experiments in vitro a change of conception
Báo cáo y học: "The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study" pdf
... (5'-GTCCCTGTTCGGGCGCCAC), D25 (5'-CTGAGACAACATCTGCTGAGGTAGG), and D26 (5'-CTGAGACAACATCTG CTGAGGTA GGA), and templates D3 6A (3'-CGAAAGTCCAGGGA CA AGCCCGCGGTG TGTATCTCT), D36C (3'-CGAAAGTC- Page of 16 (page number ... were calculated using Sigma Plot 9.0 (Systat Software, San Jose, California, USA) Drug combination data analysis Median-effect analysis The degrees of synergy and antagonism were determined using ... carried out a portion of the biochemical assays FM and DG carried out the cell-based drug combination assays KLW and ESS participated in the study design, data analysis, and manuscript preparation...
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Báo cáo khoa học: A pH-dependent conformational change in EspA, a component of the Escherichia coli O157:H7 type III secretion system potx
... Ishii K, Yokoyama K, Han CG, Ohtsubo E, Nakayama K, Murata T, Tanaka M, Tobe T, Iida T, Takami H, Honda T, Sasakawa C, Ogasawara N, Yasunaga T, Kuhara S, Shiba T, Hattori M & Shinagawa H (2001) ... pedestal formation Cell Microbiol 3, 745–751 Vlademir VC, Takahashi A, Yanagihara I, Akeda Y, Imura K, Kodama T, Kono G, Sato Y, Iida T & Honda T (2002) Cortactin is necessary for F-actin accumulation ... pH-Dependent EspA conformational change molecules, which assemble to form flagella filaments [20] The EspA-containing filamentous apparatus may form a conduit for translocation of bacterial proteins into host...
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báo cáo hóa học:" The effect of abductor muscle and anterior-posterior hip contact load simulation on the in-vitro primary stability of a cementless hip stem" ppt
... Vancouver, Canada, 4Department of Mechanical and Aerospace Engineering, Carleton University, Ottawa, Canada and 5Department of Mechanical Engineering, University of British Columbia, Vancouver, Canada ... significantly affect implant motion, and increasing the Fap to 0.6 BW only gave a significant increase in translational migration in the lateral and distal directions Park et al Journal of Orthopaedic ... resolution was smaller than 0.7 μm in all translational directions, and smaller than 0.001° in rotation The accuracy of the system in measuring translation was evaluated against a micrometer...
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Báo cáo y học: "In vitro bactericidal activities of Japanese rice-fluid against Helicobacter pylori strains"
... observed against other four strains of E coli, five strains of S aureus, S epidermidis, E faecalis and P aeruginosa, and three strains of K pneumoniae and two strains of K oxytoca, respectively (data ... bacterial species were also determined in almost the same manner as in the case of H pylori strains described above Heart Infusion agar plates (Eiken Chemical Co., Osaka, Japan) were used instead of ... saline solution, 100μl of each sample was plated onto Sheep Blood agar plates Appearing colonies were counted after days of incubation at 37°C in a microaerophilic atmosphere The remaining bacterial...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 17)
... transformation in rats J Pharm Sci 74:780–782 10) Kielbasa WB, Bauer JA, Fung HL (1999) Analysis of isobutyl nitrite inhalant in rat and human blood: application for pharmacokinetic investigations J Chromatogr ... concentration of an alkyl nitrite on the horizontal axis and peak area on the vertical axis The concentration of the analyte in a specimen is calculated using the calibration curve i Assessment and some ... on a Type-D aluminum block heater (ReactiTherm TM, Pierce, Rockford, IL, USA) to gain an equilibrium iii A 0.5-mL volume of the headspace vapor in the vial is drawn into a glass tuberculin syringe...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 67)
... GC/MS analysis for EMPA in serum (a) a TIC and mass chromatograms; (b) an EI mass spectrum of the t-BDMS derivative of EMPA; (c) a CI mass spectrum of the same derivative of EMPA data of animals According ... GC/MS analysis for DAEMS in serum (a) a total ion chromatogram (TIC) and a mass chromatogram; (b) an EI mass spectrum of DAEMS; (c) a CI mass spectrum of DAEMS Poisoning case, and toxic and fatal ... concentrations of DAEMS are spiked into blank serum specimens containing a fixed amount of DAEMO (IS) each and extracted as described before Since the base peaks of DAEMS and DAEMO (IS) equally appear...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 20)
