in vivo evaluation of putative hematopoietic stem cells derived from human pluripotent stem cells
Báo cáo y học: "Discrepancy between the in vitro and in vivo effects of murine mesenchymal stem cells on T-cell proliferation and collagen-induced arthritis" doc
... Mesenchymal stem cells (MSCs) inhibit the proliferation of CD4 + T cells in vitro by induction of nitric oxide and prostaglandin E2 (PGE2) (a) CD4+ T cells, in the presence of accessory cells, were ... upregulate expression of PD-L1, iNOS, and COX-2 in MSCs, making these molecules candidate mediators of T-cell inhibition The involvement of iNOS and COX-2 in inhibition of T-cell proliferation ... marrow -derived mesenchymal stem cells after infusion Cells Tissues Organs 2001, 169:12-20 Hara M, Murakami T, Kobayashi E: In vivo bioimaging using photogenic rats: fate of injected bone marrow-derived...
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Stability and in vivo evaluation of pullulan acetate as a drug nanocarrier
... were fixed in 10% phosphate buffered formalin, embedded in paraffin, sectioned, and stained with hematoxylin and eosin (H&E) In vivo pharmacokinetics and bioavailability In vivo pharmacokinetic study ... i.v at a dose of 200 mg/kg In vivo pharmacokinetics The plasma levels of EPI were determined following a single i.v injection of EPI or PA/EPI (10 mg/kg EPI equiv.) in female Wistar rats The plasma ... drug concentration of EPI and PA/EPI after i.v injection in rats at a single equivalent dose of 10 mg/kg Table 5. Pharmacokinetic parameters of EPI and PA/EPI i.v injected in rats at the equivalent...
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báo cáo hóa học:" In vivo evaluation of a vibration analysis technique for the per-operative monitoring of the fixation of hip prostheses" pdf
... der: The influence of contact conditions on resonance frequencies of a hip stemfemur system: a finite element analysis In Proceedings of the International seminar Prediction and evaluation of total ... stem- femur system during cement FRF graphs of a typical stem- femur system during cement curing The evolution of the FRF at various stages of cement curing i.e 6, 10, 12, and 14 minutes after ... system for intra operative manufacturing and stability testing of hip prostheses In Proceedings of TEHNOMUS XIII, the 13th International conference on New technologies and products in machine...
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báo cáo hóa học:" An in vivo evaluation of bone response to three implant surfaces using a rabbit intramedullary rod model" doc
... gas to produce coating with thickness ranging from 40-70 microns (nominal 50 microns) The coating had a minimum total crystallinity of 65% The minimum HA fraction in the crystalline phase was 90% ... finite dissolution rate of crystalline hydroxyapatite provides a continuous source of calcium and inorganic phosphate [18] In our present study, as well as in those reported by others, bone often ... approved the final manuscript Competing interests Research funds in support of this study were provided to Scripps Clinic from Stryker Orthopaedics Two of the authors are employees of Stryker Orthopaedics...
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Báo cáo y học: "In-vivo evaluation of simultaneous administration of incompatible drugs in a central venous catheter with a decreased port to port distance" pps
... length of cm, for the in vivo administration of incompatible solutions, phenytoin and TPN, using a swine model, did not lead to precipitates large enough to cause adverse clinical effects in our ... the distal lumen at the usual maintenance dose of 2.5 mg/kg/dose at a rate of mg/kg/min up to a maximum of 50 mg/min via a syringe infusion pump (1001, Medfusion Systems, Norcross, Georgia, USA) ... extravasation of fluids or drugs References Recker DH, Metzler DJ: Use of the multilumen catheter Crit Care Nurse 1984, 4:16 Jaimovich DG, Rose WW: In vivo evaluation of simultaneous administration of incompatible...
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Báo cáo y học: "In vitro and in vivo evaluation of a new active heat moisture exchange" potx
... is increased [16,30], causing an increase in carbon dioxide levels, especially during low tidal volume ventilation [31] HMEs also cause an increase the inspiratory work of breathing, with an increase ... 30 mgH2O/l) when using HMEs in patients with high minute ventilation (between 10.5 and 16.5 l/min) [19,23,24] In the present study we found that increasing or decreasing the minute ventilation ... variations We used this offset (in the order of 0.1–0.2°C) to correct the measurements obtained during the study In each condition, the average of three or four readings from the wet and dry probe...
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In vitro and in vivo evaluation of customized polycaprolactone tricalcium phosphate scaffolds for bone tissue engineering
... degree of Master of Engineering in the Department of Mechanical Engineering at the National University of Singapore under the supervision of Professor Teoh Swee Hin and Dr Alvin Yeo No part of this ... engineering in dentoalveolar application can be extremely challenging 1.1.3 PCL-TCP scaffolds: Current drawback The use of synthetic polymers in the field of tissue engineering has been widely investigated ... behaviors of porous scaffolds play an important role in the engineering of new tissue, since the degradation rate is intrinsically linked to cell vitality, growth, as well as host response In order...
