establishing an animal model of dupuytren s contracture by profiling genes associated with fibrosis
báo cáo hóa học:" Establishment of an animal model of a pasteurized bone graft, with a preliminary analysis of muscle coverage or FGF-2 administration to the graft" potx
... advantages of the method include a precise anatomical fit, and no risk of disease transmission or immunological reaction [4-10] Regardless of such advantages, clinical problems, such as over-absorption ... result was classified as mild absorption, but when the cortex disappeared because of the absorption, the result was classified as severe absorption In accordance with a previous study, we also ... (-1), no change (0), single nodules of bone formation (1) and bridging or lamellar bone formation (2) An assessment of these results was made and agreed upon by AS, TY and NT Tartrate-resistant acid...
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Báo cáo y học: "Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis" pptx
... comparisons Comparisons of nonparametric data from the modified Mankin histological scoring of the stained tissue sections were assessed using the Mann–Whitney U-test Results Histology Lateral meniscectomy ... synthesis of collagens types I and III and a change in the relative levels of the fibrilassociated SLRPs In particular there is decrease in synthesis of decorin and an increase in biglycan and lumican, ... investigation of the specific relationships between growth factors, collagens and the SLRPs in normal and diseased cartilage is warranted R859 Significant proteolysis of the SLRPs was evident in the present...
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Báo cáo y học: "The laminin b1-competing peptide YIGSR induces a hypercontractile, hypoproliferative airway smooth muscle phenotype in an animal model of allergic asthma" potx
... represent means ± SEM from n separate experiments Statistical significance of differences was evaluated using one-way ANOVA, followed by a Newman-Keuls multiple comparisons test Differences were ... increase in ASM mass (by 96 ± 3%, P < 0.001) No significant effect of YIGSR treatment was observed in saline-challenged animals To determine whether the changes in ASM content were associated with ... ovalbumin-challenged animals (n = 7) and YIGSR-treated, ovalbumin-challenged animals (n = 7) Data for the saline-treated animals (controls) have been published previously as part of a simultaneous parallel study...
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Báo cáo y học: " Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury" doc
... fibrosis was semi-quantitatively assessed according to Ashcroft and co-workers[17] Briefly, the grade of lung fibrosis was scored on a scale from to by examining randomly chosen fields of the ... days The results were analyzed by one-way ANOVA followed by a Bonferroni post-hoc test for multiple comparisons A P-value of less than 0.05 was considered significant Statistical analysis for survival ... data was calculated by Fisher 's exact probability test For such analyses, p < 0.05 was considered significant Results Histological examination of lung sections revealed significant tissue damage...
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Báo cáo y học: "Evaluation of long-term antinociceptive properties of stabilized hyaluronic acid preparation (NASHA) in an animal model of repetitive joint pain" doc
... saline and each of the HA preparations The areas used for analyses were the integrals over the time points assessed These were calculated using the mean of respective differences from the baseline ... comparisons For protocols and 3, the measures obtained from different time points were compared between groups using repeated measures analysis of variances (ANOVAs) with the between-subjects factor ... longer-lasting effect of the latter Limitations and advantages The comparison between substances was performed by establishing a dose-response relation for NASHA, and calculating the injection volumes...
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Báo cáo y học: "Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis" pps
... serum specimens were transferred to individual glass tubes, sealed with parafilm and stored at –70°C until radioimmunoassay Male Golden-Syrian hamsters weighing 80–140 g (Harlan Animals, Indianapolis, ... process [30,31] It is also possible that ProCT and its component peptides are released by non-NE cells, which normally possess regulatory mechanisms limiting the expression of ProCT mRNA; these ... promising serum markers for the sepsis syndrome These peptides are released into the central circulation and may act systemically, as opposed to many of the known mediators of sepsis, which are released...
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Báo cáo y học: "Hepatic oxidative stress in an animal model of sleep apnoea: effects of different duration of exposure" potx
... factors [43,44] Oxidative stress plays an important role in various diseases as well as in OSA, which causes an effect similar to ischemia-reperfusion [18] in which there is activation of xanthine ... was observed only in the tissue most susceptible to lesions produced by IH In the alkaline version used, the comet assay detects a broad spectrum of DNA lesions, including single strand breaks ... animals for histological analysis; the rest were frozen -80°C for later biochemical analysis The animals were euthanized by exsanguination under deep anaesthesia [27,28] Nine millilitres of phosphate...