... Yokoyama M, Okada Y, Suzuki K (1992) Determination of cannabinoids in cannabis oil by capillary gas chromatography Eisei Kagaku 38:471–475 (in Japanese with an English abstract) 5) Watanabe K, Yamaki ... construct a calibration curve with cannabinoid concentration on the horizontal axis and with peak area ratio of a cannabinoid to IS on the vertical axis GC analysis of cannabinoids in plant specimens ... 188 Cannabinoids and their metabolites GC analysis of cannabinoids in plant specimensa Reagents and their preparation • • • Extraction and purification of cannabinoids [3]: Cannabis sativa L is...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 21)
... Qualitative analysis is made by the comparison of the retention time of a peak of a specimen with that of the authentic standard and also by the confirmation of the absence of such a peak in a ... detection of low levels of morphine starting from a large amount of a specimen cannot be a proof of the intake of the drug The level of morphine in urine of healthy subjects determined by GC/MS was ... Main metabolic pathways of morphine, heroin and codeine The thick and thin arrows show the main and minor metabolic pathways, respectively ⊡ Figure 3.1 196 Morphine and its analogues GC and...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 70)
... normal cyanosis headache, dyspnea, tachypnea, tachycardia and hypertension mental derangement, listlessness and metabolic acidosis coma, convulsive attack and hypotension death A poisoning case ... methemoglobinemia for a newborn baby caused by well water Jpn J Pediatr 49:1661–1665 (in Japanese) 4) Saito T, Takeichi S, Osawa M et al (2000) A case of fatal methemoglobinemia of unknown origin but ... construct a calibration curve The peak area ratio of nitrate to IS obtained from a test specimen is applied to the calibration curve to calculate its concentration ii Analysis of nitrite i A 0.2-mL...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 71 and End)
... alminoprofen 325, 330, 332 alprazolam 284, 285, 290 alternative specimens Amanita neoovoidea 480 Amanita pantherina 469 Amanita phalloides 469 Amanita verna 469, 474 Amanita virosa 469, 473 amanitin ... 635 inorganic nitrite 649 inorganic poisons 637 interface 40 International Normalized Ratio 605 intratracheal contents 168 intratracheal gas 161, 162 in vitro interval 218 iodoplatinate reagent ... 137 aldehyde dehydrogenase 123, 137 aldicarb 566 aldrin 529 alkylated adducts 85 alkylated DNAs 85 alkylation 30 alkyl nitrites 153, 655 allobarbital 305, 308 allylesterase 624 allyxycarb 566 alminoprofen...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 22)
... shows mass spectra of the authentic cocaine, EME and BE after derivatization Setting up of cutoff values are very common in USA and Europe as a part of QC (quality control) and QA (quality assurance) ... cocaine was reported to be 5.9 on average for urine sampled 0–1 h after cocaine inhalation; the ratio was 10.6 on average for urine sampled 0–8 h after the inhalation The ratios increased according ... there was a fatal case, in which only 30 mg of cocaine had been applied to mucous membrane of a hypersensitive subject Among habitual abusers of cocaine, there are cases in which as much as g is...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 23)
... concentration in the horizontal axis and peak area ratio of pentazocine to IS in the vertical axis The peak area ratio of a test specimen is applied to the calibration curve to obtain its pentazocine ... plasma by high performance liquid chromatography Pharmazie 46:464–465 8) Seno H, Kumazawa T, Ishii A et al (2000) Determination of pentazocine in human whole blood and urine by gas chromatography/surface ... phencyclidine in human plasma using capillary gas chromatography Method Find Exp Clin Pharmacol 12:193–196 4) Hattori H, Suzuki O, Seno H et al (1993) Sensitive determination of pentazocine in whole...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 24)
