invasion intracellular trafficking and replication of brucella organisms in professional and non professional phagocytes
Báo cáo khoa học:" A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages" docx
... Post Infection Figure Replication of HSV-1 in macrophages Replication of HSV-1 in macrophages Analyses of virus replication, viral gB mRNA, and viral genomic DNA in macrophages was done as in Fig ... fold increase in HSV-1 replication in STAT1 deficient mice may be due, at least in part, to increased replication of virus in DCs and macrophages In this regard, it has been reported that HSV-infected ... is involved in suppressing HSV-1 replication in murine DCs and macrophages In addition, the lack of virus replication in wild-type APCs did not appear to be due to transcriptional blockage of...
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Báo cáo khoa học: " A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages" pps
... Post Infection Figure Replication of HSV-1 in macrophages Replication of HSV-1 in macrophages Analyses of virus replication, viral gB mRNA, and viral genomic DNA in macrophages was done as in Fig ... fold increase in HSV-1 replication in STAT1 deficient mice may be due, at least in part, to increased replication of virus in DCs and macrophages In this regard, it has been reported that HSV-infected ... is involved in suppressing HSV-1 replication in murine DCs and macrophages In addition, the lack of virus replication in wild-type APCs did not appear to be due to transcriptional blockage of...
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Báo cáo khoa học: "Prevalence of Brucella antibodies in sera of cows in Bangladesh" pps
... seidobitna allecurB rof denimaxe swoc fo sdeerB elba T swoc tnangerp ni dnuof erew sesac demrifnoc evitisop dna swoc tnangerp -non ni dnuof erew sesac demrifnoc evitisop ruoF tnacifingis yllacitsitats ... ot desoppus slamina redlo eht ,revewoH ]03[ esaesid fo noitatsefinam lacinilc esuac yam ti ro noitcefni tnetal sa rehtie niamer ot etagaporp ot yaw ereht dnuof msinagro eht erofereht dna ega ... dewollof saw ]21[ ruH fo erudecorp eht ,TAT roF ]22[ evitisop deredisnoc saw noitanitulgga fo ngis ynA devresbo neht dna ,erutarepmet moor ta nim rof yltneg dekcor saw erutxim ehT erucinam htiw...
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Báo cáo y học: " Hepatoprotective effects of Spirulina maxima in patients with non-alcoholic fatty liver disease: a case series" ppsx
... participated in the collection, design, analysis and interpretation of data and also in writing the manuscript MJO participated in the design, analysis and interpretation of data and in writing the ... treatment of a low-caloric diet, daily exercise (30-minute walk) and ingestion of Spirulina maxima Adverse side-effects included flatulence, meteorism and abdominal pain of moderate intensity ... http://www.jmedicalcasereports.com/content/4/1/103 Page of Competing interests The authors declare that they have no competing interests Authors' contributions AFH participated in the collection and analysis of data and in writing the manuscript...
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Tài liệu Nature and Properties of Micro-organisms doc
... bacteria, shorter and finer than flagella Two classes: ordinary pili ‘colonisation antigens’ Protein, attachment to host cells Can be involved in host cell invasion e.g Neisseria meningitidis ... penicillins, cephalosporins and vancomycin lipoteichoic acid, septic shock Beta-lactamases hydrolyse penicillins and cephalosporins secreted by Gram positive bacteria Within periplasm of Gram ... invasiveness of pathogenic bacteria by reducing opsonisation and protecting from phagocytosis E.g Streptococcus pneumoniae in RTI vaccination: pneumococcal; meningococcal A and C GLYCOCALYX...
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Tài liệu Báo cáo khoa học: A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion docx
... potentials and facilitates the initiation of apoptosis [22] In addition, elevated calcium levels contribute to cell invasion [23,24] In contrast, in the case of occludin, an ER-mediated increase in intracellular ... analysis of the involvement of wild-type occludin (OccWT) and variant occludin in apoptosis and invasion, as determined by assay, we revealed that exon played a major role in the induction of mitochondria-mediated ... Gu et al Exon of occludin in apoptosis and invasion A C B D E F Fig Identification of a human occludin splice variant in liver cell lines (A) Occludin protein expression was examined with an antibody...
