e g ciliated cells in primary nasal mucosal tissue from healthy subjects and np patients and in vitro with hnespcs derived from the same donors
Study of human nasal epithelial stem or progenitor cell growth and differentiation in an in vitro system
... of NP However, the information of the genes involved in the epithelial damage in NP is rare partially due to the lack of appropriate study in vitro model Identifying the causal genes and gene ... Based on the genetic defection, the atopic immunity response to microorganisms triggers the epithelial remodeling in NPs In the following parts, both the inflammatory triggers and cells involved ... pure hNESPCs in vitro Secondly, we investigated whether the growth and differentiation properties of the nasal epithelial cells from NPs and healthy controls were different We found that hNESPCs...
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Báo cáo khoa học: A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells doc
... dendrogram above to show the similarity of their gene expression patterns The expression profile of each gene is represented in the respective rows Genes are linked by the dendrogram on the left ... provides a potentially valuable resource for determination of the key molecules involved in hepatocyte differentiation and function These integrative perspectives on the gene expression profile might ... may be good candidates as stem cells for cell transplantation and tissue engineering in regenerative medicine, as a large number of AT-MSCs can be obtained easily with minimal invasiveness by...
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báo cáo hóa học:" BRCA1/2 genetic background-based therapeutic tailoring of human ovarian cancer: hope or reality?" ppt
... taken in account for the design of novel therapeutic strategies in this specific setting Clinical findings Preliminary clinical evidence appears in line with preclinical in vitro findings and indicates ... strategies or because cancer predisposing mutations have been identified when the cancer has been already diagnosed It is therefore often necessary the use of systemic chemotherapy regimens, ... ongoing trials are eagerly awaited Conclusion All together these findings introduce a provocative novel scenario where BRCA1/2 carcinogenetic process in the hereditary setting produces novel...
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Báo cáo y học: " Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions" pps
... derived from more abundant differentiated cells and the higher average gene expression in these cells is likely to have masked more subtle expression changes in rare cancer stem cells Recent advances ... committed population We then mapped significant GO terms back to the cancer stem cell signature to identify the individual genes involved These genes were then searched against the KEGG pathway ... correlation) using the expression data for the probesets (from 28 samples) define a cancer stem cell signature Blue tiles indicate down-regulated genes, and red tiles indicate up-regulated genes...
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Tài liệu Báo cáo khoa học: Two novel variants of human medium chain acyl-CoA dehydrogenase (MCAD) K364R, a folding mutation, and R256T, a catalytic-site mutation resulting in a well-folded but totally inactive protein pptx
... to generate the fulllength fragment, which was then subcloned into the pWT vector, using the EcoRI and HindIII sites The expression vectors were sequenced across the region encoding the MCAD gene, ... have been identified through screening programmes, and, where they have been characterized at the protein level, the defect has thus far mainly been in folding [9,10] It is not yet clear whether ... suggesting that other background factors must modulate the severity of clinical presentation Therefore there is no correlation evident between the effect of the mutations, as determined experimentally...
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Báo cáo y học: " Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells" potx
... core protein (p19) were not changed by AG490 treatment in HUT-102 cells (Figure 6C), suggesting that the AG490 does not drop the virus levels in these cells and the effects of AG490 on these cells ... experiments Expression of cell-cycle associated genes in AG490-treated HTLV-1-infected T-cell lines and ATL cells We next examined whether AG490 induces G1 cell-cycle arrest by modulating the expression ... change the expression of these genes in primary ATL cells (data not shown) Expression of anti-apoptotic genes in AG490-treated HTLV-1-infected T-cell lines and ATL cells We also examined the effects...
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Báo cáo y học: "nalysis of the mouse embryonic stem cell regulatory networks obtained by ChIP-chip and ChIP-PET" pptx
... increased when the whole chromosome arrays were used Therefore, the criteria used to determine a binding event, as well as the extent of genome coverage, had an effect on the overlap between the data ... are altered Further evaluation of the binding events identified through both techniques, by genetic manipulation of the corresponding genes in ES cells, will lend better insight into the genes ... data together, all raw ChIP-PET sequence reads were re-mapped to the same version of the mouse genome (mm6) used in the ChIP-chip experiments The sequence reads were between 34 and 36 bp, and only...
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The impact of human resource management practices on employee's job satisfaction in Vector Aviation Co., Ltd
... goals and receiving feedback on performance, they feel be satisfied because of goal achievement As suggested by Adams (1965), feelings about equity are the perception of employee having about the ... providing feedback on past performance, the managers or supervisors can encourage employee to perform better in the future by pointing out the strength, weakness and help employees to identify effective ... aviation services industry, employees expects to be trained regularly In the situation of Vietnam, the training needs are very hard to carry out by employees themselves There are few universities and...
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ASSESSMENT OF THE BENEFITS OF EXTENDING THE TROPICAL RAINFALL MEASURING MISSION A PERSPECTIVE FROM THE RESEARCH AND OPERATIONS COMMUNITIES doc
... advising the federal government The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior ... nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general ... Academy of Engineering, and the Institute of Medicine The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance Support...
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Báo cáo lâm nghiệp: "Discrimination of coated carbide tools wear by the features extracted from parallel force and noise level" potx
... between parallel force and noise level The results in Figure indicate that the noise level and the parallel force are close in relationship The noise level increased linearly with increasing the ... the other tools investigated [5] On the other hand the other tools investigated varied slightly in the parallel force as the cutting speed was increased The experimental results also indicated ... be almost the same in the rate of the increase (Tab IV) The TiN/AlN coated tool would be more abrupt in the increase of the noise level compared to the others However, the regression coefficients...
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Báo cáo y học: " Early detection of Varicella-Zoster Virus (VZV)-specific T-cells before seroconversion in primary varicella infection: case report" potx
... T -cells were detected Such elevated CD4+ T-cell titers have been described during acute varicella infections [9] The percentage of VZV-specific CD4+ T -cells is declining steadily over time, reaching ... sufficiently Among them (a) the diagnosis of a pathogen involvement if serological parameters are impaired, (b) the differentiation between different stages of viral infections, (c) the monitoring ... Competing interests The authors declare that they have no competing interests Received: 29 December 2009 Accepted: March 2010 Published: March 2010 References Breuer J, Schmid S, Gershon A: Use and Limitations...
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Báo cáo y học: " Identification of super-infected Aedes triseriatus mosquitoes collected as eggs from the field and partial characterization of the infecting La Crosse viruses" pot
... mosquitoes in the site (Figure 9) The role that these changes may have in conditioning the establishment of the respective phenotypes remains to be determined Sequence analysis of the Ae triseriatus ... genotypes and instead they would be manifested as a large frequency of singleton e alleles This trend was especially pronounced in the M segment in general and in the NSm gene in SI+ isolates in ... was initially used to generate five fixed starting Maximum Parsimony (MP) trees and these were then used as starting trees to estimate ML trees using a fixed setting with GTRMIX and then using the...
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Báo cáo y học: " Peripheral infusion of rat bone marrow derived endothelial progenitor cells leads to homing in acute lung injury" pps
... intestines showed no detectable homing, whereas subcutaneously administered Matrigel gave evidence of few cells having migrated in However, the number of EPC detected in the injured left lung ... lung in order to maintain the organ structure, as they integrate in the tissue and seem to differentiate or to fuse with other parenchymal cells to endothelial or epithelial cells Whether these ... for their expression of the endothelial cell marker P1H12 Cells were counted as circulating endothelial cells when they were included in the depicted gate CEC also cell death has been described...
