drug toxicities leading to market withdrawals in the period 1976 to 2005 3
Expression dynamics of the hepatic mitochondrial proteome of the sod2+ mouse in response to troglitazone administration
... in the period 1976 to 2005 Hepatotoxicity or DILI (21%) formed the majority cause for drug withdrawals Cardiotoxicity refers to heart-related toxicities other than torsades de pointes Torsades ... in acute liver failure and death The reasons for these typical hallmarks of idiosyncratic DILI have remained poorly understood so far Figure Drug toxicities leading to market withdrawals in the ... by the gut directly to the liver Drug- metabolizing enzymes detoxify many xenobiotics but bioactivate the toxicity of others to reactive intermediates This leads to the hypothesis that underlying...
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Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx
... different from CLP 231 0 Several studies have shown that interactions between KCs and endotoxin comprise the initiating event leading to hepatotoxicity in liver injury, including endotoxemia and ischemia ... Regulation of hepatic drug- metabolizing enzyme genes by Toll-like receptor signaling is independent of Toll-interleukin receptor domain-containing adaptor protein Drug Metab Dispos 36 , 95–101 10 Ghose ... reperfusion injury [14] In our studies, we employed GdCl3 to inactivate KCs based on the findings of other investigators showing the destruction of KCs after the intravenous administration of GdCl3 [15]...
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Báo cáo khoa học: Change in structure of the N-terminal region of transthyretin produces change in affinity of transthyretin to T4 and T3 pdf
... needed To determine the in uence of the N-terminal region of TTR on the binding to thyroid hormones, the construction of chimeric recombinant TTRs containing variations in structure of the N-terminal ... bound T3 over T4 Here, we tested that hypothesis that the structure of the N-terminal region in uence the binding of T3 and T4 to TTR by comparing the affinities of T3 and T4 to FEBS Journal 2 73 (2006) ... retained its function as binding protein for retinol-binding protein and thyroid hormones In the present study, the Kd values for T4 and T3 of all the recombinant TTRs were determined with the...
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báo cáo hóa học:" Using individual growth model to analyze the change in quality of life from adolescence to adulthood" potx
... change in physical health? As can be seen in Table 1, the variance for the intercepts changed from 101. 53 to 87 .34 Computing (101. 53 – 87 .34 )/101. 53 = 0.140, we find a 14.0% reduction In other ... covtest noitprint; tains the name of the dependent variable, in this case HEALTH The right-hand side contains a list of the fixedeffect variables (predictors) The intercept is contained in all models ... specified using a REPEATED statement in SAS The interested reader is referred to the SAS PROC MIXED (12), the helpful paper by Wolfinger (32 ) and the book by Singer and Willett (33 ) Conclusion...
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báo cáo hóa học:" Physical activity and change in quality of life during menopause- an 8-year follow-up study" docx
... 1.49*** 1.24 to 1. 73 1. 23 to 1.80 208 765 124 1.26** 1.20 1.07 to 1.50 0.94 to 1. 53 4 03 177 517 0. 73 1.26* 8 .38 to 24.00 4.91 to 7.19 1.67 to 2.28 0. 73 to 1.18 1.02 to 1.56 0 .34 0 Interpretation of ... hours/week 0.001 21-42 249 21.6 32 2 27.9 >42 665 57.7 677 58.6 0.068 BMI (kg/m2 )3) 30 2 63 22.8 2 63 23. 3 >0.001 Menopausal ... and to the self-administered questionnaire were included into this study (n=1,165) In the 8-year follow-up study most of the questions and indicators were similar to those in the baseline Health...
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The genius in all of us new insights in david shenk
... close to the national average in IQ But as the Colvin kids got older, their IQ scores drifted lower and lower—falling further and further behind the national average due to inadequate schooling ... vested interest in our believing in the ash of revelation, the so-called inspiration … [shining] down from heavens as a ray of grace In reality, the imagination of the good artist or thinker produces ... life-altering amounts of time—a daily grinding commitment to becoming better In the long term, the results can be highly satisfying But in the short term, from day to day and month to month, there’s...
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Báo cáo y học: " Change in level of productivity in the treatment of schizophrenia with olanzapine or other antipsychotics" ppsx
... 131 132 Characteristics Age, Mean 36 .02 36 .41 40.05 38 .24 41.67 40.45 38 .3 37 .3 38.40 39 .5 39 .8 23. 53 24.00 (SD), y (10.81) (10.6) (11.59) (12.1) (9. 53) (9.6) (10.50) (10.4) (7.90) (8.25) (8 .32 ) ... (66 .3) 106 ( 63. 5) 180 (65.0) 172 ( 63. 5) 114 (66.7) 1 13 (65.1) 194 (69.0) 190 (66.7) 115 (72 .3) 111 (70 .3) 69 (71.1) 104 (79.4) 111 (84.1) Female 58 (33 .7) 61 (36 .5) 97 (35 .0) 99 (36 .5) 57 (33 .3) ... (52.6) 67 (51.1) 72 (54.5) African 35 (20 .3) 36 (21.6) 78 (28.2) 66 (24.4) 64 (37 .4) 65 (37 .1) 87 (31 .0) 90 (31 .6) 43 (27.0) 43 (27.2) 31 (32 .0) 49 (37 .4) 50 (37 .9) 0 Gender (%) Race (%) Asian...
