... in an in vivo murine model A detailed understanding ofthe mechanisms that undermine pathogenicity andthe host-virus interactions thatinfluencethe outcome ofthe illness are critical for the ... alveoli and multifocal fibrosis in the lungs There is also increased deposition of collagen in the lungs of fibrotic lungs of subjects infected with highly virulent influenza strains 1.5 Innate immunity ... pathogenesis studies in mice Mice develop a lower respiratory tract infection with similarities in lung pathology comparing pneumonia in humans and in mice Clinical signs include anorexia, sleepiness and...
... determines the ability of radiotherapy to synergize with Figure Chest CT image showing radiation dose distribution after 40 Gy Figure Beam’s eye view ofthe lateral beam ofthe radiation therapy ... performed after the radiation therapy, which showed a remarkable reduction in the mediastinal lymph node Additionally, shrinking ofthe tumor in his right lower lobe, outside ofthe radiation field, was ... after the radiation therapy showed a lymph node swelling with a diameter of 3.5 cm in the area of origin ofthe left gastric artery At this time, AFP and PIVKA-II were elevated to 1990 ng/mL and...
... What accents itself in the mind ofthe layman who makes even a cursory study ofthe sculptors and their works at the Panama-Pacific International Exposition is the fine, inspiring sincerity and ... Fountain of Energy The Mother of Tomorrow The Nations ofthe Occident The Nations ofthe Orient The Alaskan The Lama The Genius of Creation The Rising Sun Descending Night Winter The Portals of ... upon this little figure without feeling that he is inimitably charming Pan, a god ofthe woodland, the symbol ofthe festive side ofthe Exposition, sits among the shrubs in front of Festival Hall...
... analysis: The case period (the duration of time which a child with ALRI gets admitted to the hospital) was defined to be days before the admission date The time-stratified control periods were defined ... regardless of whether SEP is measured at the individual or district level We are continuing to explore these relationships % increase in pneumonia and bronchiolitis hospitalizations, Poisson analyses, ... than simply adjusted for) season Because there is variability (on the order of days) in the time between onset of illness and hospital admission, it was not possible to definitively identify an...
... Safety and Health) for his critique of this manuscript Disclaimer: The findings and conclusions in this report are those ofthe authors and not necessarily represent the views ofthe National Institute ... considered a welding fume of low toxicity compared to the carcinogenic metal-containing SS fumes [11] Therefore, it was interesting that these fumes were associated with modification of behavioral ... Analysis identified the biological functions and/ or diseases that were most significant to the data set Genes from the dataset that met the fold change cutoff of 1.3 and were associated with biological...
... reaction (PCR) analysis of tail biopsies to detect either the presence ofthe inactivating neomycin gene and/ or the presence ofthe disrupted (IL-6-/- mice) or intact (IL-6+/+ mice) IL-6 gene Mice ... hypoxia in IL-6+/+ and IL-6-/- mice Individual and mean (horizontal line) right ventricular systolic pressures (RSVP) in normoxic IL-6+/+ and IL-6-/- mice under ventilation with room air (normoxia) ... markedly higher with hypoxia than normoxia in wild-type mice Surprisingly, similar increases were seen with hypoxia in the IL-6-/- mice, suggesting thatthe expression of ICAM-1, VCAM-1, and MCP-1...
... Progression of histologic lesions within the mesenteric lymph nodes of mice infected with "scid-adapted" MARV Figure Progression of histologic lesions within the mesenteric lymph nodes of mice infected ... model is an important indicator of antiviral activity of these potential MARV treatments Discussion In previous studies, scid mice became ill and died within 3–4 weeks after inoculation with ZEBOV ... intraperitoneal inoculation [14] Pathologic evaluation of infected mice identified similarities and differences between this model [14,15] and infections in nonhuman primates [16,17] Similarities include...
... not capable of producing neurotoxicity in all areas ofthe hippocampus in the parameters of cholinesterase inhibition and neuronal density reduction The addition of swim stress with CPF exposure ... permeability [10] One ofthe proteins associated with neuronal damage is glial fibrillary acidic protein (GFAP) GFAP is a cytoplasmic intermediate filament protein found in astrocytes They maintain ... substitution in the linear regression analysis Histomorphometric studies and estimation of GFAP expression Perfusion ofthe brains was carried out using 10% formal saline The area between the optic...
... Progression of histologic lesions within the mesenteric lymph nodes of mice infected with "scid-adapted" MARV Figure Progression of histologic lesions within the mesenteric lymph nodes of mice infected ... model is an important indicator of antiviral activity of these potential MARV treatments Discussion In previous studies, scid mice became ill and died within 3–4 weeks after inoculation with ZEBOV ... intraperitoneal inoculation [14] Pathologic evaluation of infected mice identified similarities and differences between this model [14,15] and infections in nonhuman primates [16,17] Similarities include...
... Sc im e ca J A Retention of conjugated linoleic acid in the mammary is associated with tumor inhibition during the postinitiation phase of carcinogenesis Carcinogenesis 1997, 18, 755-759 19 Ip ... depression of immune production However, the addition of vitamin ADE and/ or selenium to CLA increased the level of immunoglobulin production, even while reducing the inhibitory effect of excessively ... allergy reaction is initiated by the production of allergen-specific IgE [27, 29, 37] It is considered that treatment with a combination of CLA with vitamin ADE or selenium is more effective than...
