historical overview discoveries leading to the recognition of immune glial involvement in chronic pain
Báo cáo khoa học: " Science review: Mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids" pdf
... artery and the aorta form rich plexuses in the cortex and supply the gland The plexuses are continuous with the sinuses of the medulla, which drain into the central vein of the medulla The right ... adrenal vein drains into the inferior vena cava and the left into the renal vein Hence, the rich blood supply required by the organ and the limited venous drainage (a single vein) predispose to extensive ... access to tissues CBG is a member of the serine protease inhibitor (serpin) superfamily It has retained the stressed native structure typical of the inhibitor members of the family, and the transition...
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MECHANISMS OF HEXOSAMINE-INDUCED CHOLESTEROL ACCUMULATION AND THERAPEUTIC ACTIONS OF CHROMIUM
... gluconeogenesis in insulin-resistant states may also be due to a loss of insulin action in the CNS Regardless of the exact role of insulin action in the CNS, insulin resistance in the brain is known to contribute ... recruitment of GLUT4 to the PM in fat and muscle cells are complex and still imperfectly understood Upon binding of insulin to the PM localized insulin receptor, the intrinsic tyrosine kinase activity of ... impairment in the ability of the β cells of the pancreas to produce and secrete insulin, leading to the diagnosis of frank T2D As insulin resistance represents an early abnormality in the progression of...
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Mixture toxicity of POPs dioxins, PCBs, PBDEs considerations from mechanisms of actions and for risk assessment
... F Canton (2010) A Global Foodborne Burden of Disease? WHO-‐FERG In prep Es*ma*on of number of W-‐Europe children exceeding the TDI significantly (< 10x) in period ... almost exclusively derived from short Gme perinatal studies within a ‘sensi*ve window’ of life Weight of evidence points towards humans been less sensiGve (2-‐10 *mes?) ... not in present REP/TEF studies evaluated Mixtures of PCDDs, PCDFs and DL-‐PCBs s*ll a health risk? One order of magnitude decline in background human exposure since...
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Báo cáo y học: "Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells"
... precisely [10,11] The aim of this study was to characterize global changes in the proteins related to apoptosis during hypoxia to clarify the mechanism of hypoxia-induced apoptosis, and to find out useful ... many proteins involved in apoptosis, including the expression profiles of proteins involved in the mitochondrial (bcl-2, bax, and bcl-x, etc.) and stress reaction-related pathways of apoptosis (Fig ... 43 the balance of the expression of such positive and negative regulators of apoptosis would determine apoptotic propensity In this study, we focused on the role of Bag-1 in the regulation of...
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Study on the Photolytic Mechanisms of Red 141 Dye Wastewaters with an 185nm Vacuum-UV lamp
... being used in the treatment of ultrapure water in the semiconductor industry However, intensive basic research is still necessary to completely understand the fundamental principles of the photochemical ... special requirements of the VUV photolysis of water according to Eq (1) are related to the formation of high local concentration of hydroxyl radicals (OH.) and a series of other species (Gonzalez ... al., 1998) In practical application, a considerable disadvantage of the majority of the degradation processes introduced above is the need to add external agents into the aqueous medium In such...
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ISOTOPE HYDROGRAPH SEPARATION FOR MODELING OF RUNOFF MECHANISMS OF ATMOSPHERICALLY DERIVED CHEMICAL AND RADIOACTIVE POLLUTANTS
... value during the main part of the runoff of interest, for which f1 (t) was evaluated (0000 of Oct 22 to 1600 of Oct 23, 40 hrs in total) First, the total cumulative load (ML total) in gram was ... comparing their content with that of aluminum Aluminum was chosen as a reference because of its naturally high content in soil In principle, the ratio of their content of the depositions to that of ... as mentioned above, the fraction of new water evaluated for the main part of the runoff (0000 of Oct 22 to 1600 of Oct 23, 40 h in total) was found to be as shown in Fig 2c The fraction reached...
