epidemiology and prevention of noncommunicable and chronic disorders
Veterinary Medical Specialization: Bridging Science and Medicine Volume 39 doc
... biochemistry and pathophysiology of their disorders, develop new diagnostic tests for clinical diagnosis and research investigations, and perfect better treatment methods to prevent and control the disorders ... state of the art in each specialty, and ensure fair and legally defensible standards (Stromberg and Schneider, 1994) As pointed out in a recent review by Stromberg and Schneider (1994), the law of ... endocrine disorders especially of the thyroid gland (thyroiditis), adrenal gland (Addison's disease), and pancreas (diabetes) (Young and Mortimer, 1984; Trence et al., 1984; Shoenfeld and Cohen,...
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Autoimmune Diseases – Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies pdf
... incidence and time course of insulitis prior to diagnosis and correlating it to the presence, and persistence of circulating immune markers, will be crucial for our understanding of the disease and ... accumulation of ketones (products of fat breakdown) and acid in the blood Continued buildup of these products of disordered carbohydrate and fat metabolism result in nausea and vomiting, and eventually ... 12 and 20 Nat Genet 41, 824-828 Agranoff, B W and Goldberg, D (1974) Diet and the geographical distribution of multiple sclerosis Lancet 2, 1061-1066 Andersen, O (2010) Predicting a window of...
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Báo cáo y học: "Autoantibody profiling for the study and treatment of autoimmune disease" docx
... Hueber et al methods of binding autoantigens and of drying at the time of array production, which can distort and/ or sterically interfere with immunologic epitopes A variety of fluidphase bead, ... complexity of fluorescence-based bead and tag systems Microfluidics approaches Microfluidics utilizes microchannels for analysis of antigen–autoantibody interactions Small quantities of biomolecules ... quantitation of binding kinetics and detection of low-affinity interactions are among the important advantages of this system Arrays of living cells 292 Several groups have described arrays of living...
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Báo cáo y học: "Amplification of autoimmune disease by infection" potx
... Shiosaka T, Tanioka H, Fujita S: Detection of human herpesvirus and human herpesvirus in the submandibular gland, parotid gland, and lip salivary gland by PCR J Clin Microbiol 1996, 34:2320-2321 ... Brytting M, Bjerregaard L, Julander I, Linde A: Shedding of cytomegalovirus and herpesviruses 6, 7, and in saliva of human immunodeficiency virus type 1-infected patients and healthy controls Clin ... JN, Ross SO, Riley DE: Chronic prostatitis: epidemiology and role of infection Urology 2002, 60:8-12 14 Billis A, Magna LA: Inflammatory atrophy of the prostate Prevalence and significance Arch...
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Báo cáo y học: "Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination" pot
... intramolecular and intermolecular spreading of autoantibody responses in both CIA and EAE It is unclear whether the epitope spreading of ACPA responses observed in acute and chronic CIA and EAE are ... evolution of autoantibody responses in CIA and EAE We observe targeting of the native inducing autoantigens and a limited set of citrullinated epitopes in pre-disease and acute disease samples, and ... with the development and/ or clinical progression of RA The purpose of these studies was to characterise the development and evolution of ACPA responses in rodent models of RA and MS, to gain insights...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... all AD cases Onset is most often before 65 years of age, and the penetrance is nearly always complete The purification and partial sequencing of Ab from amyloid deposits of AD brain in the 1980s ... [54] A substantial amount of CAA is often found in transgenic mice with the Swedish mutation, which is likely to be because of the high rate of synthesis and accumulation of Ab1-40 In Tg2576, more ... accumulation of CAA in leptomeningeal and cortical vessels with few diffuse plaques, severe loss of SMCs, weakening of vessel walls leading to hemorrhage and perivascular microgliosis and astrocytosis...
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báo cáo hóa học: " Gait dynamics in mouse models of Parkinson''''s disease and Huntington''''s disease" doc
... of the left and right forelimbs of a 3NP-treated mouse demonstrating coordinated stepping, despite hind limb failure of stepping The signals of left and right hind limbs are not coordinated and ... included increased gait variability of the forelimbs and eventual failure of hind limb stepping Our findings of different effects of 3NP on gait dynamics of forelimbs and hind limbs are in accordance ... design and development of the gait imaging system and developed the software for analyses of gait data via ventral plane videography AK also participated in the collection and analyses of data...
