... radiotherapy following mastectomy to patients with early invasive breast cancer whoare at low risk of local recurrence (for example, mostpatientswhoarelymph node- negative) Dose fractionation 1.11.6 ... their sentinel lymph nodes These patients should be regarded as lymph node- negative 1.5 Breast reconstruction 1.5.1 Discuss immediate breast reconstruction with all patientswhoare being advised ... rather than lymphnode clearance, should be performed to stage the axilla forpatients with early invasive breast cancer and no evidence of lymphnode involvement on ultrasound or a negative ultrasound-guided...
... significant increases in the risk of LRI for smoking by the mother, father, both parents, and by any household member These effects are typically strongest for bronchiolitis, and particularly in ... respiratory infections are common in infants, resulting, for example, in over 33,000 hospital admissions in infants aged under two years in England alone, where about 10% are estimated to be due ... These additional hospital admissions are a significant public health burden all of which are avoidable It is thus clear that there is a need for renewed efforts to prevent the exposure of infants...
... study population [15] Statistics Statistical analysis was performed using the PASW software (former SPSS software, version 17.0.1 for Windows, SPSS Inc., Chicago, IL, USA) Non-parametric tests ... whereas examples of detrimental effects are apoptosis induction, blood brain barrier disruption and demyelination [2,3,5] In AD, the expressions of MMP-3 and MMP-9 are elevated in the brain and are ... inhibitor of metalloproteinase * n = 28 ** Levels are in ng/l for Ab42, T-tau and P-tau and in ng/ml for the MMPs and TIMP-1 The findings of this study are in alignment with the elevated expression...
... were cultured for 12 h after transfection with siHO1, siHO2, or siGAPDH, then treated with lM hemin for 12 h, and harvested for the measurement of heme content Cells were treated for 24 h with ... primers used for HO-1 were: forward, 5¢-TTAAAAGCTT ATGGAGCGTCCGCAACCCGA-3¢; reverse, 5¢-TTAAT CTAGAAAGAAGGCCTTCCACCGG-3¢ The sequences underlined are HindIII and XbaI sites, which were used for cloning ... MARE and mutated MARE, respectively, in each promoter region linked to the luciferase gene [39] HeLa cells were plated day before transfection and grown to 50–70% confluence in 24-well plates For...
... Health guidelines for the care and use of laboratory animals Tissue sampling To study OPN expression in animals with EAN, spinal cord tissue and sciatic nerves were sampled during paraparesis (day ... subarachnoid space, but only rarely infiltrated the spinal cord parenchyma OPN was expressed in some macrophages in the subarachnoid space and in some astrocytes in the parenchyma, mainly near the ... observed daily for clinical signs of EAN The progression of EAN was categorized into seven clinical stages, as follows Grade (G) 0, no clinical signs; G1, floppy tail; G2, mild paraparesis; G3,...
... higher risk of death from all causes (RR, 5.0 for women, 2.7 for men) and of deaths from obstructive lung diseases (RR, 57 for women, 34 for men,) compared with men [25] Xu and colleagues studied ... cigarette smoke may modify hormonal status in women, which may affect lung function Women whoare active smokers become relatively estrogen deficient compared with non-smokers because cigarette ... Viegi for providing additional data for this study as well as all the other authors of the primary studies who contributed their time and data to this project Page of (page number not for citation...
... All patients gave written informed consent Patients This was a prospective cohort study The inclusion criteria were consecutive adult patientswho were referred to Beijing Fuwai Hospital for ... Critical Care 2010, 14:R238 http://ccforum.com/content/14/6/R238 patients, 243 gave written consent and were enrolled in this study (Figure 1) The perioperative variables of all enrolled patientsare ... Critical Care 2010, 14:R238 http://ccforum.com/content/14/6/R238 Page of 11 Table Preoperative variables Variable All enrolled patients (n = 243) Non-delirious patients (n = 120) Delirious patients...
... results forpatientswho developed infections versus those who did not are shown in Figure In patients with EAA ≥0.40 at T2, 26.1% (6/23) of patients developed post-operative infections compared ... studies similarly did not correct for hemodilution and thus we did not to so for comparative purposes We are not aware of any validated correction factor for hemodilution for endotoxin levels with any ... endotoxemia occurs in patients exposed to CPB utilizing a novel Figure Box plots for EAA levels in patients that developed post-operative infection versus those that did not Before (T1, P = 0.0796),...
... exposure The most recent study [1] was based on prescription data and therefore uncertain exposure information and in spite of its size of 319 hypospadias cases found an adjusted OR for hypospadias ... imperative to stress that in spite of formal statistical significance, the finding may be random and the reason for publishing is of course to ask other researchers to look for the presence or absence ... case different types of congenital malformations) it is to be expected that a number of apparently significant associations will occur In this situation there are a number of problems: to publish...