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Báo cáo y học: " Change in quality of life and their predictors in the long-term follow-up after group cognitive behavioral therapy for social anxiety disorder: a prospective cohort study" pptx
... of the study might have been too small to identify statistically significant changes in the domains of the SF -36 or to detect potential baseline predictors of the SF -36 at the follow-ups Nevertheless, ... functioning Role-physical 85.6 ± 14.7 75.0 ± 43. 3 91 .3 ± 11.8 62.5 ± 43. 3 82.5 ± 22.2 56 .3 ± 51.5 88.6 ± 14 .3 68.6 ± 36 .6 0.79 0.87 Bodily pain 90 .3 ± 19.4 64 .3 ± 29.4 66.5 ± 32 .5 65.8 ± 25 .3 0.08 ... 50.0 ± 43. 0 41.7 ± 50.0 57 .3 ± 40.4 0.89 Mental health 44.9 ± 14.9 48.0 ± 3. 3 36 .0 ± 15.0 47.9 ± 20.5 0.67 SPS (total) 44.0 ± 13. 7 47 .3 ± 28.0 34 .0 ± 6.2 33 .7 ± 12.5 0.08 SIAS (total) 55 .3 ± 9.8...
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Báo cáo y học: " Development of a new ultra sensitive real-time PCR assay (ultra sensitive RTQ-PCR) for the quantification of HBV-DNA" pot
... (44.4%) (33 .3% ) Total 19 (70.4%) (29 .3% ) 27 (100%) Calibration of the HBV-DNA values obtained with the ultra sensitive RTQ-PCR against the WHO 1st International Standard for HBV-DNA The calibration ... compared to the line of equality by testing the two-tailed hypothesis of slope = and the intercept = Results The ultra sensitive RTQ-PCR was performed in a LightCycler® 2.0 apparatus using a plasmid ... analysis; AH was the study coordinator and participated to the writing and editing of the manuscript All authors read and approved the final manuscript classical spot hybridization test in chronic...
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Báo cáo y học: "The incidence of multidrug and full class resistance in HIV-1 infected patients is decreasing over time (2001–2006) in Portugal" potx
... patients The analyses were done without taking these drugs into account since they were not available at all time points of the study Furthermore, data on other factors that might influence the incidence ... Time trends in primary resistance to HIV drugs in the United Kingdom: multicentre observational study Bmj 2005, 33 1: 136 8 Frenkel LM, Tobin NH: Understanding HIV-1 drug resistance Ther Drug Monit ... the following drugs: zidovudine, didanosine, lamivudine, stavudine, abacavir, emtricitabine, tenofovir, nevirapine, delavirdine, efavirenz, saquinavir, indinavir, nelfinavir, amprenavir, lopinavir...
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Summary of doctoral dissertation epublic of korea vietnam strategic cooperative partnership and the way forward in the new context of global governance change in the 21st century
... diversity, several initiatives have been launched towards integration in the region Southeast Asia has since the 1990s played the leading role in keeping regional peace and prosperity in the Asia-Pacific ... on Additionally, the dialectic method is used to show the unity in the policies and actions of the US in the world as well as in the East Asian region, in order to explain how the US can politically ... aggressive war-making capacity Nevertheless, the leadership in regulating world order is gradually shifting to the emerging countries The article in the Financial Times entitled The End of US hegemony:...
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Báo cáo y học: "Impact of drug classes and treatment availability on the rate of antiretroviral treatment change in the TREAT Asia HIV Observational Database (TAHOD" pdf
... 567 (31 ) 37 5 (20) 502 (27) 402 (22) 1 ,33 3 (72) 192 (11) 32 1 (17) 451 (24) 859 (47) 536 (29) 432 ( 23) 215 (11) 30 9 (17) 232 ( 13) 658 (36 ) 210 (11) 256 (14) 138 0 (75) 136 3 (74) 4 83 (26) 676 (37 ) ... 1.17) 133 3 192 32 1 37 70 433 918 1052 171 268 0.28 0.40 0.29 1.00 1. 43 (1.16 – 1.78) 1.09 (0.91 – 1 .30 ) 451 859 536 1079 231 9 17 23 2 63 669 559 0.24 0.29 0 .35 1.00 1.14 (0.95 – 1 .36 ) 1 .31 (1.09 ... 1 .31 (1.09 – 1.58) 136 3 4 83 4569 552 133 1 160 0.29 0.29 1.00 1.09 (0.94 – 1.27) 432 2 13 309 232 660 1147 544 821 725 1885 33 5 145 224 221 566 0.29 0.27 0.27 0 .30 0 .30 1.00 0. 93 (0.72 – 1.20) 0.98...