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Tài liệu Báo cáo khoa học: Analyzing changes of chromatin-bound replication proteins occurring in response to and after release from a hypoxic block of replicon initiation in T24 cells pptx
... nucleosolic proteins The remaining pellet contains all DNA and structure bound proteins and is further referred to as chromatin-fraction Electrophoresis of proteins and Western blotting Cytosolic and nucleosolic ... strong incorporation of [3H]Thd into growing daughter strands occurs, preferentially sedimenting in the first third of the gradient and attributable to short chains originating from newly initiated ... BrdU staining and this again signifies that PCNA is only bound to chromatin portions where actively replicating DNA is present Recruitment of proteins involved in replication to chromatin during the...
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Tài liệu Báo cáo Y học: Regulated expression and intracellular localization of cystatin F in human U937 cells pptx
... cystatin F, through analysis of the expression, distribution and properties of the native human inhibitor in U937 cells MATERIALS AND METHODS In silico cloning and sequencing of the human cystatin ... portion of intracellular cystatin F led us to fractionate cells to determine the localization of the inhibitor Initially cells were fractionated in a debris fraction (containing nuclei and cell ... heavy and a light fraction containing mitochondria and various cell organelles, and a supernatant containing the smallest cellular vesicles Cystatin F, cystatin C and protein contents in the...
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Tài liệu Báo cáo Y học: Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4) pdf
... overexpression and are also found with other TRAF proteins containing a RING– zinc finger domain (data not shown and Fig 6) Interestingly, both a C-terminal deletion mutant lacking the TRAF domain [T4(1–268)–YFP] ... cytoplasmic retention of TRAF4 Interestingly, it has been recently shown that the oncogenic serine–threonine kinase Pim-1 induces translocation of the TRAF4-interacting protein-sorting Nexin 6–TRAF4–associated ... TRAF domain of TRAF2 and TRAF3 but were detected regularly in cells transfected with TRAF2/3 deletion mutants consisting of the RING–zinc finger domain Since TRAF proteins tend to form homo- and/ or...
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Báo cáo khoa học: Fluorescence studies of the replication initiator protein RepA in complex with operator and iteron sequences and free in solution pdf
... protein dimers not act as initiators in plasmid replication [21] A positive effect on monomer-binding afnity thus provides a way of selecting against dimer binding, favoring monomer binding and ... DNA bending [20] induced by dimer binding (61), a free energy of ()21.2 to 7.8) = )14.5 kJặmol)1 is expected for binding of a single DNA-binding domain without the need to force DNA bending This ... indicator of stoichiometry In the case of 1IR, the t resulted in a binding stoichiometry of : 1, i.e dimer binding The reactant concentrations were too high to obtain relevant information on the binding...
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Báo cáo khoa học: Two types of replication protein A in seed plants Characterization of their functions in vitro and in vivo ppt
... role, such as in DNA replication, in living cells In contrast, mutants of AtRPA70b were viable but showed high sensitivity to UV and MMS, suggesting involvement of AtRPA70b in the repair of damaged ... Interaction of human rad51 recombination protein with single-stranded DNA binding protein, RPA Nucleic Acids Res 26, 5388–5393 17 Stauffer ME & Chazin WJ (2004) Physical interaction between replication ... region, and a third, DBD-C, in the C-terminal region DBD-A and DBD-B are the most important regions for binding of ssDNA, whereas DBD-C has only weak ssDNA-binding activity At the N-terminus of RPA70kDa...
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Báo cáo khoa học: Enhancement of intracellular concentration and biological activity of PNA after conjugation with a cell-penetrating synthetic model peptide docx
... an increased intracellular availability of PNA In order to examine the ability of MAP to deliver PNA into intact cells, we investigated the cellular uptake of the conjugate of I with MAP in comparison ... internal standard e-fluoresceinyl lysine in order to eliminate irregularities of injection and buffer status Because the exact volume of the sample injected into the capillary remained unknown, the references ... the in uence of nociception on the beating rate of CM measured on day of culture without and with pretreatment with either 0.2 lM of I or II on day and after seeding The basal beating rate of...
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Báo cáo hóa học: " Co-evolution of cancer microenvironment reveals distinctive patterns of gastric cancer invasion: laboratory evidence and clinical significance" pptx
... Co-evolution of tumor cells and their microenvironment in cancer invasions Both of tumor cells and their microenvironment are involved in cancer invasions Invasion is the first observable step of cancer ... the interface of tumor nest and stroma is the main location of infiltrating macrophages in gastric cancer, and phagocytosis of cancer cells by macrophage, indicating the coexistence of M1 and ... after acquiring invasive phenotypes (upper graph) In addition, tumor infiltrating macrophages and type IV collagen also play an important role in cancer invasion In this process, cancer invasion...