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Báo cáo y học: "Renal hypoperfusion and impaired endothelium-dependent vasodilation in an animal model of VILI: the role of the peroxynitrite-PARP pathwa" ppt
... estimating equations, taking repeated measures in the same animals into account A P value less than 0.05 was considered significant Results Lung injury by LPS and MV The experimental setup is ... Dos Santos CC, Slutsky AS: Invited review: mechanisms of ventilatorinduced lung injury: a perspective J Appl Physiol 2000, 89:1645-1655 Dos Santos CC, Slutsky AS: The contribution of biophysical ... CA, USA) Comparison among groups was performed using Kruskal-Wallis test When an overall P < 0.05, a Dunn 's multiple-comparison post hoc analysis was conducted A P value less than 0.05 was considered...
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An Animal Model of Pediatric Combined Pituitary Hormone Deficiency Disease
... amphibians, the human intermediate lobe appears to be less important as it is sometimes absent in adults, and when present, consists only of a thin layer of cells between the posterior and anterior ... facility, and the sequence analyses and assembly were performed using the DNASIS (Hitachi Software Engineering, San Francisco, CA) software 2.2 Identification of Homologous Recombinants PCR Genomic ... 1.5 Diseases Associated With Mutations Within the LHX3 Gene The human LHX3 gene contains seven coding exons with six introns, and maps to chromosome at 9q34.3 (Sloop, Showalter et al 2000; Sloop,...
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Báo cáo y học: " Induction of IL-10-producing CD4+CD25+ T cells in animal model of collagen-induced arthritis by oral administration of type II collagen" pptx
... deviation Statistical significance was determined by Student s t-test using the SPSS program (version 10.0; SPSS Inc, Chicago, IL, USA) P < 0.05 was considered statistically significant Results Inhibition ... Finally, cells were washed with PBS and analyzed on a FACScalibur flow cytometer (Becton Dickinson, San Jose, CA, USA) Statistical analysis Experimental findings are presented as mean ± standard deviation ... production of IL-10 and TGF-β was assessed by sandwich ELISA analyses of culture supernatants The data represent average values from three independent measurements R217 Arthritis Research & Therapy...
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Báo cáo khoa học: Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade pptx
... experiments demonstrated that uPAR expression is associated with an active ERK and the bikunin expression is necessary for inhibition of uPAR expression possibly through suppression of ERK phosphorylation; ... filter using chemoinvasion chambers Statistical analysis Data are presented as mean ± SD All statistical analysis was performed using STATVIEW for Macintosh The Mann– Whitney U-test was used for ... clones Molecular mass standards are indicated at the left Results are representative of two separate experiments Expression of uPAR in HRA cells is associated with an active ERK1/2 AS we showed...
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Báo cáo y học: "Genetic control of disease in an experimental model for Sjögren’s syndrome Åsa Andersson" potx
... (mycobacterium-induced systemic lupus erythematosus 1) This might suggest shared disease pathways in different models for autoimmune diseases controlled by the same genes within this interval On the basis of potential ... candidate genes from susceptible and resistant mouse strains, speculations on disease mechanisms has to be considered preliminary The re-defined Aec2 locus could most likely be further reduced by a ... locus, important in the homeostasis of lipids, lipoproteins, cholesterols, and fatty acids Secondary effects of impaired lipid homeostasis could result in inflammation and cell death Results from...
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Báo cáo y học: "Genetic control of disease in an experimental model for Sjögren’s syndrome" pdf
... (mycobacterium-induced systemic lupus erythematosus 1) This might suggest shared disease pathways in different models for autoimmune diseases controlled by the same genes within this interval On the basis of potential ... candidate genes from susceptible and resistant mouse strains, speculations on disease mechanisms has to be considered preliminary The re-defined Aec2 locus could most likely be further reduced by a ... locus, important in the homeostasis of lipids, lipoproteins, cholesterols, and fatty acids Secondary effects of impaired lipid homeostasis could result in inflammation and cell death Results from...
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báo cáo khoa học: "Computing genetic evaluations through application of generalized least squares to an animal model" pot
... necessary variances and covariances for recursive prediction II The animal model The animal model is demonstrated here for - each animal has - each animal with a a single record on one a simple situation ... vector of additive genetic effects (breeding values) of animals with records in y,, random with mean zero and variance A and a;, l i e is the vector of residuals, random with mean zero and variance ... and scaling of variables can lessen problems due to loss of accuracy If X is an incidence matrix with no regressors each method produce solutions of equal accuracy Ranking animals for the purpose...
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Báo cáo y học: " Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy" pptx
... those of previous susceptibility studies using wild-type HIV-1 and HIV-2 [25,30] and is supported by similar assays conducted in the present study using HIV-1 and HIV-2 as positive controls for ... infection was assessed as previously described [57] Briefly, clusters were disrupted by pipetting; and, after h of incubation at 37°C, the formation of new clusters was assessed by light microscopy ... primate studies Animals and drug treatments The Indian Rhesus macaques used in this study were housed at BIOQUAL, Inc Rockville, MD, according to standards and guidelines as set forth in the Animal...
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Báo cáo sinh học: " Fuzzy classification of phantom parent groups in an animal model" pptx
... percentage of animals classified in the correct decile was determined for animals with and without simulated uncertainty and for animals with both parents known Fuzzy classification for parsimonious modelling ... fuzzy) and definition of genetic groups (on the basis of Table 3: Percentage of animals correctly classified in deciles created on the basis of ranking on true breeding values Group of animals Distinct ... model with groups and relationships J Dairy Sci 1988, 71:1338-1345 Strandberg E, Grandinson K: Adjusting for seasonal effects in an animal model using fuzzy classification Proceedings of the...
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Báo cáo sinh học: "Univariate and multivariate parameter estimates for milk production traits using an animal model. I. Description and results of REML analyses" pptx
... Thompson and Hill s suggestion, the initial transformation matrix was chosen so that p traits and sums of traits were analysed Subsequently, afterq = univariate analyses, a canonical transformation ... and that variances were constant across lactations A permanent environmental effect was fitted as an additional random effect for these analyses Comparing results from these analyses with results ... different samples and their contribution to the parameter estimates in each sample For analyses 1) and 2) data were split into subsets of 20 herds each, for analyses 3) into 5, and subsets (for L L and...
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Báo cáo sinh học: "Univariate and multivariate parameter estimates for milk production traits using an animal model. II. Efficiency of selection when using simplified covariance structures" docx
... (index) sources of the cow s sire and dam and the cow s own records reduction in response to selection is expected when selection is across age classes, eg across cohorts with different amounts of ... thorough study of long-term losses in response through incorrect estimation of genetic trend, thus creating an suboptimal ranking of young vs old animals, was outside the scope of this study.) ... combinations of the observations using economic values as weights For the case of just using observations for M F and P this is not I , i surprising, since these traits were so highly correlated and...
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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx
... a GSTp polymorphism is associated with PD in a Drosophila model expressing mutant parkin [35] Moreover, its expression is responsible for nigral neuron sensitivity in an experimental model of ... method [47], scanned with an Epson Perfection V750 Pro transmission scanner (Epson, Nagano, Japan) and analyzed with imagemaster 2d platinum software, version 5.0 (GE Healthcare) Spots were detected ... The membrane was incubated with mouse anti-a-synuclein (BD Transduction Laboratories, Franklin Lakes, NJ, USA), mouse antiHSP70 (Zymed Laboratories, San Francisco, CA, USA) or mouse anti-b-actin...
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An Equilibrium Model of Rare-Event Premia and Its Implication for Option Smirks potx
... This is consistent with our general discussion in Section D.3 For the purpose of option pricing, let us consider a stock that has the same set of risk exposures as the endowment shock and pays ... a sequence of securities that are increasingly sensitive to rare events At the same time, the model with only risk aversion misprices this sequence of securities with increasing proportion As ... References Andersen, P K., O Borgan, R Gill, and N Keiding, 1992, Statistical Models Based on Counting Processes, Springer-Verlag, New York Anderson, E., L Hansen, and T Sargent, 2000, ‘‘Robustness,...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ chỉ tiêu chất lượng 9 tr 25