epigenetic mechanisms in lung inflammation and chronic airway diseases and intervention by dietary polyphenols
Báo cáo y học: "Role of CD14 in lung inflammation and infection" pptx
... binding of rough LPS and binding of SP-C to CD14 augmented binding of smooth LPS [15], whereas binding of SP-A to CD14 reduced binding of smooth LPS and binding of SP-D to CD14 decreased binding ... nucleotide-binding oligomerization domain containing (Nod)2 and Nod1, respectively [19] Ligand binding to these receptors triggers interaction with the receptor-interacting protein kinase, RIP2, ... `neutralization’ in lung inflammation and lung infection Inciting ligand/pathogen Animal model* Effect of CD14 `neutralization’ in the lung* * Ref LPS (E coli +LBP) rabbit αCD14 neutrophil influx, cytokines...
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Báo cáo hóa học: "Epigenetic change in E-Cardherin and COX-2 to predict chronic periodontitis" pptx
... colorectal carcinoma and breast cancer [8] E-Cadherin and COX-2 expression are useful tools in diagnosing and treating cancer However, they are also indicators of chronic inflammatory diseases such ... E-Cadherin and COX-2 were studied in this investigation, a wide variety of other epigenetic changes may be factors involved in the progression of chronic inflammation diseases like periodontitis, and ... into the tube and the sample tissue was continually homogenized with grinding 20 μl of Proteinase K (10 mg/ml) was added to the sample mixture and mixed by vortexing The sample was lysed by incubation...
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Báo cáo y học: "Endogenous and exogenous stem cells: a role in lung repair and use in airway tissue engineering and transplantation" pdf
... hyperoxia-induced lung injury in neonatal rats [32] and reduced fibrosis in the bleomycin-induced mouse model of lung injury through the activation of production of matrix metalloproteinases (MMPs) and inhibition ... (Figure 1) They include structural matrix proteins (collagens, laminin, fibronectin, fibrin, etc.) and molecules modulating cell migration (integrins), cell-cell and cell-substrate interactions ... models of lung diseases and induced airway injury, have yielded the first successful clinical applications in lung repair The need for the introduction of new, efficient, and promising technologies...
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Báo cáo y học: " Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin" potx
... of interleukin-6 in bleomycin-induced lung interleukinbleomycinmice 38(5):566-571 inflammatory changes in mice Am J Respir Cell Mol Biol 2008, 38 34 Cavarra E, Carraro F, Fineschi S, Naldini ... induced by BLM, we comprehensively investigated the differences in the expression of cytokines involving chemokines in the BALF As shown in Fig 4A, the expression of several cytokines and chemokines ... following stimulation by BLM-induced injury, secrete a large quantity of TGF-β1 and thereby induce the lung fibroblasts in the alveolar interstitium to synthesize collagen, resulting in pulmonary fibrosis...
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Báo cáo y học: " Role of pulmonary intravascular macrophages in endotoxin-induced lung inflammation and mortality in a rat model" pot
... polyL-Lysine coated slides and used for hematoxylin and eosin staining and immunostaining Pieces of the left lung were fixed in 2% paraformaldehyde containing 0.1% glutaraldehyde for hours at 4°C and ... following injection in hepatic portal vein [12] We and others have shown that removal of PIMs with gadolinium chloride or clodronate inhibits endotoxin-induced lung inflammation[ 13,14] Interestingly, ... response in BDL rats in the absence or presence of PIMs PIM reduction protects against LPS-induced mortality in BDL rats We delineated role of PIMs by comparing LPS-induced lung inflammation and mortality...
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Báo cáo y học: " Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice" ppt
... cause of increased risk of lung infections in children and adults Smoke exposure is linked in adults to an increased incidence and severity of asthma, impaired lung function and airway inflammation ... shown) and leukocytes Inflammation was more apparent in smoke and influenza mice (F, H) with prominent mucus exudates in the airways At d10 smoke and influenza mice had minor inflammation, but in ... Irving L, Anderson GP: Differential protease, innate immunity, and NF-kappaB induction profiles during lung inflammation induced by subchronic cigarette smoke exposure in mice Am J Physiol Lung...
