for los paths the path clearance is set so that there are
Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf
... ER stress When the available acyl-CoAs are in excess, they are channeled towards TAG synthesis The main findings of the present investigation were the observations that TAG synthesis in liver cells ... responsible for lipid synthesis In particular, excess availability of FFAs, as is the case in the present experimental model, leads to increased formation of TAGs, which are either released from the ... observed in this investigation (Fig 5B) The ER is the site of synthesis of all secretory proteins and resident proteins of the membrane system, and any perturbation that compromises the proteinfolding...
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Tài liệu THE MEDICAID EXPANSION IS GOOD MEDICINE FOR MISSOURI pptx
... whether Missouri moves forward with the expansion is up to the legislature There are many factors that policymakers must consider in deciding whether to implement the ACA’s Medicaid expansion The ... for assistance with analysis of U.S Census data Finally, the author thanks the Missouri Foundation for Health for providing grant funding for health policy analysis, including the work on this ... Missouri, The Significance of Missouri’s Uninsured, Missouri Foundation for Health (and citations therein), available at http://covermissouri.org/docs/Significance%20of%20Missouris%20Uninsured%20-%20FS%20Final.pdf...
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Báo cáo khoa học: The F13 residue is critical for interaction among the coat protein subunits of papaya mosaic virus doc
... Therefore, on the basis of our results, it is likely that a deletion of 32 amino acids will be tolerated by PVX without disturbing the assembly process Alignment of this F residue is also shared ... in the PapMV CP Therefore, on the basis of the alignment, we propose that a hydrophobic residue at the position that corresponds to PapMV CP F13 is preferred in half of the potexvirus CP It is ... those for F13L and F13Y disks, and suggest that there is still some RNA associated with recombinant F13L and F13Y disks This could partially explain the decreased affinity of F13L and F13Y disks...
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High Remittance Costs in Africa: Is Building Regulatory Capacity for Microfinance Institutions the Answer? doc
... matters For exam- are high enough to be sustainable The requi- ple, the most popular methods for sending or rement for government assistance is solely for receiving money within Kenya are informal ... most of the directives dated 10 March 1998 These formalize the support of most of the supervision of MFIs by the BCEAO and the Banking Commission, as referred to in section 44 of the Act for poor ... sub-Saha- the necessary resources for their enlarged ope- ran Africa, some countries are dominated by ration, on the one hand, and to reconcile the formal institutions, some by NGOs, and some social...
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Báo cáo khoa học: b-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins pot
... or APLP2 CTFs Therefore, it is reasonable to suppose that the levels of CTFs are regulated, possibly by degradation of excess CTFs Together, these results demonstrate that BACE1 is involved in ... of APP CTFs This suggests that there is a discrete pool of FLAPP that is directed towards processing, and that a-secretases and b-secretases have access to the same cellular pool For APLP1, ablation ... compensated for by APP and APLP1 [13] There is also considerable evidence that the APP family of proteins have a role in cell–cell and cell– matrix adhesion, and that they can form both cis and trans...
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Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx
... carnitine: mm (for standard comparison with other published data), and a concentration equal to the Km for carnitine of each enzyme (for comparison between mutants) In this article, we show that Glu17 ... In this model, Asp17 does not face the C-terminal fragment A possible explanation for this is that, in the case of CPT1B, the docking of the N-terminal fragment might differ from that of the established ... when compared to that of rat CPT1A, but still has the low carnitine Km, characteristic of the CPT1A isotypes [10,23] By contrast, pig CPT1B behaves kinetically as a CPT1A isotype [high IC50 for malonyl-CoA...
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Báo cáo khoa học: The b domain is required for Vps4p oligomerization into a functionally active ATPase potx
... to the vacuole lumen These data clearly demonstrate that the conserved C-terminal motifs that are required for efficient fluid-phase endocytosis are also critical for ubiquitindependent MVB sorting ... proteins destined for the cell surface into a pathway that takes it via endosomes to the vacuole In vps4D cells, CPY is missorted at the late Golgi into vesicles destined for the cell surface ... within the AAA domain We provide evidence that the b domain is important for full ATPase activity of Vps4p We also show that the b domain is required for two protein interactions The first is a...
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Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency doc
... hemorrhagic episodes are usually associated with injury or surgery, but may be so severe as to demand replacement therapy [16] The genetic basis of this rare coagulation disorder is invariantly ... Our results are consistent with the FXI:C and FXI:Ag measured in the patients plasma, further supporting the hypothesis that the Val371Ile mutation is a 6130 type II defect leading to the production ... specicity of the substrate) [26] Consequently, substitution of Val371 to isoleucine might prevent the full development of the active conformation This hypothesis is further conrmed by the results...
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Industry Standard Financial Statement - This Statement is for use in the MARP pdf
... assist you in setting out your current financial circumstances We consider that the completion of the SFS is a serious undertaking and we will work with you to ensure that the information is ... arrangement is not offered to you, we will give you a reason for that decision in writing You will have the right to appeal that decision; you may appeal to us initially and subsequently to the Financial ... understand that the information provided will only be used for the purpose of assisting my lender to assess my financial situation under its Mortgage Arrears Resolution Process Protecting Your Information...
