... after initiation of APC Of the 34 remaining patients, nine had major bleeding episodes The clinical characteristics of these 34 patients are presented in Table Five out of 10 patients (50%) with ... major bleeding episodes, as opposed to four out of 24 patients without episodes (16.7%) (P = 0.04) The bleeding events experienced by the patientswith ALD included two gastrointestinal hemorrhages, ... ALD) Patientswith ALD are at increased risk both for severe sepsis and for bleeding These data suggest that they may be at greatly increased risk for bleeding while receiving APC Because such patients...
... count and, in the case of lymphopenia, CD4 lymphocyte count c C-reactive protein c Urine analysis inpatientswith a history of urinary tract infection, and urinary symptoms c VZV serology inpatients ... advances in clinical practice be a problem because purified protein derivative (PPD) screening is difficult to interpret inpatientswith previous BCG vaccination, and because of frequent anergy inpatients ... against tetanus, poliomyelitis and 552 diphtheria.54 Patientswith IBD should be vaccinated against influenza annually Vaccine for pneumococcal diseasewith the 23-valent strain should be administered...
... authors were involved in drafting and revising the final manuscript Key messages • Percutaneous dilational tracheostomy inpatientswithliverdisease or following liver transplant for acute liver failure ... investigations lies in the stringent a priori definition of refractory coagulopathy and the sole inclusion of patientswith liver- related disease processes Only patientswith a repeat INR of greater ... of patients receiving platelet transfusions (Table 6) patientswithliverdiseaseand following liver transplantation, despite a high incidence of refractory coagulopathy Only one patient in...
... assess the inter-laboratory variability of FibroTest and ActiTest, including their six serum liver components, inpatientswith chronic liver disease, and to identify factors associated with that ... accurate (quantitative and reproducible) picture of fibrogenic events occurring within the liver Furthermore, and because treatment is now so effective inpatientswith genotype or infection, the utility ... [2], and has a high risk of sampling error [3] Biochemical markers for liver fibrosis (FibroTest) and necroinflammatory features (ActiTest) are an alternative to liver biopsy, inpatients with...
... vascular events in this population (27) In a recent study C-reactive protein and low albumin has been shown to be the predictor of morbidity and mortality in CKD 3-5 patientsin Spain (31) Our study ... malnutrition and atherosclerosis inpatientswith kidney failure (38, 40) In some studies the relation between hypoalbuminemia and CVD is the reflection of inflammation induced malnutrition The underlying ... malnutrition, inflammation and oxidative stress inpatientswith CKD In order to reduce cardiovascular mortality, nutritional, anti-inflammatory and antioxidant intervention will need to be assessed in...
... were more prevalent in sera from patientswithadvanced ESCC than in sera from patientswith early stage disease (P < 0.001) and that in the patientswith clinical stage III-IV and N1 subgroup, ... presence of CDC25B-Abs and ESCC clinical stage (P = 0.002) The percentage of CDC25B-Abs seropositivity was higher inpatientswithadvanceddisease than inpatientswith early disease Dong et al ... humidified incubator containing 5% CO2 at 37°C The immortalized esophageal cell line NE-3 was obtained from Dr Jin (the University of Hong Kong, P R China)[26] and cultured in KeratinocyteSFM (Invitrogen,...
... The vaccine was administered within one hour of thawing and reconstituting in mL of sterile saline Patients were scheduled to receive six IDD-3 immunizations at two-week intervals during the ... fixed and permeabilized with the Intrastain kit, and stained for intracellular IFN-a with an anti-IFN-g-APC antibody Cells were resuspended and stored for up to days in PBS 1% Cytofix before being ... IL-4 were matured with TNF-a, IL-1b, IL-6 and prostaglandin E2 (PgE2), pulsed with a mixture of 20 MHC class I and II-binding peptides and administered subcutaneously Disappointingly, the DC arm...
... (within one week before the beginning of the intervention), immediately post training (within one week after the last training session) and four weeks after the completion of the training (follow-up ... posture and balance with increasing difficulty and complexity These included: (1) static posture control-achieving better upright position while sitting andin standing (improving upper limb and ... sit-to-stand and stand-to-sit transfers Patients were instructed to stand up and sit down five times as fast as possible Page of starting in the sitting position and stopping after sitting down...
... knees and arms hanging Timing commence after achieving the position, with or without outside assistance After conducting two trials, another two trials are conducted with eyes closed Timing is interrupted ... with clinical performance tests, subjective ratings of fear of falling and posturography Materials and methods Patients Ten patients (median age 66, range 59–69 years) with PD were included in ... exclusion criteria: concomitant diseases interfering with balance testing, an inability to cooperate or an inability to stand for two minutes without support One patient declined participation Page of...
... province of China Mandarin is spoken Due to the pictorial nature of Chinese writing, both Cantonese and Mandarin-speaking Chinese would be able to read the Chinese version of the HADS In Europe, ... screening and case detection utility and accuracy [16] The present study was designed to examine the underlying factor structure of the Chinese version of the HADS in a mainland Mandarin-speaking ... were males In terms of the clinical data, over two thirds of subjects were angina The finding of high proportions of Chinese CHD patients screening positive with anxiety and depression using the...
