drug toxicities leading to market withdrawals in the period 1976 to 2005
Expression dynamics of the hepatic mitochondrial proteome of the sod2+ mouse in response to troglitazone administration
... in the period 1976 to 2005 Hepatotoxicity or DILI (21%) formed the majority cause for drug withdrawals Cardiotoxicity refers to heart-related toxicities other than torsades de pointes Torsades ... in acute liver failure and death The reasons for these typical hallmarks of idiosyncratic DILI have remained poorly understood so far Figure Drug toxicities leading to market withdrawals in the ... genes/products using bioinformatics 194 x LIST OF FIGURES Figure Drug toxicities leading to market withdrawals in the period 1976 to 2005 Figure Chemical structure of troglitazone Figure...
- 226
- 1,830
- 0
benkel et al - 2006 - the assassination between corporate governance and earning management
... decisions (including supervisory board composition) by combining under the Association of Individual Investors, which strives to involve individual investors in the companies’ general meetings.32 Other ... directors, including the president.25 Therefore, in being granted preferential access to shares, workers gained the right to express their views through the shareholders meeting and when they ... auditors to render opinions on the fairness of the presentations in the financial statements The auditors fail in their oversight role when they ignore management’s manipulations of the financial...
- 157
- 742
- 0
lee et al - 2006 - auditor conservatism and audit quality - evidence from ipo earnings forecasts
... report to be misleading, they should bring the matters to the attention of the directors or promoters If the matters are not resolved to the auditor’s satisfaction, they should not consent to the inclusion ... since the costs of relying on an inaccurate earnings forecast are generally borne by new investors In contrast, if managers intend to return to the capital market they will have incentives to provide ... response to the prior disclosure of an earnings target The incentives for such earnings management and their role in determining the extent of earnings management would appear to be worthy of further...
- 17
- 328
- 0
jennings et al - 2006 - strong corporate governance and audit firm rotation- effects on judges' independence perceptions and litigation judgments
... Additionally, the scenario included summarized income statement and balance sheet information for the current year Finally, to add stress to the situation, we included the need for the company to restate ... reduction from rotating auditing firms may be minimal The GAO decided against requiring firm rotation in part due to a question concerning whether other provisions of SOX (such as mandating minimal thresholds ... considering rotating auditors a full year following passage of SOX (U.S General Accounting Office [GAO] 2003, 15) Nevertheless, both regulators and the business press continue to consider the proposition...
- 18
- 325
- 0
nasser et al - 2006 - auditor‐client relationship- the case of audit tenure and auditor switching in malaysia
... Introduction Auditor independence is the cornerstone of the auditing profession In general, auditor independence can be of two forms: “independence in fact” and “independence in appearance” The ... lead to audit staff being too sympathetic to the client interest Since, the relationship between the auditor and his client can be close in one way or another regardless of the number of years in ... risk, the length tenure in the office before being switched, the changes in operating income, market value of equity as well as the changes in total assets) explain the behaviour of ending audit...
- 15
- 596
- 0
raiborn et al - 2006 - should auditor rotation be mandatory
... employee to enter the new position at the client company Such actions are essential to maintaining the integrity of the audit, obtaining the desired employee for the position, and eliminating a ... According to PricewaterhouseCoopers (2002), audit quality depends on numerous factors, ordinarily including the experience, integrity, and training of the auditors and the firm with which they ... allegiance to the corporation’s creditors and stockholders, as well as to the investing public’” (Goodkind, 2000) Second, in the primary sense of the term, the audit firm is not a customer of the audit...
- 13
- 742
- 0
![[cg-sr] aguilera et al - 2006 - corporate governance and social responsibility - uk and us](https://media.store123doc.com/images/document/2015_01/06/small_xvi1420548465.jpg)
[cg-sr] aguilera et al - 2006 - corporate governance and social responsibility - uk and us
... actors might have to ask firms to engage in CSR initiatives, and we apply this model to the action of institutional investors to explain the greater emphasis on CSR issues in the UK versus the ... stock-based incentives in the US are much higher than in the UK Another area of divergence is in the relationship between the firm and its equity investors As noted above, institutional investors ... (Jensen, 2005) Consequently, institutional investors in the US not play the strategic consulting role that is becoming more common in the UK Corporate social responsibility in the UK vs the US In addition...