... 108–109 (in Japanese) 2) The Pharmaceutical Society of Japan (ed) (1992) Standard Methods of Chemical Analysis in Poisoning – With Commentary – Nanzando, Tokyo, p 43 and p 151 (in Japanese) 3) ... combined chloroform extract is evaporated to dryness; the residue is dissolved in a small amount of methanol to be subjected to further analysis TLC analysis Analytical conditions TLC plate: a ... EI mass spectrum of LSD is shown in > Fig 6.1 The molecular ion appears as the base peak Fragment peaks can be observed at m/z 221, 207, 181 and 167 The fragmentation pathways are shown in >...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 25)
... However, the main metabolic pathway of MDMA in humans is the 233 234 3,4-Methylenedioxyamphetamines ⊡ Figure 7.3 Mass spectra of TFA derivatives of MDA, MDMA, MDEA, MBDB and HMDMA obtained by GC/MS ... urinary MDAs recommended by the Substance Abuse and Mental Health Services Administration (SAMHSA) is 250 ng/mL Symptoms, and toxic and fatal concentrations MDMA causes increased catecholamine ... tachydysrhythmias hypertension intracranial bleeding altered mental status altration in muscle tone/activity automatic instability hyperthermia diarrhea hyponatremia seizures rhabdomyolysis acute...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 26)
... responding verbally; the levels of serum creatinin kinase and aspartate aminotransferase were more than 100-times the normal limits On hospital day 2, he became rigid, diaphoretic and had a temperature ... Levine B et al (2002) Intra- and interindividual variations in urinary concentrations of endogenous gamma-hydroxybutyrate J Anal Toxicol 26:340–346 26) Yeatman DT, Reid K (2003) A study of urinary ... brain [3], and is an agonist of GABAB receptors [4–8] GHB was first synthesized in 1960 and used as an anaesthetic adjuvant or induction agent [9] This application is still in use in Europe In...
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Tài liệu Explaining Ethnic Minority Poverty in Vietnam: a summary of recent trends and current challenges ppt
... in remote areas are less concerned about low interest rates than about being able to obtain a loan Enhancing loan availability, as well as making available a wider range of loan products 15 in ... the cadastral maps of forest land publicly available would also be one important way of promoting greater transparency and accountability • Third, a major coordinated effort in research, training ... people that have…… (%) health insurance health insurance health health or free healthcare health Health or free Regions insurance insurance card insurance insurance healthcare card North East 18...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 27) ppt
... Louis, MO, USA) Pure powder of perazine and clospirazine was donated by Mitsubishi Welpharma, Osaka, Japan; that of flupentixol by Takeda Chem Ind Ltd., Osaka, Japan; that of thioproperazine by Shionogi ... concentration on the horizontal axis and of peak area ratio of a drug to IS on the vertical axis The above peak area ratio obtained from a specimen is applied to the calibration curve to obtain its ... GC/MS At least vials containing various concentrations of a target compound are prepared for a calibration curve Assessment of the method All eleven kinds of phenothiazine drugs gave the base peaks...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 28) pptx
... diphenhydramine was injected into her intravenously; she recovered days after admission For the male baby, similar treatments, such as intravenous injection of mannitol and diphenhydramine, were carried ... of low concentrations of haloperidol in plasma J Chromatogr 431:113–122 8) Hariharan M, Kindt EK, Van Noord T et al (1989) An improved sensitive assay for simultaneous determination of plasma ... haloperidol in total (combined amount for both children); both were brought to a hospital in the comatose state and showed bradycardia, hypotension and sinus arrhythmia Mannitol was injected into...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 29) ppt
... concentrations of tricyclic and tetracyclic antidepressants Compound amitriptyline amoxapine carbamazepine clomipramine desipramine dosulepin imipramine lofepramine maprotiline mianserin nortriptyline ... and tetracyclic antidepressants and carbamazepine obtained by HPLC-UV A: carbamazepine, B: desipramine, C: maprotiline, D: nortriptyline, E: amoxapine, F: setiptiline, G: mianserin, H: imipramine, ... antidepressants Name amitriptyline amoxapine carbamazepine clomipramine desipramine dosulepin imipramine lofepramine [9] maprotiline mianserin nortriptyline setiptiline [5] trimipramine MW 227.18...
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