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Mechanisms of Unstable Nitrite Inhibition of Aerobic Phosphate Uptake
... During initial 120 minutes of anoxic phase, nitrate was introduced into the reactor to theoretically result in 46 mgN/l in the reactor Other experimental conditions were the same for all the reactors ... 39% On the other hands, in the case of AA with 1.9 mgN/gVSS of initial nitrite concentration, the size of inhibition was the smallest among them The phosphate uptake rate in the presence of nitrite ... amount of nitrite that theoretically resulted in mgN/l in the reactor at initial minute of aerobic phase, while AO SBR did not Allylthiourea (ATU) was periodically added to both of the reactor to...
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Transmission mechanisms of monetary policy the evidence
... growth is the driving force behind the business cycle • A Monetary History documents several instances in which the change in the money supply is an exogenous event and the change in the business ... Examines whether one variable affects another by using data to build a model that explains the channels through which the variable affects the other • Transmission mechanism – The change in the ... out be more accurate than the other Historical Evidence • If the decline in the growth rate of the money supply is soon followed by a decline in output in these episodes, much stronger evidence...
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Tài liệu Women''''s attitudes towards mechanisms of action of family planning methods: survey in primary health centres in Pamplona, Spain doc
... sample, indicating the difficulties in communicating the information about the mechanism of action To assess the influence of inconsistent responses, we repeated all analyses excluding women with inconsistent ... among the study sites, but the data from the pilot project were not The following is an outline of the questionnaire: the first page was an informed consent form to participate in the study The ... Implantation Other * Total Not important Important Unsure Total Yes No Unsure Total Yes No Unsure Total Stop using Continue using Unsure Total Stop using Continue using Unsure Total 266 (46.3) 103...
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Tài liệu Báo cáo khoa học: Mechanisms of amyloid fibril formation – focus on domain-swapping doc
... chains of partially open monomers exchange the whole parts of their chains from the hinge loop to the termini, and fold back to two monomeric domains The extended surface of the ‘hinge loop’ is the ... taking into consideration the known data, including intrinsic and external factors [83–85] The universe of proteins capable of forming amyloid-like fibrils has been named the ‘amylome’ [86] The ... b-sheets The capacity of unlimited interchain hydrogen bonding in the absence of structural restraints is considered to drive the assembly of susceptible proteins into amyloid fibrils [19] The structure...
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Tài liệu Báo cáo khoa học: Survival mechanisms of pathogenic Mycobacterium tuberculosis H37Rv ppt
... family of protein tyrosine kinases These kinases result in the increased tyrosine phosphorylation of multiple macrophage proteins and the activation of phospholipase D [82] Activation of protein ... bacteria into surrogate hosts such as Escherichia coli, followed by the analysis of survival of recombinant E coli in macrophage cell lines To identify the genes involved in the invasion of macrophages ... tuberculosis, aiming to identify the presence of genes encoding the GTP-binding proteins The genome sequence of M tuberculosis demonstrated that, in addition to homologs of Obg and Era, the additional...
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Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx
... and increases blood flow to the corpus cavernosum The increased blood flow stimulates the endothelium lining the lacunar spaces of the corpus cavernosum to release endothelial NO from the endothelium ... deprivation therapy is associated with increased levels of proinflammatory factors and decreased antiinflammatory cytokines [125,126] Interestingly, testosterone therapy prevents a gain in visceral ... measurements to assess obesity and this, in addition to the age of the cohort being studied, has in uenced the strength of the correlation between ED and obesity The International Index of Erectile...
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Tài liệu Báo cáo khoa học: Reaction mechanisms of thiamin diphosphate enzymes: redox reactions pdf
... cluster (suspected to be located in close proximity to the ThDP cofactor), followed by sequential reduction of the other two clusters leading towards the surface of the protein, where FEBS Journal ... recruited to the biological membrane only after reduction of the flavin cofactor At the membrane, electrons are transferred to final acceptor Q8, a mobile electron carrier of the respiratory chain Binding ... [20] Thus, the high reducing power of the enamine intermediate is by far sufficient to initiate downhill transfer of the reducing equivalents to the final electron acceptors ferredoxin (E°¢ [Fe++...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... iron-peroxo intermediate [11] The sum of these ndings points at the involvement of more than one active oxidant in the diverse types of P450-catalyzed substrate processing [1215] The goal of the present ... In line with this, alkaline hemin (ferriprotoporphyrin IX) has been shown to activate O2 to the hydroperoxide anion in the presence of NAD(P)H [150] with the immediate insertion of oxygen into ... oxygen into the benzene ring of aniline to yield p-aminophenol [151] Formation of the oxygenating species has been recognized to be facilitated by the binding to HbO2 of aniline and some of its derivatives,...
