implications for transformation and progression of prostate cancer
PULMONARY HYPERTENSION – FROM BENCH RESEARCH TO CLINICAL CHALLENGES pot
... domain of EGFR and ErbB2 and the nuclear translocation of both receptors In fact, phosphorylated EGFR and ErbB2 were detected at sites of cell-cell contacts and in the nucleus of some cells of the ... activation of PYSTAT3 and upregulation of Bcl-xL are observed within 48 hrs of MCT injection, i.e before the onset of PH Other EC membrane proteins such as PECAM-1 and Tie2 are lost in tandem with ... Remarkably, the adhesion to pFN and organization of the endothelial cells into monolayers of polarized cells involving formation of AJs and reorganization of MTs in the absence of serum or growth factors...
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Báo cáo y học: " Involvement of mast cells in monocrotalineinduced pulmonary hypertension in rats" pot
... pathogenesis of PH and pulmonary vascular remodeling However, a systematic examination of pulmonary MCs in clinical and experimental PH and an elucidation of the role of MCs in animal model of progressive ... ratio of weight of the right ventricular wall (RV) and that of the free left ventricular wall and ventricular septum (LV+S) Histology and Pulmonary Vascular Morphometry Lung histology and vascular ... inhibition of perivascular MC degranulation and reduction of pulmonary MC count, suggesting that the amelioration of PH may be associated with the reduced accumulation of MCs and prevention of their...
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Báo cáo y học: "Inhaled nitric oxide in persistent pulmonary hypertension of the newborn refractory to high-frequency ventilatio" ppsx
... are essential for the management of PPHN High-frequency ventilation has been introduced as a mode of therapy in PPHN There were no randomized studies of HFOV in the management of infants with ... potential of HFOV to reduce the need for extracorporeal membrane oxygenation (ECMO) A number of reports identify a number of infants who, although referred for ECMO, survived without using this type of ... HFOV and INO in reducing the need for ECMO has been studied Kinsella et al [8] combined HFOV and INO in the treatment of infants with hypoxic respiratory failure and PPHN who were ECMO candidates...
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Báo cáo y học: "Prophylactic antibiotic treatment is superior to therapy on-demand in experimental necrotising pancreatitis" pptx
... WH, RL and JW played a pivotal role in planning and carrying out the experiments KW-S and MK performed bacterial and mycological analysis of the experimental animals SF, WH, TH, LS, MB and JW ... number of patients in the future Due to variations in methodological quality, treatment regimens and the difficulty of including enough patients for a powerful study, the question of efficiency of ... assessments of blood, ascites, pancreas and mesenteric lymph nodes of both the colon and small bowel, as well as by 24-hour mortality rates In a second set of experiments, treatment effects of meropenem...
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Báo cáo y học: " Effects of inhaled iloprost on right ventricular contractility, right ventriculo-vascular coupling and ventricular interdependence: a randomized placebo-controlled trial in an experimental model of acute pulmonary hypertension" ppt
... Materials and methods This investigation conforms to the Guide for the Care and Use of Laboratory Animals, published by the US National Institutes of Health (Publication No 85-23, revised 1996) [17] and ... pressure and RV-Mw, when a level of significance of 0.05 and a power of 80% were to be achieved Results were statistically analyzed using a commercially available software package (Statistica© for ... ± 0.06 7.47 ± 0.04 Values are shown for baseline and in pulmonary hypertension before inhalation and minutes after inhalation of either iloprost or control For the complete experimental time course,...
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báo cáo hóa học: " Development and validation of a preference based measure derived from the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) for use in cost utility analyses" doc
... 'Fair', and 'Poor') Items that significantly predicted this variable were candidates for inclusion in the utility exercise Page of (page number not for citation purposes) Health and Quality of Life ... is the mean TTO value for each health state and x is a vector of dummy explanatory variables (x∂λ) for each level λ of dimension ∂ of the simplified CAMPHOR classification For example, x31 denotes ... than 0.05 (35% for the mean level model and 38% for the random effects models, respectively) and both models resulting in two predictive errors greater than 0.10 In both mean and random effects...
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Báo cáo y học: "Cold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertension" ppt
... http://arthritis-research.com/contents/7/3/126 Figure Dysfunction of cellular components of the arterial wall and of inflammatory and haemostatic systems are interrelated predicted survivals of 69% and 57%, respectively Although ... deposition and inhibition of NF-ΚB activation [5,12,13] Since there are commonalities in the pathophysiology of PAH and RP, particularly in the context of connective tissue disease, inhibition of the ... role in the management of PAH They also appear to be of limited benefit for RP in patients with SScl [19] In contrast, the prostanoids improve function and survival in PAH, and may also be antiproliferative...
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Báo cáo y học: "Role of chymase in cigarette smoke-induced pulmonary artery remodeling and pulmonary hypertension in hamsters" doc
... C-3’ and (reverse) 5’-TCT CGG CTG TGG TGG TGA AG-3’ The PCR program for chymase was initiated by a denaturation step at 94°C, followed by 35 cycles of 94°C for 30 s, 63°C for 30 s and 72°C for ... Primers for chymase PCR (738 bp) were (forward) 5’CTG AGA GGA TGC TTC TTC CTG C-3’ and Page of 10 (reverse) 5’-AGA TCT TAT TGA TCC AGG GCC G-3’ [23] Primers for b-actin PCR (194 bp) were (forward) ... O) for 30 min, and then the right lung was removed and submersed in the same fixative overnight at room temperature for paraffin embedding, sectioning and histological staining The remainder of...
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Báo cáo y học: " Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27kip1 in rats" ppsx
... 59°C for 30 s and 72°C for min, and a final extension at 72°C for 10 min; and for b-actin was began with a denaturation step at 95°C, followed by 35 cycles of 95°C for 30 s, 55°C for 30 s and ... cycles of 95°C for 30 s, 51°C for 30 s and 72°C for min, and a final extension at 72°C for 10 min; for Skp-2 was initiated by a denaturation step at 95°C, followed by 35 cycles of 95°C for 30 ... Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the...
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Báo cáo y học: " Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats" pps
... exposure and femurs and tibias of the rats were dissected sterilely After cutting each end of the femurs and tibias to expose marrow, we placed each bone into a 1.5 ml sterile eppendorf tube and centrifuged ... performed with a Laser SORP BD LSR II Data were collected with DIVA software on LSR II and analyzed with FlowJo v8.8.6 Measurement of right ventricular hypertrophy The ventricles and septum of ... Proteins were isolated form rat lungs and Western blot was performed for analysis of GFP protein expression Quantitative data (upper panel), setting hypoxia BMC as 1, and representative images...
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Báo cáo y học: " Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model" potx
... Center of Shandong University of Traditional Chinese Medicine (Shandong, China) Rats were housed with free access to food and water under a natural day/night cycle Rats were acclimated for days before ... from the heart for serum preparation, and lung and heart were processed for histological evaluation or frozen in liquid nitrogen for further analysis Drugs and materials Measurement of RV hypertrophy[17] ... elevation of TNF-a and IL-6 (Figure 3) Hydrogen-rich saline treatment decreased MDA and 8OHdG concentrations and increased SOD activity in serum and lung tissues Concentrations of MDA and 8-OHdG...
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Báo cáo y học: " Adrenomedullin in inflammatory process associated with experimental pulmonary fibrosis" pot
... http://respiratory-research.com/content/12/1/41 Page of 12 Figure Effects of adrenomedullin (AM) on production and expression of TNF-a and IL-1b The evaluation of the lung production of the pro-inflammatory cytokines TNF-a and IL-1b showed ... (Figure 1D) and 21 days (Figure 1G) AM-treatment prevented both ECM deposition and tissue damage at 14 (Figures 1F) and 21 days (Figure 1I) Effects of AM on production and expression of TNF-a and IL-1b ... 2Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Via C Valeria Gazzi - 98100 Messina, Italy 3Deparment of Pharmacology, School of Pharmacy,...
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Báo cáo y học: " Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension" pot
... analysis of the pulmonary vessels (medial wall thickness and degree of muscularization) and for the assessment of index of proliferation (IOP), as described previously [35] Determination of collagen ... invasive measurements of heart ratio (RV/(LV+S)) and RVWT and echocardiographic measurements of RVWT and RV dimensions Because remodelling of the right-heart structure is an attribute of the RV hypertrophy, ... Research and Development, Sandwich, UK Authors’ contributions DK, HAG, NW, WS, FG and RTS conceived and designed the study DK, BK and HL performed experiments DK, BK, HL, BKD, HAG, NW, FG, WS and...
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Báo cáo y học: " Endothelial-like cells in chronic thromboembolic pulmonary hypertension: crosstalk with myofibroblast-like cells" pptx
... Regulation of Autophagy: Co-Regulators of Autophagy and Apoptosis Regulation of Autophagy: Co-Regulators of Autophagy and Apoptosis Regulation of Autophagy: Co-Regulators of Autophagy and Apoptosis ... immunofluorescence staining for anti-Factor VIII (green) and antia-SMA (red) to confirm the phenotypes of the cells A), B) and C), ELCs before sorting; D), E) and F), ELCs after sorting; A) and ... immunohistochemical staining and harvested to extract RNA for quantitative RT-PCR and to extract protein for ELISA Co-culture of human pulmonary microvascular ECs and MFLCs Co-culture of human pulmonary...
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Báo cáo y học: "Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice" ppt
... nmol/L), and 100 ng random primers in a total volume of 12 μL was incubated for minutes at 65°C and chilled on ice Then, μL of 1st Strand Buffer, μL of DTT (0.1 mol/ L), and 40 U of ribonuclease inhibitor ... Bradford method For standardization, serial dilutions of recombinant mouse IL-6 were assayed at the same time Lung immunohistochemical labeling of IL-6 and macrophages Paraffin sections of lung ... expression of ICAM-1, VCAM-1, ET-1 and MCP-1 mRNAs in IL-6-/- and IL-6+/+ during normoxic and hypoxic conditions Lung expression of ICAM-1, VCAM-1, ET-1 and MCP-1 mRNAs in IL-6-/- and IL-6+/+...
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Báo cáo y học: " Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease" ppsx
... patients of similar (A) Intensity 2of staining forage eNOS, (B) iNOS and (C) nNOS in lungs from infants with pulmonary hypertension and from conIntensity of staining for (A) eNOS, (B) iNOS and (C) ... E) and from control patients of similar age (B, D, F) stained for (A and B) eNOS, (C and D) iNOS, (E and F) nNOS (A) Cardiac patient small pulmonary artery showing mild endothelial positivity for ... dysfunction becomes severe The aims of the present study were therefore to immunohistochemically determine the expression of the three isoforms of NOS in the lungs of infants with secondary pulmonary...
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Báo cáo y học: "Collagen V-induced nasal tolerance downregulates pulmonary collagen mRNA gene and TGF-beta expression in experimental systemic sclerosis" doc
... 2Department of Radiology, Discipline of Oncology of the School of Medicine of the University of Sóo Paulo (FMUSP), Sóo Paulo, SP, Brazil 3Department of Pathology of the School of Medicine of the University ... acquisition of histologic and morphometric data and performed the statistical analysis; RK, CCO and MHK contributed to the acquisition of molecular data and performed the statistical analysis; VLC and ... experiments, and drafted the manuscript; WRT contributed to conception and design of the original study and analysis and interpretation of histological, immunohistochemical and molecular data; DMA and...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25