- 12
- 325
- 0
conte r., et al. (eds.) direct and inverse methods in nonlinear evolution equations (lnp632, springer, 2003)(283s)
... contents outlining the structure of the book together with abstracts of all contributions to be included Final acceptance is issued by the series editor in charge, in consultation with the publisher, ... solutions in closed form The basic tool is the appropriate use of the singularities of the solutions, and this can be done without knowing these solutions in advance Since the elaboration of the singular ... developed in Sect 7.3 The constraints on U reflect the integrability level of the PDE If the only constraint on U is to satisfy some PDE, one is on the way to an auto-BT if the PDE for U is the same...
- 283
- 1,246
- 0
transmission line matrix (tlm) in computational mechanics - d. de cogan, et al., (crc, 2006) ww
... f in one of the lines, a transmission of f/2 to the other three lines and a reflection of -f/2 in the incident line Similar results apply to all four lines, so that the total scattering is the ... the net flow into the node from each line is the incident minus the reflected pulses divided by the impedance of the line (Equation [2.9]) No matter how many lines meet at the node, if the line ... to the real string at the boundary point, superposing on the existing wave in the string approaching the boundary This virtual wave is a mirror image of the outgoing wave, either inverted or not...
- 275
- 514
- 0
color atlas of histopathology of the cervix uteri 2nd ed - c. dallenbach - hellweg, et al., (springer, 2006)
... of the ectocervical epithelium usually seen in older women It is thought to originate from Müllerian epithelium of the early genitourinary system with the potential to differentiate into urothelium ... The reasons for using immunohistochemistry in routine practice are manifold The immunohistochemistry method helps to determine the histogenesis of a given tumor In most instances that determination ... detecting antigens in sections of formalin-fixed and paraffin-embedded tissues The epitope of the antigen must be unmasked in most instances, because formalin fixation causes proteins to cross-link,...
- 206
- 591
- 0
color atlas of immunology - g. burmester, et al., (thieme, 2003)
... NK interleukin Ig-like transcript chromosomal inversion IL-1 receptor-associated kinase interphotoreceptor retinoid-binding protein immunoreceptor tyrosine-based activation motif immunoreceptor ... receptor's gamma chain and rearrangement of the beta chain also occurs in the thymus These cells are described as double negative since they contain neither the CD4 nor the CD8 antigen In the ... receptors The structure of c and d chains is similar to that of the a and b chains The amino acid sequence of the c chain very closely resembles that of the b chain, and the sequence of the d chain...
- 336
- 596
- 0
contact dermatitis 4th ed - p. frosch, et al., (springer, 2006)
... bring together the knowledge of the past, in such a way that the reader/investigator can have readily available the information necessary to study the patients, patch test them, and interpret the ... produce proinflammatory cytokines and chemokines Thereby, more inflammatory cells are recruited further amplifying local inflammatory mediator release This leads to a gradually developing eczematous ... their activation and, thereby, control the type of immune response (IFN Interferon, IL interleukin, LT lymphotoxin, TGF transforming growth factor) 2.5.3 Cytokine Environment In the skin-draining...
- 1,080
- 514
- 0
colonoscopy - principles and practice - j. waye, et al., (blackwell, 2003)
... rectum and the vagina, as well as an approach from a wound in the abdomen of the corpse The first attempt to apply the device to a living patient was made in the same gathering The building of Josephs ... illumination, and the shaft was m in length Partly because the shaft was too stiff, insertion into the descending colon was still very difficult When inserting into the proximal sigmoid colon, the ... from the mouth into the proximal colon and used as a pulley through which the anal pull-string could be used to tug the endoscope into the proximal colon [36] In the “string guidance” method, the...