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THE PATH TO PROSPERITY A BLUEPRINT FOR AMERICAN RENEWAL pdf
... basis as the nation’s fiscal hole grows deeper The good news is that solutions to these problems are more attainable today than they have been in years: There is an ... favoritism, but by the soundness of their practices and the value of their services • Reform the Credit Reform Act to stop the transfer of taxpayer risk to FHA As the ... amount to this: Let somebody else propose a path forward, and then attack them for political gain This budget offers a better path The following report lays out the challenge...
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Báo cáo khoa học: ATPase activity of RecD is essential for growth of the Antarctic Pseudomonas syringae Lz4W at low temperature potx
... with the b-phosphate of ATP-Mg2+ and thereby plays a role in the catalytic reaction [17,18] Consistent with these results, our data show that the K229 residue is essential for ATP hydrolysis and ... indicated that the recB and recC mutants of P syringae also are cold-sensitive like the recD mutants, suggesting that function of the entire RecBCD machinery is important for growth In the case ... in which it formed inclusion bodies Therefore, the protein was subsequently expressed in soluble form in Antarctic P syringae (Fig S2) using the plasmid pRecDHis, a derivative of the broad host...
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Báo cáo Y học: The cytoplasmic C-terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking pdf
... explanation for this is that the trafficking in these two systems is quite different Indeed it is now well established that the commonest of the mutations (DF508) in the CFTR protein (cystic fibrosis transmembrane ... It is interesting that the coexpression of two SUR hemi molecules is necessary for the full reconstitution of the sulfonylurea binding site [38] Our data are compatible with the idea that the ... Biochem 269) There are several potential explanations for these different results Firstly, there are differences in the expression system used (Cos cells in [11] vs Xenopus laevis oocytes in...
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Báo cáo sinh học: " The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World" pdf
... results indicate that WNV strain IS- 98-ST1 is suitable as viral model for West Nile encephalitis in the Old World The Israeli strain IS- 98-ST1 that caused the epizootic in Israel in 1998, was found ... 1:9 by the fact that an Israeli WNV strain was introduced in New York City in 1999 [4] The murine model of WNV-associated encephalitis has been widely used to address the viral pathogenesis[5] ... to the route of inoculation (Fig 1C and 1D) In all sections, WNV-infected cells were negative for GFAP (Fig 1F) This suggests that neurons are the principle targets of infection in the CNS For...
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Water is for life:How the Water Framework Directive helps safeguard Europe’s resources doc
... species in our waters Pressure on water resources is increasing the risk of drought in some areas Solving the problems There is much that can be done to improve the quality and quantity of our water ... across the EU In this context the WFD is backed up by other EU environmental legislation on pollution control, such as the REACH regulation and the IPPC The Commission will regularly review the list ... – toolbox for integrated management of water The river basin management plans are the key tools for the implementation of the Directive in the river basin districts, and are valid for a sixbas...
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Peace is every step the path of mindfulness in eve
... happy The Eucharist The practice of the Eucharist is a practice of awareness When Jesus broke the bread and shared it with his disciples, he said, “Eat this This is my flesh.” He knew that if his ... discover that there are three components: the giver, the gift, and the one who receives the gift The giver is our parents; we are the continuation of our parents and our ancestors The gift is our ... paper The cloud is essential for the paper to exist If the cloud is not here, the sheet of paper cannot be here either So we can say that the cloud and the paper inter -are “Interbeing” is a word that...
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Báo cáo toán học: "An asymptotic Result for the Path Partition Conjecture" pps
... b)-partition for every pair (a, b) of positive integers such that a + b = τ (G), then we say that G is τ -partitionable The following conjecture is known as the Path Partition Conjecture (or the PPC, for ... Rv + P vτ is longer than P − → ← − (c) If u− ∈ N (vτ ) , then v1 P u−1 vτ P uv1 is a cycle of order τ in G But then there is a path of order τ + in G consisting of this cycle together with a ... greater than τ is obtained from P by replacing the edge uu+ with a u − u+ path whose internal vertices are in Hi (b) Suppose, to the contrary, that {u+ , v + } ⊆ NP (Hj ) for some j Then it follows...
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Báo cáo y học: "Rheumatoid arthritis seropositive for the rheumatoid factor is linked to the protein tyrosine phosphatase nonreceptor 22-620W allele" docx
... and association in the TDT RA samples Linkage and association analysis were performed using the TDT [33] and the genotype relative risk (GRR) test [34] The TDT compares the transmission of the ... cases, the TDT RA cases and the controls from the TDT RA samples (controls are derived from nontransmitted parental chromosomes) For the linkage-based association test, the RF+ index cases that shared ... stronger association for the homozygous genotype [19] The US study confirmed this association was restricted to RF+ RA and also showed a significantly higher risk for the homozygous genotype [23] These...
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Báo cáo khoa học: "Age is not a limiting factor for brachytherapy for carcinoma of the node negative oral tongue in patients aged eighty or older" docx
... time period The background comparison was shown in Table Radiation therapy All implantation was done under local anesthesia For patients in the LDR group, the treatment sources consisted of an ... soft tissue (ulceration lasting months or more) and/or bone (bone exposure and necrosis) reactions occurred Statistical Analysis For a statistical analysis, a Student’s t-test for normally distributed ... surgery is not encouraged for the same reasons It is important for their quality of life and life expectancy to attain local control of symptomatic primary lesions Carefully planned radiation therapy...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose