inflammation tissue injury and disability in multiple sclerosis
báo cáo hóa học: " Production of IL-16 correlates with CD4+ Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions" pptx
... lesions in brain, (Fig 3A) and in acute spinal cord lesions (Fig 3B), corresponding to increases in IL-16 Levels of T-bet in spinal cord were greatest in acute lesions, and gradually decreased in ... in MS lesions Extensive IL-16 immunostaining, confined to infiltrating cells, was observed in MS lesions Less widespread immu- nostaining was found in normal-appearing white matter of brain and ... abundantly present in MS lesions in brain and spinal cord In brain, levels of proIL-16 did not differ significantly between acute and chronic lesions Interestingly, in normal-appearing white matter...
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báo cáo hóa học: " Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis" pptx
... D: Combining beta interferon and atorvastatin may increase disease activity in multiple sclerosis Neurology 2009, 72:1965-1966, 1965; author reply 43 Sorensen PS, Lycke J, Eralinna JP, Edland A, ... diseasemodifying therapy, with the remainder on combination Weinstock-Guttman et al Journal of Neuroinflammation 2011, 8:127 http://www.jneuroinflammation.com/content/8/1/127 Table Demographic, clinical and ... disease-modifying agents and brain volume changes in multiple sclerosis Neurology 2008, 71:136-144 25 Zivadinov R, Weinstock-Guttman B, Zorzon M, Uxa L, Serafin M, Bosco A, Bratina A, Maggiore...
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Báo cáo sinh học: " Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients" docx
... 3-nitro-L-tyrosine as an internal standard The coefficient of variation of intra- and interassay determinations for trp and kyn was below 5% Recovery of trp and kyn was determined by measuring trp and kyn in ... W, Coats ME, Goodkin DE, Weinstock-Guttman B, Herndon RM, et al: Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis Multiple Sclerosis Collaborative ... emerging in immunology: cells expressing IDO can inhibit T cells responses and consequently induce tolerance and reduce inflammation Therefore, kyn/trp ratio could be regarded as a potential index...
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báo cáo hóa học:" Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients" pot
... 3-nitro-L-tyrosine as an internal standard The coefficient of variation of intra- and interassay determinations for trp and kyn was below 5% Recovery of trp and kyn was determined by measuring trp and kyn in ... W, Coats ME, Goodkin DE, Weinstock-Guttman B, Herndon RM, et al: Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis Multiple Sclerosis Collaborative ... emerging in immunology: cells expressing IDO can inhibit T cells responses and consequently induce tolerance and reduce inflammation Therefore, kyn/trp ratio could be regarded as a potential index...
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Báo cáo khoa hoc:" Genetic variation in the myeloperoxidase gene and cognitive impairment in Multiple Sclerosis" pot
... Ratios and CI were estimated using logistic regression adjusted for age and sex gene being involved in AD pathology, possibly through oxidation of Aβ or ApoE, promoting their aggregation into insoluble ... possible role of MPO polymorphism in the development of cognitive decline in MS This study was mainly designed to investigate whether some clinical and individual variables and the occurrence of the ... Immunohistochemical and genetic evidence of Myeloperoxidase involvement in Multiple Sclerosis J Neuroimmunol 1997, 78:97-107 Kantarci OH, Atkinson EJ, Hebrink DD, McMurray CT, Weinshenker BG: Association...
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Nursing Practice In Multiple Sclerosis: A Core Curriculum doc
... others, including the responsibility to preserve integrity and safety, to maintain competence, and to continue personal and professional growth The nurse participates in establishing, maintaining, and ... in brain volume Associated Pathology Inflammation Increasing inflammation Edema associated with inflammation Possible demyelination and axonal loss Disruption of blood-brain barrier Changes in ... nursing and define basic roles and responsibilities in each domain CHAPTER 1: THE HISTORY OF MULTIPLE SCLEROSIS CARE ■ C Support multiple sclerosis nursing research, basic research, and clinical...
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Economic Implications Of Chronic Illness And Disability In Eastern Europe And The Former Soviet Union pptx
... Employment, and Schooling Kinnon Scott and Cem Mete Introduction Measuring Disability Incidence of Limited Physical Functioning and Health To What Extent are Disabled Individuals Poor, Less Educated, and ... cannot investigate the linkages between household characteristics (including poverty) and disability using these data 18 Examples include significant medicine shortages in Romania in 2003; and not ... Disability in Eastern Europe and the Former Soviet Union Another example is the finding that in Bosnia and Herzegovina, after the onset of the disability, the decline in the number of hours worked and...
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báo cáo hóa học: " Fatigue characteristics in multiple sclerosis: the North American Research Committee on Multiple Sclerosis (NARCOMS) survey" pot
... design, data collection and analysis, manuscript planning and editing TV and MOB were involved in study design, manuscript planning and editing All authors read and approved the final manuscript Acknowledgements ... LB: Fatigue in multiple sclerosis: definition, pathophysiology and treatment CNS Drugs 2003, 17:225-234 Multiple Sclerosis Clinical Practice Guidelines Council: Fatigue and multiple sclerosis: ... fatigue in multiple sclerosis In Multiple sclerosis clinical practice guideline Washington, DC: Paralyzed Veterans Association; 1998 Freal JE, Kraft GH, Coryell JK: Symptomatic fatigue in multiple sclerosis...
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Báo cáo hóa học: "Adaptive robot training for the treatment of incoordination in Multiple Sclerosis" doc
... directly compared (planned comparisons) Baseline and Baseline (effect of Robot Training), Baseline and Wash-out (effect of Subject Training) and finally Baseline and wash-out (overall phase effect) As ... (d = 3): Figure Training protocol and study design Top: Phases of the training protocol: Baseline (B1), Robot Training, Baseline (B2), Subject Training, Wash-out The phases in which the robot ... regards changes within one session, to distinguish between the changes in performance occurring during the Robot Training phase from those occurring during the Subject Training phase, we directly...
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Báo cáo hóa học: " The Armeo Spring as training tool to improve upper limb functionality in multiple sclerosis: a pilot study" ppt
... [28] and the 9HPT [29] For the TEMPA, the median execution time of the unilateral activities (i.e grasping and moving a jar, pouring water from a jug into a cup, inserting coins in a slot, pinching ... technology enables independent and repetitive movement practice, and this in a motivating, enriched and interactive virtual learning environment in which complex motor tasks, involving central neural ... velocity, linearity and smoothness of reaching movements after training sessions over and weeks respectively [16,17] This was clinically accompanied with a decrease in ataxia and tremor scores and a...
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Báo cáo hóa học: " Objective assessment of motor fatigue in multiple sclerosis using kinematic gait analysis: a pilot study" docx
... fatigue in MS patients are increased and extensive cortical activation (including that of non-motor cortical areas) and reduced cortical inhibition during simple motor tasks [14,15], and white and ... analyzed and interpreted the data and outlined the manuscript AM participated in data analysis, interpretation and presentation, and prepared the manuscript KS and SS contributed to identifying pathological ... participated in its design and coordination and helped draft the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests...
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báo cáo hóa học: " Interferon-β1a reduces plasma CD31+ endothelial microparticles (CD31+EMP) in multiple sclerosis" pptx
... role in cell adhesion, i.e slowing and initiating cell rolling, they have been shown to have a dominant role in allowing non-specifically activated cells to gain access to the CNS [5], independent ... anatomic and physiologic barrier to inward trafficking of various molecules and cells in the intravascular compartment.2 Inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interferon-γ ... changes in EMP levels with change in EDSS disability scores A change in EDSS score ≥ is considered a decrease in disability and a change in score ≤ is an increase in disability Except for one case,...
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báo cáo hóa học: " Saliva soluble HLA as a potential marker of response to interferon-β1a in multiple sclerosis: A preliminary study" pdf
... Danish Multiple Sclerosis Study Group: Clinical importance of neutralizing antibodies against interferon beta in relapsing-remitting multiple sclerosis Lancet 2003, 362:1184-1191 Chadha K, Winstock-Guttman ... well as at three and six months and this included expanded disability status scores (EDSS) during each visit MRI protocol Brain MRI was performed using a 1.5 T machine with a standard quadrature ... L, Paolino E, Tola MR, Granieri E, Baricordi OR: Beneficial effect of interferon-beta1b treatment in patients with relapsingremitting multiple sclerosis is associated with an increase in serum...
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báo cáo hóa học: " Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple sclerosis" pdf
... oil red (ORO) and hematoxylin scoring as being acute, containing numerous phagocytic macrophages that had recently engulfed lipid-containing debris, or subacute, containing demyelinated areas ... lymphocytes during neuroinflammation is dependent on a4 integrin Brain 2011 Page 12 of 12 35 Saunders PA, Hendrycks VR, Lidinsky WA, Woods ML: PD-L2:PD-1 involvement in T cell proliferation, cytokine production, ... Post-mortem brain sections from tissue donors without CNS disease and patients diagnosed clinically and confirmed by neuropathological examination as having MS were obtained from the NeuroResource tissue...
