differential diagnosis of amyloid in surgical pathology organized deposits and other materials in the differential diagnosis of amyloidosis
Control of Dioxins (and other Organochlorines) from the Pulp and Paper Industry under the Clean Water Act and Lead in Soil at Superfund Mining Sites: Two Case Studies in EPA''''s Use of Science potx
... byproduct of combustion, some chemical manufacturing, some bleaching of pulp and paper, and other industrial processes involving chlorine and other halogens In the U.S., municipal and medical waste incineration ... of the vernacular of many of those providing the information and of many of the ultimate users of the study results Figure A presents a simplified model of the fate and transport of science in ... Dioxin from Pulp and Paper and Lead in Soil at Mining Sites i Abstract This paper discusses EPA’s acquisition and use of science in addressing dioxins (and other organochlorines) from the pulp and...
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Báo cáo y học: " Cysteine 95 and other residues influence the regulatory effects of Histidine 69 mutations on Human " potx
... proviruses replacing the six point mutations in the wtpse backbone with the corresponding NL4-3 amino acids individually or in combination (Figure 1B) and tested their Gag processing efficiencies ... highlighted in red or green and histindine 69 in blue (B) The pGEX-3X derived plasmids encoding for GST-TFR-PR-FLAG fusions bearing the indicated mutations were introduced into E coli BL21(DE3) and induced ... facilitating Figure Cysteine 95 and other residues dampened the inhibitory effect of H69E on protease autoprocessing in transfected mammalian cells (A) The indicated proviral DNAs were transfected into...
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Báo cáo khoa học: Differential involvement of protein kinase C alpha and epsilon in the regulated secretion of soluble amyloid precursor protein docx
... processing of APP in these cells In summary, the results indicate that PKCa and PKCe have differential roles in the regulation of APP processing and sAPPa release in SH-SY5Y cells – the former being ... data in the literature that indicate PKCe as the only protein kinase isoform involved in the signalling pathway downstream of muscarinic m3 receptors in SK-N-BE(C) neuroblastoma cells [15] The ... resulted in the inhibition of phorbol ester-induced sAPPa release [14] It is worth mentioning that the involvement of PKCa in these experiments has been ruled out because of the lack of inhibition...
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Báo cáo y học: "ncreased serum HO-1 in hemophagocytic syndrome and adult-onset Still''''s disease: use in the differential diagnosis of hyperferritinemia" docx
... malignancy, including non-Hodgkin's lymphoma, multiple myeloma, and acute myeloid leukemia, in three; and ASD and viral infection in the others The patients having more than two lineages of cytopenia, ... for the work reported in the manuscript, and no other financial interests that any of the authors may have could create a potential conflict of interest or the appearance of a conflict of interest ... for the diagnosis of HPS and ASD and for monitoring disease activity Further studies are required to determine the mechanism and sources of increased serum HO-1 in these diseases Clarification of...
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Báo cáo y học: " the Value of Serum Biomarkers (Bc1, Bc2, Bc3) in the Diagnosis of Early Breast Cancer"
... surrounding cytoplasmic membrane in at least 10% of invasive carcinoma cells or presence of membranous staining in less than 30% provided that the staining is intense (++) Score 3: Presence of intense ... were included in the study Blood sampling was performed after surgery in the patients who were underwent surgical intervention (in group1 and 2) The serum samples in group were obtained after the ... tumor antigens, and other gene products These approaches, however, have poor sensitivities and specificities since none of them alone is useful for the majority of the BC and none of them is specific...
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Báo cáo y học: Esterified Hyaluronic Acid and Autologous Bone in the Surgical Correction of the Infra-Bone Defects"
... without the application of a membrane in the treatment of infra bone defects, our clinical results are encouraging considering that in a similar study a mean value of the increase of the bone ... of bone graft in the damaged site and on the other hand, it creates an environment with a rich content of HA, with all the advantages deriving from the phenomenon The present study’s clinic and ... decisive role in 67 the regulation of proliferation, migration, and differentiation of the epithelial cells [2,12,18,19] Following the surgical treatment of adult periodontitis, the epithelial regeneration...
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Tài liệu Role of diffusion-weighted imaging in the diagnosis of gynecological diseases pdf
... with nine chemotherapy and/ or radiation therapy, ten controls) Further study using larger numbers of patients is needed to establish the accuracy of ADC measurement in monitoring the effect of therapy ... satisfactory in the evaluation of nodal status in this patient group Since the highly cellular tissue in reactive lymph nodes may also show increased intensity, the role of DWI and ADC in distinguishing ... demonstrates the tumor as hypointensity and the normal myometrium as hyperintensity (arrow) The ADC value within the mass is 0.87×10–3 mm2/s potential usefulness in the differential diagnosis The cystic...
