in vitro wear testing of conventional versus sequentially cross linked polyethylene liners in combination with different sizes of ceramic femoral heads
... alone did not increase the extent of staining However, in cells that had been cocultured with CDO and a cytotoxic drug, staining was significantly increased, indicating the presence of senescence ... culture of CDO with any cytotoxic drug resulted in further increases in SA-b-gal staining that were significantly greater than those seen in cells cultured with SO and drug (all P < 0.001), indicating ... significantly increased in GEO cells treated with the combinationof CDO and 5-FU (Fig 6A) In both HCT116 and GEO cells, there were no significant changes in the levels of CDK 4, cyclin D or CDK in response...
... of Figure Apoptosis induction by isoproterenol or propranolol incombinationwith irradiation in BGC-823 and SGC-7901 cells There was an increasing rate of apoptosis in gastric cancer cell lines ... (OS) in resected adenocarcinoma of the stomach and gastroesophageal junction: Update of the results of Intergroup Study INT-0116 (SWOG 9008) Gastrointestinal Cancers Symposium 2004, Abstract Sminia ... shown in Figure A significant difference in the colony forming rate was found incombinationwith irradiation and propranolol at 50 μmol/L in SGC-7901 and BGC823 cells (p < 0.01) compared with...
... Phosphoinositide 3-kinase Promyelocytic Leukemia Zinc Finger protein Phosphatase of Regenerating Liver Retinoblastoma Protein Red Fluorescence Protein RNA interference Receptor Tyrosine Kinase ... values obtained for ABT-869 incombinationwith Ara-C and Dox employing three sequences are shown in Table To determine whether the combination therapy produce synergism in induction of apoptosis, ... RPMI1640 (Invitrogen, Carlsbad, CA) with 10% of fetal bovine serum (FBS, JRH Bioscience Inc, Lenexa, KS) Cells were maintained in density of x 105 to 10x105 cells/ml in a humid incubator with 5%...
... effect of 1% increase in GDP per 24 capita in LA and South and East Asia was 0.206 and 0.158% increase of Gini index correspondingly Education, being insignificant in most of the countries including ... point starts to decline iv Chapter INTRODUCTION Income inequality dynamics differ a lot across countries, but the sharp rise of inequality in some of them has made income distribution one of ... and disrgarding the size of the countries, inequality between countries using GDI per capita but taking into account the size of countries and ignoring inequality within countries and inequality...
... data indicate that increasing the hesperidin from 100 mg to 1,000 mg reversed some of the thermogenic effects of 100 mg hesperidin incombinationwith 50 mg p-synephrine plus 600 mg naringin It ... This increase in thermogenesis is similar to the increases reported in previous studies involving p-synephrine [17, 18] The increase in RMR between Group 4, the combinationof p-synephrine with ... observed in response to p-synephrine or p-synephrine incombinationwith naringin and hesperidin (Table 2) p-Synephrine differs from ephedrine in that it has a hydroxyl group on the para position of...
... Households with children defecating in open field Households with children defecating in room Households with children defecating in verandah Households with children defecating in latrine defecating ... defecating in room Households with children defecating in verandah Households with children defecating in latrine Hygiene practices Hand washing with soap before eating Hand washing without soap ... NCD Hand washing with soap before eating Hand washing without soap before eating No hand washing before eating Hand washing after defecation with soap Hand washing after defecation without soap...
... value in increasing level, followed by Quy Nhon and Can Tho This is quite compatible with the temperature happening in the past (increasing level declined southwards) In addition, temperatures in ... Assumption testing the magnitude of the correlation coefficient Rxy + Assumption testing the magnitude of the coefficient of regression equation + Assumption testing the efficiency of regression ... are often June to August in all three cities with 1.7 - 2.9 oC in Da Nang, 1.5-2.6 oC in Quy Nhon and 1.4-2.5 o C in Can Tho 3.2 Rainfall scenarios Rainfall scenarios show that rainfall in dry...
... Other minor side effects included nausea-vomiting involving about 50% of patient in both cohorts, transaminase increase in patient in cohort A, and asthenia in patient in cohort B The median of delivered ... necessary in patients in cohort A and in patients of cohort B due to severe thrombocytopenia Chemotherapy was also delayed in patients of cohort A and in patients of cohort B because of failure of hematologic ... arising in the metastatic lesion without evidence of disease progression Interestingly, one PR in cohort B, occurred in a female with a disseminated disease involving axillaries lymph nodes, diffuse...
... internal to external exposure Additionally we assessed the influence of smoking on internal exposure by measurement of cotinine in the urine of the workers In view of the explanatory nature of ... Worker no Worker no Worker no Worker no Skin condition of hands o-Toluidine in the air (µg/m3) o-Toluidine in urine (µg/l) Cotinine in urine (µg/l) Healthy skin 58.29 74.83 4471 µg/L (= smoker) Mild ... Drexler H, Korinth G: Penetration of β-naphthylamine and o-toluidine through human skin invitro Arch Toxicol in press 2006, Apr Korinth G, Geh S, Schaller KH, Drexler H: Invitro evaluation of the...
... for individuals in the early stage of degeneration found by MRI examination[16] An[17] reported that the intradiscal administration of osteogenic protein-1 by injection in vivo resulted in an increased ... [6,7] To investigate the therapeutic potential in the treatment of disc degeneration, we investigated the effects of TGF-β1 and IGF-1 on the proliferation of human NP cells in single or combination ... However, cell viability showed a trend of decreasing in response to further elevation of the concentrations Time-course effect of growth factors in single or combinations The optical density was assessed...