- 666
- 245
- 0
stuber et al., das allgemeine gleichbehandlungsgesetz in der betrieblichen praxis (2006)
... (z B Interviewtrainings oder -leitfäden) Erlassen Sie interne Richtlinien Neben der Beseitigung etwaiger Schwachpunkte in einzelnen Prozessen sollten Sie auch an den Erlass interner Richtlinien ... MitarbeiterInnen, in Jahresgesprächen oder Vergütungsverhandlungen usw Allgemeine Information an die Beschäftigten Darüber hinaus ist eine allgemeine Information an die Beschäftigten dringend zu ... Entlassung • Verhalten gegenüber InteressentInnen und KundInnen Beispiel: Einzelfälle und allgemeine Situationen Die Auditierung behält sinnvollerweise einerseits Einzelfälle im Auge (z B Analyse...
- 269
- 403
- 0
benston et al - following the money; the enron failure and the state of the corporate disclosure (2003)
... provide investors with insights that they want Prospective investors then might have to incur costs to obtain information elsewhere or discount the amount they are willing to pay for the shares, using ... critical input in most attempts to project future performance of firms To the extent the market deems accounting information unreliable, investors confront “information risk” in making investment ... to entry in the analyst industry In the process, the industry should become more competitive, assuming sufficient investor demand exists to support analysts independent of brokerage or other investment...
- 135
- 207
- 0
barton et al - dangerous markets; managing in financial crises (2003)
... contributed to the role of English as the unofficial language standard for business Emerging Markets Are Linking to Global Capital Markets Beginning in the 1980s in Latin America and gaining steam over the ... beside private sector participants in the quest to turn Singapore into an Asian financial center In Indonesia they were joined by Roberto, who helped other McKinsey colleagues serve the Indonesian Bank ... tumbling to a negative percent the following year Unemployment rose to percent in 1998 The banking system melted down, forcing the government to intervene, first in the merchant banks and then the...
- 321
- 205
- 0
![gompers et al - 2003 - corporate governance and equity prices [cgi-g-index]](https://media.store123doc.com/images/document/2015_01/02/small_qgt1420194792.jpg)
gompers et al - 2003 - corporate governance and equity prices [cgi-g-index]
... [1997] 48 industries The key independent variable in these regressions is the Democracy dummy, set equal to one if the stock is in the Democracy Portfolio and zero if the stock is in the Dictatorship ... directors against job-related liability or to compensate them following a termination The Other group includes the six remaining firm-level provisions These provisions tend to cluster within firms ... expected, and the firm’s value at the beginning of the period would have been too high Hypothesis II is that managers in the 1980s predicted poor performance in the 1990s, but investors did not In this...
- 49
- 634
- 0
xie et al - 2003 - earnings management and corporate governance - the role of the board and the audit committee
... earnings management may impact investors by giving them false information Capital markets use financial information to set security prices Investors use financial information to decide whether to ... written consent of the board since these involve less director action and input and are less likely to result in effective monitoring We, therefore, only include faceto-face board meetings For our ... securities Market efficiency is based upon the information flow to capital markets When the information is incorrect, it may not be possible for the markets to value securities correctly To the extent...
- 22
- 526
- 0
daily et al - 2003 - corporate governance decades of dialogue and data
... evidence again calls into question the shareholder-centered models of corporate governance Institutional investors' increasing reliance on indexing investment strategies is also a factor in funds' ... Starbuck, 1976; Shen, see this issue) The challenge for directors is to build and maintain trust in their relationships with executives, but also to maintain some distance so that effective monitoring ... come to outweigh those of shareholders Research investigating the presence of institutional investors in the financially declining firm has yielded less consistent results than research addressing...
- 13
- 598
- 0
engel et al - 2003 - ceo turnover and properties of accounting information
... why increases in the timeliness parameter g lead to increases in the weight on earnings and decreases in the weight on change in market value An increase in g strengthens the signal in earnings ... increases in timeliness on the weight on earnings in the optimal contract First, increases in timeliness make the signal in earnings about current managerial actions stronger, leading to an increase ... that the weight on earnings in an incentive contract is decreasing in the variance of earnings Further, controlling for the variance of earnings, the weight on returns is decreasing in the variance...
- 30
- 388
- 0
Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu