disease s severity and monitor patients with amyotrophic lateral sclerosis lessons from neurophysiology
báo cáo khoa học: "A patient with amyotrophic lateral sclerosis and atypical clinical and electrodiagnostic features: a case report" pptx
... consistent with a lower motor neuron variant of motor system disease, but the sensory loss would argue for a polyneuropathy Sensory loss unless otherwise explained is considered inconsistent with ... amyotrophic lateral sclerosis Subcommittee on Motor Neuron Diseases /Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial “Clinical ... amyotrophic lateral sclerosis is a fatal illness, however, the possibility of this disease in patients with atypical clinical features should not diminish the need for a thorough diagnostic evaluation and...
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Structure function studies of vesicle associated membrane protein associated protein b (VAPB) associated with amyotrophic lateral sclerosis (ALS
... mutation-causing disease 1.2 What is Amyotrophic lateral sclerosis? Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig s disease, motor neuron disease (MND) or Charcot s disease was first described ... ALS ALS is divided into two forms, sporadic ALS (SALS) and familiar ALS (FALS) SALS constitute the majority of ALS cases and the disease occurs apparently at random with no clear associated risk ... STRUCTURE AND FUNCTION STUDIES OF VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN B ASSOCIATED WITH AMYOTROPHIC LATERAL SCLEROSIS Lua Shixiong B.Sc (Hons.), NUS A THESIS SUBMITTED...
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Risk Factors Affecting the Development of Tuberculosis Infection and Disease in Household Contacts of Patients with Pulmonary Tuberculosis pptx
... was searched times in cases who had complaints and whose microfilms revealed suspicious lesion Child cases or household contacts who needed advance search, were sent to chest disease hospitals ... BCG scar s presence, age group and TST positivity Our findings were similar with the survey from India for TST positivity household contacts with smear-positive pulmonary tuberculosis patients ... constitute great risk for TB infection and disease in household contacts Close follow up of household contacts of such patients for tuberculosis is essential and important for tuberculosis control...
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Báo cáo khoa học: " Long term outcome of adolescent and adult patients with pineal parenchymal tumors treated with fractionated radiotherapy between 1982 and 2003 - a single institution’s experience" pot
... neurofilaments (less aggressive) from those with or more mitoses and a lack of neurofilament staining (more aggressive) In the pineocytoma patients of our series histological diagnosis was reached by stereotactic ... all patients with PPT to detect recurrence at an early state, since successful salvage therapy is possible Pineoblastomas are classified as PNETs The main indicators of prognosis for PB seem ... biopsy only, none of the patients underwent open resection This increases the likelihood of misdiagnosis, since in small tissue samples potentially less-differentiated tumor cells might be missed...
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Báo cáo y học: "Positive anti-citrullinated protein antibody status and small joint arthritis are consistent predictors of chronic disease in patients with very early arthritis: results from the NOR-VEAC cohort" pot
... persistent synovitis In conclusion, our results show that ACPA positive early arthritis with involvement of small joints in the extremities is likely to progress to persistent disease As well as supporting ... for chronic disease Our results confirm that RA patients and patients prescribed with DMARDs have common characteristics, and this supports the validity of the strategy This is further supported ... Persistent synovitis Ninety-eight (25.5%) patients had persistent synovitis during follow-up Joint counts, positive ACPA or RF status, morning stiffness, HAQ, and higher age were factors associated...
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Báo cáo y học: " Vascular endothelial growth factor: an angiogenic factor reflecting airway inflammation in healthy smokers and in patients with bronchitis type of chronic obstructive pulmonary disease?" ppsx
... basis, the aim of this study was not only to assess VEGF levels in induced sputum of healthy smokers and of smokers with bronchitis type of COPD, but to further assess smoking as a potential cause ... immunosorbent assay kit (ELISA) (R & D Systems, Minneapolis, Minnesota, USA) Statistical analysis Data were expressed in mean (± SD) or median values Inflammatory markers and VEGF were expressed ... values and inter-quartile range Differences between subjects' groups were initially assessed by Kruskal-Wallis test, and if significant, the Mann-Whitney rank test was then assessed Correlations...