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In vitro and in vivo evaluation of transferrin conjugated lipid shell and polymer core nanoparticles for targeted delivery of docetaxel
... microtubules, an essential part of the cytoskeleton of eukaryotic cells The vinca alkaloids prevent the protein from polymerizing into microtubules by binding specifically to β-tubulin In contrast, the taxanes ... high plasma protein binding effect happening once the drugs enter the physiological system Plasma protein binding is part of the opsonisation process The opsonin proteins present in the blood serum ... protein binding after IV administration (Extra et al., 1993) Docetaxel is mainly bound to alpha acid glycoprotein, lipoproteins, and albumin Among them, alpha acid glycoprotein is the main determinant...
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Báo cáo hóa học: " CdTe quantum dots with daunorubicin induce apoptosis of multidrug-resistant human hepatoma HepG2/ADM cells: in vitro and in vivo evaluation" pptx
... and development of multidrug resistance Human hepatoma HepG2 cells were purchased from the Institute of Hematology of Tianjin, Chinese Academy of Medical Sciences (Tianjin, China) To develop ... MDR1 levels of HepG2 and HepG2/ADM cells The drug-resistant HepG2/ADM cells were cultured in the cell culture medium containing μg/ mL adriamycin (Sigma) Both cell lines were maintained in RPMI-1640 ... Access CdTe quantum dots with daunorubicin induce apoptosis of multidrug-resistant human hepatoma HepG2/ADM cells: in vitro and in vivo evaluation Gen Zhang1, Lixin Shi2, Matthias Selke2 and Xuemei...
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Tài liệu Báo cáo Y học: Identification and characterization of the Escherichia coli stress protein UP12, a putative in vivo substrate of GroEL pptx
... observations indicate that maintenance of the correct folding state of GatY in E coli probably requires the assistance of two chaperone systems The identification of UP12 as a putative in vivo substrate of ... identified by other means as an in vivo substrate of GroEL [27] Interestingly, GatY is also included in a list of proteins that aggregate at 42 °C in E coli containing a dnaK deletion mutation (DnaK ... nutrient exhaustion In order to examine whether UP12 is induced by starvation, we tested the expression of UP12 in cells grown in minimal media containing limited concentrations of phosphate or a...
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báo cáo hóa học:" Transplantation of vascular cells derived from human embryonic stem cells contributes to vascular regeneration after stroke in mice" docx
... muscle actin; hESECs+MCs: a mixture of ECs and MCs derived from human ES cells; hES-ECs: ECs derived from human ES cells; hESMCs: MCs derived from human ES cells http://www.translational-medicine.com/content/6/1/54 ... transplanted vascular cells derived from human ES cells (HES-3) Characterization of the transplanted vascular cells derived from human ES cells (HES-3) A, Flow cytometric analysis of VE-cadherin and VEGF-R2 ... Translational Medicine 2008, 6:54 cells, the number (cells/ mm2/mouse) of single stranded DNA (ss-DNA)+ cells in one field in the ischemic core from each mouse in the saline- or hES-ECs+MCs-injected group...
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Báo cáo sinh học: " Phosphoproteomic analysis of apoptotic hematopoietic stem cells from hemoglobin E/b-thalassemia" pot
... culture is capable of sustaining a large number of cells, which can confer specific advantages and disadvantages The use of freshly isolated human hematopoietic stem cells from thalassemic patients ... SMUF1 _HUMAN E3 ubiquitin SMUF1 1.099 CBL _HUMAN E3 ubiquitin CBL 5.746 DCA15 _HUMAN DDB1 2.290 OTU7A _HUMAN OTU domain 1.071 HERC3 _HUMAN Probable E3 ubiquitin HERC3 4.907 UBQL1 _HUMAN Ubiquilin 1.275 ... phosphatidyl inositol (PI3) kinase, and apoptosis The 14-3-3 proteins are a family of multifunctional phosphoserine/phosphothreonine binding molecules and are involved in various cellular processes including...
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o cáo hóa học:" Phosphoproteomic analysis of apoptotic hematopoietic stem cells from hemoglobin E/b-thalassemia" pptx
... culture is capable of sustaining a large number of cells, which can confer specific advantages and disadvantages The use of freshly isolated human hematopoietic stem cells from thalassemic patients ... SMUF1 _HUMAN E3 ubiquitin SMUF1 1.099 CBL _HUMAN E3 ubiquitin CBL 5.746 DCA15 _HUMAN DDB1 2.290 OTU7A _HUMAN OTU domain 1.071 HERC3 _HUMAN Probable E3 ubiquitin HERC3 4.907 UBQL1 _HUMAN Ubiquilin 1.275 ... phosphatidyl inositol (PI3) kinase, and apoptosis The 14-3-3 proteins are a family of multifunctional phosphoserine/phosphothreonine binding molecules and are involved in various cellular processes including...