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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
... that loss of copper binding (residues 92 and 75 are lost) contributes to the progress of amyloidogenesis Effect of copper binding on amyloid formation of other proteins A number of other amyloidogenic ... partitioning of the protein into an aggregated state The effect of copper binding on the secondary structure was determined using CD in the far UV To prepare proteins without Cu2+, part of each protein ... high affinity copper binding protein, and (b) that amyloid fibril formation of this protein is diminished in presence of Cu2+ ions Another interesting finding is that copper binding gets less strong...
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Tài liệu Báo cáo Y học: BIGH3 (TGFBI) Arg124 mutations influence the amyloid conversion of related peptides in vitro Implications in the BIGH3-linked corneal dystrophies pptx
... suggesting both these elements are of equal importance for the formation of amyloid from the C110)131 peptide Role of the NH2-terminal sequence The role of the NH2-terminal sequence of the 124 ... and 113 Our studies with the peptides lacking the residues 110–113 (excluding the two valine amino acids), showed a decrease in the formation of amyloid fibrils, suggesting the importance of the ... NH2-end of the peptides In the same way, removing the CONH2-terminus of the peptides resulted in increased amyloid fibril formation This increase may be due to a direct inhibitory effect of this nine-amino-acid...
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Tài liệu Báo cáo khoa học: A point mutation in the ATP synthase of Rhodobacter capsulatus results in differential contributions of DpH and Du in driving the ATP synthesis reaction pptx
... differences the ÔacidicÕ solution contained 20 mM Tricine instead of succinic acid Assuming complete equilibration of the K+ during the h preincubation (see above), the value of the K+/valinomycin diffusion ... enlarged view of Fig 3A showing only the rates obtained in the absence of a Du In this case, the impairment of the ATP synthesis rates in the mutant was higher than twofold, especially in the low DpH ... derivative of the fitting functions of the mutant and wild-type data and plotting their ratio, as in Fig 1C This derivative represents the rate of ATP synthesis at each time point The twofold difference...
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Báo cáo Y học: Differential regulation of the Fe-hydrogenase during anaerobic adaptation in the green alga Chlamydomonas reinhardtii pot
... detection of the protein using antibodies raised against the Fe-hydrogenase, the localization of the mature protein in the chloroplast stroma is indicated by a high content of hydroxylated and basic ... that the proteins containing two [4Fe–4S] clusters are ancestors of the Fe-hydrogenases [55] The N-terminus of the C reinhardtii and S obliquus proteins is strongly reduced, and conserved cysteines ... (ferredoxin) directly to the H-cluster Protein sequencing of the enzyme and recombinant expression of HydA in E coli To verify that the hydA ORF encodes the Fe-hydrogenase of C reinhardtii, the enzyme was...
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Báo cáo khoa học: Identification and expression of the first nonmammalian amyloid-b precursor-like protein APLP2 in the amphibian Xenopus laevis ppt
... present in the other members of the APP superfamily, such as the absence of the exon encoding the KPI domain and the lack of a second heparin-binding domain [3,4,13,26] Comparative analysis of the ... number of regions even more conserved (Fig 1) All 12 cysteine residues in the aminoterminal part of APLP2 are present in X-APLP2 The zinc-binding domain consensus sequence (GxExVCCP [13]) in the ... proteins are 91% and 100% identical, respectively, including the GYENPTY sequence that is present in all APP superfamily members and is involved in the intracellular routing of the proteins [17]...
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Accuracy of Clinical Signs in the Diagnosis of Pulmonary Tuberculosis: Comparison of Three Reference Standards Using Data from a Tertiary Care Centre in Rwanda doc
... testing was part of routine examination For HIV testing, specific informed consent was asked and counseling offered Approval for this study was obtained from the relevant authorities of the Ministry ... findings are not dissimilar from those of other authors A good sensitivity of fever and HIV infection, and a high specificity of haemoptysis and cavities have been found also in a study done in ... apical infiltrates, HIV infection, haemoptysis and fever) We identified the LCA model providing the best fit to the data by comparing the difference in likelihood statistic (L ), the Bayesian Information...
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Báo cáo khoa học: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein doc
... Supporting Information) We also determined the levels of c-secretase-unrelated ER protein (calnexin) and cytoskeleton protein (tubulin) in these cells as the internal control proteins The calnexin and ... Synoviolin is involved in the degradation of nicastrin gene p53 [19] and Parkin-associated endothelin receptor-like receptor [20] In this study, we addressed whether Synoviolin is involved in the ... Accumulation of immature NCT in synoviolin-null cells To investigate whether Synoviolin is involved in the degradation of PS cofactors, we first compared the levels of PS cofactors by immunoblotting between...
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UPDATES IN THE DIAGNOSIS AND TREATMENT OF VASCULITIS pot
... extravasation and perivascular deposition of immune complexes The increased tissue staining during the resolution phase, on the other hand, suggests a possible function of VEGF in the resolution of vascular ... activation of innate immunity Elevated levels of inflammatory cytokines are usually detectable in the serum and affected tissues in these diseases 15 16 Updates in the Diagnosis and Treatment of Vasculitis ... and prolonged survival of patients with AASV, it has its drawbacks; the worst being life-threat‐ ening infections early in the course of the disease and risk of malignancy in late stages of the...
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Báo cáo khoa học: Quenched hydrogen ⁄deuterium exchange NMR characterization of amyloid-b peptide aggregates formed in the presence of Cu2+ or Zn2+ ppt
... (broken lines), either in the form of aggregates formed in the presence of Cu2+ [(i) and (iii)] or Zn2+ [(ii) and (iv)], or as fibrils formed in the presence of EDTA [(v) and (vi)] The amount of amyloid ... Error bars indicate the experimental uncertainty of the measurements observed between the Cu2+-induced and Zn2+-induced aggregates, reflecting the differences in metal-binding properties of Ab [26,30,33–35] ... further assembly into amyloid Identification of structural differences between the fibrillar and the metal-bound aggregate forms is therefore of interest with respect to understanding the mode of...
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Báo cáo khoa học: Effects of sphingomyelin, cholesterol and zinc ions on the binding, insertion and aggregation of the amyloid Ab1)40 peptide in solid-supported lipid bilayers ppt
... line), and the binding affinity values and the magnitude of the spectral shift are given in Table Interaction of Ab with binary lipid bilayers As shown by the data in Fig 3, and by the KD values in ... 4.7 of the SM bilayer membrane Therefore, peptide binding is occurring to three different membrane structures in these studies The data presented in Table show that the binding interaction of the ... Factors affecting Ab binding in lipid bilayers Fig Binding and aggregation of Ab in a DOPC ⁄ SM ⁄ cholesterol (1 : : 1) bilayer in the presence of mM zinc ions Spectra were obtained using a high-resolution...
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Báo cáo khoa học: The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein ppt
... ADAM10 and TACE are involved in the shedding of APP, neither ADAM is involved in the shedding of ACE Furthermore we show that APMA can distinguish between the shedding of ACE and APP Materials and ... for the other ADAM, confirming the specificity of these ASOs [19] The ASOs reduced the level of their respective proteins in cell lysates but had little effect on the other protein (Fig 1B,C) The ... expressing ACE were transfected with the ASOs and then exposed to APMA and the levels of soluble ACE in the medium examined (Fig 5) APMA caused a twofold increase in the shedding of ACE from the...
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Updates in the Diagnosis and Treatment of Vasculitis Edited by Lazaros I. Sakkas and Christina Katsiari pptx
... extravasation and perivascular deposition of immune complexes The increased tissue staining during the resolution phase, on the other hand, suggests a possible function of VEGF in the resolution of vascular ... and prolonged survival of patients with AASV, it has its drawbacks; the worst being life-threat‐ ening infections early in the course of the disease and risk of malignancy in late stages of the ... activation of innate immunity Elevated levels of inflammatory cytokines are usually detectable in the serum and affected tissues in these diseases 15 16 Updates in the Diagnosis and Treatment of Vasculitis...
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Guidelines for the Diagnosis and Management of Food Allergy in the United States docx
... disease of the skin Symptoms include scaly, itchy rashes and blistering, weeping, or peeling of the skin The causes of the disease are unclear There may be a problem in the skin’s ability to maintain ... Howwere the Guidelinesdeveloped? The Guidelines are the culmination of a 2-year effort in which the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of ... involving IgE Why not use them? The safety of immunotherapy is uncertain Early studies of allergen-specific immunotherapy have had promising results, but the therapeutic effect and duration of...
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