... accelerate at impact, resulting in diffuse braininjury (Foda and Marmarou, 1994; Marmarou et al., 1994) Depending on the severity of injury, the induced braininjury results in hemorrhages, neuronal ... al., 2008) In the traumatically injured brain, the temporal and spatial distribution of apoptosis is highly dependent on the type and severity of injuryIn both experimental braininjuryand human ... brain injuries close to the clinical conditions ranging from focal to diffuse brain injuries 1.1.3.2 Fluid percussion injury (FPI) models FPI models produce braininjury by rapidly injecting...
... (in 0.1% milk in PBS containing 0.05% TWEEN) and murine recombinant mouse C5a at defined concentrations for establishing the standard curve After incubation and subsequent washing steps, biotinylated ... JW, Stover JF, McIntosh TK: Pharmacology of traumaticbraininjury Curr Opin Pharmacol 2003, 3(1):27-32 Doppenberg EM, Choi SC, Bullock R: Clinical trials intraumaticbrain injury: lessons for ... extracted from homogenized murine brains at hours, 24 hours, and days after traumaticbraininjury (TBI) The murine primers for GAPDH, Bcl-2, Fas and C1-Inh are depicted in table The technique for...
... injuries [6-8] Competing interests SMM is an investigator in the TraumaticBrainInjury Clinical Trials Network JDK is a Principal Investigator in the Resuscitation Outcomes Consortium References Xiao ... Neuroprotection intraumaticbrain injury: a complex struggle against the nature of biology Curr Opin Crit Care 2007, 13:134-142 Wang KK, Larner SF, Robinson G, Hayes RL: Neuroprotection targets after traumatic ... preclinical promise to clinical reality are vital to those of us seeking to expand our armamentarium of therapeutic options in the treatment of these injuries [6-8] Competing interests SMM is an investigator...
... Hyperglycemia andbrain tissue pH after traumaticbraininjury Neurosurgery 2004, 55:877-881 12 Bilotta F, Spinelli A, Giovannini F, Doronzio A, Delfini R, Rosa G: The effect of intensive insulin therapy ... to mmol/l) in patients with severe traumaticbraininjury Crit Care 2008, 12:R98 Lam AM, Winn HR, Cullen BF, Sundling N: Hyperglycemia and neurological outcome in patients with head injury J Neurosurg ... pressure profile during the second week after injuryin the intensive control group, the preponderance of data points against the use of intensive glycemic control This finding stands in sharp contrast...
... of standardization were integrated in the US into a much larger interagency initiative towards ‘an integrated approach to research in psychological health andtraumaticbraininjury This initiative ... towards ‘an integrated approach to research in Psychological Health andTraumaticBrainInjury References Maas AIR, Stocchetti N, Bullock R: Moderate and severe traumaticbraininjuryin adults ... Steyerberg EW: Prognosis and clinical trial design intraumaticbrain injury: the IMPACT study J Neurotrauma 2007, 24:232-238 Brain Trauma Foundation [http://www.braintrauma.org/site/ PageServer]...
... HQ, Jenkins LW, Marion DW, Dixon CE: Acute systemic administration of interleukin-10 suppresses the beneficial effects of moderate hypothermia following traumaticbraininjuryin rats Brain Res ... global ischemia Brain Res Mol Brain Res 2001, 86:34-47 33 Lyeth BG, Jiang JY, Robinson SE, Guo H, Jenkins LW: Hypothermia blunts acetylcholine increase in CSF of traumatically brain injured rats ... alpha expression and protein levels after fluid percussion injuryin rats: the effect of injury severity andbrain temperature Neurosurgery 2004, 55:416-424 21 Kline AE, Bolinger BD, Kochanek...
... simulation study evaluating approaches to the analysis of ordinal outcome data in randomized controlled trials intraumaticbrain injury: results from the IMPACT Project Clin Trials 2010, 7:44-57 ... N, Knoller N, Pharmos TBI investigators: Efficacy and safety of dexanabinol in severe traumaticbrain injury: results of a phase III randomised, placebo-controlled, clinical trial Lancet Neurol ... improving the design and analysis of clinical trials in moderate to severe traumaticbraininjury Neurotherapeutics 2010, 7:127-134 McHugh GS, Butcher I, Steyerberg EW, Marmarou A, Lu J, Lingsma...
... distribution in testing reports 72 3.2 Evaluation result for medical findings inbrain CT radiology reports 73 3.3 Evaluation result for modifiers of the medical findings inbrain CT radiology reports ... This is compressing the underlying brainand distorting the left lateral ventricle Figure 1.2: The radiology report associated with the CT image series 15 For traumaticbrain injury, CT is a ... skull results in compression injury to the adjacent brain (coup) and stretching on the opposite side (contrecoup) This may result in contusion, shearing injuries and rupture of intra-axial or...
... McLaughlin, K A., Pavese, A., Heidrich, A., & Posner, M I (2000) Evaluation of attention process training andbraininjury education in persons with acquired braininjury Journal of Clinical and ... demographics The following demographic information was taken: age at injury (in years), age at first assessment (in years), time since injury (in months), days of post -traumatic amnesia (PTA) and years of ... for TBI incorporating action video gaming and psycho-education Participants in the attention-training condition showed significant improvements in game performance (shooting accuracy and the...
... Post -Injury (hours) E * D Brain IL-2 (pg/mg protein) Brain TNF (pg/mg protein) B Time Post -Injury (hours) C Brain IL-4 (pg/mg protein) * Brain IL-1 (pg/mg protein) Brain IL-6 (pg/mg protein) A Page of 16 ... Moderate and severe traumaticbraininjuryin adults Lancet Neurol 2008, 7:728-741 Gaetz M: The neurophysiology of braininjury Clin Neurophysiol 2004, 115:4-18 Masel BE, DeWitt DS: Traumaticbrain injury: ... Post -Injury (hours) Figure Increase inbrain edema does not differ intraumatic axonal injury rats with or without hypoxia Brain water content was determined at 2, 24, 48, 72 and 96 h post -injury, ...
