hodgkin apos s lymphoma biology new prognostic factors and outcome prediction using gene expression signatures
Báo cáo khoa học: "Marjolin''''s ulcers: theories, prognostic factors and their peculiarities in spina bifida patients" ppsx
... understanding of the process of pressure ulcer development amongst spina bifida patients, and their subsequent degeneration into malignant ulcers is limited The purpose of this study was to collect ... ‘Marjolin s ulcers’, ‘malignant pressure ulcers’, ‘prognosis’, prognostic features’, in various combinations Results The two patients, both females, were aged 20 and 26 years While one of the patients ... best explains this process It is to be noted that some of these theories may overlap Marjolin s ulcers complicating pressure ulcers in spina bifida patients are rarely reported: there are less...
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báo cáo khoa học: "Synchronous perforation of non-Hodgkin’s lymphoma of the small intestine and colon: a case report" ppsx
... was made Other symptoms include bleeding, obstruction, perforation, and intussusceptions No sex predominance exists Some patients remain asymptomatic until intestinal perforation At diagnosis ... Revised European and American Lymphoma (REAL) classification in 1994 generated new interest in T cell lymphomas According to this classification, peripheral T cell lymphomas (PTCLs) are a subset ... outcome Pre-operative shock is also a significant poor prognostic factor for such patients Conclusions Surgeons should always be alert for the possibility of multiple sites of malignancy during...
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Báo cáo y học: "Intentional overdose with insulin: prognostic factors and toxicokinetic/toxicodynamic profiles" pot
... lack of insulin antibodies, insulin resistance and endogenous insulin secretion, in response to glucose infusion [1,7,33] Thus, because fixed and excessive glucose load may induce significant ... patient when conscious or from the next of kin when not Plasma insulin and C-peptide concentrations were determined using the same samples as those used for glucose measurements Plasma insulin concentration ... Pharsight, Mountain View, CA, USA) Statistical analysis Results are expressed as median (25th to 75th percentiles) or percentage when appropriate Fisher 's exact tests and nonparametric tests were...
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Báo cáo khoa học: " Intensive care unit-acquired Stenotrophomonas maltophilia: incidence, risk factors, and outcome." docx
... ventilation, and duration of ICU stay Statistical methods SPSS software (SPSS Inc., Chicago, IL, USA) was used for data analysis Proportions were compared using the χ2 test or the Fisher exact test whereas ... multi-resistant S maltophilia, has evaluated risk factors for mortality [40] McCabe score and organ dysfunction were associated with increased risk for mortality in these patients These results suggest ... pulmonary disease; ICU, intensive care unit; SAPS, Simplified Acute Physiology Score Discussion Our results suggest that S maltophilia colonisation and/ or infection is not common in this population...
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Báo cáo khoa học: " Chemotherapy followed by low dose radiotherapy in childhood Hodgkin''''s disease: retrospective analysis of results and prognostic factors" ppt
... overall survival The prognostic factors associated with improved EFS were female gender, clinical stage, absent B symptoms and age less than ten years These factors revealed that more efforts are still ... the OS at five years (Fig 3) For patients with no adverse prognostic factors (n = 52) the OS was 96%, for patients with one adverse prognostic factors (n = 98) the OS was 84.6% and for patients ... areas of initial bulk disease was possible to be used in 15% of the cases (stage III and IV) and in other cases mantle and extend fields were used mainly in stage III and IV (85%) Protocols with...
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Hodgkin''''s Lymphoma Edited by Nima Rezaei potx
... Advances in Classical Hodgkin s Lymphoma Biology: New Prognostic Factors and Outcome Prediction Using Gene Expression Signatures Advances in Classical Hodgkin Lymphoma Biology: New Prognostic Factors ... Prediction Using Gene Expression Signatures 27 Chapter Advances in Classical Hodgkin Lymphoma Biology: New Prognostic Factors and Outcome Prediction Using Gene Expression Signatures 29 Beatriz S nchez-Espiridión, ... alternative survival signals (Figure 1) Advances in Classical Hodgkin Lymphoma Biology: New Prognostic Factors and Outcome Prediction Using Gene Expression Signatures 31 Fig Chemical crosstalk between...
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HODGKIN''''S LYMPHOMA potx
... Advances in Classical Hodgkin s Lymphoma Biology: New Prognostic Factors and Outcome Prediction Using Gene Expression Signatures Advances in Classical Hodgkin Lymphoma Biology: New Prognostic Factors ... Prediction Using Gene Expression Signatures 27 Chapter Advances in Classical Hodgkin Lymphoma Biology: New Prognostic Factors and Outcome Prediction Using Gene Expression Signatures 29 Beatriz S nchez-Espiridión, ... alternative survival signals (Figure 1) Advances in Classical Hodgkin Lymphoma Biology: New Prognostic Factors and Outcome Prediction Using Gene Expression Signatures 31 Fig Chemical crosstalk between...
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Hodgkin''''s lymphoma potx
... khoảng s ng quanh nhân, lưới nhân thô Yếu tố nguy cơ: - Tỷ lệ mắc bệnh nam giới gấp đôi nữ giới - Một s virus: EBV (Epstein-Barr virus), HIV làm tăng nguy phát triển u lympho Hodgkin - Suy yếu ... Một s xét nghiệm cần tiến hành như: - Sinh thiết hạch cho chẩn đoán xác định bệnh - Xét nghiệm máu - X-quang lồng ngực, cần chụp CT MRI - Sinh thiết tuỷ xương - Có thể đề nghị nội soi để quan s t ... theo triệu chứng toàn thân sau: - S t kéo dài, thường s t hồi quy kèm hạch to tiến triển - S t cân nhanh không rõ nguyên nhân - Mồ hôi trộm - Ngứa ngáy, dùng thuốc kháng histamin không giảm *Bệnh...
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Báo cáo y học: "Hodgkin''''s lymphoma presenting with markedly elevated IgE: a case report" potx
... history of allergic rhinitis (seasonal or perennial), asthma, sinusitis, otitis or other allergic disease Her physical examination was entirely normal Skin tests were positive to trees, grass and ... node biopsy was consistent with Hodgkin' s lymphoma, nodular sclerosing subtype, grade I/II She was reassessed by Hematology and treatment with ABVD (adriamycin, bleomycin, vinblastine and dacarbazine) ... associated with high serum IgE levels and pruriginous skin lesions:successful therapy with IFN-α 2b after failure on IFN-γ Dermatology 1996, 192:110-115 Samoszuk M: Reed-Sternberg cells of Hodgkin' s...
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Báo cáo khoa học: "Primary multifocal osseous Hodgkin''''s lymphoma" ppt
... simultaneously in osseous and non-osseous sites; or recurrence of disease at osseous sites We consider that in order to make a diagnosis of POHL there should not be any signs or symptoms of systemic disease ... after presentation showing loss of height of L1 with surrounding soft tissue mass and impingement on the conus vey Guidelines) for Hodgkin' s disease, and antituberculous treatment was stopped Staging ... multiple sites, in all ages, in the scientific literature since 1927 Table details these 32 cases as well as this current case It does not include patients who presented with disease at non osseous and...
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Báo cáo khoa học: " Radiotherapy of large target volumes in Hodgkin''''s lymphoma: normal tissue sparing capability of forward IMRT versus conventional techniques" docx
... Patient and disease characteristics Patient Age Gender Stage Disease sites 19 M II-B Mediastinum*, bilat LCV and axill nodes 2285.2 19 M IV-AS Mediastinum, bilat LCV, SCV, and axill nodes 2449.6 ... planning based on the 3D dose distribution as well as on dose-volume histograms (DVHs) DVHs were also used to evaluate the quality of the plan through dose volume constraints and target dose homogeneity ... increase in MUs was 15.6%, that is, considering a dose rate of 200 MU/min, just less than 10 seconds of machine treatment increment Discussion Radiation treatment of Hodgkin' s lymphoma is an efficient...
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Báo cáo khoa học: " Clinical outcome of breast cancer occurring after treatment for Hodgkin''''s lymphoma: case-control analysis" pdf
... this population is worse, better or the same as that of primary BC This report serves to address issues of diagnosis, management and outcome of BC that occurs after HL Patients and methods With ... overall survival Exact Fisher 's test was used to assess differences between the study group and the comparison group in the distribution of prognostic variables and treatment approaches Survival ... Abbreviations: DCIS, ductal carcinoma in situ * Patient was not treated for her first breast cancer at Massachusetts General Hospital - Synchronous disease: second breast cancer diagnosed within six...
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Báo cáo khoa học: "Radiation-induced cancer after radiotherapy for non-Hodgkin''''s lymphoma of the head and neck: a retrospective study" ppsx
... diseases such as tuberculous lymphadenitis, skin diseases, thyroid diseases and spondylitis, however, at present, RT is mainly used to treat malignancies The limitation of the prior disease treated ... and proposed that the poorer prognosis of radiation-induced osteosarcoma was related to the higher expression of adverse prognostic markers, such as p53, TP53 mutations, ezrin expression, and the ... distribution These results were statistically analyzed by the SPSS for Windows (SPSS Inc Chicago, Illinois) http://www.ro-journal.com/content/4/1/21 Results The patient characteristics are listed...