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IMPACT OF FOREIGN DIRECT INVESTMENT ON ECONOMIC STRUCTUAL CHANGE IN HO CHI MINH CITY
... FDI on the other sectors in engineering due to lack of information However, the results seem to show that FDI has not really contributed much to the development of the city's engineering sector ... of FDI inflows into industrial investment towards increasing the technology sector, with knowledge content and high added value, investment focus in depth, and also developed the industry industry ... flowing into Vietnam (the first wave of FDI) In the period 2001 - 2005, FDI activitied faced many difficulties due to the impact from the international context and the fact that many countries in...
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Báo cáo y học: " Implementation of a new emergency medical communication centre organization in Finland an evaluation, with performance indicators"
... May 31 , 2006 During the study period the population in the area increased from 2 73 000 to 281 000 and the death rates varied from 1809 to 1820 per year [8] Performance indicators The identification ... arrived at the scene [7] If the patient was not transported, the ambulances sent feedback to the EMD with a code explaining the reason for not transporting the patient to the hospital The ambulances ... in the local organization During the reform of EMCC organization the priority codes remained the same but became standardized and were regularly monitored The definitions of prioritizing in the...
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Negotiating agrarian change livelihood agriculations of the commercial craft peasantry in northern vietnam
... produced during the Ming Dynasty in China and is now being reproduced in Kim Thieu 4 .3 This screen was produced during the Ming Dynasty in China and is now being reproduced in Kim Thieu 4.4 Qing railed ... obtaining information via other actors, I walked around the wood marketplace, in order to listen to the conversations taking place Thanks to their discussions, I was able to recognize both the ... at the communal house, at the pagoda and in the individual houses Similar to other villages in the region, the main focus of village rituals, both before the First Indochina War and up to the...
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Empirical investigation of market value change in vietnam stock market
... 107.8 63 50. 230 2 36 .33 49 3. 10646 132 .879 150.014 34 .32 35 6.95257 810.495 1892.58 14.0680 0.51506 159 .37 7 459 .32 1 39 07 .38 73. 2480 248.822 17.0421 238 0.85 99 .35 22 Observations 33 0 33 0 33 0 33 0 33 0 33 0 ... 3. 27 532 33 0. 032 10 0.02 632 0.09524 0.00000 0.02 536 33 0 .39 455 0. 434 13 1.00056 -0.45872 0.27025 33 12.17070 12.02 736 13. 09 231 11. 130 65 0.54891 33 0.70496 0.69897 1.00000 0 .30 1 03 0.17469 33 7 .38 9 63 ... 0. 039 2 0.0 233 39 0 .30 03 -0.450610*** 0.0000 0.0 731 28 0.5825 0.48 436 8*** 0.0000 33 0 0.5 134 17 0.496586 30 .5 033 7 0.000000 Model 3B Period fixed with dummy Coefficient Prob 2. 430 433 0.0 031 0.8 133 23* * 0.0112...
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Tài liệu Women Sufficiently Represented in New Drug Testing, but FDA Oversight Needs Improvement doc
... 715 1,406 7 53 789 56 32 4 642 233 36 6 54 39 1 764 520 4 23 450 1 ,37 5 1,420 1,882 1,512 227 637 658 699 677 2 23 738 762 1,1 83 835 4 73 332 537 486 886 199 31 2 549 31 9 428 156 4 63 2 73 2 63 156 86 46 ... 3, 404 1, 432 498 7 43 37 100 28 52 57 67 46 43 60 53 65 57 240 155 529 528 720 11 19 23 92 89 81 77 1 ,30 3 2 ,30 0 4,160 7,556 3, 745 50 43 41 35 47 50 57 48 64 53 50 17 16 37 15 39 30 7 35 2 289 39 1 578 ... found to increase the risk of bleeding into the brain or tissue around the brain in women, but not in men Certain classes of drugs can in some circumstances prolong the interval between the heart...
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Tài liệu Báo cáo khoa học: Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the ABC drug transporter, MDR1 Cyclosporin A can lower serum and liver globotriaosyl ceramide levels in the Fabry mouse model doc
... also evident in the Fabry mice (Fig 7A) The VT1 binding in the Fabry mouse lung (Fig 7C) was increased in the bronchiolar epithelium Staining of bronchiolar epithelial cells in the lung was significantly ... In order to begin to address this potential, we determined the effect of CsA on Gb3 synthesis in the Fabry mouse model Our studies have further delineated the abnormal Gb3 synthesis in this model ... studies [ 13] However, although the VT1 staining of renal tubules is dramatically increased in the Fabry mouse (Fig 3A), compared with the sporadic VT1 staining seen in the wild-type animal [ 13] , the...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008