... known to protect the brain against focal ischemia [35] In order to investigate theroleofthe endocannabinoid system inthe neuroprotection afforded by estrogen, the effect of acute treatment ... with the guidelines ofthe European Community Council Directive 86 ⁄ 609, included in D.M 116 ⁄ 1992 ofthe Italian Ministry of Health Focal cerebral ischemia Brain ischemia was induced by MCAo in ... from the carotid bifurcation, until mild resistance was felt, thereby indicating occlusion ofthe origin ofthe MCA inthe Willis circle The silk suture was tightened around the intraluminal...
... as the development of offshore financial centers and off-balance-sheet methods of financing); • the diminishing effectiveness of traditional controls due to financial innovation (including the ... 1980s Inthe case of S&Ls the insurance premium was set by statute in 1950 at 1/12 of 1% ofthe assessable deposits and was the same for all insured institutions regardless ofthe riskiness of their ... to being changed and enforced inthe interest ofthe regulated industry, rather than inthe interest ofthe economy at large General laws, on the other hand, tend to be more immune and therefore...
... in Finland Arthritis Rheum 2003, 48:59-63 Hakkinen A, Kautiainen H, Hannonen P, Ylinen J, Makinen H, Sokka T: Muscle strength, pain, and disease activity explain individual subdimensions ofthe ... ried out in compliance with the Declaration of Helsinki Ethics committees or internal review boards of participating institutes approved the study, and informed consent was obtained from the patients ... and mortality in RA, in other conditions, and inthe general population [49] HAQ is an important outcome measure in clinical trials and inthe documentation of patient status in clinical care [33]...
... upper gastrointestinal surgeons with training in these techniques may have an increasing roleinthe diagnosis of lymphomas In cases of intrathoracic lympahadopathy, newer minimally-invasive techniques ... University inthe late 1960s which showed that the performance of a staging laparotomy altered the stage ofdiseasein 42% of cases, up regulating in 28% and down regulating in 14% of cases [2] The ... baseline against which the effects of chemotherapy may be judged The aim of this study was to examine whether the 21st century surgeon still has a role to play inthe diagnosis and management of...
... in Finland Arthritis Rheum 2003, 48:59-63 Hakkinen A, Kautiainen H, Hannonen P, Ylinen J, Makinen H, Sokka T: Muscle strength, pain, and disease activity explain individual subdimensions ofthe ... ried out in compliance with the Declaration of Helsinki Ethics committees or internal review boards of participating institutes approved the study, and informed consent was obtained from the patients ... and mortality in RA, in other conditions, and inthe general population [49] HAQ is an important outcome measure in clinical trials and inthe documentation of patient status in clinical care [33]...
... Recombinant activated factor VIIa in an unselected series of cases with upper gastrointestinal bleeding Thromb Res 2005, Epub ahead of print 18 Rizoli SB, Chughtai T: The emerging roleof recombinant ... Stein Dr Rizoli presents accurate and important information concerning the off-label use of rFVIIa The clinical situation presented, however, is more akin to the coagulopathy seen in trauma, in ... Frolke JP: Theroleof recombinant factor VIIa inthe treatment of life-threatening haemorrhage in blunt trauma Injury 2005, 36:495-500 Boffard KD, Riou B, Warren B, Choong PI, Rizoli S, Rossaint R,...
... old, weight 20 ± kg) were anesthetized using propofol (3 mg/kg) and orotracheally intubated inthe supine position Anesthesia was maintained with a continuous infusion of midazolam (0.3 mg/kg per ... inoculation pneumonia and it was therefore impossible to separate the effects of lung infection from those of mechanical ventilation inthegenesisof bronchiolar and alveolar distention Inthe ... monitoring and blood sampling All animals were treated according to the guidelines ofthe Department of Experimental Research ofthe Lille University (Lille, France) and to the Guide for the Care...
... apoptosis in a single model of lung injury To evaluate theroleof VEGF inthe apoptosis of endothelial cells and their barrier function inthe injured lung, we evaluated the effects of exogenous ... monolayer To determine the protective effect of VEGF on the endothelial cells, we measured the albumin influx into the lower chamber through the endothelial monolayer If the tightness ofthe monolayer ... staining and immunostaining ofthe pro-apoptotic proteins caspase-3, Bax, AIF, and cytochrome C VEGF attenuated the increases in permeability ofthe HPAEC monolayer and the apoptosis of HPAECs induced...