... differences in median values, scoring range and sensitivity to change after intervention and the low agreement show that the EQ-5D and SF6D yield incomparable scores Even within a group of patientswith ... domain, imputing that value for missing items in that domain, rounding imputed values to the nearest integer, and then recalculating the SF-6D We performed parametric and non-parametric testing ... SF6D and the EQ-5D cross-sectionally, in domain content, in scoring distribution, andin the amount of change measured after intervention We addressed these questions by comparing the SF-6D and...
... cardiovascular disease requiring therapy with acetylosalicylic acid, both withand without gastrointestinal symptoms, two weeks after Coronary Care Unit discharge In their study, in contrast to our investigation, ... consecutive outpatients with CAD-11 female (23%) and 37 male (77%)-diagnosed with recurrent stable angina-like chest pain refractory to standard anti-angina therapy and without indications for ... Vascular Diseases and Internal Medicine, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum, Bydgoszcz, Poland 2Clinical Ward of Vascular Diseases and Internal Medicine, Dr...
... clinical measures in combination in a single model to predict the EQ-5D index In this case, disease severity was taken into account using a single variable, and more implicitly from the point of view ... described in Tables and There were 1106 records in the estimation data with non-missing covariates in the final model The variables in the base model - age, sex anddisease stage proxy - only explained ... measure of HRQoL If interest centres on mapping the EQ-5D index in another disease area, disease specific measures for the diseasein question may also be important The mapping exercise was initially...
... gastrointestinal diseases and conditions, and presence or history of other non-gastrointestinal serious diseases and conditions Patients treated with proton pump inhibitors or prokinetic drugs during ... translation of the gastrointestinal symptom-rating scale and quality of life in reflux and dyspepsia questionnaire inpatientswith gastro-oesophageal reflux disease Clin Drug Invest 2004, 24:205-215 ... Spanish of the gastrointestinal symptoms rating scale (GSRS) and quality of life in reflux and dyspepsia (QOLRAD) inpatientswith gastroesophageal reflux disease] Revista Clinica Espanola 2005,...
... Undetermined Yes (marginal increase in creatinine) Not available Undetermined Renal failure Creatine kinase (U/liter) Peak Normal range Creatine kinase >10¬ULN Creatinine elevation (or urinary ... end points in a blinded fashion An independent data and safety monitoring board with its independent statistical-support group from the University of Wisconsin performed interim monitoring and ... cardiovascular events and death with pravastatin inpatientswith coronary heart diseaseand a broad range of initial cholesterol levels N Engl J Med 1998; 339:1349-57 12 Scandinavian Simvastatin Survival...
... Examination (MMSE) [9] scores were 17/32 and 20/30, respectively Treatment with fluvoxamine (25 mg) was initiated after dinner, and next day increased to 50 mg At days after beginning treatment with ... the incidence of delirium associated with the combination of sertraline (or paroxetine) and benztropine are currently unclear Recent findings suggest that sigma-1 receptors might be involved in ... DRS and MMSE scores were 17/32 and 21/30, respectively Treatment with fluvoxamine (50 mg, twice a day) was initiated, and the next day increased to 100 mg since there were no gastrointestinal...
... Piccart M: A phase I and pharmacokinetic study of docetaxel administered in combination with continuous intravenous infusion of 5-fluorouracil inpatientswithadvanced solid tumors Clin Cancer Res ... synthase and dihidropyrimidine dehydrogenase were decreased and that of orotate phosphorybosyl transferase was increased when docetaxel was administered in combination with S-1 In addition, in recent ... advanced or recurrent gastric cancer In this study, combination therapy with docetaxel and S-1 showed good clinical activity with acceptable toxicity inpatientswithadvanced or recurrent gastric cancer...
... current standard using cisplatin This finding is in line with what was found in a larger study by the GOG which also compared concurrent single agent CTRT consisting of either weekly cisplatin or ... CTRT inadvanced carcinoma of the cervix using various chemotherapy regimens such as 5-Fu, epirubicin, 5-Fu with mitomycin C, hydroxyurea, gemcitabine, carboplatin, tirapazamine, topotecan, or vinorelbine ... combination cisplatin-topotecan and GOG trial 0219 is testing the added value of tirapazamine to cisplatin for CTRT in carcinoma of the cervix The rate of gastrointestinal (GI) toxicity in our...
... tumor control inpatientswithadvanced head and neck carcinomas and thereby survival So stage IV patients might be diagnosed with DM and this might become a relevant problem in achieving long-term ... at our institution as well as patterns of failure and help finding ways to improve prognosis, morbidity and mortality inpatientswithadvanced HNSCC The treatment regime used in our patients ... 14 months inpatientswith multiple locations, 13 months with metastases to the skeletal system, 21 months withliver metastases, months with brain metastases and 15 months with skin metastases...
... al Taking all of these considerations into account, we support the use of surrogate markers to determine the cardiovascular risk of patientswith inflammatory rheumatic diseases Competing interests ... Martin J, Gonzalez-Gay MA: Carotid intima-media thickness predicts the development of cardiovascular events inpatientswith rheumatoid arthritis Semin Arthritis Rheum 2008 [Epub ahead of print] ... declare that they have no competing interests References Veldhuijzen van Zanten JJCS, Kitas GD: Inflammation, carotid intima-media thickness and atherosclerosis in rheumatoid arthritis Arthritis...