... respect to the mechanism by which the binding ofthe ligand to a segregated site transmits the conformational change to the rest ofthe LBDs to trigger the rotation Furthermore, the extent ofthe applicability ... mediate the transmission ofthe conformational change through the 'top' ofthe LBD, which may then transmit through the rest ofthe structure The charge interactions between the acidic residue in the ... chain on either side from the ligandbinding box to the surface ofthe 'inner sheet' at the top ofthe LBD [9,28] It is likely that these residues form a conduit for the propagation ofthe conformational...
... Book of Abstracts ofthe 63rd Annual Meeting ofthe European Federation ofAnimal Science EAAP - European Federation ofAnimal Science The European Federation ofAnimal Science wishes ... presentation of material in this publication not imply the expression of any opinion whatsoever on the part ofthe European Federation ofAnimal Science concerning the legal status of any country, ... important scientiic meetings of professionals working in the area ofanimal production One ofthe main objectives ofthe meeting is to focus on sustainability and eiciency ofthe livestock sector Programme...
... eVect ofthe communication act is the making of a mental representation If that is the case, then the eVect of one of these monkeys giving the call usually associated with the presence of a leopard ... traversed on the frames of wax represents a distance of several tens or even hundreds of metres outside the hive; the vertical direction represents the direction ofthe sun; the direction ofthe central ... of Xight, performed outside the hive When the dance is done in the darkness ofthe hive, the replacement ofthe angle ofthe sun by the bee’s alignment, vertical rather than horizontal, say, or...
... the meaning ofthe symptoms: what they signify, what they represent, and, most of all, why they are happening to them A diagnosis of depression on its own does not explain the why, offers no interpretation ... proportion ofthe test period As with the Tail Test, the simplest interpretation oftheanimal s immobility is that the mood system rapidly down regulates effort to conserve energy in the face of an ... diseases and are not part of normal variation By the tenets ofthe disease model, the symptoms of depression must reflect abnormal functioning The problem is that the architects ofthe DSM system were...
... example, in the small intestine, Tcf4 is required for the rapid proliferation ofthe embryonic intervillus epithelium that gives rise to the crypts [7] These contain the stem cells ofthe adult ... cells, the various subsets of secretory Clara cells, and the pulmonary neuroendocrine cells) The epithelium ofthe smaller, peripheral tubes that appear towards the end of gestation gives rise to the ... groups of cells scattered throughout the epithelium This pattern is reminiscent ofthe distribution of Paneth cells in transgenic intestines, in which the spatial segregation ofthe crypt from the...
... at the surface of a cell, it blocks degradation ofthe co-factor -catenin and frees it to interact with the transcription factors ofthe TCF/LEF family, thereby triggering the transcription of ... signals from the Wnt receptor at the cell surface into the nucleus, where it switches on the activity of new genes http://jbiol.com/content/3/3/9 via the action of transcription factors ofthe TCF/LEF ... types appear in parts ofthe body where they don’t normally belong, and which can lead to cancer (see the ‘Behind the scenes’ box for more ofthe rationale for the work) In the bladder, for example,...
... amount of data and type of prior, i.e the more data are available the less are the estimates of responses influenced by the choice of priors And similarly for the variances ofthe estimate, they ... number of generations, and the main interest is to evaluate the effect of selection on the means ofthe selected populations On the other hand, long-term selection experiments with laboratory animals ... decreasing function ofthe degree of overlap between generations, or ofthe degree of connectedness ofthe data Obviously, when generations not overlap the situation is that of design 1, with no...
... government These deals are intended to improve the welfare ofthe members of those coalitions and ofthe group in control ofthe government, not of society at large Because the economic incentives ofthe ... minimize the public visibility ofthe costs of bailouts and the allocation ofthe losses The existence of a system of deposit insurance, ironically, generates incentives for the parties in control of ... with other players that have an interest in the organization ofthe banking system? What are the terms of exchange among the members of these coalitions? Are there differences in the way the game...
... The gist of their response was that, while they had their finger on the pulse and their eye on the data, they had made two related diagnostic mistakes: the error of extrapolation and the (rather ... characteristic ofthe global political economy was the reversal ofthe flow of trade and capital surpluses between the United States and the rest ofthe world The hegemon, for the first time ... they were by no means in the majority) saw their labour diverted from the farms to the workshops and the factories There, separated from the countryside of their ancestors by the tall walls of...
... Part ofthe decomposition above 700°C (not shown on the graph) was attributed to the calcium carbonate ofthe sample, the content of which was about 45% in ash Therefore, the DTG peaks ofthe ... cj is the fraction of combustibles in component j, aj(t) is the reacted fraction of component j in time t and m∞ is the normalized amount ofthe solid residues (minerals) at the end ofthe experiment ... Ej is the activation energy of component j, g expresses the effect of ambient gas composition and f describes the change of surface reactivity as a function ofthe fractional burn off: As the function...
... legs and the widest part ofthe trunk Then draw the curved shapes ofthe tusks on either side ofthe base ofthe trunk Step Three Now, using the basic shapes as a guide, draw the outline ofthe elephant's ... length as the distance from the top ofthe head to the base ofthe body Step Two Now refine the outlines and begin marking the placement ofthe major feathers on the body Then start developing the ... shading the dark areas ofthe fur with the broad side ofthe pencil Use straight strokes that follow the direction of hair growth, radiating from the center ofthe face and chest Next shade in the...
... for the roof height Using the vanishing point, draw a line for the angle ofthe roof ridge; then draw the back ofthe roof The angled roof lines will meet at a third VP somewhere in the sky BASIC ... shape ofthe blocking object Here is a simple example ofthe way to plot the correct shape and length of a shadow for the shape and the height ofthe light Front view (foreshortened) If the light ... filling in the negative spaces around the slats Don't draw the slats—instead draw the shapes surrounding them and then fill in the shapes with the side of a soft lead pencil Once you establish the shape...
... view The tree shapes on the left and the right lean slightly toward the center, drawing the eye into the middle ofthe composition In the example to the right, notice how the elements direct the ... leaves on each tree First sketch the trunk, and then draw the general shape ofthe whole group of leaves before shading the foliage Use the side ofthe pencil lead for the basic layout sketches American ... depth is obvious in the line drawing to the left; the road narrows as it travels back into the distance, and the hills overlap each other To offset the slanting curves ofthe hills and foliage,...
... ofthe head to the eyes, from the eyes to thethe nose, and from the nose to the chin, took at where the mouth falls between the nose and the chin and where the ears align with the eyes and the ... interesting features are a lot of fun to draw from the side, where you can really see the shape ofthe brow, the outline ofthe nose, and the form ofthe lips Drawing the Profile Some people have very ... other The tips ofthe fingers fall at the first line, the second knuckle at the middle line, and the first knuckle at the last one The third knuckle falls halfway between the finger tips and the...
... stage of your drawing Blending the Cast Shadows As shown in the closeup above, the cast shadow needs the smoothest blending Position the shadows using the side of an HB pencil; then blend softly ... "section," using the stroke and lift technique; begin at the edge, stroke toward the middle, and lift the pencil at the end ofthe stroke Finally shade the cast shadow smoother and darker than the fruit ... from the white ofthe paper (See page 13 for more on negative space.) 28 Establishing Detail Draw the shapes ofthe spiked scales, which change in size from one end ofthe cone to the other In...