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Báo cáo sinh học: " Thiol-reactive reagents inhibits intracellular trafficking of human papillomavirus type 16 pseudovirions by binding to cysteine residues of major capsid protein L" pot
... containing mM of DTNB, MBTA or MTSET for days grew and were maintained 1 C C C CC C C C C Figure Alignment of L1 amino acid sequences of papillomaviruses Alignment of L1 amino acid sequences of ... concentration of mM 3B) The data indicate that BPEOIA bound to the free thiol of cysteine residue(s) of L1 Binding of BPEOIA to the L1 cysteine residues of 16PV BPEOIA, capable of making a complex ... bound to C146, C225, and C229 of the 16PVs In the 3dimentional-structure model of L1 [15], C146 is involved in forming the DE-loop and C225 and C229 are involved in forming the EF-loop Because...
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Báo cáo sinh học: " Cellular apoptosis induced by replication of hepatitis B virus: possible link between viral genotype and clinical outcome" pptx
... family of proteins is involved in the development of liver diseases [9,10] The Bcl-2 family of proteins is defined as the key regulator of apoptosis in the mitochondria-dependent way They consist of ... found in HBV infected liver and shown to induce apoptosis through a hitherto unknown mechanism [16,17] It was also indicated to contain a BH3 domain in the N-terminal and naturally expressed during ... externalization of phophatidylserine (PS) on cell membrane [15] Double staining with FITC (FL1-H) and PI (FL2-H) would indicate apoptotic cells in the bottom-right square of FACS profile as shown in Fig...
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Báo cáo sinh học: " The herpes simplex virus UL20 protein functions in glycoprotein K (gK) intracellular transport and virus-induced cell fusion are independent of UL20 functions in cytoplasmic virion envelopment" docx
... However, mutagenesis of both Y38 and Y49 amino acid residues in the amino terminus of UL20p, inhibited virus-induced cell fusion, while allowing efficient intracellular transport and TGN localization ... cellsurfaces and in TGN-labeled intracellular compartments: Previously, we characterized a series of carboxyl terminal truncations including the 204t and 211t encoding carboxyl terminal truncations of ... show that the amino and carboxyl termini of UL20p contain distinct domains that function in infectious virion production and intracellular gK/UL20 transport Results Mutagenesis of HSV-1 UL20 Previously,...
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Báo cáo hóa học: " Thiol-reactive reagents inhibits intracellular trafficking of human papillomavirus type 16 pseudovirions by binding to cysteine residues of major capsid protein L1" pdf
... containing mM of DTNB, MBTA or MTSET for days grew and were maintained 1 C C C CC C C C C Figure Alignment of L1 amino acid sequences of papillomaviruses Alignment of L1 amino acid sequences of ... concentration of mM 3B) The data indicate that BPEOIA bound to the free thiol of cysteine residue(s) of L1 Binding of BPEOIA to the L1 cysteine residues of 16PV BPEOIA, capable of making a complex ... bound to C146, C225, and C229 of the 16PVs In the 3dimentional-structure model of L1 [15], C146 is involved in forming the DE-loop and C225 and C229 are involved in forming the EF-loop Because...
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Báo cáo hóa học: " Cellular apoptosis induced by replication of hepatitis B virus: possible link between viral genotype and clinical outcome" docx
... family of proteins is involved in the development of liver diseases [9,10] The Bcl-2 family of proteins is defined as the key regulator of apoptosis in the mitochondria-dependent way They consist of ... found in HBV infected liver and shown to induce apoptosis through a hitherto unknown mechanism [16,17] It was also indicated to contain a BH3 domain in the N-terminal and naturally expressed during ... externalization of phophatidylserine (PS) on cell membrane [15] Double staining with FITC (FL1-H) and PI (FL2-H) would indicate apoptotic cells in the bottom-right square of FACS profile as shown in Fig...
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Báo cáo hóa học: " Infectious salmon anaemia virus replication and induction of alpha interferon in Atlantic salmon erythrocytes" potx
... salmon and rainbow trout (Oncorhynchus mykiss) [11] In contrast, the uptake of influenza A virus by avian and mammalian erythrocytes via pinocytosis was non- specific [10] indicating a lack of involvement ... (eIF-2α)-specific kinase subfamily It is a serine/threonine characterized by two kinase activities: autophosphorylation in response to binding of dsRNA with high affinity and ssRNA with low affinity, and phosphorylation ... The PKZ (a Z-DNA binding orthologue of the mammalian double stranded RNA binding PKR) primer was designed using the coding sequence of Atlantic salmon Z-DNA binding eIF-2α kinase (GenBank Accession...
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