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Báo cáo y học: " Multiple exposures to swine barn air induce lung inflammation and airway hyper-responsiveness" pptx
... that single and multiple exposures to swine barn air will induce lung inflammation and a decline in lung function The data show that single and multiple exposures cause increase in AHR, inflammatory ... linked to chronic lung inflammation including chronic bronchitis, decline in lung function and higher incidence of asthma [3,11,12] Pig farmers with an average exposure history of 10.5 years and ... in the winter season to conserve heat Conclusion Our data show that, single and multiple exposures to endotoxin rich-swine barn air induce lung inflammation characterized by infiltration of inflammatory...
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Báo cáo y học: " Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin c" ppsx
... Figure and lung damage caused by intratracheal instillation of p-BSQ in guinea pigs and prevention by vitamin C Apoptosis Apoptosis and lung damage caused by intratracheal instillation of p-BSQ in ... N-acetyl cysteine (NAC) on CS-induced protein oxidation in vitro and apoptosis and lung damage in guinea pigs in vivo Effect of N-acetyl cysteine (NAC) on CS-induced protein oxidation in vitro and apoptosis ... AECS in inducing protein oxidation, proteolysis and apoptosis both in vitro and in A549 epithelial cells pBSQ also mimics CS-induced inflammation, apoptosis and lung damage in vivo Tracing to...
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Báo cáo y học: "Acute lung inflammation and ventilator-induced lung injury caused by ATP via the P2Y receptors: an experimental study" pdf
... http://respiratory-research.com/content/9/1/79 Figure Lung inflammation caused by P2Y and P2X selective agonist Lung inflammation caused by P2Y and P2X selective agonist Hematoxilin-eosin staining of the lung 24 h after the instillation ... Figure Induction of expression of inflammatory cytokines by instillation of ATP Induction of expression of inflammatory cytokines by instillation of ATP A Inflammatory cytokine expression in early ... Figure Infiltration of inflammatory cells after instillation of ATP Infiltration of inflammatory cells after instillation of ATP A Hematoxilin-eosin staining of the lung The instillation of ATP increased...
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Báo cáo y học: " Wnt signalling in lung development and diseases" pot
... inflammatory diseases and evidence for Wnt regulated signalling in inflammation in the joint [34], we have addressed the potential involvement of Wnt signalling in inflammatory diseases of the lung troversial ... several acute and chronic stimuli including inflammation caused by infections, autoimmune reactions (asthma, allergic alveolitis), and drugs and toxins (bleomycin, asbestos) or mechanical injury (surgery, ... supported by evidence, while based on indirect evidence a role for Wnt signalling in inflammatory lung diseases can also be postulated Certainly, better understanding of Wnt signalling in the lung...
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Báo cáo y học: " Isolation of human β-defensin-4 in lung tissue and its increase in lower respiratory tract infection" ppt
... cells in normal lung tissues, hBD-4 immunostaining in lung tissue of chronic LRTI was observed in the bronchial lumen as well as in the cytoplasm of epithelial cells Also, IHC and ELF findings ... length of 50 µm in all panels hBD-4 levels in ELF in patients with chronic LRTI Since β-defensins are expressed constitutively or inducibly in response to infection, we measured the ELF and serum concentrations ... patients lining fluid levels of hBD-4 in controls (n = 6) and Epithelialwith chronic lower respiratory tract infection (n = Epithelial lining fluid levels of hBD-4 in controls (n = 6) and patients...
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Báo cáo y học: "Growth factors in lung development and disease: friends or foe?" pptx
... local budding and to maintain proximal airways in an unbranched form by suppressing epithelial cell proliferation and by promoting synthesis of extracellular matrix components around airways [1,2] ... instillation of FGF7 in rats ameliorates radiation-induced and bleomycin-induced lung injury, reduces alveolar damage by hydrochloric acid instillation, and decreases hyperoxia-induced mortality ... in development and disease follows Growth factors in development Growth factors are involved in virtually all aspects of lung development During the initial stages of lung bud morphogenesis and...
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Báo cáo y học: " Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS" pot
... CD8+ T cells, and NK cells, and by increase in cytokines and chemokines This host inflammatory response against SARS-CoV infection may contribute to persistent HRCT abnormalities during recovery ... of an ongoing active inflammatory process in most patients with increased macrophages, NK cells and T cells, and augmented levels of chemokines and pro-inflammatory cytokines These inflammatory ... analyzed using Becton Dickinson BD LYSYS II and Cytometric Bead Array (CBA) software (San Jose, CA) Levels of cytokine and chemokine in BAL fluid The levels of cytokines and chemokines in BAL fluid...