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báo cáo hóa học: " Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer''''s disease" potx
... inflammation and microgliosis around areas of plaque deposition [4-7] Chronic administration of ibuprofen can reduce plaque pathology and brain Aβ levels in these animal models of AD [8,9] There ... cytokines IFN-γ and IL-12, TNF-α, IL-1α, IL-1β and IL-6 [12,22] Pathological analysis of tissue from AD patients and from mouse models of AD shows that there is extensive astrocytic and microglial ... IL-1R, and therefore have similar activities Both are capable of inducing inflammatory cascades in-vivo and in-vitro, and it has been shown that they are capable of up-regulating expression of astrocyte-derived...
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Báo cáo y học: "The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease" pot
... 4% isoflurane and L/minute oxygen Once mice were anaesthetised they were transferred to a mask and maintained on 2% isoflurane and 0.8 L/minute oxygen The surgical area was shaved and a three-part ... Overview of( MTX) and partial meniscoectomygenerate meniscotibial transection (MTX) and partial meniscoectomy (PMX) models (a) Schematic representation of the joint (Adapted from Kamekura and colleagues ... completion of the surgery the inhalation anaesthesia was turned off and to control pain and infection, the mice were injected subcutaneously with buprenorphine (Schering-Plough, Hertfordshire, UK) and...
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Báo cáo y học: " Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune disease" pot
... of CD3-ζ and ZAP-70, downregulation of mitogen-activated protein kinases such as extracellular signal-related kinase and c-Jun N-terminal kinase, and inhibition of the nuclear translocation of ... occur by the interaction of CD86 with CTLA-4 Activation of CTLA-4 by binding to its ligands leads to the phosphorylation of tyrosine residues in the cytoplasmic tail of CTLA-4 and its association ... CTLA-4 function and dissociates from CTLA-4 upon ligand binding The ligands are the dimeric CD80 and the monomeric CD86 Binding of CD80 to the divalent CTLA-4 leads to the formation of a lattice-like...
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Báo cáo y học: "Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus" pptx
... rheumatoid arthritis and part of the development of the disease might be related to the activity of RUNX2 in these tissues and its effect on some of the target genes, many of which, such as osteopontin ... cellular models and the use of retroviral vectors have permitted the study of the RUNX proteins in more detail, although still in the mouse, and have provided evidence for the importance of the RUNX ... assays and transfection experiments with which they could show the allelic effect of the polymorphisms on gene expression in reporter assays and their effect by cotransfection of RUNX1 In spite of...
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Báo cáo y học: "The current status of targeting BAFF/BLyS for autoimmune diseases" pps
... emergence of IgG anti-double-stranded DNA antibodies but they induce B cell depletion and a marked delay in the expansion of activated and memory T cells The addition of a short course of cytotoxic ... Mechanism of action of BAFF blockade BAFF blockade mediates profound effects on B cells in mice Within 1–2 weeks of administration of TACI-Ig or BAFF-R-Ig to normal mice, the spleen and lymph ... Ramanujam and Davidson Figure Interactions of BAFF and its homologs with the three BAFF receptors Sites of action of potential blockers are described in Table APRIL, a proliferation-inducing ligand;...
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báo cáo khoa học: " Multi-locus models of genetic risk of disease" pptx
... genetic epidemiology of complex genetic diseases can be described in terms of the observable parameters of disease prevalence and relative risk to relatives of diseased probands (Table 1) Risks of ... in the righthand tail of the normal distribution; x, number of risk alleles harbored by an individual, between and 2n Author details Genetic Epidemiology and, Queensland Institute of Medical Research, ... becomes
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Báo cáo y học: " Coxiella burnetii as a possible cause of autoimmune liver disease: a case report" pps
... presence of chronic Q-fever hepatitis and autoimmune liver disease Serology for C burnetii is highly specific, and we are not aware of any reports of false-positive Q-fever serology in the context of ... features of both diseases Hepatic cytolysis and/ or cholestasis are present Histological findings may be non-specific or typical of either AIH or PBC Serology shows markers of AIH (ANA, SMA) and of ... necrosis and without granulomas, supported the hypothesis of drug toxicity Interruption of doxycycline and hydroxychloroquine therapy resulted in a rapid improvement of hepatic cytolysis and cholestasis...
