shoot) I will show you my new house some time next week (show) Last night I slept in my bed for the first ... four windows since she was born (break) Jim had never driven the car until he was 18 (drive) The sun shone the whole day yesterday (shine) She has lost her keys She has been looking for them since ... Monday but she hasn’t found them yet (lose, find) I have been ringing all afternoon but I cant get any reply (ring) How often have you cut the grass this summer (you, cut) Frank had eaten the whole...
... _ (flap) about But I couldn't scream and I couldn't shout Couldn't scream and I couldn't shout I opened my mouth to scream and shout I _ (wave) my arms and flapped about But I couldn't scream, ... shout I _ (wave) my arms and flapped about But I couldn't scream, I couldn't shout The song was coming from my mouth ...
... of adenine nucleotides, (b) the decrease in ATP and the increase in inosine, promoted by H2O2, cannot be explained solely by a change inthe level of the enzymes more directly involved inthe nucleotide ... depicted in Fig 6BF show that the inhibition inthe rate of synthesis of ATP from ADP is accompanied by an increase inthe rate of synthesis of Ino, without any need to modify the kinetic parameters ... of the enzymes involved inthe pathway from ATP to Ino Being aware of the simplications involved in these calculations (where so many more enzymes participate in vivo), these results would indicate...
... calnexin-containing but not in calnexin-deficient cells HPV16 E5 decreases HLA-I surface expression in calnexin-containing but not in calnexin-deficient cells CEM-C7 (calnexin) and CEM-NKR (no calnexin) ... inthe ER/Golgi of the infected cell A direct binding of E5 to the heavy chain of HLA-I seems under the light of our results improbable This is further supported by our findings using calnexin-deficient ... processing route, it can be hypothesized that HPV16 E5 binds to the calnexin-HLA-I complex and that this binding blocks further trafficking of the HLA-I complex to the plasma membrane, leading instead...
... conserved inverted repeat inthe 3'-noncoding region of the S segment seems to be involved in recombi- nation events, leading, however, to the deletion of the hairpin-forming sequences (A Plyusnin, ... predicted for the recombination "hot-spot" inthe plus- and minus- sense S RNA of TULV Hairpin-like Hairpin-like structures predicted for the recombination "hot-spot" inthe plus- and minus- sense ... prerequisite for recombination [25,24] The hairpin in TULV plus-sense S RNA (Fig 3) is formed by the almost perfect inverted repeat that includes nt 344 to 374 Inthe minus-sense RNA, the structure is...
... calnexin-containing but not in calnexin-deficient cells HPV16 E5 decreases HLA-I surface expression in calnexin-containing but not in calnexin-deficient cells CEM-C7 (calnexin) and CEM-NKR (no calnexin) ... inthe ER/Golgi of the infected cell A direct binding of E5 to the heavy chain of HLA-I seems under the light of our results improbable This is further supported by our findings using calnexin-deficient ... processing route, it can be hypothesized that HPV16 E5 binds to the calnexin-HLA-I complex and that this binding blocks further trafficking of the HLA-I complex to the plasma membrane, leading instead...
... conserved inverted repeat inthe 3'-noncoding region of the S segment seems to be involved in recombi- nation events, leading, however, to the deletion of the hairpin-forming sequences (A Plyusnin, ... predicted for the recombination "hot-spot" inthe plus- and minus- sense S RNA of TULV Hairpin-like Hairpin-like structures predicted for the recombination "hot-spot" inthe plus- and minus- sense ... prerequisite for recombination [25,24] The hairpin in TULV plus-sense S RNA (Fig 3) is formed by the almost perfect inverted repeat that includes nt 344 to 374 Inthe minus-sense RNA, the structure is...
... a ligand for the tyrosine kinase receptor Mer and that MFG-E8 can bind to the vitronectin receptor ␣v3 [16,24] Other molecules that bind PS with varying specificity are the lectin-like oxidized ... developing nervous system, with most intense staining inthe forebrain, hindbrain and neural tube At this stage of embryogenesis, high levels of Ptdsr expression could also be detected inthe developing ... highest in neural tissues and somites, inthe branchial arches, the developing limbs, the heart, the primitive gut and the developing eye (c-e) Sectioning of E12.5 -galactosidase-stained embryos...
... with the usual binomial coefficients on the right hand side When r = 2, the map returns theregular binomial coefficients inthe Pascal triangle We obtain theregular Pascal pyramid if r = For the ... negative integer t ≤ n, multiplies the tth row in it by the binomial coefficient n then the nth layer inthe Pascal pyramid is obtained t Figure 2: Pascal pyramid It is well known that if t is even, then ... then the tth row of the Pascal triangle has a peak at t/2, otherwise (when t is odd) there is a plateau with the two elements ⌊t/2⌋ and ⌈t/2⌉ The situation is the same inthe nth level of the...
... have important roles either during the initiation phase of arthritis or inthe perpetuation and exacerbation of the disease after the onset, or they might simply maintain immunity to CII and ... Competing interests It is possible that the pro-inflammatory cytokines induced and/or secreted by the co-transferred CII-specific cells could provide a constant cytokine milieu in or near the joints ... enhancement inthe frequency of arthritis inthe T cell-deficient mice and the B cell-deficient mice suggest that these cells might play regulatory roles inthe initiation of disease 100 90 % of incidence...
