flap where is the line of greatest tension
Báo cáo y học: "Standards of evidence in chronobiology: critical review of a report that restoration of Bmal1 expression in the dorsomedial hypothalamus is sufficient to restore circadian food anticipatory rhythms in Bmal1-/- mice" pot
... differs between the two versions of these data this software Regardless, the fact that a significant misalignment occurred raises concerns about the accuracy of other figures in the paper 1b Careful ... Clearly, the peak in temperature in D is not reflected by the density of the same data in B In addition, the temperature curve in both waveforms is a mirror image on either side of the blue line Therefore, ... mealtime The average waveforms and actogram-style plots exhibit clear discrepancies that could be caused if one is misaligned relative to the other This misalignment issue exists regardless of whether...
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Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf
... Kit-8 is a colorimetric method in which the intensity of the dye is proportional to the number of the viable cells Briefly, 200 lL of a suspension of PC-9 cells was seeded into each well of a 96-well ... examined the effect of AG1478 on the viability of human NSCLC cell line PC-9 Treatment of the cells with AG1478 markedly suppressed the cell viability, as determined by the results of a colorimetric ... apoptosis in PC-9 cells There is a general agreement on the hypothesis that the inhibition of ERK1 ⁄ MAPK and ⁄ or PtdIns3K ⁄ Akt growth ⁄ survival signaling cascades leads to apoptosis of cancer...
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Báo cáo khoa học: The F13 residue is critical for interaction among the coat protein subunits of papaya mosaic virus doc
... among the CP subunits monomeric form of the protein [10] This protein failed to assemble, form disks or interact with RNA in vitro [10] On the basis of this result, we hypothesized that the N-terminus ... CP F13 Therefore, on the basis of our results, it is likely that a deletion of 32 amino acids will be tolerated by PVX without disturbing the assembly process Alignment of this F residue is also ... in the PapMV CP Therefore, on the basis of the alignment, we propose that a hydrophobic residue at the position that corresponds to PapMV CP F13 is preferred in half of the potexvirus CP It is...
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Báo cáo khoa học: Total chemical synthesis and NMR characterization of the glycopeptide tx5a, a heavily post-translationally modified conotoxin, reveals that the glycan structure is a-D-Gal-(1fi3)-a-D-GalNAc pot
... that even in the synthesis of nondisulfide bridge-containing glycopeptides the yield is dramatically affected by the scale of the reaction, the excess of amino acids used, and the level of purity ... validate the activity of the endo-O-glycosidase enzyme, which was unable to hydrolyze native tx5a Together these data suggest that the glycan configuration of native tx5a is distinct from the synthetic ... did not further determine the configuration of this carbohydrate However, the different elution profiles of the native tx5a and the synthetic peptides constructed with the carbohydrate in the T-antigen...
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Báo cáo Y học: Barley a-amylase Met53 situated at the high-affinity subsite )2 belongs to a substrate binding motif in the bfia loop 2 of the catalytic (b/a)8-barrel and is critical for activity and substrate specificity pot
... schematics of the reaction mechanism (Fig 3) Under the present assay Fig Schematics of the double displacement mechanism of retaining glycoside hydrolases [3,66] In transglycosylation the covalent ... view of the global structure of the AMY2 (top) and TAA (bottom) complexes [16,17] The inhibitors are in green and the arrow indicates the nitrogen (in dark blue) that corresponds to the oxygen of ... [3638] that the bond cleavage pattern of PNPG7 was identical to or very similar to wild-type with the notable present exception of Met53Trp Thus even though the rates of hydrolysis of the oligosaccharide...
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báo cáo hóa học:" Activation of PKA, p38 MAPK and ERK1/2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ ADAM17 gene expression during in vitro maturation of porcine COCs" doc
... Although the lower level of these gene expressions resulting from the addition of U0126 was not overcome by the addition of EGF, the addition of EGF to H89- or SB203580-containning medium overcame the ... suppressed the GVBD rate, whereas the addition of EGF did not overcome the negative effects The culture of COCs with FSH and LH for 40 h induced the full expansion of COCs (Figure 5) The expansion was ... One role is the induction of EGF-like factor and TACE/ADAM17 expression The other is direct induction of cumulus expansion of porcine COCs In granulosa cell specific Erk1/2 knockout mice, the cumulus...
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Báo cáo hóa học: "Recovery and Visualization of 3D Structure of Chromosomes from Tomographic Reconstruction Images" potx
... 253 Intensity Histogram (d) Histogram of slice 35 Figure 2: (a) Slice is one of the earlier slices of the CT scan images with a unimodal histogram distribution of intensity (c) The histogram for ... with the highest peakiness [21] The peakiness is min(H(i), H( j))/H(k), where i and j are the intensity values of the neighboring local maxima and H(x) is the histogram value at the intensity of ... Overview The objective of this step is to refine and correct the contour of the chromosome regions in each 2D slice of the volume data recovered after segmentation and noise removal This Sabarish Babu...
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Báo cáo khoa học: " Biological impact of geometric uncertainties: what margin is needed for intra-hepatic tumors" ppsx
... increase the number of analyzed plans in this study consisting of smaller extents of motion The trajectories of the movements were also plotted as a motion distribution of fp(r) where r is the displacement ... point p; ζ is the period; A is the motion amplitude; t is the beam-on-time, and to is the initial phase In the calculation of the convolution, the specific patient motion trajectory distribution ... motion impact is outside the scope of this study, too These are issues warrant further study The radiation sensitivity of the cell type has a strong influence on the sensitivity of the target to...