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Báo cáo y học: "B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin" pdf
... (BAFF) -and a proliferation-inducing ligand (APRIL) are members of the tumor necrosis factor (TNF) family and are important regulators of B-cell maturation, survival, and function [1,2] The TNF ligands ... heterotrimers, and endogenous levels of heterotrimers in the sera of healthy donors and patients with SLE or RA were measured and compared with BLyS and APRIL homotrimer levels in a subset of the same ... nonsignificant) of the samples from patients with RA (Table 1) Analyses of BLyS and APRIL homotrimer levels were performed in a subset of the samples from healthy donors and patients with SLE, and for all of...
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Báo cáo y học: "Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases'''' pps
... expand in numbers, acquire immune cell features, produce proinflammatory cytokines and enzymes, and contribute to the inflammatory process and the eventual destruction of the joint A number of ... inhibition Seow and colleagues [40] examined the effect of piceatannol, a Syk inhibitor, on ovalbumin-induced anaphylactic contraction of isolated guinea pig bronchi and release of histamine and peptidoleuketrienes ... that one intranasal dose of R112 is clinically safe and significantly reduces the level of prostaglandin D2, a key mediator of allergic nasal congestion, but not histamine and tryptamine levels [54]...
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Báo cáo y học: " Models of chronic obstructive pulmonary disease" pps
... many benefits that can accrue from the development of animal models of COPD, most important of which is understanding of mechanisms and development of specific drugs for COPD http://respiratory-research.com/content/5/1/18 ... 50:139-149 Reid LM: Measurement of human bronchial glands in chronic bronchitis: experimental study of the response of the bronchial tree to irritation; types of emphysema in chronic bronchitis Am Rev ... expression and tight junction modification leading to inflammatory cell influx and increase of lung permeability with oedema formation [130] However, the nature and extent of these responses are often...
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Báo cáo y học: "Animal models of copper-associated liver disease" doc
... abnormality of copper metabolism [3,7] Excess accumulation of copper also occurs as a consequence of chronic liver diseases such as primary biliary cirrhosis, and chronic hepatitis in both humans [8] and ... lamp current 17 mA Standards used are 3, and 12 ppm prepared from 1000 ppm stock standard in 0.2 M HNO3 Peak area is read with a read delay of s, and a read time of s Standard reference materials ... Howell JM and Cook RD An ultrastructural and morphometric study of the liver of normal and copper-poisoned sheep Am J Pathol 1980, 99:429-449 Gopinath C and Howell JM Experimental chronic copper...
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Báo cáo y học: " A mechanistic model of infection: why duration and intensity of contacts should be included in models of disease spread" ppt
... tal knowledge that the risk of disease transmission is not only a function of the infectivity of the infectious agent and the quality of the immune response but also of the host's exposure to a ... formulation of an exponential relation between exposure and the risk of infection, we extrapolate the actual exposure from information about the duration and intensity of a contact between an infector and ... expected number of secondary cases SC and the number of contacts S by calculating SC for the 720 person days as separate units of observation SC is calculated according to Equations and and based on...
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Báo cáo y học: "Relationships between free radical levels during carotid endarterectomy and markers of arteriosclerotic disease"
... production and concentrations of MCP-1, ICAM-1, MMP-9 and oxLDL, mean values for all the OXANO concentrations measured during clamping and reperfusion and for the markers sampled before, during and ... correlation between MCP-1 and radical levels and a negative correlation between ICAM-1 and these levels The lack of a positive correlation between radicals and these markers of inflammation, as well ... ICAM-1, MMP-9 and oxLDL Blood samples were withdrawn for an analysis of markers of arteriosclerosis together with OXANO samples 1, and 9, i.e before clamping, just before declamping and 15 minutes...
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