functional role and therapeutic application
Báo cáo khoa học: A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer pot
... emerging role of miRNAs in neoplasia highlights their potential value as mechanism-based therapeutic targets and biomarkers for diagnosis, prognosis of disease-specific outcomes and prediction of therapeutic ... in overview, a summary of the potential application of miRNAs as diagnostic and therapeutic targets in cancer TranslaƟonal repression Fig miRNA generation and gene regulation [9] Mature miRNAs ... growth of breast cancer cells in vitro and in xenografts in mice [48] miRNAs as biomarkers in cancer Their fundamental role in development and differentiation, and their pervasive corruption in lineagedependent...
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Báo cáo hóa học: "Future research and therapeutic applications of human stem cells: general, regulatory, and bioethical aspects" ppt
... (Iceland, Lithuania, Denmark, Slovenia, Germany, Ireland, Austria, Italy, Norway, and Poland); ii) Countries with a liberal political model (Sweden, Belgium, United Kingdom, and Spain); and iii) ... biodegradable and assimilable without causing an inflammatory response, and should have certain structural and mechanical properties Their primary role is to facilitate location and distribution ... technical staff and maintenance of overall technical and staff support, specialized facilities, the need for producing small and highly unstable batches and, of course, design and development...
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báo cáo khoa học: "Phenotype and functional evaluation of ex vivo generated antigen-specific immune effector cells with potential for therapeutic applications" pps
... http://www.jhoonline.org/content/2/1/34 Functional( see previous DC-activated and ex vivo expanded immune effector cells Figure analyses of page) Functional analyses of DC-activated and ex vivo expanded immune effector ... LMP2A-specific expression of IFN-γ, IL-2 and CD107a in the CD8 T cells, and to a lesser extent, the CD4 T cells (Fig 8A top: IL-2 and IFN-γ, and bottom: CD107a and IFN-γ) The antigen-specific effector ... Baker E, Sutherland GR, Din WS: Molecular and biological characterization of human 4-1BB and its ligand Eur J Immunol 1994, 24:2219-2227 Wen T, Bukczynski J, Watts TH: 4-1BB ligand-mediated costimulation...
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Báo cáo "The role of color luminescence centers Mn, Cu, Co in the semicondutors with wide band gap ZnS, ZnO and their applications " pptx
... bands are equal to each other and they merge into one wide band ranging from 476 nm to 533 nm The blue and green bands are characterized by radiation transition of electrons from conduction band ... appear luminescence bands at around 533 nm, 582 nm and 693 nm, respectively These luminescence bands are characterized by Cu2+, Mn2+, Co2+ ions [7-11] In this paper, we study the role of color luminescence ... luminescence centers Cu, Mn, Co in the semiconductors with wide band gap of ZnS, ZnO and test application of ZnS:Cu material Samples and experimental devices Bulk samples of ZnS, ZnS:Cu (xCu = 0÷5.10-4...
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Báo cáo khoa học: Functional role of fumarate site Glu59 involved in allosteric regulation and subunit–subunit interaction of human mitochondrial NAD(P)+-dependent malic enzyme pptx
... that Arg67 and Arg91 are the ligands for fumarate binding The side chains of Arg91 and Arg67 form salt bridges with the carboxylate group of fumarate (Fig 1B) Site-directed mutagenesis and kinetic ... In the present study, the functional roles of Glu59 in the regulatory mechanism of the enzyme are elucidated Glu59 is substituted by Asp, Gln and Leu Detailed kinetic and analytical ultracentrifugation ... distribution of the wild-type and E59 mutants The sedimentation coefcients of 6.5 S and 9.0 S represented the dimer and tetramer, respectively, corresponding to molecular masses of 124 and 248 kDa The quaternary...
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![enterprise network testing [electronic resource] the role and applications of testing in pre-peployment, migration, and post-deployment, network operations](https://media.store123doc.com/images/document/14/y/oy/small_bedjLstRkh.jpg)
enterprise network testing [electronic resource] the role and applications of testing in pre-peployment, migration, and post-deployment, network operations
... particular Ixia Networks and Spirent Communications, for their outstanding products and technical support; and Thomas Maufer, for an excellent contribution on application simulation, and the Mu Dynamics ... Scalability and Convergence Test Plan Chapter 17 WAN and Application Optimization: Performance Routing and Wide Area Application Services Test Plan 433 Chapter 18 Using the Lab for Hands-on Technology ... infrastructures to handle them On the contrary, companies are demanding that their existing converged networks be capable of handling the demands of TelePresence and other next-generation applications...