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Báo cáo y học: " Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: a randomized controlled trial" potx
... analysis to examine the effects of enrollment characteristics on the ventilator-free days among survivors at day 28 The magnitude of the treatment effect of heparin was similar regardless of whether ... influenza, aspiration, exacerbation of chronic obstructive airway disease, or other acute lung disorder Statistical analysis On the basis of previous data from a trial of intravenous heparin to limit ... Laboratory of Experimental Intensive Care and Anesthesiology, The Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands 3Division of Respiratory Therapy, School of Health Professions,...
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TRANSCRIPTIONAL REGULATION OF ATF4 IS CRITICAL FOR CONTROLLING THE INTEGRATED STRESS RESPONSE DURING eIF2 PHOSPHORYLATION
... factors in the ISR .23 15 Differential regulation of the ISR .24 16 The role of the ISR in determining cellular fate following stress .27 17 Dysregulation of the ISR can lead to diseases ... 88) The C-terminal bZIP domain is conserved in each of the isoforms, but the LAP/ LAP* contain an N-terminal trans-activation domain, which is missing in the short LIP isoform (Figure 6A) The ... translation of the BCL-XL mRNA (102) Therefore, the stress context for induction of the ISR can not only change the induction of key regulatory factors in the ISR, but also the mechanistic roles...
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The small GTPASE ARF like protein 1 (ARL1) is a new regulator of golgi structure and function
... ring is partly recognized by the G-4 box, NKXD The G-5 box, (T/G)(C/S)A, enforces the interaction of GTPase with the guanine ring Comparison of the structure of the GTP form (active) to that of the ... βphosphates of the guanine nucleotide The G-2 box contains a conserved Thr residue involved in the coordination of Mg2+ The G-3 box, DXXGQ, is responsible for binding of the γ-phosphate of GTP The guanine ... mammalian cells, are still unknown The lack of studies of Arl1 is in stark contrast to the extensive work conducted on ARFs This thesis describes the characterization of Arl1 and its effectors, especially...
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ON THE DETERMINANTS OF CAPITAL STRUCTURE: AN EMPIRICAL STUDY OF VIETNAMESE LISTED FIRMS
... this section will be the trade-off theory, the agency cost theory and the pecking-order theory 2.2.1 THE TRADE-OFF THEORY The trade-off theory explains firms’ choice of leverage by a trade-off ... assets The capital structure decision is one of the most important decisions made by financial management The capital structure decision is at the center of many other decisions in the area of corporate ... because of the collapse of the stock market in Vietnam The following is an analysis of the components of the capital structure of Vietnam enterprises in the industries represented in the Vietnam...
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ON THE DETERMINANTS OF CAPITAL STRUCTURE: AN EMPIRICAL STUDY OF VIETNAMESE LISTED FIRMS
... company on a daily basis The other type of representative is chosen externally and is considered to be independent from the company The role of the board is to monitor the managers of a corporation, ... to maintain the smooth operation of the firm, with the assistance of senior management Often, the CEO will also be designated as the company's president and therefore also be one of the inside ... mechanism in the governance of modern corporations Fama and Jensen (1983) view the board as the apex of the internal decision control systems of organizations To date, the often-researched mechanism...
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CRITICAL THINKING IS CRITICAL
... substituted for the real letters For example, the code letter R is the real letter O; the code letter N is the real letter L; and the code letter O is the real letter C Substitute the appropriate ... Funny People The Home of the Bears, Cubs, Black Hawks, and White Sox That Which One Imagines at the Place Where the Aria Is Performed The Quite Pleasant Aroma of Winning Absence of Life’s Body ... Zindel The Pigman William Shakespeare The Merchant of Venice 10 Anne Frank The Diary of a Young Girl 11 S E Hinton The Outsiders 12 J D Salinger Catcher in the Rye 13 Jack London The Call of the...
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Tài liệu Chapter 2: Indicators of Financial Structure, Development, and Soundness ppt
... reinforced or offset by a strengthening of the other In particular, capital account crises typically occur because of a sudden loss of confidence in the soundness of the balance sheets of one of the countries’ ... sector If one is to determine the exposure of the banking sector to the real estate sector, it is important to have information on the size of the credit exposure and the riskiness of the exposure ... on the degree of access to financial savings The ratio of private sector bank credit to GDP is a common measure of the provision of credit to the economy, as well as of banking depth Often, this...
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Tài liệu What it is and How to Prepare pdf
... Controlling the Spread of the Flu It may take six months or longer to make a vaccine for pandemic flu The supply of vaccine will be small in the early stages of a pandemic We not know if the medicines ... home in case you cannot be there or you become ill A local and an out of town emergency contact Health information for each member of the family including the date of birth, blood type, allergies, ... mouth The flu often spreads this way • Cover your mouth and nose with a tissue when you cough or sneeze Throw the tissue away and wash your hands If you not have a tissue, cough or sneeze into...
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an economic analysis of financial structure
... Structure III The financial system is among the most heavily regulated sectors of the economy Only large, well-established corporations have easy access to securities markets to finance their activities ... Problem • George Akerlof, The Market for Lemons, QJE (1970) • If quality cannot be assessed, the buyer is willing to pay at most a price that reflects the average quality • Sellers of good quality ... control of the firm – Managers pursue personal benefits and power rather than the profitability of the firm Tools to Solve the Principal-Agent Problem • Monitoring (Costly State Verification)...
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