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Báo cáo y học: " Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis"
... previously described [1] The null hypothesis was rejected at the 0.05 level in all analyses Statistical analysis Results Statistical analyses were performed using SigmaStat (version 3.0, SPSS Inc., ... progression, as assessed by scores of muscle strength Consistently, in experimental studies we found that Vgf content in the CSF, serum and spinal cord motorneurons is a specific predictor of onset ... diagnose ALS and associates with clinical severity Quantitative ELISA assay revealed that the decreased CSF levels of total full-length Vgf (P
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báo cáo hóa học: " Vascular endothelial growth factor-A and chemokine ligand (CCL2) genes are upregulated in peripheral blood mononuclear cells in Indian amyotrophic lateral sclerosis patients" pot
... considered significant at ≤0.05 Statistical analysis was performed by statistical package and service solutions (SPSS) 16 software Results were analyzed by two independent and masked researchers ... levels The increased PBMCs CCL2 is consistent with reports where elevated CCL2 mRNA was observed in spinal cord and skeletal muscles of ALS patient s autopsies and SOD1 mutated ALS mice [14,22] As ... Indian ALS patients is ~9 years after disease onset which is significantly higher as compared to their Western counterparts who survive for 3-6 years after disease onset [6-8] Because of this contradicting...
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Báo cáo toán học: "Flexible Color Lists in Alon and Tarsi’s Theorem, and Time Scheduling with Unreliable Participants" pot
... each such v ∈ V1P \ V1C Mrs Correct has to use (and use up) one eraser from the corresponding stack Sv She loses if she runs out of erasers and cannot that, i.e., if already Sv = ∅ for a still ... Apart from this very successful study of the algebraic method behind Alon and Tarsi s Theorem, combinatorialists always search for purely combinatorial proofs, since this usually helps to understand ... already have lost more erasers One example where Paint s winning strategy is like this is K3,3 with one eraser at each vertex Alon and Tarsi s Theorem In this section we discus a surprising connection...
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Báo cáo y học: "Binge eating symptomatology in overweight and obese patients with schizophrenia: a case control study" ppt
... distress [10] Those characteristics argue for an assessment of this eating disorder in patients with schizophrenia, a population more vulnerable to distress and low self esteem A previous descriptive ... by a senior psychiatrist or psychologist Purging and other compensatory behaviours were also investigated With regard to this assessment, patients and controls were classified as having (1)no ... induced by AP drugs is not necessarily associated to obesity Due to this consideration, the threshold of BMI = 28 was chosen Data analyses Statistical analysis was performed by SPSS 12.0 program...
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Báo cáo y học: "Serum IL-15 in patients with early systemic sclerosis: a potential novel marker of lung disease" potx
... Hesselstrand R, Scheja A, Akesson A: Mortality and causes of death in a Swedish series of systemic sclerosis patients Ann Rheum Dis 1998, 57:682-686 Steen V: Predictors of end stage lung disease ... three groups of systemic sclerosis patients Low, intermediate and high serum IL-15 levels patients depict three groups of systemic sclerosis patients with different skin score (white bars), different ... (SSc)); fine dotted line, detection level dcSSc, diffuse cutaneous systemic sclerosis; lcSSc, limited cutaneous systemic sclerosis; n .s. , not significant cutaneous SSc predominated The VC was...
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Báo cáo y học: "Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia" docx
... considerations Such SNPs were associated not only with the diagnosis of FM, but also with the severity of the illness as assessed by FIQ scores Additionally, we found SNP rs4633 to be associated with ... rs6269 and pain and fatigue as well as between rs165599 and disability and morning stiffness LD analyses between the six SNP markers showed that four of them – rs6269, rs4633, rs4818, and rs4680 ... (24) rs6269 0.015a NS rs4633 NSa NS rs4818 0.001 NS rs4680 0.023a NS rs20907 NSa NS rs16559 aχ2 test; NSa NSa NS, not significant in amino acid composition), was not found to be associated with...
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báo cáo khoa học: " Amyotrophic lateral sclerosis-motor neuron disease, monoclonal gammopathy, hyperparathyroidism, and B12 deficiency: case report and review of the literature" potx
... symptoms and signs with PHP and ALS Patients with PHP may develop muscle weakness and atrophy involving the lower extremities but the weakness tends to be symmetric and involves the proximal muscles ... brisk muscle stretch reflexes are seen along with plantar responses and muscle cramps Importantly, patients with PHP often also display non-motor findings such as ataxia, paresthesias, and cognitive ... of ALS [6], most of the subsequent literature argues against this, with less than successful trials using various immunomodulatory agents and Rison and Beydoun Journal of Medical Case Reports 2010,...