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Báo cáo sinh học: " Research Article Estimation of Time-Varying Coherence and Its Application in Understanding Brain Functional Connectivity" potx
... a time series x(t), let μt and σt denote the mean value and standard deviation of the series at time t, respectively The autocorrelation between two time points t1 and t2 is mathematically defined ... process and established an evolutionary spectrum theory Hedges and Suter [15, 16] considered numerical means of measuring local stationarity in a time- and frequency-domain, while Galleani, Cohen, and ... Application in Studying the Brain Functional Connectivity We now apply the time-varying coherence based on the Stockwell transform to study functional connectivity between the contralateral and...
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Báo cáo toán học: "EMILION, a tree functional-structural model: Presentation and first application to the analysis of branch carbon balance" pdf
... I + diff – and upward diffuse PAR Idiff Except for Idir, I + and diff – Idiff , these properties are set equal to the parameter values at the stand level Light distribution in the stand The PAR ... parameters Vcmax, Jmax, α, and Rd as a function of needle age Age (year) and needle temperature T (°C) Adapted from Porté and Loustau [18] Photosynthetic parameters and units Vcmax Jmax α Rd (µmol.m–2.s–1) ... b and c are positive and common to all the axes of a tree [2] Consequently, for a same diameter and per unit length, respiration decreases with age, reflecting differences in axis vitality APPLICATION...
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Báo cáo y học: "A human functional protein interaction network and its application to cancer data analysis" potx
... in breast and colorectal cancers, and Tables S3, S4, and S5 from [11] for somatic mutated and CNV genes in pancreatic cancers All network diagrams were drawn with Cytoscape [97] The functional ... molecular functional categories are usually broad and the purpose of our NBC is to predict if two proteins may be involved in the same specific reactions (see below) Construction and training of a functional ... more of the proteins in the hand-curated GBM pathway In this way we were able to extend the hand-curated pathway from 73 proteins and 187 interactions to 181 proteins and 768 interactions A total...
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Functional role of low density lipoprotein receptor related protein 5 and 6 in alzheimers disease
... better understand the underlying pathological mechanisms and to develop novel therapeutic drug targets Despite acting as Wnt co-receptors and apoE4 receptors, the functional role of LRP5 and LRP6 ... the functional role of LRP5 and LRP6 in AD, but also xv provided a better understanding in the mechanisms underlying apoE4-induced AD pathology With further characterization and studies, LRP5 and ... lipoprotein-related protein and LRP5 and LRP6 are type I single transmembrane proteins with 1615 and 1613 amino acid residues respectively They share 73% and 64% identity in extracellular and intracellular...
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Functional cellulose derivatives and their applications in food and pharmaceutical products
... storage and application on the skin Hence, the interaction of water with the non aqueous gel system and its distribution within the gel network is of great interest and critical to its application ... Chemistry and the Department of Pharmacy for their technical assistance especially Chooi Lan and Huey Lee I wish to thank my friends and fellow graduate students, Jiang Bin, Preeti, Lee Wah and Shen ... Heng Wan Sia and Professor Stefan Kasapis for their advice and guidance throughout the course of my PhD candidature My warm thanks to all the laboratory staff of the food science and technology...
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Design and synthesis of functional graphene composites and their applications
... mg-1), and PNPB (2 ×10-6 M), measured with ns laser pulses at a) 532 and b) 1064 nm Nonlinear scattering response of PNP+GO-, GO and PNPB solutions at laser pulses of 532(c and e) and 1064 nm (d and ... TMPyPcomposite and its performance as optical probe Cd+2 detection[40] and (b) Formation of CCG-PDI nano wires and its solar cell performance.[41] (I) Fabrication and solubility test of CCG- PFVSO3 [42] and ... possibilities to develop functional graphene composites for various applications In this thesis, the design and synthesis of various graphene-based composites and their potential applications have been...
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Synthesis of functional nanocomposites and their bio imaging applications
... band (VB) and conduction band (CB) contributed by the ensemble electrons eventually split and show discrete energy states In the meantime, the bandgap, the energy difference between valence band ... Illustration of band structure of inorganic semiconductor as bulk material, nanocrystal and atom (b) Schematic depiction of band diagram of QDs and corresponding electron transition between CB and VB upon ... structure and properties, it is still challenging to successfully modify and functionalize the nanoparticles, which is the linking bridge between the nanoparticles and their biomedical applications...