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Motivating Better Hygiene Behaviour: Importance for Public Health Mechanisms of Change doc
... for drawing, a communal cup was kept on top of the pot to dip into the water and drink from Having discussed the risks of touching the water with soiled hands, the women decided to replace the communal ... Women in a resettlement area in Kenya decided to improve their water storage habits when they were convinced of the benefits of keeping drinking water clean They already kept drinking water in a ... poor The facilitator first discovers themes that are meaningful to the group and helps the group to analyze their situation This helps the group to gain critical insights into the structures ofpower...
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Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt
... deal of interest has been devoted to dissecting the role of the endocannabinoid system in physiology as well as in pathological processes The system incorporates the endocannabinoids, their synthetic ... or toxic responses in ischemia, depending on a number of factors Among these, two of the most important appear to be (a) the dose of the administered CB drug and (b) the specific endocannabinoid ... following toxic administration of kainic acid [74,95], suggesting that brain-derived neurotrophic factor may be another important mediator of the neuroprotective effects of CBs CB receptor-independent...
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Báo cáo khoa học: Molecular mechanisms of the phospho-dependent prolyl cis ⁄ trans isomerase Pin1 docx
... catalytic domain could induce structural changes in the N-terminal proline-rich domain of IRF-4 In the same field of immunology, Pin1 also regulates the production of such proinflammatory cytokines as ... of the parallel between Pin1 and CKS in protein degradation Top: Model of the SCFCDC4 E3 ligase and the role of Pin1 Pin1 is brought in with the cyclin E substrate, through interaction with the ... colony-stimulating factor [80], interleukin-2 and interferon-c [81] The ARE-containing cytokine mRNAs interact with AUF1 factors, and this interaction targets them for degradation Pin1 interferes...
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Báo cáo khoa học: Two L-amino acid oxidase isoenzymes from Russell’s viper (Daboia russelli russelli) venom with different mechanisms of inhibition by substrate analogs pdf
... competitive inhibition is obtained if binding of one inhibitor molecule at the active site facilitates binding of the second inhibitor molecule, so that two molecules of inhibitor contribute to the exclusion ... leads instead to anchoring at other sites in L1 In both enzymes, the carboxylate group of the inhibitors improved the afnity for the respective sites To determine the importance of the amino group ... two binding sites for OAB in L2 Taken together, these data indicate that the number of inhibitor-binding sites in L2 is two, whereas it is three in L1 Inhibitor cross-competition kinetics The...
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Báo cáo khoa học: Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail A comparative study of acylation systems of phospholipids in rat and the fish species Seriola quinqueradiata pot
... enrichment of arachidonate in PtdIns in mammals Further experiments are needed to clarify the involvement of the PtdIns cycle in the accumulation of arachidonic acid in PtdIns of fish Fig Effects of docosahexaenoic ... PtdIns observed in the fatty acid analysis of tissues of yellowtail Furthermore, they indicate that the one-sided incorporation of arachidonic acid into lysoPtdIns can be accomplished in the ... itself, whether into PtdCho or PtdIns However, in the presence of a large amount of docosahexaenoic acid, docosahexaenoic acid effectively inhibits the incorporation of arachidonic acid into PtdCho...
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Báo cáo khoa học: Kinetic mechanisms of glycine oxidase fromBacillus subtilis docx
... spectrophotometrically The binding of iminoglyoxylate to the oxidized form of glycine oxidase was investigated by static titration using increasing amounts of glyoxylate in the presence of 400 mM ammonia (to shift ... evolution and the mode of functioning of this class of enzymes The main goal of this project was to elucidate the structure-function relationships in glycine oxidase, with the aim of clarifying the modulation ... determined using sarcosine as substrate are quite close to those obtained using glycine (Table 1) D-Proline The reaction of glycine oxidase with the D-isomer of the cyclic amino acid proline was...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25