... seconds of PDT (Fig 1E-G) The changes after PDT were observed only inthe irradiated area The remainder ofthe retina was intact; thus the significance of retinal histological changes inthe irradiated ... well defined by comparison with the non-irradiated retina On the basis of these preliminary findings, we performed PDT for 20 seconds inthe following experiments, since this duration of PDT did ... and protein levels increased immediately and transiently inthe retina after PDT Influence of VEGF inhibition after PDT To explore theroleof increased VEGF after PDT, we injected a VEGF inhibitor,...
... anesthesia with a combination of ketamine/xylazine inthe dose of 20 mg/kg/5 mg/kg (intraperitoneal) Treatment was initiated on the same day of arthritis induction Drugs The reference drug indomethacine ... measurements of tibiotarsal joint is that it measures the limb in three dimensions and therefore takes into account any variability ofthe pattern of swelling of individual limbs The volume of a hind ... treadmill as the input A mirror is placed at an angle of 45° below the belt section ofthe chamber, which allows the viewing of floor/paw contacts The video essentially captures the footprints of the...
... autopsy The lack of a decrease inthe proportion of missed diagnoses during the past decades does not indicate a lack of progress in medical science since the types of missed diagnoses varied inthe ... guidelines ofthe Infectious Diseases Society of America on the treatment of invasive candidiasis in intensive care reinforce this [21] Autopsies are useful for understanding pathophysiology There ... to 32% inthe 1980s, and an increase in undiagnosed infections of 30% Gerain and colleagues [36] studied the causes of death in oncology patients who died in an ICU In 23.5% of all deaths the primary...
... number of NK cells, and the increase of NK cells might play an important roleinthe pathogenesis of BD Conclusions Qa-2 levels were lower inthe PBMC of BD mice than inthe PBMC of normal mice In ... frequency Furthermore, we found that thein vivo injection of Qa-2 siRNA reduced the Qa-2 mRNA and protein levels in PBMC of BD mice and deteriorated BD symptoms Taken together, these findings indicate ... did not increase the level of IFNγ These findings are in accordance with the finding that HLA-Gexpressing cells showed significantly reduced levels of IFNγ [33] Lee et al Journal of Inflammation...
... considerations supporting its roleinthe treatment of vasodilatory shock have been demonstrated Vasopressin inhibits the synthesis of iNOS, blunts the increase in cGMP induced by NO and directly inactivates ... mcg/kg/min Arginine-vasopressin (Pitressin; Monarch Pharmaceuticals, Bristol, United Kingdom) infusion was started at a rate of 0.0003 U.I./Kg/min Within minutes, a pump flow at 100 ml/kg/min generated ... (iv) boluses of 500 mcg of epinephrine (by institutional protocol: 25 mcg/kg every minutes) were given while oxygen inspiratory fraction was increased to CPB was instituted in minutes in order to...
... modulate the inflammatory profile after a viral infection by blocking the poly(I: C) induced chemokine and cytokine production while maintaining the antiviral activity [28,59] As epithelial cells ... the review, all authors contributed in writing and reviewing the paper All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests ... The effect of additions of fluorine to the diet ofthe rat on the quality ofthe teeth 1925 Studies on experimental rickets XXI An experimental demonstration ofthe existence of a vitamin which...
... and elafin inthe lung SLPI Gene structure, protein and antiproteinase activity SLPI is one ofthe two members ofthe ALP superfamily of proteinase inhibitors (the other being ESI/elafin; see ... fight infection together with other molecules ofthe collectin family [such as the surfactant proteins A (SP-A)] and defensins (indicated by 1) In addition, SLPI and elafin have a rolein modulating ... Because ofthe previously mentioned characteristics of SLPI and elafin as ‘alarm molecules’ involved inthe regulation of early events inthe inflammatory process, the overexpression of these inhibitors...
... eosinophils also synthesize interleukin-5, indicating that autocrine production of interleukin-5 may contribute to the chronicity of inflammation [41,42] The interleukin-5 receptor is inthe ... autophosphorylation Like interleukin-3 and GM-CSF, interleukin-5 induces rapid tyrosine phosphorylation of several proteins, further indicating that tyrosine kinases are involved inthe cellular activation ... but there is no difference between the two groups inthe expression of Th1-type cytokine mRNA such as interferon-γ [82–85] The predominant source of interleukin-4 and interleukin-5 mRNA in asthmatic...
... data) These findings suggest, both in humans and in mouse models of SCD, that there is increased oxidative burden and that alterations inthe redox state may play a roleinthe development of vaso-occlusion ... suggesting that the development of ACS in SCD may be accompanied by PMN infiltration into the lungs [31] SCD patients have increased levels ofthe PMN chemokine IL-8 during VOC, suggesting that during ... [35] Roleofthe endothelium in oxidant production during acute chest syndrome In addition to being a potential target for oxidative damage, thevascular endothelium may play a primary rolein the...