diagnosis prophylaxis and treatment of central nervous system involvement in acute lymphoblastic leukemia
báo cáo khoa học: "Extensive central nervous system involvement in Merkel cell carcinoma: a case report and review of the literature" docx
... Page of Table Intraspinal metastases of Merkel cell carcinoma reported in the literature Year Age/gender Other metastasis Intraspinal involvement Level Time since detection Survival after diagnosis ... carcinoma of the spine J Clin Neurosci 2010, 17(8):1069-1071 doi:10.1186/1752-1947-5-35 Cite this article as: Abul-Kasim et al.: Extensive central nervous system involvement in Merkel cell carcinoma: ... report in the literature of spinal intradural metastases of MCC, which further contributed to worsening the patient’s prognosis because it restrained a debulking and decompressive laminectomy...
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The role of hydrogen sulfide in the central nervous system implications in the treatment of alzheimers disease
... tau is involved in microtubule assembly It serves as a binding for the tubulin Mutations in α-synuclein lead to loss of this binding ability, resulting in tubulin and α-synuclein aggregation Properly ... peroxynitrite-mediated tyrosine nitration and inactivation of alpha1-antiproteinase inhibiting peroxynitrite-induced cytotoxicity, intracellular protein nitration and protein oxidation in human neuroblastoma ... neurotransmitter in the brain The interaction of glutamate with the N-methyl-D-aspartate (NMDA) receptor is important in the workings of memory and learning In AD an increase in glutamate activity results in...
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Role of central nervous system ceramides and free radicals in a mouse model of orofacial pain
... acid, capsaicin and resiniferatoxin, leading to burning pain or itch It is found that NGF and bradykinin can induce changes in TRPV1 by activating of cAMP-dependent (cyclic adenosine monophosphate-dependent) ... prostaglandin E2 Chapter I Introduction General introduction of orofacial pain Similar brain structures are involved in the process of nociception and related expression of nociceptive behaviors in ... of clustering and segregation of sphingolipids, cholesterol and certain types of glycerophospholipids in the cell membrane, and evidence also showed the existence of raft-type domains in living...
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Effects of central nervous system free fatty acids, prostaglandins and lysophospholipids on allodynia in a mouse model of orofacial pain
... (Neuropathic Pain) These are abnormal pain states and are defined as pain initiated or caused by a primary lesion or dysfunction in the nervous system In clinical terms, Phase and pains are symptoms of peripheral ... damage, including neuropathies and central pain states Phases of Pain There are three phases of pain known: (a) Phase (Acute Nociceptive Pain) The mechanism involved can be viewed as a simple and ... limb of the internal capsule to the face area of the postcentral gyrus Orofacial Pain Diagnosis of orofacial pain is complicated because of the region’s density of anatomical structures, rich innervations...
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Diagnosis, Management, and Treatment of Hepatitis C: An Update docx
... been examined in the hope of limiting exposure to and the side effects of therapy Achieving an RVR is highly predictive of obtaining an SVR independent of genotype and regardless of the treatment ... strategy and remain within acceptable standards of treatment The issue of treatment of chronic HCV infection is in constant flux There is highly active clinical research in this area, and new information ... that treatment of HCV-infected children with peginterferon and ribavirin is safe and leads to SVR rates that are superior to those of standard interferon Accordingly, the combination of peginterferon...
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DIAGNOSIS, SCREENING AND TREATMENT OF ABDOMINAL, THORACOABDOMINAL AND THORACIC AORTIC ANEURYSMS pptx
... 0.49 % in women were caused by ruptured AAA in England and Wales Including the insufficiently defined cases, AAA caused 1.18% of all deaths in men and 0.56 % in women In men 65 years of age or ... (overall, at years these interventions occurred in 4.1% of patients in the EVAR group and 9.7 % in the open Diagnosis, Screening and Treatment of Abdominal, Thoracoabdominal and Thoracic Aortic Aneurysms ... process and studies have investigated a link between interleukin gene 28 Diagnosis, Screening and Treatment of Abdominal, Thoracoabdominal and Thoracic Aortic Aneurysms polymorphisms and AAA...