... lining but not penetrate the cartilage [25] We co-transfected the synovial lining with an adenovirus overexpressing TGF-β and an adenovirus overexpressing Smad7 The transfected synovial lining ... Safranin O stains PGs inthe cartilage red The amount of PGs is determined by a computerized calculation of the amount of blue light passing through the red-stained cartilage An increase in PGs ... averaged per joint as previously described [27] (Qwin; Leica Imaging Systems Ltd., Cambridge, UK) In short, the width of the joint from bone edge to joint capsule, minus the width of the joint space...
... understanding of the molecular events leading to cartilage destruction Many alternative hypotheses and conditions, including but not limited to the following, need to be investigated: (a) whether the ... according to the manufacturer's instructions Extraction of the cartilage explants The amount of S-GAG inthe cartilage explants after termination of the culture was determined by extraction of the ... self-repair, butthe rate at which repair is initiated and then continued is less in explants receiving the longer treatment Very little proteoglycan synthesis was possible in explants exposed to the...
... serpiginous appearance Single nerve fascicles in a well defined tissue mass containing fat was found (Figure 1) The condition extended from the proximal humerus to the wrist and thereafter the median nerve ... and the microscopical examination by EB All authors have contributed in different important ways to the present manuscript All authors have read and approved the final manuscript Competing interests ... FPL and FDP to the index finger However, the long-term results are obscure of fibrolipomatous hamartoma Meticulous information to the patient and a regular follow-up are recommended The present...
... [5] Their fine book demonstrates that all of the proposals emanating from the gaseous environment on Capital Hill have been considered over and over again in previous adminis rations None of them ... policy without provoking confusion and outright anger in both the medical establishment and many of the patients who actually benefit (or inthe latter case think they benefit) from the current mess? ... Saskatchewan Province had a different problem The province was thinly populated and unattractive to physicians In response to its chronic deficiency of medical access, the province introduced a state-sponsored...
... are involved in coordinating the incoming triphosphate Inthe process, Arg72 donates hydrogen bonds to the a-phosphate and the ε-amino group of Lys65 donates hydrogen bonds to the g-phosphate These ... of the dNTP binding pocket which can restrict dNTP binding resulting in inefficient DNA synthesis at low dNTP concentrations [36] RT codons 65 and 74 are parts of the highly flexible b3-b4 linkage ... viruses in different assays but no statistical significance was noted Previous studies analyzing the risks and incidence of K65R and L74V mutations inthe largest single clinic cohort in Europe (The...
... phagocytosis inthe diseased lung In contrast, the expression of the Hb monomers inthe alveolar epithelial cells is in full agreement with previous findings on the airway epithelium [39] The distributions ... the total protein pattern visualized by silver staining blot analysis The results showed clear nitrotyrosine positivity, especially inthe epithelial cells and inflammatory cells but not inthe ... included intheregular therapy of all IPF patients and Stage IV (very severe) COPD, none of the other subjects were receiving regular corticosteroid therapy The Ethics Committee of the Helsinki...
... described integrons can capture multiple gene cassettes, express them, and then integrate them into the chromosome [7] The genes found in integrons often encode antibiotic resistance, including proteins ... resistances are questionable considering the remarkable stability of mecA inthe MRSA, vancomycinresistant determinants inthe enterococci, or integrons in nature, even inthe absence of antibiotic pressure ... be obtained between hospital administration, health carers, and pharmacists: all prescribers have to follow the guidelines; the different regimens used inthe rotation must be chosen inthe light...
... Importin α binds to NLS containing proteins, whereupon importin β is responsible for the docking of the importin cargo complex to the cytoplasmic side of the NPC, followed by translocation of the ... further confirmed in another laboratory [35] which also demonstrated that the NLS domain was confined to the 40 first N-terminal amino acids We also demonstrated that the region spanning amino ... residues with the individual scores noted (see column heading), the other is a graphical plot of the values given inthe table The prediction server calculates the NES score from the HMM and Artificial...
... similar to our findings (22.8 vs 22.3 in our study inthe high morbidity group and 17.6 vs 18.8 inthe low morbidity group) Another study associated increased length of stay inthe ICU in association ... course? The baseline characteristics of the recipients are shown in Table The underlying liver diseases of the 144 patients are presented in Table The incidence of hepa- The analysis of the 147 ICU ... retransplantation, incidence of rejection on the ICU and reoperations during the ICU stay, and the incidence of acute coronary syndrome Inthe case of four primary graft nonfunctions inthe ICU with a following...
... blast fishing in Southeast Asia, from which it is originated In Southeast Asia, blast fishing was practiced during the colonial era inthe late 19th Century, before the nation states in Southeast ... trying to increase their catch, they may not care about conserving the resources for the next generation The responsibility of taking care of their family requires them to work as hard as they ... they not have sense of belonging with the local natural resources They tend to exploit the resources for their benefit rather than thinking about the common benefit of the natural resources The...