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Báo cáo y học: "Homeostatic mechanisms in dopamine synthesis and release: a mathematical model" pptx
... not include explicitly the effects of the autoreceptors on dopamine release and firing rate Finally, we are focusing on the nerve terminal and on synaptic mechanisms and therefore not include mechanisms, ... Modelling 2009, 6:21 exchange between tyrosine and a tyrosine pool that represents all the other uses and sources of tyrosine in the terminal Tyrosine is converted into L-3,4dihydroxyphenylalanine ... substrate inhibition of tyrosine hydroxylase by tyrosine [23] Substrate inhibition means that tyrosine can bind non-enzymatically to TH preventing TH from performing its function of converting tyrosine...
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Ghosts in english literature and dracula by bram stoker
... 12 or in "Voodoo Island" by Michael Duckworth: When old Kee finishes a strange song, a cold wind began to move in the wind There were clouds in the sky, and it began to rain Soon the wind and the ... strange day, windy and noisy, Stephen stood in the garden and felt as if was full of ghosts- people he could not see - who were flying in the wind and trying to contact with living people in the real ... types, mainly according to three main criteria: - According to semantics - According to psychological standard of ghosts - According to shape shifting 2.1.1 According to semantics Ghosts, according...
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Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx
... of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparently playing a less important role in side-chain binding Taken together, the results of this and previous ... consistent with loss of penicillin binding Arginines 306 and 307 Fig Proposed binding mode for penicillin N to the iron(II)-2-oxoglutarate complex of DAOCS, showing possible involvement of selected residues ... clavaminic acid synthase [20,21]) have suggested that prime substrate binding activates the enzyme–iron(II)-2-oxoglutarate ternary complex to oxygen binding, thereby initiating catalysis and ensuring...
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Báo cáo hóa học: " Research Article Steganography in 3D Geometries and Images by Adjacent Bin Mapping" ppt
... “100110100” can be embedded by mapping the elements with the indices 2, 3, 6, 8, and into the left bin and the remaining elements into the right bin to generate the stego object To minimize the distortion ... within every bin Since the operations in one embedding unit are independent from those in the other units, we only discuss the operations in an arbitrary unit In the normal LSB hiding, a string ... 0s) In this way, the amounts of 0s and 1s in the LSBs are unchanged by data embedding In the decoding process, the embedded bits are extracted one by one in the same order as in the embedding...
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Báo cáo y học: "Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy: a prospective single-centre study" ppt
... psoriasis and PsA Decreased cell infiltration in both skin and synovial tissue associated with clinical improvement might be explained in part by deactivation of vascular endothelium and by inhibition ... stainings Pictures represent the expression of von Willebrand Factor (vWF), αvβ3 integrin, vascular stainings endothelial growth factor (VEGF) and intercellular adhesion molecule (ICAM)-1 in skin ... effects of infliximab It is known from clinical experience that after weeks of infliximab therapy a beneficial clinical effect can be observed in both skin lesions and inflamed joints in PsA In addition,...
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Báo cáo y học: " Improvement of pain and regional osteoporotic changes in the foot and ankle by low-dose bisphosphonate therapy for complex regional pain syndrome type I: a case series" pptx
... treatment, including physiotherapy and NSAID administration, was initiated in another clinic, the pain in his ankle progressively worsened and he demonstrated gait disturbance A physical examination ... events Although treatment, including physiotherapy and NSAID administration, was initiated in another clinic, the pain and swelling of his right foot progressively worsened, and he demonstrated gait ... decreased pain and regional osteoporotic findings in the foot or ankle Also, since the discontinuation of the bisphosphonate treatment, our patients have not complained of bone pain, and normal...
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Báo cáo y học: "The TGF-beta-Pseudoreceptor BAMBI is strongly expressed in COPD lungs and regulated by nontypeable Haemophilus influenzae" doc
... regulated by NTHI in the human lung This finding may be important for the understanding of inflammatory mechanisms and remodeling in COPD patients The combination of enhanced proinflammatory cytokine ... samples representing bronchial epithelial cells (BEC) we found intense positive staining of these cells targeting NTHI infection in vivo and in vitro using ISH (figure 1d and 2c) In lung tissues ... TGF-β expression in infected lung tissue was also observed using IHC (figure 4g and 4h) BAMBI is strongly upregulated in lung tissue in response to NTHI infection in vivo and in vitro BAMBI was...
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