... in an incomplete understanding of their contribution to injury- induced pathology, but have indicated that the receptor is affected by injury Sihver et al [12] found a decrease in GABAAR binding ... the injuryinduced decrease in expression (M = 74.93) [F(3,9) = 14.907, p < 01], indicating DZ decreased α3 expression, regardless of injury condition DZ normalized γ2 injuryinduced decreases in ... phosphorylation of subunit proteins Increases in glutamate after injury trigger VGCC and NMDA receptors, increasing [Ca2+]i, and resulting in activation of CaMKII A single dose of DZ can downregulate...
... MS and IU performed postoperative video documentation during reprogramming IU performed all pre- and postoperative neuropsychological examinations and tests and interpreted these MS and AS finalized ... competing interests Authors’ contributions MS and AS performed intraoperative micro-recording, macro-stimulation and functional testing KS performed the surgical procedure and the trajectory planning ... Targeting the basal ganglia for deep brain stimulation in Parkinson’s disease Neurology 2000, 55:S21-S28 Richter EO, Hoque T, Halliday W, Lozano AM, Saint-Cyr JA: Determining the position and size...
... less than 2% severe traumaticbrain of surface P-selectin in with healthy controls Changes in expressioninjury patients comparedplatelets isolated from severe traumaticbraininjury patients compared ... Relative increases in norepinephrine-induced expression of P-selectin in arterial (blackhealthy controls (white bars) expressed as a percentage of severe traumaticbraininjury (TBI) patients and ... percentage of baseline values Baseline values were determined in platelets not stimulated in vitro with norepinephrine During the first week, the norepinephrinemediated increase in P-selectin-positive...
... severe braininjury Curr Opin Clin Nutr Metab Care 2008, 11:134-139 Schneider HJ, Kreitschmann-Andermahar I, Ghigo E, Stalla GK, Agha A: Hypothalamopituitary dysfunction following traumaticbraininjury ... admitted (in fact, missing urine output was significantly and independently associated with increased mortality; data not shown) In some other cases, exact urine output recording was missing during ... saline [54] In that study, hypertonic saline use increased the risk of hypernatremia, increased the number of infection days, increased the hospital length of stay, increased the creatinine and...
... Liquide Santé International, Paris, France) Traumaticbraininjury All slices subject to traumaticbraininjury were first incubated for 30 minutes at 37°C, 95% air and 5% CO2 in EM containing 4.5 ... McIntosh TK: Apoptosis after traumaticbraininjury J Neurotrauma 2000, 17:927-938 Faden AI: Neuroprotection andtraumaticbrain injury: theoretical option or realistic proposition Curr Opin ... before by us and others when testing possible treatments [8,19,25] for traumaticbraininjury Nevertheless this is a simplified imitation of brain trauma, which lacks pathomechanisms involving systemic...
... be insulin-dependent because insulin administration was associated with significantly increased interstitial brain glucose This is in line with the findings of insulin-mediated increases in mean ... pre-defined criteria in terms of glucose level and insulin dose are required to interpret the present findings and to define safe brain- glucose dependent insulin dose Influence of insulin on cerebral ... increases inbrain glutamate at low brain glucose levels below mM compared with episodes in which insulin was not administered At brain glucose levels above mM, administered insulin did not influence...
... disorders in patients with isolated head injury Although data regarding blood transfusion in early and late coagulopathy intraumaticbraininjury are limited, an increasing number of investigations ... coagulopathy in isolated traumaticbraininjury may contribute to improved patient outcome • Coagulation measurements in severe isolated traumaticbraininjury should be frequently performed and continued ... isolated traumaticbraininjury is at risk for the development of coagulopathy • The number of patients with isolated traumaticbraininjuryand coagulopathy doubles within 72 hours post-trauma and...
... Cognitive function andtraumaticbraininjuryin refugees and asylumseekers attending mental health services – a preliminary study And Clinical Research Portfolio Volume (Volume ... function andtraumaticbraininjuryin refugees and asylum-seekers attending mental health services – a preliminary study Plain English Summary 38 Abstract 39 Introduction ... function andtraumaticbraininjuryin refugees and asylumseekers attending mental health services – a preliminary study Zara Christie1 Address for Correspondence: Mental Health and Wellbeing University...
... Ng, 2006) 1.1 Defining And Diagnosing Mild TraumaticBrainInjury (MTBI) Mild traumaticbraininjury (MTBI) is the least severe in the spectrum of traumaticbraininjury (Stein, 1996) Recent ... 1.1 1.2 1.3 1.4 DEFINING AND DIAGNOSING MILD TRAUMATICBRAININJURY (MTBI) EPIDEMIOLOGY AND CAUSES OF MILD TRAUMATICBRAININJURY (MTBI) COURSE AND OUTCOME OF MTBI ... increase in our understanding of problems surrounding PCS and PPCS From a definition and diagnostic point of view, there remains much to be examined in establishing consistent terminologies and...
... traumaticbraininjuryInjury 2006;37:1125-1132 Coplin WM Intracranial pressure and surgical decompression for traumaticbrain injury: biological rationale and protocol for a randomized clinical ... Surgeons The Joint Section on Neurotrauma and Critical Care Management and prognosis of severe traumaticbrain injury, part 1: Guidelines for the management of severe traumaticbraininjury J Neurotrauma ... vessels supporting the portion of brain run in the artificial “vascular tunnel” between the brain tissue and dura Finally, the dura was closed as in augmentation duraplasty In the latest report, they...