fallacies or being forceful but not cheating at argument
Báo cáo khoa học: Protein crystallography for non-crystallographers, or how to get the best (but not more) from published macromolecular structures potx
... R-factor may decrease), indicating over-interpretation of the data This is because the superfluous parameters tend to model the random errors of the working data set, which are not correlated with ... so heavily based on calculations that data are not easy to fake Perhaps the best known case of that sort was a discovery that the published diffraction patterns attributed to valyl tRNA were actually ... way Unfortunately, PDB files not contain any information about the procedures that were used for metal assignment and refinement, and even the relevant papers often relegate this information to...
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Social capital and Health status: a protective impact among elderly or inactive but not among active ? doc
... distribution of professional status is however quite homogenous between both populations 10 Migratory status To build migratory status, we use information relating to the nationality and the country ... occupations Administrative employee Business employee Skilled worker No occupation To have autonomy at work To have no autonomy at work Not applicable Occupational Status : In employment Non-working ... to report a good health status among both active and inactive populations Individuals who report not having autonomy at work are more likely to have a poorest health status among both populations...
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Báo cáo y học: " High sensitivity C-reactive protein is associated with lower tibial cartilage volume but not lower patella cartilage volume in healthy women at mid-life" pdf
... 15 Authors' contributions FH was responsible for data collection and analysis and interpretation of the data RB was responsible for analysis and interpretation of the data AW performed data analysis ... illness, women were asked not to attend for their blood test on a day they were not well Another limitation to our study is that the cross-sectional design does not provide information regarding the ... to 18 months later This observation was true whether or not the analysis was controlled for BMI This observation did not hold true for the patella compartment Although BMI is a major determinant...
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Báo cáo y học: "CCR5 signalling, but not DARC or D6 regulatory, chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway" pdf
... that U83A exercises a complex and thorough control of CCR5 signalling receptor activity, while bypassing clearance by D6 or DARC regulatory receptors (Table Page of 12 (page number not for citation ... model system to compare to regulatory receptors In order to investigate U83A activities on regulatory receptors and to compare them to those on signalling receptors, U83A binding competition was ... show that not only U83A delays the internalisation but it also hijacks CCR5 receptors to caveolin rich membrane domains, implicating diversion toward different internalisation or signalling pathways...
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Báo cáo y học: " A Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus" pptx
... fixed at room temperature with ml of phosphate-buffered saline (PBS) containing 1% formaldehyde and 0.2% glutaraldehyde for The cells were washed four times with PBS and incubated for 50 at 37°C ... sterilized water Half of the DNA was mixed with formamide-dye mixture and heated at 95°C for two minutes in a water bath The purified products were run on 6% polyacrylamide sequencing gel electrophoresis ... RCs calculated by antigen p24 or RT activity determinations The observed attenuated phenotype of viruses containing point mutations K65R and L74V was in agreement with previous documentations [7,12,15]...
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Báo cáo y học: "Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk – A Meta-Analysis"
... now clear that disruption of p53 pathway, such as through inactivating p53 mutations, is associated with the formation and progression of malignancies For example, it has been shown that >50% of ... important form in the esophagus.[35] It can eliminate DNA oxidative products of thymidine or uracil propenal.[36] The 105Val form shows altered affinity and enzymatic activity for some substrates.[37-39] ... are morphologically wild-type, the Pro/Pro genotype is less effective in suppressing cellular transformation.[15] Several studies have reported that the p53 codon 72 polymorphism may be associated...
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Báo cáo y học: "TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders"
... neither correlate to either platelet counts, TPO or sIL-6R concentrations at that time, nor to changes between time points and months for the latter three variables Discussion We report here that serum ... investigators At this time no clear explanation for the discrepancies of results can be offered Material and Methods Patients 60 patients with a diagnosis of myeloproliferative disease were treated ... purpura patients respond to therapy with raised platelet counts However, this hypothesis is not supported fully by the lack of correlation between the changes for platelet counts and TPO concentrations...