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Báo cáo y học: "Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection" ppt
... cytokines including interleukin-4 and -10 counteract the production of neopterin [21] The same is true for anti-inflammatory compounds including certain HMG-CoA reductase inhibitors (statins) and ... Neopterin Macrophage lineage Figure Induction of neopterin formation in brain cells Pro-inflammatory cytokines like interferon-γ (IFN-γ) induce expression of GTP-cyclohydrolase I in various brain ... confound diagnosis of ADC using CSF neopterin, particularly in the case of CMV encephalitis which may also be difficult to distinguish by neuroimaging and non-focal clinical findings, emphasizing...
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Exergoeconomic optimization and improvement of a cogeneration system modeled in a process simulator using direct search and evolutionary methods
... rate of exergy transfer, subscripts F and P indicate system fuel and system product, respectively, NK is the number of system components, and NP and NF are the numbers of system products and fuels, ... be minimized is the sum of the specific costs of the system products, which include the costs of capital investment, fuel, and operation and maintenance The total system product is the sum of ... variables on the system exergetic efficiency and on the system total cost; (iii) ranking of system components into main, secondary, and remainder; (iv) identification of the predominant cost (exergy...
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Study on epidemiologic and pathological characteristics and measures of prevention and treatment of infection caused trichocephalus spp in pigs in thai nguyen and bac kan
... medicines in experimentally and naturally infected porcines Determining of safety medicines by observing the response of porcines during 30 minutes to hour 2.4.7 Examination method in preventing and ... status of parasitic prevention and control in two provinces Formulating evaluation indicators, directly observing present status of porcine husbandry in studied regions Interviewing and collecting ... characteristics of Trichocephalosis in porcines 2.3.2.1 Survey on present status in preventing and controlling of parasitic disease in porcines in two provinces 2.3.2.2 The prevalence and infection intensity...
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Báo cáo y học: " Clinical review: Timing and dose of continuous renal replacement therapy in acute kidney injury" ppsx
... based on the BUN at initiation of treatment ‘Early’ and ‘late’ initiation of therapy were defined by stratifying patients using the BUN at initiation of therapy, using a value of 60 mg/dl to separate ... approximately mg/dl and were dialyzed to maintain a predialysis BUN of < 60 mg/dl in the intensive treatment arm and approximately 100 mg/dl in the non-intensive arm The average time to initiation of dialysis ... data remain inadequate to answer the question of appropriate indications and timing of initiation of CRRT in AKI The vast majority of patients with AKI are never treated with RRT, yet have increased...
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Báo cáo khoa học: "Mitochondrial DNA alterations of peripheral lymphocytes in acute lymphoblastic leukemia patients undergoing total body irradiation therapy" ppt
... China Dose-dependent plasmid-constructed ß-actin, HVR2 and CD standards were used in each run of real-time PCR Of these, both plasmids containing the CD breakpoint and the HVR2 region were kindly ... to detect single molecule of CD and high linearity was found (y = 3E-12e-0.6358x) in the range of standard samples CD levels in most of the samples were detected between Ct 35 and 39 In all samples ... mean of 39.4 ± 10.5 Of these, 10 are females and 16 males Besides, a total of 39 healthy volunteer individuals without IR were included in this study for comparing the difference of basal mtDNA and...
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Cancer of the Brain and Other Central Nervous System doc
... Cancer of the Brain and Nervous System Histologic Type of Tumor Classification NOS, C716 - Cerebellum, NOS, C717 - Brain Stem, C718 - Overlapping lesion of brain and C719 - Brain, NOS; SPINE: C701 ... Other Central Nervous System National Cancer Institute 205 SEER Survival Monograph Chapter 25 Cancer of the Brain and Nervous System Table 25.3: Cancer of the Brain: Race, Sex, Age (20+), Grade and ... Brain Stem, C718 - Overlapping lesion of brain and C719 - Brain, NOS For other CNS cancers, primary site of tumor is classified as the following: BRAIN: C700 - Cerebral meninges, C709 - Meninges,...
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báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... expressed within inflammatory brain lesions in MS [18,39-41], and CCL3 has been demonstrated in cerebrospinal fluid of MS patients with relapsing-remitting disease course [42] In Interestingly and consistent ... restricted areas of the spinal cord displaying focal inflammation and demyelination (Fig 2E) Quantification of CCR1, CCR2 and CCR5 mRNAexpressing cells in relation to the stage of demyelinating activity ... formation of focal areas of demyelination [31] and axonal injury and loss [32] Our results demonstrate a prominent accumulation of monocytes and macrophages expressing CCR1, CCR2 or CCR5 mRNA within and...
