diffusion tensor imaging in rat models of invasive brain tumors
Tài liệu Role of diffusion-weighted imaging in the diagnosis of gynecological diseases pdf
... MR imaging: fast MR imaging and diffusionweighted imaging Int J Clin Oncol 11:278–285 26 Thoeny HC, De Keyzer F (2007) Extracranial applications of diffusionweighted magnetic resonance imaging ... (2005) Diffusionweighted echo-planar MR imaging and ADC mapping in the differential diagnosis of ovarian cystic masses: usefulness of detecting keratinoid substances in mature cystic teratomas ... suppression and parallel imaging technique (SENSE factor of 2) Imaging time of DWI was 90 s for 20 slices Detection of uterine malignancy The ADC values of uterine cancers are lower than of normal tissue...
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Báo cáo y học: " Ranking candidate genes in rat models of type 2 diabetes" pptx
... Department of Genome Sciences, University of Washington, Seattle; 2005 Johnson JD, Misler S: Nicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human ... "irrelevant" in the manual rating The mean CGC point in this group of genes was 7.5, ranging from 2.4 to 20.3 Niddm18 In total, 72 genes were ranked by the CGC application In the manual inspection ... suggest an increased risk of type diabetes as a consequence of low adiponectin levels [24] In the CGC application, CDH13 obtains 38.9 points from only one single matching keyword ("adiponectin") However,...
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Báo cáo y học: "Diffusion tensor imaging of frontal lobe white matter tracts in schizophrenia" pps
... directionality of water diffusion at a single voxel with high values indicating all diffusion in one direction and low values indicating diffusion in all directions Diffusion tensor analysis also yields ... whole brain Each tract length is measured from the individual voxel location in the internal capsule region of interest along the tract to its termination Manual tracing of the anterior limb of ... brain width 100 Tract path termination locations We separately examined the x, y, and z coordinates of the centroids of tracts termination positions, for the tracts in each subject that originated...
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Báo cáo y học: " In vivo imaging approaches in animal models of rheumatoid arthritis" pot
... possible An alternative mode of imaging is the use of single photon imaging of γ-emitting isotopes like 11 1In or 99Tc Imaging of γ-emitting isotopes is referred to as single photon emission commuted ... rheumatologists interested in surgical procedures for in vivo imaging, there is a rich arsenal of procedures for imaging within almost all major organs of mice or rats Almost all were developed originally ... No Dustin Table Summary of in vivo imaging methodologies Imaging mode Invasiveness Sensitivity, resolution, time scale Advantages Disadvantages Bioluminescence Anesthesia ~100 cells, mm, minutes...
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Báo cáo khoa học: Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization pot
... in the expression of p27Kip, a cyclin kinase inhibitor Thus, the increased expression of cyclin E and cyclin E ⁄ CDK2 appeared to be the result of increased production and not decreased cyclin ... The increased FAEES activity resulted in increased production and accumulation of ethyl esters in the choroid of alcoholfed rats, with the size of the increase related to the number of weeks of ... further regulated by cyclin kinase inhibitors [33,48,49] Although we observed a 3.0-fold increase in the expression of cyclin E and cyclin E ⁄ CDK2 in the choroid of alcohol-fed rats at 10 weeks, we...
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Báo cáo sinh học: "Histone modification enhances the effectiveness of IL-13 receptor targeted immunotoxin in murine models of human pancreatic cancer" doc
... NI, Husain SR, Kreitman RJ, Haas GP, Pastan I, Debinski W: Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 ... significant decrease in tumor size was observed In addition, 50% of mice showed complete elimination of their tumors in combination group Next, we evaluated anti-cancer effect of combination of SAHA and ... be used in cancers expressing even low levels of IL-13 a2 to enhance the intensity of the immunotoxin anti-cancer response Indeed, we demonstrate that pre-treatment of tumor cell lines in vitro...