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báo cáo hóa học: " Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis" pot
... cysteine and thus prevents renaturing of MOG While 8.18c5 reactivity is lost after denaturing/fixating, anti-His mAb reactivity is sustained indicating the MOG polypeptide remains coated in the ... the individual background binding and the amount of specific IgG bound to the Menge et al Journal of Neuroinflammation 2011, 8:161 http://www.jneuroinflammation.com/content/8/1/161 well interpolated ... overnight incubation at RT and extensive washing wells were blocked as above, subjected to either 8.18c5 or anti-His mAb (Invitrogen, Carlsbad, CA), and binding was detected as above Data processing and...
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báo cáo hóa học: " Innate Immunity in multiple sclerosis white matter lesions: expression of natural cytotoxicity triggering receptor 1 (NCR1)" pptx
... 10] NCR1 in disease Activating NK receptors recognise stress-induced ligands and viral products Following influenza virus infection, an increased recognition and binding of NK cells with infected ... were counterstained in Mayer’s Haemalum for 2-5 sec and rinsed for Sections were dehydrated and placed in 70% methylated spirit for min, then 90% for min, then 100% for min, and again at 100% for ... containing pages Page contains the staining of NCR1 (mouse monoclonal extracellular domain) on positive control tissue (appendix and tonsil) Page contains a graphic representation of NCR1 and staining...
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Báo cáo hóa học: " The effect of red blood cell transfusion on tissue oxygenation and microcirculation in severe septic patients" pdf
... results, drafting and revising the manuscript, and approving the manuscript in its final form RA, KK, and JO contributed to acquiring and managing the data, revising the manuscript, and approving the ... analyzing the data and interpreting the results, revising the manuscript, and approving the manuscript in its final form Competing interests The authors declare that they have no competing interests ... the manuscript in its final form EA contributed to performing statistical analysis, acquiring and managing the data, revising the manuscript, and approving the manuscript in its final form RT contributed...
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báo cáo khoa học: "More expressions of BDNF and TrkB in multiple hepatocellular carcinoma and anti-BDNF or K252a induced apoptosis, supressed invasion of HepG2 and HCCLM3 cells" docx
... specimens were examined, and by neutralizing BDNF or inhibiting TrkB kinase activity in HCC cell lines to observe the effects of BDNF/TrkB interruption on cell apoptosis and invasion Methods HCC ... BDNF and TrkB immunoreactivity in multiple HCC C and D, positive BDNF and TrkB immunostaining in solitary HCC Original magnification: all ×400 Table Clinicopathological characteristics and BDNF ... having chemotherapy or radiation therapy Formalin-fixed paraffin-embedded sections of tumor were stained routinely with hematoxylin and eosin (HE), and reviewed by two senior pathologists in...
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Báo cáo khoa hoc:" Vitamin D receptor gene polymorphisms in multiple sclerosis patients in northwest Greece" docx
... PPMS = MS: Multiple sclerosis; BMI: body mass index; EDSS: Expanded disability scale score; BMD: Bone mineral density; LS: Lumbar spine Hip: Total hip area; RRMS: Relapsing-remitting MS; SPMS: ... vitamin D intake [9] In the present study there was increased frequency of low BMD in MS patients compared to controls, especially involving the hip area and to a lesser degree the lumbar spine ... using DXA in the laboratory of nuclear medicine and overview of the study All authors read and approved the final manuscript Competing interests The authors declare that they have no competing...
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Báo cáo khoa hoc:" Objective assessment of motor fatigue in multiple sclerosis using kinematic gait analysis: a pilot study" pot
... fatigue in multiple sclerosis : Multiple Sclerosis Council for Clinical Practice Guidelines; 1998 Iyengar V, Santos MJ, Ko M, Aruin AS: Grip force control in individuals with multiple sclerosis ... right and left leg, and trunk sway were measured and compared using paired t-tests (α=0.005) In addition, variability in these parameters during one-minute intervals was examined The fatigue index ... fatigue and ten to cognitive fatigue Scores between 22 and 26 points indicate light motor fatigue, scores between 27 and 31 points indicate moderate fatigue, and scores of 32 points or higher indicate...
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