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Five stories that are almost true, but not quite
... happy with my work I am not famous but I have independence I cannot create some of the more daring clothes that I would perhaps have been able to create in Europe but what I is appreciated and it ... the latest gossip or scandal, ridicule this and that and laugh heartily together The theory that opposites attract, did not hold in their case They were, in fact, so attuned to one another that ... was for the few Mainly tourists, foreigners, novelists and the native moneyed class Not much romance for the lower classes; servants, workers, farm laborers and villagers living in squalor and...
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Tài liệu Báo cáo khoa học:Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau ppt
... incubated with the appropriate fluorophore-conjugated goat secondary antibody (IRDye800 goat anti-rabbit; Rockland, Gilbertsville, PA, USA or Alexa Fluor 680 goat anti-mouse; Invitrogen) for h at ... presented here suggest that tyrosine phosphorylation mediates the association of tau with Fyn-SH2, but not with Fyn-SH3 This demonstrates that different molecular mechanisms exist for these two distinct ... amounts of protein were incubated with GST, GST– Fyn-SH2 or GST–Fyn-SH3 beads for h at °C with rotation The beads were pelleted by centrifugation at 500 g for at °C, the supernatant was discarded, and...
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Tài liệu Báo cáo khoa học: Dual P2Y12 receptor signaling in thrombin-stimulated platelets – involvement of phosphoinositide 3-kinase b but not c isoform in Ca2+ mobilization and procoagulant activity pdf
... Akt activation In platelets that were stimulated with thrombin alone or in combination with ADP, Akt was phosphorylated at its activation site of Ser473, peaking after 5–10 This phosphorylation ... phosphorylation and activation is completely dependent on autocrine-produced or externally-added ADP via stimulation of the P2Y12 and PI3-Kß pathway These results not only show that the regulatory ... thrombin-stimulated platelets mediates thrombin generation, this indicates that P2Y12 signaling via PI3-Kb plays a regulating role in the positive feedback loop of thrombin-induced platelet activation, platelet...
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Tài liệu Báo cáo khoa học: Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process docx
... An attractive hypothesis is that Rac1 ubiquitination depends on a similar regulatory mechanism, but confirmation of this must await the identification of Rac1 E3 ligase To date, the only candidate ... and therefore not support this hypothesis Except for a recent report on the role of proteasome-mediated degradation of Rac1–GTP in hepatocyte growth factor-induced epithelial cell scattering, ... nucleotide exchange factors [34]; these structural data therefore support our results showing that the K147R mutation is conservative with respect to Rac1–GTP conformation and molecular interactions...
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Cytoskeleton reorganization mediates alpha beta integrin-associated actions of laminin on proliferation and survival, but not on steroidogenesis of ovine granulosa cells pdf
... above (see isolation of GC), or prepared for western immunoblotting For studies of ERK1/2 phosporylation, GC were cultured on LN or plastic, with and without inhibitors, for 24 h before western ... incubated for h at room temperature with 20 mM Tris-buffered saline (TBS, pH 7.6), containing 3% BSA and 0.1% Tween-20 to saturate nonspecific sites They were then incubated for h at room temperature ... gonadotropins and numerous paracrine factors that are critically involved in determining the fate of follicles, atresia or ovulation From the primordial to the preovulatory follicular stage, the outer...
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Blackwell Science, Ltd Group breeding dramatically increases reproductive success of yearling but not older female scrubwrens: a model for cooperatively breeding birds? ppt
... are poor at detecting or identifying potential predators, then they would benefit from being warned by others that a predator is near By contrast, an older female would not benefit by being informed ... ‘worse’ and ‘better’ conditions for breeding Worse conditions for breeding Measure of breeding performance Bicolored wren Poor & average vs most productive territories Depredation vs predator ... the date of failure or fledging of the final attempt, but females were excluded that died before they had the opportunity to lay again that season It was assumed that females had had the opportunity...
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Dangerous But Not Omnipotent pptx
... and pragmatism in Iran’s policy formulation Our exploration of Iranian strategic thinking revealed See The 9/11 Commission Report: Final Report of the National Commission on Terrorist Attacks ... of Foreign Affairs MOIS Ministry of Intelligence and Security NATO North Atlantic Treaty Organization NAVCENT U.S Naval Forces Central Command OIC Organization of the Islamic Conference OIR Organization ... United States—Foreign relations—Iran Iran—Foreign relations—United States Iran—Politics and government—1997– Iran—Military policy Political culture—Iran State-sponsored terrorism—Iran Terrorism—...
