... on the firms, including the decrease in expected future earnings andthe increase in cost of capital (Hribar and Jenkins, 2004) We are interested to examine theroleof financial analysts in ... suppliers, and its industry warrants them the service fee However, the growing number of earnings restatements andthe accompanying problems in financial reporting bring about many criticisms on the financial ... an in- depth investigation Chapter Introduction The growing number of earnings restatements reflects weakness inthe chain of several parties involved inthe current corporate governance and financial...
... about the nature of dialogue structures, about the validity and usefulness ofthe concept of a dialogue structure, about theroleofthe task structure in determining dialogue structure, andinthe ... Thus, the node N-1 immediately dominates N, the node N-2 dominates N-I, and so on The nodes subordinate to each ofthe nodes dominating N are indexed beginning with the left-most node and proceeding ... nonpronominal noun phrases will tend to occur more frequently at the beginning of subdialogues than later inthe subdialogues On the other hand, pronominal noun phrases play a rolein indicating and...
... reported for the detection ofthe presence of colorectal cancerand independently associated with the increased risk of colorectal cancerin men [14], and overall cancer risk [15] Interleukin-6 (IL-6) ... allowed us to investigate the timing of vaccinations with respect to the CRP cycle, while examining the clinical responses Since the periodicity ofthe L-CRP oscillatory cycle was consistent and recurrent, ... have investigated this hypothesis further by examining the timing of chemotherapy doses with respect to the LCRP immune oscillatory cycle, in patients with advanced melanoma, while examining the...
... that pain and appetite loss are independent determinants of overall survival One found that a 40-point increase inthe pain subscale ofthe EORTC QLQ-C30 was associated with a 27% increase inthe ... each other, in many instances when one includes both physical functioning and performance status inthe regression models, the likelihood of finding inconsistent results can be expected In other ... may contribute to the initiation of morbidity, the biology ofthe disease appears to predominate, overriding thepotential influence of life-style and psychosocial variables once the disease process...
... pattern of care and main outcomes, and a discussion ofthe feasibility of this kind of approaches inthe specific setting, the second about the effects (effectiveness) of treatments on patients (and ... expected: the first reporting on the results ofthe "epidemiological" part ofthe study, including a description of patients' characteristics in terms of baseline socio-demographic and clinical ... variance to analyze and separate the effects of treatments and time and test the interaction between the two, as well [33] worst and average pain score of ≥ points (pain intensity difference,...
... needle is introduced into the last portion of internal jugular vein This vein was reached through the transducer placed at the point of insertion ofthe sternocleidomastoid muscle into the clavicular; ... removal ofthe CVC The follow-up consisted of: patient’s clinical examination, catheters flushed with heparinized solution and catheter exit side dressing Assesment of endpoints The primary endpoints ... allowed the completion ofthe therapeutic program for 1,930/ 1,978 (97.6%) ofthe catheters inserted The absence of pneumotorax and other major complications indicates that US guidance should be mandatory...
... inthe design ofthe study and writing ofthe manuscript MN and NH assembled the data TM and YK performed the statistical analysis HI and HK performed the study of flowcytometry YN designed the ... Distribution in Th1 and Th2 subsets of CD4+T cells in peripheral blood of colorectal cancer patients and involvement incancer establishment and progression Cancer Immunol Immunother 1996, 42:1-8 ... of 4% formaldehyde fixative After washing and incubating with PBS/BSA/saponin for 10 min, cells were incubated with for 30 min, respectively Results were analyzed using the XL/XL-MCL system and...
... the C-terminal protein kinase domain (PI3K-domain), 2) the substrate binding domain inthe N-terminal ofthe protein necessary for activation of p53 in response to DNA damage, 3 )the FAT domain ... mutations in each allele ofthe gene, a large proportion of which are reported to be truncating, giving rise to shorter versions ofthe protein where the C-terminal domain ofthe protein often is ... involved inthe detoxification of reactive oxygen species [18,19] The ATM protein is involved inthecell cycle control and is a member ofthe phosphatidylinositol 3-kinase family, implicated in the...
... anticoagulation over the course ofthe increased risk of VTE (during and postsurgery) with the minimum of adverse events such as post-operative bleeding For cancer patients, there is also increasing evidence ... effects of heparin and short-length oligosaccharides of heparin on themetastasisandgrowthof LMD MDA-MB 231 breast cancer cells in vivo Br J Cancer 2007, 97:761-768 101 Folkman J, Langer R, Linhardt ... coagulation and fibrinolytic pathways The association between cancerand VTE works both ways, with cancer inducing a hypercoagulable state andthe pro-thrombotic changes in turn facilitating cancer growth...
... a fishy taste inthe mouth might certainly cause detection bias Assessment ofthe trial reporting in terms of risk of bias, the use of random assignment, and subsequent concealment of allocation ... Aalborg, Denmark Competing interests The funding agencies (The Oak Foundation andThe Danish Rheumatism Association) had no rolein writing the report or inthe decision to submit the manuscript for ... the taste of fish oil during a 3-month trial, probably as difficult as it is to hide the taste of ginger [5] Finally, deviations from protocol and loss to follow-up often lead to the exclusion of...
... in oncology and/ or R195 intensive care, and take part in regular training of oncology and intensive care nurses The nurse/patient ratio ranges from 1.2 to 1.7 Routine clinical rounds, including ... the impact of missing data on the performance of models; inthe present study prothrombin time, and serum albumin and bilirubin were not obtained in all patients The differences between the predicted ... patients (with a diagnosis of cancer) may be admitted because of life-threatening illness identified during assessment ofthe extent of their cancer and/ or consideration ofthe therapeutic options This...
... cytoreductive therapy and develops in 20% to 40% of BMT recipients [47] Amphotericin during conditioning Acyclovir during conditioning Vancomycin during conditioning The main site of liver damage in this ... obstruction located within the kidneys (crystals and proteins) or downstream ofthe kidneys The clinical manifestations vary with the site, degree, and rapidity of obstruction Urinary findings are classically ... chains bind to a specific peptide domain on the Tamm-Horsfall protein [17]; variations in CDR3 in both the κ and λ light chains influence binding [20] Additionally, hypovolaemia, sepsis, urinary...
... used to increase blood pressure Then, the use of epinephrine, norepinephrine, and/ or dobutamine was decided by the physician in charge ofthe patient Stress-dose steroids were routinely administered ... that they have no competing interests Authors' contributions DM collected and analyzed the data and reviewed and coordinated the study AS and MF collected and analyzed the data J-PB, J-LB, DB, and ... factors by the univariate analysis (cutoff p < 0.05) To avoid increasing the risk of collinearity for the same variables measured at days and (LOD and NT-proBNP), we decided to include only the most...
... study, individual organ failures were diagnosed in case of a SOFA score ≥ points in each domain [14] In addition, patients receiving dialysis inthe context of acute kidney injury and invasive ... according to the suspected primary focus of infection Demographic, clinical and laboratory data were collected using standardized case report forms during the first day of ICU stay including main ... in patients with febrile neutropenia to assess their performance inthe diagnosis of infection [18-24], inthe identification ofthe underlying agents [18-20,22,24], inthe characterization of...
... with those obtained in other studies that have investigated the addition of another drug inthe taxane-based chemotherapy Inthe study of Albain et al [28], the addition of gemcitabine to paclitaxel ... following steps: definition ofthe outcomes (definition ofthe question the analysis was designed to answer), definition ofthe trial selection criteria, definition ofthe search strategy, and ... the combination of clinical and molecular factors will guide the clinician in identifying the most effective therapy for a given patient, leaving more space and giving more importance to the molecular...
... separates the aminoterminal DNA-binding domain ofthe enzyme from the carboxy-terminal catalytic domain resulting inthe loss of normal PARP1 function Although theroleof PARP in apoptosis remains ... photodynamic therapy for the derivation of molecules of interest incancer therapy including photofrin, purpurins, xanthenes, phthalocyanines, oxazines, cyanines, chlorines (Pervaiz, 2001; Pervaiz and ... associated proteins, and intermediate filament proteins including vimentin keratin and nuclear lamins (Luthi and Martin, 2007; Taylor et al., 2008) Caspase mediated clevage ofthe protein kinase ROCK1...
... for binding to proteins containing LXCXE motifs while the pocket-domain andthe C-domain are involved in binding E2F proteins Mdm2 (as well as c-Abl) binds to the C-domain All pocket proteins ... made in cells lacking pRb inthe retina Somatic inactivation of pRb, even inthe absence of p107 and p53, inthe outer nuclear layer had no obvious consequences, indicating that in some settings ... expression of an E2F variant containing the DNA binding motif but not the pRb-binding or transactivation domain or introduction of a competitor plasmid containing multiple E2F binding sites, preventing...
... Visbal AL, Horgan AM, Guindi M, Hornby J, Xu W, Ringash J, Keshavjee S, Chen E, Haider M, Darling G: Phase trial of preoperative irinotecan plus cisplatin and conformal radiotherapy, followed by ... Mayer R: Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781 J Clin Oncol 2008, 26(7):1086-92 ... Oncology Group; Australasian Gastro-Intestinal Trials Group: Surgery alone versus chemoradiotherapy followed by surgery for resectable cancerofthe oesophagus: a randomised controlled phase III trial...
... clavicular fossa and above the seventh rib Any relapse involving the axillary lymph nodes, and/ or other nodes inthe infra or supraclavicular fossa or inthe internal mammary chain was considered ... supraclavicular and internal mammary lymph nodes alone) Local recurrence was defined as any relapse inthe area of surgery between the sternum andthe anterior axillary line, and below the inferior ... time, theroleof PMRT for women with to positive lymph nodes remains uncertain and is being examined in a randomized clinical trial” Many surgeons and radiation oncologist are not recommending...
... various cancercell lines, including gastric cancer cells, colon cancer cells, breast cancer cells, lung cancer cells, bladder cancer cells, renal cancer cells, and melanoma cells [22] Inthe present ... expression of these splicing variants was shown only inthe thymus [22] We then analyzed the survivin expression inthe protein level In all the oral cancercell lines examined inthe present ... blotting analysis of survivin protein in oral cancercell lines Western blotting analysis of survivin protein in oral cancercell lines Lysates from oral cancercell lines or normal oral mucosal...