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Báo cáo sinh học: "Pro-apoptotic activity of a-bisabolol in preclinical models of primary human acute leukemia cells" pptx
... instructions Proteins were detected using the ChemiDoc XRS Imaging System (Bio-Rad) Cytosolic and mitochondrial fraction preparation Cell pellets were suspended in 100 μL of solution containing ... on proliferation of the cell line Means ± SD of experiments Right side Plot showing the corrisponding combination index (CI) vs the fraction affected (Fa) CI values are
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báo cáo hóa học: " Gait dynamics in mouse models of Parkinson''''s disease and Huntington''''s disease" doc
... administration (i.p 30 mg/kg/day) Gait indices, including stride duration, stance duration, swing duration, and stride length, change with changes in walking speed We eliminated the confounding ... was increased and stride duration was decreased in forelimbs and hind limbs of MPTP-treated mice A decrease in stride duration can be attained by decreases in stance duration and swing duration ... demonstrating coordinated stepping, despite hind limb failure of stepping The signals of left and right hind limbs are not coordinated and reflect artefacts associated with the belt contacting the...
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báo cáo hóa học: " Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD" pptx
... profile Alternative activation gene profiles in mouse models of AD Since alternative activation could be demonstrated in vitro using the expression of specific genes, we determined if mouse models ... Resistin family lar to those stages observed in chronic inflammatory diseases of the lung or liver, including the induction of alternative activation A shift to alternative activation in brain innate ... the involvement of Th-1 cytokines such as interferon-γ (IFN-γ), a "master" cytokine that orchestrates the coordinated induction and production of the "killing" phase [4-6] However, the gene profile...
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báo cáo hóa học:" Histone modification enhances the effectiveness of IL-13 receptor targeted immunotoxin in murine models of human pancreatic cancer" pot
... NI, Husain SR, Kreitman RJ, Haas GP, Pastan I, Debinski W: Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 ... significant decrease in tumor size was observed In addition, 50% of mice showed complete elimination of their tumors in combination group Next, we evaluated anti-cancer effect of combination of SAHA and ... be used in cancers expressing even low levels of IL-13 a2 to enhance the intensity of the immunotoxin anti-cancer response Indeed, we demonstrate that pre-treatment of tumor cell lines in vitro...
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Báo cáo hóa học: " Research Article Imaging Arterial Fibres Using Diffusion Tensor Imaging—Feasibility Study and Preliminary Results" potx
... successful in determining their lead angles Results The process of determining the fibrous structure of the aortic tissue is illustrated in Figure 3, where all of the steps in the imaging and postprocessing ... Biospin, Germany) Magnetic Resonance Imaging (MRI) scanner The sample was scanned within 24 hours of slaughter according to the following Diffusion Tensor Imaging (DTI) acquisition protocol: spin ... kinds of acquisitions, MedINRIA applies a maximum likelihood strategy The estimation of the tensor, together with the use of Log-Euclidean metrics for tensor processing, improves the quality of...
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Báo cáo khoa học: "Study on mechanism of multistep hepatotumorigenesis in rat: development of hepatotumorigenesis" pdf
... activity increased continuously during our study The effect of carcinogenesis on the free radicals concentration needs further examination In the present study, DEN administration initially 57 induced ... localization of inducible nitric oxide synthase and 3-nitrotyrosine in preneoplastic and neoplastic rat livers induced by continuous infusion of N-nitrodiethyl amine with osmotic mini-pumps Carcinogenesis ... samine in the rat Institute of Basic Science of Inhwa University 1992, 13(2), 85-96 Luciana, T., Paolo, P and Mario, U D Mechanisms of the enhanced liver carcinogenesis by choline in female rats:...
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Báo cáo y học: "The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease" pot
... regulated by retinoic acid and is often induced upon activation of this pathway [33] We were interested in confirming these findings and determining the kinetics of Crabp2 induction during OA Further, ... to joint instability or in OA Manipulation of the retinoic acid signalling pathway may prove useful in modifying the clinical course of OA The joint instability models presented herein in contrast ... retinoid signalling pathway were found to be significantly elevated in the joints of the aforementioned rat OA joint instability model, including genes encoding proteins involved in retinoic acid...
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Báo cáo y học: "4th meeting of the EU research network EUROME: From the identification of genes and cellular networks in murine models of arthritis to novel therapeutic intervention strategies in rheumatoid arthritis, London, UK, 9 March 2004" pot
... activation resulting in innate cell mediator activation and the production of inflammatory cytokine interleukin-1 and TNF-α, leading to joint destruction In recent studies, mice depleted of macrophages ... More importantly, knocking out the expression of gelsolin, an actin-binding protein with filament-severing properties found downregulated in RA, resulted in mild exacerbation of the arthritic phenotype ... as expression of antiapoptotic proteins Bcl-2 and members of the inhibitor of apoptosis family (cIAP-1, XIAP and survivin, which directly bind to and inhibit caspases), was strikingly reduced...
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Báo cáo y học: " Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients" pdf
... reduction in local production of proinflammatory cytokines, thereby reducing their circulating levels and abolishing a sensitizing effect on naïve joints A conflicting finding was the protection of ... infect proliferating and quiescent cells Direct injection of adenoviruses into the joint cavity results in significant transduction in the synovial lining Injection of firstgeneration, replication-deficient ... be injected into the enclosed joint cavity, with minimal risk of leakage to the blood circulation Because of this, precise targeting is not needed in RA, unlike in the treatment of cancer Findings...
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Báo cáo y học: "The role and clinical implications of G6PI in experimental models of rheumatoid arthritis" pptx
... dilution (1:50) in the serum of 64% of RA patients but not in control individuals However, a number of other investigators did not find increased levels of α-G6PI antibodies in the serum of patients ... preparation used in the initial study was found to be contaminated with other proteins, and RA sera contained antibodies against some of these other proteins [81] Taken together, these findings indicate ... RA in many clinical and pathological respects This surprising finding induced intense research into the pathophysiology of arthritis in the K/B×N mice Autoantibodies are important players in...
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Báo cáo y học: "Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis" potx
... assessment of zygapophyseal joints (a) Macroscopic picture of a zygapophyseal joint from a patient with ankylosing joints spondylitis (AS) (b) Hematoxylin and eosin staining of a zygapophyseal joint ... signs, superior and inferior articular processes of the zygapophyseal joint; hash sign, processus spinosus) (b) Hematoxylin and eosin staining, revealing dense infiltrations of mononuclear cells ... and inferior articular processes of the zygapophyseal joint; hash sign, processus spinosus) (b) Hematoxylin and eosin staining of the zygapophyseal joint, revealing numerous mononuclear cells in...
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Báo cáo y học: "Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis" doc
... significantly inhibited FGF8-induced incorporation of [3H]thymidine Articular destruction by intraarticular injection of FGF8 into the rat knee joint The activity of FGF8 on the knee joint was tested ... administered intraperitoneally instead of the antibody solution In a saline group of animals, saline was injected in the knee joint instead of the administration of MIA After days, synovial lavage ... An injection of 50 μg/site FGF8 increased the concentration of S-GAG in joint fluid (Figure 5a) The amount of S-GAG in the FGF8 injection group was 4.2 times higher than that of the saline injection...
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Báo cáo y học: "Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination" pot
... the development of RA [13] Alterations in the citrullination of myelin proteins and autoimmune targeting of citrullinated myelin proteins have been observed in MS Myelin basic protein (MBP) is partially ... inflamed CIA joint and EAE brain tissue Our results suggest that citrullination of synovial proteins in CIA and brain proteins in EAE generate neoantigens capable of provoking anti-citrulline antibody ... with citrullinated filaggrin, a protein expressed in stratified epithelium but not in joints [4,6] It is interesting that many of the citrullinated proteins identified in inflamed CIA joint tissue...
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