... periods without the risk of premature germination [9, 10] A combinationof GA3 and chilling at TMC levels might increase germination potential while reducing the risk of premature germination in alder ... Percentage germination, including or excluding premature germination, in fully imbibed alder and birch seeds in response to chilling and priming Chilling duration (weeks) 18 Premature germination included ... during chilling on dormancy release in FI and TMC seeds of alder and birch In addition, the effect of priming at 15 ◦ C with or without PEG on the germination response of FI and TMC seeds without...
... symptoms of both psoriasis and PsA In comparison with previously performed clinical trials in PsA with mg/kg infliximab [33], we demonstrated that a low-dose treatment regimen with mg/kg incombination ... that after weeks of infliximab therapy a beneficial clinical effect can be observed in both skin lesions and inflamed joints in PsA In addition, we recently showed in patients with rheumatoid ... Representative images of immunohistochemical staining are shown in Fig Discussion The results of the present study confirm that anti-TNF-α treatment with infliximab is effective in reducing clinical signs...
... wall of the cavity and its position is not altered with the patient’s movements [5] and particularly in case of preexisting factor of lung cancer Frozen section examination of a Wedge excision of ... found in healthy persons with no risk factors, lung cancer must be ruled out by frozen section of a pulmonary excision of aspergilloma If combination is confirmed, a carcinologic surgery with ... H: Aspergilloma incombinationwith adenocarcinoma of the lung Can J Surg 2008, 51(1) Bardana EJ: Pulmonary aspergillosis In Aspergillosis Edited by: Al-Doory Y, Wagner GE Springfield (IL): Charles...
... safety of radiation therapy combined with the newer generation of PIs in treatment of non-AIDS defining malignancies which are increasingly common in the era of improved ART The series included ... valuable information about the acute toxicity of combining radiation with current PI therapies Review of this contemporary series of patients did not find an increase in acute toxicity from the combination ... histologies, including HIV-defining (0 with PIs; [23%] without PIs), HIV-associated (11 [58%] with PIs; [38%] without PIs), non-HIV-associated malignancies (8 [42%] with PIs, [38%] without PIs),...
... where the investigators also combined a fixed weekly dose of gemcitabine (1000 mg/m2) with an escalating dose of RT [20] Escalation was achieved by increasing the fraction size in increments of 0.2 ... (G) was administered on day of week 1, 2, 3, and in a single dose of 300 mg/m2 as a 30-min IV infusion at least one hour prior to RT; the starting dose of RT was 45 Gy in 25 fractions of 1.8 Gy ... considerations The study intent was to determinate the DLT of escalating doses of RT delivered concurrently with a fixed dose of gemcitabine (300 mg/m2) administered on a weekly basis within the same overall...
... alone, or incombinationwith equitoxic single doses of 5-FU, oxaliplatin, or both drugs The same single doses of 5-FU and oxaliplatin were combined with split dose radiation Results A total of 265 ... oxaliplatin Both drugs were administered intraperitoneally Single doses of 5-FU (Mayne Pharma) 0-200 mg/kg and of oxaliplatin (Mayne Pharma) 0-10 mg/kg were administered alone or incombinationwith ... although again with large error bars at this dose level http://www.ro-journal.com/content/4/1/61 Increasing doses of oxaliplatin resulted in an essentially linear decrease in the number of surviving...
... cytotoxicity invitroof a variety of chemotherapeutic agents withdifferent modes of action, including carboplatin, doxorubicin, paclitaxel, and gemcitabine [19] In addition to its favorable preclinical ... protein kinase (MAPK) signaling protein, mitogen activated protein kinase kinase (MKK4), in canfosfamide treated cells, as well as the activation of jun-N-terminal kinase (JNK), p38 MAP kinase ... the combination There were no dose limiting toxicities (DLTs) The MTD was full doses of both agents Full doses of canfosfamide incombinationwith PLD were administered in 88.4% and 87.3% of cycles,...
... proportion of type I fibres in the tibialis anterior muscle of patients with COPD [10] This is in line with previous studies [3,7-9] and together with previous findings of a decrease in oxidative ... activities in COPD [6,7] our findings indicate the occurrence of a shift towards a more glycolytic profile in the limb muscle of COPD patients Furthermore, the number of capillaries around a single ... capacity determined by the 6-min walking test In the Page of context of motor unit recruitment during different muscular activities it is known that low intensity muscle activities mainly recruit...
... steroid-induced myopathy; d) pulmonary hyperinflation with increased residual volume; e) reduced blood flow to the respiratory muscles [13-19] The measurement of MIP and MEP is indicated in any of ... pressures and functional parameters at different stages of COPD Methods During year 110 patients suffering from COPD were enrolled in this study All patients were in a clinically stable condition and ... examination, we excluded those patients whose FEV1 improvement, after a bronchodilatory test, was ≥ 12% and 200 mL of the baseline value and with a history of asthma Other patients, with clinically...
... replication in U1 and ACH-2 cells, and toxicity in uninfected JurPotencies Potencies ofdifferent HDACIs in terms of activation of HIV-1 replication in U1 and ACH-2 cells, and toxicity in uninfected ... largely disappointing so far Valproic acid, a relatively weak HDACI, was tested in a small clinical trial incombinationwith antiretroviral therapy intensified with the fusion inhibitor enfuvirtide ... HDACIs capable of activating HIV-1, we first tested the HIV-1 activating ability of our institutional library of HDACIs [see Additional file 1] in cell lines in which HIV-1 is inducible (i.e...