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Báo cáo y học: "Sequestration and homing of bone marrow-derived lineage negative progenitor cells in the lung during pneumococcal pneumonia" ppsx
... hours) there during pneumococcal pneumonia Furthermore, these progenitor cells also remained in the lung tissues and rarely migrated into the alveolar air spaces, suggesting that BM -derived progenitor ... colleagues [38]), increasing the number of infused progenitor cells will increase the number of these cells that home to injured lung tissues and become available for tissue regeneration and repair ... of lineage negative progenitor cells For the purified progenitor cell transfusion experiments, lineage negative progenitor cells (Lin- PCs) were separated from whole BMCs using a mouse progenitor...
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Báo cáo y học: " A comparative study of a theoretical neural net model with MEG data from epileptic patients and normal individuals" docx
... (41) Experimental procedure We compared the theoretical results with the experimental findings obtained using MEG measurements from 10 epileptic patients and 10 healthy volunteers Informed consent ... the normalized MEG histogram theoretical model represents the state of epilepsy, whereas the Gauss connectivity represents normal behavior The magnetic field derived from the theoretical model ... over an interval of s duration The MEG recorded from an epileptic patient over an interval of s duration The x-axis represents the time sequence and the y-axis the magnetic field where the neural...
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Báo cáo y học: " Effect of neutrophil elastase and its inhibitor EPI-hNE4 on transepithelial sodium transport across normal and cystic fibrosis human nasal epithelial cells" pot
... represents the difference between the value of Isc at the end of aprotinin exposure and baseline Isc at the moment of aprotinin addition The change in Isc induced by hNE represents the difference ... changes in Isc (ΔIsc , representing the difference between the value of Isc at the end of exposure to drug or vehicle and the baseline I sc at the moment of drug or vehicle addition), and are presented ... treatment with the exogenous serine protease trypsin had no effect on sodium current in human nasal epithelial cells and in rat alveolar epithelial cells [15,21], suggesting that in these primary...
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Báo cáo y học: "Low temperature tolerance of human embryonic stem cells"
... first few reported studies [7, 8] on the establishment of new hESC lines emphasized the use of temperature-heated stage and pre-warmed and pre-equilibrated culture media Nevertheless, the results ... indicated by red fluorescence under a wavelength of 570 nm (Rhodamine) The hESC colonies were assigned into grades [9] according to their degree of spontaneous differentiation (Figure 1): (1) Grade ... number of cells before exposure to low temperature, a 6-well culture dish with the same 125 density of hESC colonies was subjected to the MTT assay on the same day that the other dishes were being...
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Tài liệu Báo cáo khoa học: Reversible tetramerization of human TK1 to the high catalytic efficient form is induced by pyrophosphate, in addition to tripolyphosphates, or high enzyme concentration ppt
... co-operative behavior To further elucidate this, the relationship between the oligomerization status and the kinetic behaviour was investigated, i .e whether the tetrameric and dimeric forms in Figs and ... supported by the kinetic behaviour of the recombinant enzyme as shown in Fig 5D, where the enzyme was diluted from 0.5 mgÆmL)1 immediately before the kinase assay Under these conditions, the kinetic ... that the nature of the base is insignificant for the tetramerization effect The next goal was to determine the role played by the sugar and phosphate groups As seen in Fig 1F, ADP was able to induce...
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Tài liệu Báo cáo khoa học: Transcriptional upregulation of inflammatory cytokines in human intestinal epithelial cells following Vibrio cholerae infection pptx
... Cytokine response in infected epithelial cells A Bandyopadhaya et al in ammatory mediators The response of the intestine to infection by pathogens represents a complex interaction between nonspecific ... Cytokine response in infected epithelial cells A Bandyopadhaya et al Fig (A) Secretion of CT in tissue culture medium and in the presence of Int407 cells Different V cholerae strains (toxinogenic ... (toxinogenic and nontoxinogenic) were inoculated in the tissue culture medium (MEM) in the presence or absence of Int407 cells, and the secretion of CT was measured by ELISA as described in Experimental...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25