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Báo cáo sinh học: "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system" doc
... displayed scattered foci of demyelinated axons, including partial or complete loss of myelin sheaths and increases in inter-laminar splitting of the myelin sheaths Analysis of transverse sections (Figure ... following information: routinely used continuous intravenous infusions of 5-FU can result in steady-state plasma and cerebrospinal fluid (CSF) concentrations in the range 0.3-71.0 µM, and continuous ... repair of the myelinopathy found at this time point, examination of animals six months after 5-FU treatment revealed eventual loss of almost all cells and myelin in this tissue Hematoxylin and eosin...
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Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
... nNOS and iNOS in neurons increased when bacterial encephalitis occurred This is the first study of NOS expression in the goat brain with listeriosis The involvement of iNOS in bovine and caprine ... hematoxylin Magnification A and B, ×66 C and D, ×132 Immunohistochmical study of nitric oxide synthase in the central nervous system of goat Enhanced expression of nNOS and iNOS in L monocytogenes-infected ... of nNOS and iNOS in the nonneurological control brain Both nNOS and iNOS immunoreactivity was recognized in the brain of control goats No inflammatory cells were found in the brain sections of...
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báo cáo khoa học: "Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature" pdf
... central nervous system: serial MRI of brain and spinal cord Neuroradiology 2001, 43:599-607 14 Moore PM: Diagnosis and management of isolated angiitis of the central nervous system Neurology ... angiitis of the central nervous system: initial and follow-up MR features Neuroradiology 2009, 51:651-659 12 Ay H, Sahin G, Saatci I, Söylemezoğlu F, Saribaş O: Primary Angiitis of the Central Nervous ... Vasculitis of the nervous system Curr Opin Neurol 2004, 17:317-336 16 Calabrese LH, Furlan AJ, Gragg LA, Ropos TJ: Primary angiitis of the central nervous system: diagnostic criteria and clinical...
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Báo cáo y học: "The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI" ppsx
... below The finding of similar outcomes in males and females is reassuring Initial reports of inferior outcomes in girls came from relatively small studies using combinations of methotrexate and cranial ... effects of treatment Here, we report the results of intelligence tests for patients and controls assessed at baseline and at and year time-points after initiation of treatment Results During the ... boys Again, changes in therapy protocols such as lack of co-administration of high-dose methotrexate and avoidance of radiotherapy in young patients may explain the lack of difference in IQ in our...
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Báo cáo y học: "Ischemia as a possible effect of increased intraabdominal pressure on central nervous system cytokines, lactate and perfusion pressures" ppsx
... irrespective of the level of IAH Key messages • Intra-abdominal hypertension led to increases of ICP and ISP • Increased ICP and ISP resulted in decreases of CPP and SPP, respectively Marinis et ... marked in bold IAP, intra-abdominal pressure Cytokines (Table 1) Interleukin Lactate (Table 1) Abdominal insufflation to IAP 20 mmHg (T2) resulted in a statistically significant increase of IL-6 in ... concentration of N O and isoflurane was monitored continuously throughout the study in order to ensure that depth of anaesthesia was maintained and boluses of 25 to 50 μg fentanyl and mg midazolam...
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Báo cáo y học: "MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system" docx
... miRNAs1expressed in proliferating and/ or differentiating cells in the developing and adult zebrafish brain miRNAs expressed in proliferating and/ or differentiating cells in the developing and adult ... 20, and Table D in Additional data file 27) In contrast, miR-34 expression is absent from forebrain and midbrain and present only in the caudal ventral and lateral isthmus and hindbrain, including ... expressed in maturing cells of the CMZ (which are likely to still be proliferative) but expression is maintained only in amacrine cells of the inner nuclear layer (INL in Figure 2d) These patterns indicate...
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Báo cáo y học: "Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender" pdf
... latter findings, evidence for reduced energy metabolism in the brain during normal aging [47], and our finding of significantly reduced expression of Werner in the brain during normal aging suggest ... aging (Table S7c in Additional data file 1), including those encoding proteins involved in proteolysis (ubiquitin-specific peptidase 46 and cathepsin Z), transforming growth factor-β signaling ... during aging in brain regions were upregulated in the spinal cord, including genes of the UPS, for example (Table S3 in Additional data file 1) In contrast to the spinal cord, very few genes in the...
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