... (Fujifilm, Japan) The results were quantified using the measurement program ofthe LAS-3000 Immunoprecipitation and kinase assays Immunoprecipitation of mTOR and eukaryotic translation initiation ... Pi is normally taken from the diet, andthe intestinal absorption of Pi is efficient and well regulated The kidney is a major regulator of Pi homeostasis and it can increase or decrease its Pi ... Moreover, an improved understanding ofthe responses ofthe developing lung of young animals to stimulation may provide critical functions for coping with diverse changes including alteration of pulmonary...
... significant increase in SAA was observed in mice treated with IgG in comparison withthe IL-6RA group 150 days after irradiation, whereas the mice treated with IL-6RA showed a significant induction of IL-6 ... use of a different mice strain might cause changes in the pathogenesis of radiation pneumonia and thus alter the survival of mice receiving lethally irradiation ofthe whole thorax A significant ... antibody inhibits the synergistic induction of SAA [21] These findings indicate that IL6RA has some beneficial effects In our study, however, no significant difference was observed in severity of...
... alterations Additionally, it is also possible that gender influences the metabolism or bioavailability of ritonavir This gender difference has been shown for the HIV protease inhibitor, indinavir ... weight gain Interestingly, ritonavir increased epicardial fat in males This may correlate withthe increased susceptibility of males to the development of atherosclerosis in this model of HIV protease ... ovariectomized female mice, suggesting an interaction at the site of action of ritonavir and ovariectomy in the ability ofthe two to influence body mass Whether this interaction involves gonadal hormones,...
... estimate the effect of smoking on COPD development Our study highlighted the importance of smoking cessation in the HIV-positive population in terms of improving lung function and reducing respiratory ... subjects had similar loss of lung function as their HIVnegative counterparts [13,14], which did not support the hypothesis that lung function decline is greater in the HIV-positive population We should ... attending regularly scheduled clinical visits at the SIS clinic Participants provided signed informed consent, filled out a questionnaire, and underwent spirometry testing The questionnaire contained...
... of Daily profile of locomotor activity of representative mice ofthe B6 and AhR strains in LD 12:12 as a function of circadian time Profiles were generated in the "Activity Profile" module in Clocklab ... from wheel-running In the timing ofthe siesta (a feature common to the locomotor activity profile of certain strains of inbred mice) B6 and AhR differed About 8–9 hours after their activity begins ... and A/J strains of inbred mice Error bars represent the SEM Daily profile of locomotorLD 12:1 2of representativecircadian Figure time the B6 and AhR strains in activity as a function of mice of...
... normal conditions Since the airway epithelium – like the intestine epithelium – is in constant contact with multiple pathogen-related antigens like LPS, the hyporesponsiveness of these epithelial cells ... expression in poly (I: C) stimulated cells were significantly inhibited by a neutralizing anti-IFN-β antibody indicating an IFN-β dependent mechanism of IP-10 and I- TAC induction by poly (I: C) (Fig 2D) In ... after h of stimulation with IFN-γ alone or in combination with IL-1β or TNF-α Similarly, the mRNA expression of TRIF was induced by the type-1 cytokine IFN-γ alone or in combination with IL-1β...
... HAV titers obtained by the ARTA and ELISA endpoint Figure of Analysis anti-HAV antibodies in IG preprations Analysis of anti-HAV antibodies in IG preprations Semi-quantitative analysis of anti-HAV ... dilutions ofthe Lab 1, Lab 2, andthe WHO Standard IG preparations reacted similarly in the HAVAB EIA test indicating that these IG preparations contained comparable levels of anti-HAV antibodies ... antibodies The absorbance values of all the dilutions ofthe negative control plasma were above the cutoff indicating the absence of anti-HAV antibodies Evaluation of anti-HAV neutralizing antibodies...
... Pharmaceuticals, Talecris Biotherapeutics, Bioclinica and CSL Behring His institution has received grant monies from Bio-Imaging (now Bioclinica), Roche, Talecris and Medis Medical Imaging Systems ... version to be published AD was the principal investigator ofthe multicentre, randomised clinical trials of augmentation therapy with AAT He has revised the submitted article critically for important ... been lacking The individual and combined analysis ofthe Danish-Dutch and EXACTLE trials confirms that AAT augmentation therapy has a beneficial effect on the decline in lung density, which is a...
... ALI/ARDS Apoptosis of endothelial and epithelial cells, which is induced by a variety of stimuli, contributes to the impairment ofthe barrier function of pulmonary endothelium and epithelium and ... contribute to the endothelial and epithelial injury that is characteristic of ALI/ARDS in humans [25] In this study, pre-incubation with VEGF significantly attenuated the increase in the permeability ... participated in the design ofthe study and performed the statistical analysis SF participated in in vitro measurements KY participated in the animal study AI conceived ofthe study, and participated...
... damage The changes in the quantities ofthe specific receptors in this process requires the development of specific ET-1 receptor antibodies to visualize the altered distributions ofthe ETA and ... observed in the group C Following ET-1 administrations η exhibited significant increases only in the animals of group C at 30 s, while this parameter showed no statistically significant changes in the ... coinciding withthe heart rate and its harmonics were omitted from the fitting if the cardiac activity caused a low signal-to-noise ratio at these frequencies and thus, leading to elevations in the...