... the left chest wall The thyroid tumor was not palpable in the residual left lobe of the thyroid gland Ultrasound (US) examination subsequently revealed no thyroid tumor and no regional lymphadenopathy ... left chest wall tumor Hematoxylin and eosin stain (A) revealed follicular growth, and immunohistochemical stain was positive for thyroid transcription factor-1 (B) and thyroglobulin (C) Page of (page ... uptake and better patients’ QOL, although just in restricted cases care and editing of the manuscript YR, MM and TI participated in final revision of the manuscript and guidance All authors read and...
... papillary andfollicularthyroid carcinoma: benefits and limits of radioiodine therapy J Clin Endocrinol Metab 2006, 91:2892-2899 Ghfir I, Ccedil Aoui M, Ben Rais N: Follicularthyroid carcinoma: ... Cutaneous metastases from follicularthyroid cancer Presse Med 2000, 29:1557-1558 Koller EA, Tourtelot JB, Pak HS, Cobb MW, Moad JC, Flynn EA: Papillary andfollicularthyroidcarcinoma metastatic ... from follicularthyroid carcinoma: a case report Changgeng Yi Xue Za Zhi 1996, 19:77-82 Caron P, Moreau-Cabarrot A, Gorquet B, Bazex J: Cutaneous metastasis from follicularcarcinoma of the thyroid...
... and GL provided study materials or patients HSB, PS, JG, AB, CW and GL participated in collection and assembly of data CP and AS participated in data analysis and interpretation CB, HSB, AB and ... tumor cells binds to TLR4 on dendritic cells and is required for cross-presentation of tumor antigens and a subsequent effective anti-tumor immune response This effect was impaired in HeLa cells ... polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomas Journal of Translational Medicine 2011 9:139 Page of Submit your next manuscript to BioMed Central and take full advantage...
... and GL provided study materials or patients HSB, PS, JG, AB, CW and GL participated in collection and assembly of data CP and AS participated in data analysis and interpretation CB, HSB, AB and ... tumor cells binds to TLR4 on dendritic cells and is required for cross-presentation of tumor antigens and a subsequent effective anti-tumor immune response This effect was impaired in HeLa cells ... polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomas Journal of Translational Medicine 2011 9:139 Page of Submit your next manuscript to BioMed Central and take full advantage...
... the three cell lines tested, MCF7 cells had high levels of Her3, BxPC3 cells had intermediate Her3, and A549 cells had low Her3 (Figure 1) We analyzed the expression pattern of Her2 and Her3 proteins ... contributions J-YC and SMH conceived of the study and devised the experimental design SMH and CM designed and build the tissuemicroarrays MT, J-YC, and YK performed experiments RX, HC, J-YC and SMH performed ... head and neck carcinoma Anticancer Res 1992, 12:2273-2276 27 Field JK, Spandidos DA, Yiagnisis M, Gosney JR, Papadimitriou K, Stell PM: CerbB-2 expression in squamous cellcarcinoma of the head and...
... the three cell lines tested, MCF7 cells had high levels of Her3, BxPC3 cells had intermediate Her3, and A549 cells had low Her3 (Figure 1) We analyzed the expression pattern of Her2 and Her3 proteins ... contributions J-YC and SMH conceived of the study and devised the experimental design SMH and CM designed and build the tissuemicroarrays MT, J-YC, and YK performed experiments RX, HC, J-YC and SMH performed ... head and neck carcinoma Anticancer Res 1992, 12:2273-2276 27 Field JK, Spandidos DA, Yiagnisis M, Gosney JR, Papadimitriou K, Stell PM: CerbB-2 expression in squamous cellcarcinoma of the head and...
... mechanisms in thyroid follicularcell neoplasia Nat Rev Cancer 2006, 6(4):292-306 Giuffrida D, Gharib H: Cardiac metastasis from primary anaplastic thyroid carcinoma: report of three cases and a review ... anaplastic thyroidcarcinoma metastatic to the right cardiac atrium and ventricle in a pacemaker-dependent patient Tina Dasgupta*, Igor J Barani, Mack Roach III* Abstract Anaplastic thyroidcarcinoma ... surgical bed and the draining lymph nodes A subsequent left lung nodule was treated with thoracotomy and wedge resection in December 2008, with documented metastatic anaplastic thyroid carcinoma...
... had histologically confirmed squamous cellcarcinoma Histological grading was recorded in 134 patients and 76 (50.3%) had poorly differentiated squamous cellcarcinoma Stage distribution was classified ... entire cohort of 151 patients the OS rates were 67.5% and 58.3%; the CSS rates were 75.1% and 66.8% and PFS rates were 72.5% and 67.2% at and 3-years respectively Survival rates Median follow ... parotid-sparing 3D-CRT or IMRT and of the 21 LRR, 17 were in-field and were marginal [18] Studer et al reported a 80% and 87% local and regional control rate, respectively and 95% of failures occurred...
... genes (hot and cold spot genes (Additional File 1, Table S4 and Table S5), stroma and epithelium networks genes (Figure 2, Additional File 1, Table S6 and Table S7) and their intersection, and only ... Society: Cancer Facts and Figures 2009 Chen Y, Chen C: DNA copy number variation and loss of heterozygosity in relation to recurrence of and survival from head and neck squamous cell carcinoma: A review ... invaluable knowledge in understanding the inter-compartmental and inter-network-based events in HNSCC tumorigenesis and importantly, guide empiric molecular and cellular biology experiments in...