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Immunological characterization of human umbilical cord lining derived cells and their therapeutic application in a diabetic mouse model
... premixes and analogs and close glucose monitoring, the risks of postprandial hyperglycemia and hypoglycemia are present and long-term complications may still develop 1.1.2 Pancreas and islet ... Chien Tei and Desmond Chan Co iii workers from Prof Phan’s lab, especially Audery, Khoo Ying Ting and Dr Anandaroope Mukhopadhyay, taught me the basic molecular biology techniques, and Jeyakumar ... comprehensively investigated and a potential therapeutic application for CLECs has been tested in the treatment of a type diabetes mouse model xiv LIST OF FIGURES AND TABLES Figure 3.1 Schematic...
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Functional role of p16INK4A and n myc downstream regulated gene 1 (NDRG1) up regulation in cervical carcinoma
... to non-cancerous and normal cervical tissues This current work focuses on elucidating the functional roles of p16 and NDRG1 in cervical cancer and our findings suggest that p16 and NDRG1 are able ... Introduction and Literature Review 1.5.3 NDRG1 plays a role in cell differentiation 30 1.5.4 NDRG1 and stress response 30 1.5.5 NDRG1 and cancer: a putative metastasis suppressor 31 1.5.6 NDRG1 and tumour ... suppressor genes 31 1.5.6.1 NDRG1 and PTEN 31 1.5.6.2 NDRG1 and p53 32 1.5.6.3 NDRG1 and MYC 33 1.5.7 NDRG1 plays diverse roles in different cell types 34 1.6 Objective and approaches for identifying...
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Structural characterization of nogo proteins implications for biological functions and moleculedesign of therapeutic applications
... Nogo-60 and Design of Structured and Active Nogo-54 76 3.2.1 Preliminary structural characterization 77 3.2.2 Structure and 15N backbone dynamics of Nogo-60 78 3.2.3 Design of structured and active ... Characterization of Nogo-B and Systematic Dissection of the Am-Nogo-A 92 3.3.1 Bioinformatics analysis 93 3.3.2 CD and NMR characterization of N- and C-termini of Nogo-B 97 3.3.3 CD and NMR characterization ... of bioinformatics analysis, and biochemical and biophysical approaches Firstly, two identified inhibitory domains (Ngogo-A_567-748 and Nogo-66) had been studies CD and NMR characterization indicated...
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Structural studies of cysteine and serine protease inhibitors towards therapeutic applications
... Inhibitor and a Diazomethylketone Inhibitor 74 3.1 Introduction 75 3.2 Materials and Methods 77 3.2.1 Crystallization and data collection 77 3.2.2 Structure Solution and Refinement 79 3.3 Results and ... and SA Cystatin C is distributed in the extracellular space, cortical neurons, in pancreatic islet cells, in the thyroid glands and in parotid glands Cystatin S is located in the salivary glands, ... archaea and fungi and involved in nutrition and some are pathogenic Furin, a protease is used by several viruses such as HIV, Anthrax and Ebola viruses for entry into the host Subtilisin and Proteinase...
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Identification and characterization of protein kinase CK2 as a novel interacting protein of neuronal CDK5 kinase and its functional role in microtubule dynamics
... for sharing his materials and helpful discussions and Wong Boon Seng for helpful advices and critical comments of my manuscript All the past and present members of IMCB and our laboratory for making ... and its immunoreactivity as predominantly cytoplasmic (Singh and Huang, 1985; Girault et al., 1990) Using immunofluorescence and immunoelectron microscopy, Yu and coworkers showed that CK2α and ... both Cdk5 and Cdk2, resulting in inhibition of activity Green and red arrows represent stimulatory and inhibitory phosphorylation events, respectively 29 1.3.2 Physiological roles of Cdk5 and its...
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Báo cáo y học: "Primary lower limb lymphedema: a focus on its functional, social and emotional impac"
... care givers and through the continuity of care that they can offer, may play an important role in the diagnosis and the monitoring of the long-term impact of lymphedema on physical and emotional ... (SF-36) [7], translated and validated in Greek language [8] It is a self-administered questionnaire that comprises domains of quality of life: physical functioning, role physical, role emotional, bodily ... vitality, mental health, social functioning, and general health SF-36 metric patterns of the two patients were registered and are shown in Table and a description of these two cases follows below...
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Báo cáo y học: "yrosine kinase – Role and significance in Cancer"
... PDGFR and IGF receptors and their associated ligands [22] 4.2.1 EGFR in autocrine paracrine loops Strong associations have been studied among the expression of EGFR and it’s primary ligand EGF and ... kinases and phosphatases: The yin and yang of protein phosphorylation and signalling Cell, 1995 80: 225-236 Schenk, PW and Snarr-Jagalska, BE Signal perception and transduction: the role of protein ... ligand receptor complex and provides the simplest mechanism of receptor dimerization e.g VEGF and VEGFR The receptor dimerization is also stabilized by receptor– receptor interactions Some ligand...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25