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Báo cáo y học: " Effectiveness of an intercultural module added to the treatment guidelines for Moroccan and Turkish patients with depressive and anxiety disorders" ppt
... Trimbos/iMTA questionnaire for costs associated with psychiatric illness (TIC-P) Rotterdam, Institute for Medical Technology Assessment; 2002 32 Meadows G, Harvey C, Fossey E, Burgess P: Assessing ... ([33,34,33,35]); severity of depressive symptoms (Inventory of Depressive Symptoms self report version (IDS) [36]); severity of generalised anxiety and panic symptoms (Beck Anxiety Inventory self-report version ... Recruitment and measurement protocol intervention therapists’ knowledge, awareness and skills in diagnosing and treating Moroccan and Turkish patients with depression and anxiety disorders To improve...
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Báo cáo y học: " B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both " pot
... groups are shown * - P ≤ 0.05; ** - P ≤ 0.01; ***- P ≤ 0.001 from MS patients with active and stable MS as well as from healthy and disease controls Sera from MS patients with active disease exhibited ... human endogenous retroviruses with multiple sclerosis and possible interactions with herpes viruses Rev Med Virol 2005, 15:179-211 Simmons A: Herpesvirus and multiple sclerosis Herpes 2001, 8:60-63 ... antibodies measured by TRIFMA vs the levels of surface expression of HERV-H Env and HERV-W Env epitopes on B-cells and monocytes from patients with active MS (AMS), stable MS patients (SMS), and healthy...
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Báo cáo y học: " Effect of oral beta-blocker on short and longterm mortality in patients with acute respiratory failure: results from the BASEL II-ICU study" ppt
... (version 15.0, SPSS Inc., Chicago, IL, USA) Comparisons were made using the t-test, Mann-Whitney U test, Fisher s exact test and chisquare test as appropriate Mortality risk was estimated using ... exclusion of patients with sepsis or shock our findings cannot be generalized to these subgroups of ICU patients No adjustment for APACHE or SAPS II score has been performed in our linear regression ... records, the response to therapy and autopsy results in those patients who died in the hospital Adjudicated diagnosis was performed by choosing one or more diagnoses from a pre-specified list that...
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Báo cáo y học: "Persistence with anti-tumour necrosis factor therapies in patients with psoriatic arthritis: observational study from the British Society of Rheumatology Biologics Register" pps
... Materials and methods Subjects included in the study were selected from the British Society for Rheumatology Biologics Register (BSRBR) [10] The BSRBR aims to recruit patients with rheumatic diseases ... chronic obstructive pulmonary disease, diabetes, thyroid disease, peptic ulcers, hepatic disease, renal disease, demyelinating disease, epilepsy, depression, tuberculosis, cancer bReference category, ... persistence rates with anti-TNF therapies in a large unselected population of patients with PsA We have demonstrated that persistence in patients with PsA is at least as good as in those with RA, and that...
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Báo cáo y học: "Seropositivity is associated with insulin resistance in patients with early inflammatory polyarthritis: results from the Norfolk" pot
... polyarthritis (IP) and is particularly associated with seropositive disease [1-4] Insulin resistance (IR) is known to be increased in patients with established RA [5,6] and has been shown to be a risk ... serological status (RF and ACPA) and insulin resistance measured as HOMA-IR This association persists after adjustment for classic cardiovascular risk factors and other IP-related factors As far as we ... analysed using an ELISA kit from DRG diagnostics (Immunodiagnostic Services, UK) on fasting frozen serum samples in Manchester Serum insulin was measured by sensitive ELISA (Immunodiagnostic Systems...
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Báo cáo khoa học: Proteomic characterization of lipid raft proteins in amyotrophic lateral sclerosis mouse spinal cord pot
... changes in ALS disease pathology is discussed Results Lipid raft fraction isolation and purity analysis Lipid rafts are specialized areas on the plasma membrane, and act as platforms for spatiotemporal ... recent studies have shown that ALS is not an autonomous disease; that is, various non-neuronal cells, including astrocytes and microglia, can contribute to disease progression [9–11] As plasma membrane ... rafts isolated from WT mouse spinal cord THIL_MOUSE Acetyl-CoA acetyltransferase, mitochondria precursor SYUA_MOUSE a-Synuclein NEGR1_MOUSE SPRE_MOUSE DHSA_MOUSE PP2AA_MOUSE SPN90_MOUSE SUSD2_MOUSE...
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