if the fair value of one of the companies or businesses is significantly higher than the fair value of the other or others involved in the transaction the acquirer shall usually be the company with the highest fair value
... could be essential for the binding of CP12 The presence of this region at the interface of GAPDH and CP12 could also explain the kinetic changes observed for the binding ofthe substrate when the ... C reinhardtii PRK isinvolvedinthe interaction of this enzyme withthe GAPDHCP12 subcomplex This report describes the behaviour of four GAPDH mutants to explore the specic interactions between ... GAPDH into alanine or glutamic acid Comparison ofthe kinetics of these mutants with those ofthe wild-type recombinant GAPDH shows that the behaviour of R197A mutant is not affected by the mutation,...
... involvedin affinity for the 43-kDa protein Instead of Val23, Ile25 was found to be important for binding to the 43-kDa protein The topology ofthe sidechains of Ile25, Val29, Phe31 and Ile33 in ... inthe 4-kDa peptide was similar to that ofthe active area in insulin (Fig 7F) Ifthe mechanism ofthe interaction between the 4-kDa peptide and 43-kDa protein has the minimum components of insulin–insulin ... contains hairpin-b [14] These structures form the sheet ofthe putative binding area (Fig 7A,B) Ofthe two fragments, fragment appears to bethe most important in binding to the 43-kDa protein...
... 3-Ureidopropionase of C elegans ofother organisms [4] Because such predictions can be misleading [8], it is important to verify them at a functional level Accordingly, we cloned the cDNA coding for the predicted ... full other functions inthe cell The degradation product of uracil, 3-aminopropionate (b-alanine), for example, can be condensed with histidine to form the dipeptide carnosine Carnosine and other ... discrepancy In plants, the 3-ureidopropionase isinvolvedinthe synthesis ofthe pantothenate moity of coenzyme A and 3-aminopropionate can serve as osmoprotectant [9] Those different roles in...
... pitching close inside is an act of intimidation, an attempt to instill fear inthe batter For the art of pitching is more than just messing with a batter’s timing; it isthe art of messing with his ... outstanding prospect inthe St Louis Cardinals organization In 1933 he was playing second base for the Springfield (MO) Cardinals inthe Class A Western League Inthe top half ofthe second inning of ... or mechanical, including photocopying or recording, or by any information storage and retrieval system, without permission in writing from the publisher On the cover: Illustration depicting the...
... to the induction of these responses remain to be characterized in this species Recently, two genes encoding transcription factors ofthe WRKY family and potentially involvedin grapevine resistance ... and Vitis vinifera strongly suggests that VvNPR1 is a component ofthe SA defense signalling pathway in grapevine This implies the existence of highly conserved mechanisms for regulation of defense ... [12] Members ofthe AtNPR family encode proteins sharing two domains involvedin mediating protein-protein interactions: the Broad Complex, Tramtrack and Bric a brac/Pox virus and Zinc finger (BTB/POZ)...
... [17–19] This isin remarkable contrast to cell binding by filipin, another cholesterol-binding reagent Filipin staining is significantly retained under the same depletion conditions [19] Thus BCh binds ... major component of lipid rafts Previously, we designed the novel cholesterol probes Ch and BCh [16,17] by modifying h-toxin (perfringolysin O), a cholesterol-binding, pore-forming cytolysin produced ... were determined as the amounts of inorganic phosphorus bAmount of proteins inthe BCh-bound membrane fraction was estimated by subtracting the amount inthe unbound fraction from that inthe total...
... was all thehighestin root, and sanguinarine is found exclusively in root (data not shown), root is likely the main organ for the biosynthesis and storage of sanguinarine in E californica These ... an intermediate at the branch point leading to benzophenanthridine alkaloids in E californica or berberine in C japonica The pathway from (S)-scoulerine to berberine is thought not to exist in ... as STS, whereas CYP719A3 might beinvolvedinthe biosynthesis of stylopine and inother biosyntheses However, analysis of their expression in E californica plant tissues showed that CYP719A3 mRNA...
... in protein–protein interactions by forming homo- or heterooligomers withother SAM domains or by interacting withother proteins [23] The SAM domain ofthe protein Smaug, however, has been shown ... reflecting the effect of a proline on helix termination The p63a and p73a SAM domains form a distinct subset ofthe SAM domain family SAM domains, in general, were initially thought to beinvolvedin ... SAM domains not form homo-oligomers or associate with each other Analysis of mutations involvedinthe AEC syndrome Inthe AEC syndrome, the SAM domain of p63a is found to undergo a number of mutations...
... (striped) are indicated (C) Alignment of DhbE and YbtE amino acids forming the aryl substrate binding pockets The differing amino acids are indicated by asterisks The amino acids withthehighest proposed ... Therefore, a model of a putative binding pocket valid for SAL activating domains can be proposed and is exemplified here for YbtE in comparison withthe DHB binding pocket of DhbE (Fig 3A–C) In ... overall binding, which probably explains the smaller differences ofthe Ki values for DHB-AMS and SAL-AMS compared to the differences ofthe Km values for DHB and SAL This, again, isin agreement with...
... intensity values on each scale, and then joining the points Results ofthe sensory tests on the ecotypes harvested inthe three different fields are shown in Figure The profiles obtained through the ... inthe data, withthe first component alone (PC1) accounting for more than 23% ofthe variation and the second component (PC2) accounting for 15% ofthe variation The first factor was strongly ... important components Six principal components were obtained that explained approximately 80.3% ofthe variability inthe dataset The first two factors explained about 38% ofthe variation in the...
... antigens, and other gene products These approaches, however, have poor sensitivities and specificities since none of them alone is useful for the majority ofthe BC and none of them is specific for cancer ... 185.28+95 *: Bc1 level is statistically lower inthe control group thantheothers †: Bc2 level issignificantlyhigherinthe malignant group tan theothers http://www.medsci.org Int J Med Sci 2011, ... (p=0.015) Unfortunately again the AUC values were below the 0.70 for Bc1 in all groups The relevance of this finding is that it was the result ofthe first subgroup analysis for these biomarkers...
... (51–75% of tumor cells); and 4+ (greater than 75% of tumor cells) Furthermore, staining in less than 50% ofthe tumor cells was considered focal, and staining in more than 50% ofthe tumor cells ... (84.6%) DISCUSSION The diagnosis ofthe metastatic carcinoma of unknown origin can be very difficult The determination ofthe primary site ofthe metastasis is a challenge to both oncologists and ... site is a common clinical problem Determining the cytokeratin (CK) 7/CK20 pattern of tumors isoneofthe most helpful procedures for this purpose since the CK7−/CK20+ pattern is typical of colorectal...
... explicit form, in this orother way, not making use ofthe boundedness results, oneis able to conclude that the singular operator is bounded inthe Lebesgue space with weight generated by the coefficient ... the proof ofthe final part of previous theorem the number M in formula (4.12) can be replaced by ν(ϕ) = inf ϕ − ψ C , where thein num is taken over all rational functions ψ The problem of linear ... (11.1) the Noether p(·) theorems are valid and its index inthe space Lρ (Γ) is equal to κ = κ (Gµ ), where κ is interpreted in accordance with (8.3) Inthe case V = the solutions of (11.1) in the...
... By Theorem 2.1 the function v = uts still satisfies the boundary conditions Therefore from inductive hypothesis and by repeating arguments ofthe proof inthe case s = 0, we obtain (2.11) Since ... solution ofthe problem (2.19) - (2.21) inthe ◦ space H 1,0 (e−γt , Ω∞ ) We consider the following cases: Case n = Assume that in a neighborhood ofthe coordinate origin, ∂Ω coincides with a rectilinear ... the number of multi-indices which have order not exceeding m, μ0 isthe constant in (1.3) From Theorems 3.1, 3.2 in [5] and by using induction we obtain the following result Theorem 2.1 Let ∂apq...
... even ifthe information is obtained from an indirect measurement ofthe intrinsic physical characteristics Competing interests The authors declare that they have no competing interests References ... human cartilage ofthe elbow and knee during mosaicplasty for osteochondritis dissecans ofthe elbow: an in vivo study Am J Sports Med 2008, 36:2345-2353 Page of (page number not for citation purposes) ... Huang YP: More intrinsic parameters should be used in assessing degeneration of articular cartilage with quantitative ultrasound Arthritis Res Ther 2008, 10:125 Kuroki H, Nakagawa Y, Mori K, Kobayashi...
... humans We shall therefore focus the remaining of this commentary on the evidence for nicotine addiction in human smokers, beginning with self administration studies This is what the present report ... disturbing bias by the authors ofthe SG report Another example ofthe same bias isthe way in which a study by Perkins et al [20] is presented inthe SG report The authors ofthe report refer to it as ... effects of nicotine can fully account for theother finding noted in point (1), namely that smokers smoke more following administration of a nicotinic receptor antagonist As mecamylamine, the nicotine...
... never been performed in Norway The necessity of 39 chapters and the content ofthe chapters should be evaluated The large majority ofthe red responses were given a NACA score indicating non life-threatening ... reminders were needed during collection of medical records from different parts ofthe health care system and continued until October 2008 To secure a uniform recording ofthe variables inthe ... the AMIS program, a meeting between the persons in charge ofthe participating EMCCs was held Based on information from all AMIS forms and medical records we classified the situations according...
... The reactivated adsorbent was packed into the column again, and phosphorus was effectively adsorbed Figure Concentration of each type of phosphorus inthe influent and effluent ofthe phosphorus ... phosphorus was then accumulated inthe sludge inthe subsequent oxic tank by normal oxygen-utilizing PAOs The residual phosphorus was removed inthe final anoxic tank without oxygen Especially in ... effluent ofthe phosphorus adsorption column are shown in Fig During the operation, about 70% ofthe phosphorus inthe sludge was solubilized by ozonation, and a large part ofthe solubilized phosphorus...