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Báo cáo khoa học: H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae An experimental and theoretical approach pot
... phosphorylation/transformation of substrates with participation of ATP in the reverse direction (E8r): ADP ỵ X-P $ ATP ỵ X where X and X-P represent a pool of unphosphorylated and phosphorylated unspecied substrates, ... study from our laboratory [3] In that work, the metabolic pathways of AMP, GMP, IMP and XMP catalyzed by rat brain cytosol were explored using two complementary (experimental and theoretical) approaches ... disappearance of ATP or appearance of Ino were observed Theoretical approach mathematical simulation of some metabolic pathways related to adenine nucleotide metabolism This was a theoretical approach...
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CONFLICT OR CONSENT? THE PLAM OIL SECTOR AT A CROSSROADS pdf
... international laws ratified by Liberia remain binding on the state whether they have been incorporated into national law or not Relevant international legal instruments formally incorporated into ... gathering crayfish, for growing seasonal crops of rice and maize, and for gathering rattan and roofing materials It was reported that before the clearing by Sime Darby, bush-meat from the forested ... states that Any decision, agreement, or activity affecting the status or use of community forest resources shall not proceed without the prior, free, informed consent of said community’.14 Forest...
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Báo cáo Y học: Ruk is ubiquitinated but not degraded by the proteasome ppt
... were incubated for the time indicated with various inhibitors or with vehicle alone [Final concentrations: 50 lM for ALLN, 50 lM for Lactacystin (Lacta), 20 mM for NH4Cl and 200 lM for chloroquine ... 2-glycero-phosphate, mM sodium pyrophosphate, mM vanadate, 10% glycerol, mM phenylmethanesulfonyl fluoride and a cocktail of protease inhibitors (Roche) at °C for 20 Lysates were cleared by centrifugation for ... proteasome or lysosome pathways DISCUSSION Ubiquitination is now recognized as a regulatory protein modification whose functional significance is comparable to that of phosphorylation Degradation of...
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Báo cáo khoa học: Amyloid structure – one but not the same: the many levels of fibrillar polymorphism potx
... demonstrate that the fibrils consist of two or more protofilaments that twist regularly We speculate that the twists may be necessary for fibrils to send out branches or that cavities created on ... structural anchoring material for a range of purposes ranging from biofilm formation to a matrix to anchor melanin as well as for the reduction of interfacial tension, coating of spores and many ... inconsistent with type A being a structural prerequisite for the formation of type Bunagitated fibrils, but consistent with the quantitative cross-seeding data [44] that suggests type Bunagitated fibrils are...
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Báo cáo khoa học: Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation pot
... and that insulin promoted amylin fibril formation after long-term incubation These results indicate that insulin may be not only a natural inhibitor of amylin aggregation, but also a contributor ... formation after incubation for a longer time Moreover, our results show that insulin facilitated amylin fibril formation by copolymerization with amylin It was also notable that the promotional ... of ThT fluorescence Intensity of light scattering 600 features as the light scattering assay The data show that insulin obviously inhibited amylin aggregation after short-term incubation (Figs...
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Báo cáo khoa học: Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart potx
... high-power waterbath sonicator ‘Bioruptor’ (Diagenode, Liege, Belgium) or the traditional probe sonicator (Bandelin, Berlin, Germany) Unlike the latter, ‘Bioruptor’ does not require contact between ... and the supernatant of the sonicated mitochondria ‘Bioruptor’ sonication was performed by repeated sonication cycles of 0.5 sonication at high power followed by a 1.5 pause Supernatant was collected ... are half-saturated with 2-oxoglutarate at 0.2 mm [37–39], OGDHC from brain requires higher concentrations for full saturation (Km,2 = 0.40 ± 0.06 mm), being sensitive to lower concentrations of...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn đặc tuyến hiệu suất h fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25