... comparable to other cancer cells, e.g cervical adenocarcinoma cells [43], osteosarcoma cells [42], lung adenocarcinoma cells [37,41], and gastric and colon cancer cells [44] Despite this, nanoparticle ... exited the cells In contrast, our data implicates that both internalized Ru@SiO -OH and Ru@SiO -NH remain within the celland are apparently distributed between daughter cells at cell division ... Switzerland Authors’ contributions CM and EBG designed all of the experiments and wrote the manuscript EBG and XD performed all the experiments together HW and MB contributed clinical expertise AWH and...
... Muir-Torre syndrome Sebaceous gland carcinoma is a rare neoplasm arising from the Meibomian glands, Zeis glands, or sebaceous glands of the caruncle and eyebrow, and represents 1-6% of all eyelid ... fibroids, and benign renal cysts as less common findings Papillary thyroidcarcinoma (PTC) is the most common thyroid malignancy worldwide, comprising 50% to 70% of differentiated follicularcellthyroid ... that leads to endocrine gland tumors and/ or hyperfunctioning commonly involving the pituitary, adrenal, andthyroid glands, as well as myxomas (skin, heart, and breast) and lentiginosis in select...
... formation and function, contributing to the genomic instability of the cell [30] The separate pathological effects of high-risk HPV E6 and E7 on the cell cycle complement each other, and together E6 and ... epithelial cell transformation, and promote cellular genomic instability that predisposes the infected cells to full malignant transformation High-risk HPV E7 activates the DNA synthesis andcell replication ... inactive in matured epithelial cells, thus initiating pathological cell growth By inducing cell survival and delayed apoptosis of cells with DNA damage, E6 allows E7 to exert and sustain its pathological...
... evidence for a link between HPV and squamous cellcarcinoma of the mouth and oropharynx In order to prove a causal relationship between HPV and SCC of the mouth and oropharynx, as has been proven ... exfoliated cells and risk of head and neck cancer J Natl Cancer Inst 2004, 96:449-455 Kreimer AR, Clifford GM, Boyle P, Franceschi S: Human papillomavirus types in head and neck squamous cellcarcinoma ... factor in carcinomas of the oral cavity and oropharynx Int J Cancer 2003, 104:336-344 22 Hennessey PT, Westra WH, Califano JA: Human papillomavirus and head and neck squamous cell carcinoma: ...
... resected thyroid, parathyroids or cervical lymph nodes During follow-up, his thyroglobulin level remained low Hypothyroidism and hypoparathyroidism were noted after the radical thyroidectomy and these ... either thyroid papillary carcinoma or early to mid stage (before Stage IIIa) nonsmall cell lung carcinomas (NSCLCs) Therapeutic strategies for the management of double primary thyroidand lung carcinomas, ... were controlled by thyroid hormone and calcium supplements The pathology findings confirmed the diagnosis of a double primary pulmonary adenocarcinoma andthyroid papillary carcinoma (see figure...
... for OSMF and OSCC, in which viral integration and the expression of viral oncogenes (E6 and E7) have been shown [8] HPV detection in potentially malignant and malignant oral squamous cellcarcinoma ... was performed as per standard protocol and the tissue was processed by paraffin embedding 2-3 micrometer thick sections were cut and stained by haematoxylin and eosin (H and E) Biopsies, which ... reaction; (OSMF): Oral submucous fibrosis; (HNSCC): head and neck squamous cell carcinoma; (HCII): Hybrid Capture; (OSCC): Oral squamous cellcarcinoma Acknowledgements Authors are thankful to persistent...
... protein and is involved in transcriptional regulation of a variety of genes [95], cell growth arrest [96,97], and apoptosis andcell death [96] Borghaei and coworkers [98] found that both ZBP-89 and ... C, Carey T, et al.: Genetic and expression profiles of squamous cellcarcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients Clin Cancer Res ... cells Figure p53 genotype and protein expression in UM-SCC cell lines p53 genotype and protein expression in UM-SCC cell lines (a) The p53 genotype of ten University of Michigan series head and...
... States are transitional cell in origin Pure squamous cancers with keratinization constitute 3%, adenocarcinomas 2%, and small cell tumors (with paraneoplastic syndromes)
... T1, and T2 or greater lesions, tumors with alterations in p53, p21, and/ or RB have a higher probability of recurrence, metastasis, and death from disease Clinical Presentation, Diagnosis, and ... Selective catheterization and visualization of the upper tracts should be performed if the cytology is positive and no disease is visible in the bladder Ultrasonography, CT, and/ or MRI may help to ... tumors should be resected, and a sample of the muscle underlying the tumor should be obtained to assess the depth of invasion Normalappearing areas are biopsied at random to ensure no field defect...
... surgery that requires appropriate preoperative evaluation and management The procedure involves removal of the bladder and pelvic lymph nodes and creation of a conduit or reservoir for urinary flow ... conservative management (e.g., due to multicentric and frequent recurrences resistant to intravesical instillations); high-grade tumors (T1G3) associated with CIS; and bladder symptoms, such as frequency ... be achieved, there is no CIS in other sites, and the bladder capacity is adequate after the tumor has been removed This occurs in 5–10% of cases Carcinomas in the ureter or in the renal pelvis...
... Carcinoma of the Renal Pelvis and Ureter About 2500 cases of renal pelvis and ureter cancer occur each year; nearly all are transitional cell carcinomas similar to bladder cancer in biology and ... vinblastine, doxorubicin, and cisplatin (M-VAC); cisplatin and paclitaxel (PT); gemcitabine and cisplatin (GC); or gemcitabine, paclitaxel, and cisplatin (GTC) M-VAC was considered standard, but the toxicities ... a comparative trial of M-VAC versus GC that showed less neutropenia and fever, and less mucositis for the GC regimen Anemia and thrombocytopenia were more common with GC GTC is not more effective...