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Báo cáo khoa học: " A comparison of mantle versus involved-field radiotherapy for Hodgkin''''s lymphoma: reduction in normal tissue dose and second cancer risk" docx
... limitations, and is based on four assumptions [see Additional file 1] These assumptions include those regarding estimating risks for mradiat, the number of pre-malignant stem cells, dose per fractionation ... protocols, were assessed using the Wilcoxon signed rank test To quantify the reduction in the volume of breast and lung tissue exposed to lowdose radiation, we utilized dose-volume thresholds that ... cells carry and pass on pre-malignant damage produced earlier in the treatment This extended model thus predicts substantial second-cancer risks even at doses as high as the prescribed tumor dose,...
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báo cáo khoa học: "Lenalidomide induced good clinical response in a patient with multiple relapsed and refractory Hodgkin''''s lymphoma" pptx
... lenalidomide dose selected for this patient was based on the standard dose used in multiple myeloma, nonHodgkin 's lymphoma, and classic Hodgkin' s lymphoma (25 mg daily for 21 days of every 28-day ... her university studies, and was able to go on vacation She remains on continuous lenalidomide and her disease progression is expected to remain limited in the immediate future Conclusions The lenalidomide ... toxicity The patient 's physical condition improved and she was able to resume normal daily activities, such as her university studies A PET scan performed months after continuous lenalidomide (Figure...
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báo cáo khoa học: " Diffuse large B-cell non Hodgkin’s lymphoma in a 65-year-old woman presenting with hypopituitarism and recovering after chemotherapy: a case report" pptx
... pituitary based on clinical findings, histology from liver and lymph nodes and PET scan results Pituitary lymphomas are described as firm, vascular and adherent to surrounding structures and needing ... highly suggestive Prognosis in previous reported series ranges between nine weeks after presentation to greater than 20 years [5] Prognostic factors include age, comorbidity and histology at presentation ... pituitary dysfunction was present in six of a series of 13 patients previously reported [8] Typically, MRI reveals a pituitary mass which on T 1and T2-weighted images is either iso- or hypodense and enhances...
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báo cáo khoa học: "An osseous lesion in a 10-year-old boy with Hodgkin’s lymphoma: a case report" ppsx
... involvement and from osseous metastases in advanced stage of disease Due to the nature of HL, most cases are associated with synchronous lymph node involvement Bone scintigraphy has a sensitivity and ... aggressive disease with a relative poor prognosis, associated with unfavorable histological subtypes Primary osseous HL is very rare and must be distinguished from systemic HL with diffuse bone and bone ... in cases of hereditary multiple exostoses syndrome (HMES) with an autosomal dominant inheritance Most children are asymptomatic OC usually presents as a solitary mass, as a fracture or as a mechanical...
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Báo cáo y học: " Large cell non-Hodgkin’s lymphoma masquerading as renal carcinoma with inferior vena cava thrombosis: a case report" docx
... lymphoma, is generally characterized by proliferation of lymphoma cells in smaller blood vessels In rare patients, intravascular large B-cell lymphoma can present as masses in large blood vessels ... (PET) scan uptake in renal mass and abdominal metastasis Axial PET image (A) Intense fluorodeoxyglucose activity is seen in right renal mass (white arrows) Contralateral abdominal disease is also ... all cases of superior vena cava syndrome are caused by Page of Figure Anterior abdominal subcutaneous tumor Subcutaneous abdominal mass (source of diagnostic biopsy) (A) Subcutaneous mass at initial...
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báo cáo khoa học: " Hypercalcemia and huge splenomegaly presenting in an elderly patient with B-cell non-Hodgkin’s lymphoma: a case report" potx
... most cases due to suppression of the parathyroid glands and renal a-hydroxylase secondary to hypercalcemia It is also evident that hypercalcemia is a manifestation of advanced disease and, as ... Table shows the clinical and laboratory data of 10 such patients, including ours As shown in Table 2, the hypercalcemia was severe and life-threatening and immediate therapeutic modalities such as ... mechanisms Majumdar in his study on 112 patients with B-cell NHL showed that eight patients (7.1%), six with high grade and two with low grade disease had elevated serum calcium levels [8] Most patients...
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Báo cáo khoa hoc:" Tissue is the issue-sarcoidosis following ABVD chemotherapy for Hodgkin''''s lymphoma: a case report" potx
... lymphoma Discussion and conclusion Sarcoidosis is a multisystem disorder of unknown etiology characterized by non-caseating granulomas [1] The diagnosis is established by clinical presentation and confirmed ... definitive tissue confirmation of relapsed Hodgkin' s is essential Clinical presentation, physical exam, lab investigations and, as this case illustrates, even PET/CT scans may not be able to discriminate ... times higher than expected in patients with sarcoidosis [2] Hodgkin' s lymphoma following a diagnosis of sarcoidosis is well reported in the literature[3] and concomitant lymphoma and sarcoidosis...
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