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báo cáo khoa học: " MicroRNAs involved in neoplastic transformation of liver cancer stem cells" pot
... differentiation of normal stem cells strongly suggest that miRNA may be involved in the transformation of normal stem cells into cancer stem cells Therefore, screening for differences in miRNA expression ... differentiation According to the hierarchical model of cancer, the origin of the cancer stem cells may be long-lived somatic stem cells Therefore, markers of “normal” stem cells are being sought with ... described in most previous reports of SP in human HCC cell lines[17] To the best of our knowledge, this is the first report demonstrating the existence of SP cells in both fetal liver cells and in primary...
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Báo cáo khoa học: "In vivo and in vitro evaluation of an Acetobacter xylinum synthesized microbial cellulose membrane intended for guided tissue repair" ppt
... multipotent mesenchymal stem cells are becoming a subject of increasing interest because of their potential in tissue engineering applications [20] They can be obtained from adult bone marrow ... ratios, strain of Acetobacter and extended times of fermentation interfere in the final product obtained [2,19] In addition, the choice of a particular cellulose structure will depend on the clinical ... Committee at the School of Veterinary Medicine and Animal Science, São Paulo State University Before surgery, anesthesia was induced by intramuscular injection of a combination of xylazine 2%, 10 mg/kg...
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Báo cáo sinh học: " In vitro evaluation of a double-stranded selfcomplementary adeno-associated virus type2 vector in bone marrow stromal cells for bone healing" pptx
... non-enveloped single-stranded DNA virus [19] This unique viral vector has the distinct advantage of being capable of infecting a wide range of host cell types including dividing and non-dividing cells ... a distinct affinity for certain cell types that is because of differences in cell binding and/or intracellular trafficking [21] AAV2 is the most widely used serotype in human clinical trials ... broad range of tissue tropism in several species [21] A number of clinical trials have been approved by the FDA to assess AAV2 in treatment of a variety of human diseases including inflammatory...
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Photoimmunotherapy of melanoma via combination of hypericin photodynamic therapy and in vivo stimulation of dendritic cells by PNGVL3 HFLEX plasmid DNA
... systemic mobilization of DCs using Flt3 ligand, local injection of chemokines such as macrophage inflammatory protein (MIP)-3β, use of DNA vaccines containing bacterial CpG motifs and the use of ... be discussed in detail later Intra-tumoral injection of DCs offers the theoretical advantage of in vivo loading and activation of DCs which should be superior to in vitro loading of DCs with tumor ... number of memory T -cells in tumor draining lymph nodes as compared to PDT alone In another study, schizophyllan (SPG) used in combination with Photofrin-mediated PDT of mice harboring SCCVII increased...
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Tài liệu Aesthetic preferences and the attribution of meaning: Environmental categorization processes in the evaluation of urban scenes ppt
... provide important information in terms of optimizing processes of environmental sampling To overcome some of the above-mentioned limitations, an evaluation procedure was designed in a previous study ... subjects interviewed Exploring the generality of such a categorization in other geographical scenes, incorporating the analysis of places considered ‘‘unattractive,’’ is one of the aims of the ... guiding the design of this study is establishing categories of urban places from the perspective of their daily observers, as well as attempting to identify some of the important dimensions of...
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PET in the Evaluation of Alzheimer’s Disease and Related Disorders docx
... have undergone significant distinct alterations in brain metabolism The increasing use of brain PET stems from the high sensitivity of this imaging tool in identifying those alterations The third ... Future of Neuroimaging in Clinical Evaluations Innovations in neuroimaging techniques and tracer development hold promise for new clinical applications Brain imaging will play an important role in ... which it is being applied In our imaging facility, we routinely employ a systematic approach for evaluating regional metabolism throughout the brain In addition, beginning in 2004, software tools...
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Báo cáo khoa học: In vivo production of catalase containing haem analogues pot
... spectrum of the porphyrin contained in Zn-PP-KatA, in a pyridine ⁄ water ⁄ NaOH ⁄ Tween-80 mixture, was not similar to that of the reference solution of Zn-PP in the same solvent, indicating that ... ion of the porphyrin is removed during transport of the porphyrin from the medium to the catalase protein in the cytoplasm Alternatively, but less likely, the metalloporphyrin is incorporated into ... et al an in vivo system for the production of cofactor-substituted haem proteins It is sometimes desirable to replace the metal of a metalloporphyrin in a specific protein For example, investigations...
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