... therapy in most postmenopausal patients Bisphosphonates Candidates for bisphosphonate treatment include premenopausal women at increased risk for osteoporosis, postmenopausal women who forgo HRT, ... risedronate are similar to those reported in the control group Alternative dosage formulation and administration of bisphosphonates is under investigation Calcitonins Forpatientswhoare unable ... (wrist, forearm, heel) It has become the gold standard to which all other bone densitometry techniques are compared [95-97] Techniques for determining bone mineral density at various sites are summarized...
... that the identifying formulae for αm for m ≥ was a difficult problem, and he only estimated the values of αm for m 10 Now, in this paper, we are interested in the identifying αm for m = and we show ... ) ∈ { , , } 2 2 for all t1 ∈ supp µ1 Assume that the lemma is true for n = k, i.e., µk (sk ) ≥ µk (tk ) for all tk ∈ supp µk n We will show that the lemma is true for n = k + For any y = (y1, ... Proof i) For n = we have (x1 ) = (x′ ) = {(2)} Therefore, 10 µ1 (s1 ) = µ1 (s′ ) = P (X1 = 2) = For n = we have (x1 , x2 ) = {(2, 3), (3, 0)} and (x′ , x′ ) = {(2, 2), (1, 5)} Therefore, 110...
... t i o n as to who or what is being talked about This additional information is necessary because without it, there would be insufficient evidence with which to d e t e r m i n e who or w h a t ... r m a t i o n c o n t a i n e d within the relative must therefore be matched against information which already exists in the hearer's model of the universe This matching process presumably requires ... examples (which are s i m i l a r to t h o s e used by Crain, 1980) In the absence of any preceding discourse, there can e x i s t no d i s c o u r s e model within which to integrate the information...
... [8,14] Compared with other substrate series so far reported, for example, maltooligosaccharides [15] or a-NP-maltooligosaccharides [10], the CNP-maltooligosaccharides, which are b-glycosides, are unique ... results confirm that the nine subsites for BLA and the five subsites for PPA, originally assumed from our experimental data, are correct and bond-cleavage frequencies are predicted correctly Table BCFs ... pattern The relative rate of formation of each product is called bond cleavage frequency (BCF), which gives information about the subsite-binding energy By using BCFs for a series of oligomeric...
... diagram of a metal and Si, the temperature for SiNW formation must be above the eutectic point as liquid droplets can form under this condition Here we give an example of using Au as the catalyst As ... supersat- uration of the formed liquid alloy with silicon atoms, which leads to nucleation and growth of a SiNW [19] Therefore, the diameter and location of the SiNW are determined by the features ... (such as T1), a liquid alloy can form and will assist the growth Considering the production output, a temperature of 620 °C was used for the case of Au and 900 °C for the case of Ni to fabricate...
... tag images (paths) for a given sentence can be exponential in the length of the sentence if all words are ambiguous It is therefore desirable to filter out invalid tag images before (or during) ... than one interpretation, thus giving rise to exponentially many tag images for a sentence SCr (t,k) for t in T and for k = 0,1,2,3 Izl=k or Izl < k if "> $' is the last tag in z, and there exists ... of a sentence The basis for the automaton Which checks a tag stream (path) for validity as a tag-image relative to the local constraints, is the function next(t), which for any t in T defines...
... extension of Qp , [42] For m prime to p, Ki (K, Z/m) = Ki (k, Z/m) ⊕ Ki−1 (k, Z/m) by Gabber-Suslin, [44], and for k finite, the K-groups on the right are known by Quillen, [36] For any linear category ... B¨kstedt for valuable help and comments o We are particularly indebted to Mike Mandell for a conversation which was instrumental in arriving at the definition of the spectrum T (A|K) as well as for ... this category are called G-spectra, and the monoids for the smash product are called ring G-spectra Let H ⊂ G be a closed subgroup and let WH G = NG H/H be the Weyl group There is a forgetful functor...
... (Sigma) and 30 mM ethanol for human ADH1B1 and ADH1B2; 2.4 mM NAD+ and 100 mM ethanol for human ADH4; 0.3 mM NAD+ and 10 mM ethanol for mouse ADH1; 2.4 mM NAD+ and 2.5 M ethanol for mouse ADH4 Commercially ... prepare 11-cis-retinal by oxidation with MnO2 [34] For the synthesized retinoids, the retinals were the forms of storage Synthesis of 7-cis-retinol, 9-cis-retinol and 11-cisretinol were performed ... determined for human and mouse ADH1 and ADH4 enzymes (Tables and 3, respectively) Except for the 13-cis isomers, all enzymes showed similar Km values for all retinoids assayed, ranging from to 35 lM for...